Association of VAMP5 and MCC genetic polymorphisms with increased risk of Hirschsprung disease susceptibility in Southern Chinese children.

abstract：:Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis ...

journal_title：Aging

authors： Wang C,Just A,Heiss J,Coull BA,Hou L,Zheng Y,Sparrow D,Vokonas PS,Baccarelli A,Schwartz J

更新日期：2020-06-19 00:00:00

abstract：:The estrogen membrane receptor GPR30 (also known as G-protein coupled receptor 30) has recently been shown to be involved in the regulation of oocyte maturation and cumulus expansion. However, whether GPR30 expression is regulated by gonadotropin stimulation and how it participates in the regulation of the maturation ...

journal_title：Aging

authors： Liu J,Yao R,Lu S,Xu R,Zhang H,Wei J,Zhao C,Tang Y,Li C,Liu H,Zhao X,Wei Q,Ma B

更新日期：2020-10-28 00:00:00

abstract：:Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA...

journal_title：Aging

authors： Chen K,Huang X,Xie D,Shen M,Lin H,Zhu Y,Ma S,Zheng C,Chen L,Liu Y,Liao W,Bin J,Liao Y

更新日期：2021-01-20 00:00:00

abstract：:Many studies have investigated how aging decreases human strength and endurance. However, understanding the effect of aging on human motor ability requires more than knowledge of the separate temporal profile of individual motor function because the structure of human motor ability is multi-dimensional. We address the...

journal_title：Aging

authors： Panday SB,Pathak P,Moon J,Ahn J

更新日期：2019-07-30 00:00:00

abstract：:Previous studies have shown that PCB1254 has an adverse effect on zebrafish retinal development, but the basic mechanism behind it is not clear. The purpose of this study was to investigate the molecular mechanisms of PCB-induced retinal dysplasia. RT-qPCR, immunoblotting, HE staining and immunofluorescence were adopt...

journal_title：Aging

authors： Zhang X,Zhang Q,Jiang Y,Zhang S,Hong Q,Guo X,Chi X,Tong M

更新日期：2019-10-16 00:00:00

abstract：:Family with sequence similarity 83, member A (FAM83A), as a potential tumor promoter, was reported to contribute to the progression of several malignant tumors. However, the significance of FAM83A in invasion and metastasis of non-small cell lung cancer (NSCLC) remains largely unknown. In this study, we found that FAM...

journal_title：Aging

authors： Zhou F,Geng J,Xu S,Meng Q,Chen K,Liu F,Yang F,Pan B,Yu Y

更新日期：2019-08-24 00:00:00

abstract：:To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA ...

journal_title：Aging

authors： Ko CH,Wu SJ,Wang ST,Chang YF,Chang CS,Kuan TS,Chuang HY,Chang CM,Chou W,Wu CH

更新日期：2020-07-26 00:00:00

abstract：:Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...

journal_title：Aging

authors： Tian Y,Yang J,Lan M,Zou T

更新日期：2020-12-26 00:00:00

abstract：:An intriguing area of research has demonstrated the ability of extracellular vesicles (EVs) as biological vehicles for microRNAs (miRNAs) transfer. Mesenchymal stem cells (MSCs) produce large amounts of EVs. Rat models of ischemia/reperfusion (I/R) were established to explore the expression profile of thioredoxin-inte...

journal_title：Aging

authors： Ou H,Teng H,Qin Y,Luo X,Yang P,Zhang W,Chen W,Lv D,Tang H

更新日期：2020-07-13 00:00:00

abstract：:Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...

journal_title：Aging

authors： Soare A,Weiss EP,Holloszy JO,Fontana L

更新日期：2014-02-01 00:00:00

abstract：:The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA....

journal_title：Aging

authors： Long R,Liu Z,Li J,Yu H

更新日期：2019-10-17 00:00:00

abstract：:Impaired quality of life (QOL) is common in hepatocellular carcinoma (HCC) patients. In this study, we used a large hospital-based multiethnic HCC patient cohort to systematically identify factors associated with QOL and investigate the prognostic value of QOL.The Short Form-12 questionnaire was used to assess QOL. Th...

journal_title：Aging

authors： Deng Y,Zhu J,Liu Z,Huang M,Chang DW,Gu J

更新日期：2020-03-07 00:00:00

abstract：:Our goal was to examine whether multicomponent exercise performed by older adults with mild cognitive impairment or dementia as group-based exercise in community have beneficial effects on cognition and brain-derived neurotrophic factor. Eight studies were identified through Emabase, Medline, PubMed. Searches combined...

journal_title：Aging

authors： Wang X,Wang H,Ye Z,Ding G,Li F,Ma J,Hua W

更新日期：2020-03-19 00:00:00

abstract：:Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR impairs immunity against certain pathogens. However, little is known about the effects of long-term moderate CR on immune function in humans. In this multi-center, randomized cli...

journal_title：Aging

authors： Meydani SN,Das SK,Pieper CF,Lewis MR,Klein S,Dixit VD,Gupta AK,Villareal DT,Bhapkar M,Huang M,Fuss PJ,Roberts SB,Holloszy JO,Fontana L

更新日期：2016-07-01 00:00:00

abstract：:Commensal microbes have mutualistic relationships with their host and mainly live in the host intestine. There are many studies on the relationships between commensal microbes and host physiology. However, there are inconsistent results on the effects of commensal microbes on host lifespan. To clarify this controversy...

journal_title：Aging

authors： Lee HY,Lee SH,Lee JH,Lee WJ,Min KJ

更新日期：2019-07-12 00:00:00

abstract：:Acute ischemic stroke (AIS) is a major public health problem in China. Impaired angiogenesis plays crucial roles in the development of ischemic cerebral injury. Recent studies have identified that microRNAs (miRNAs) are important regulators of angiogenesis, but little is known the exact effects of angiogenesis-associa...

journal_title：Aging

authors： Du K,Zhao C,Wang L,Wang Y,Zhang KZ,Shen XY,Sun HX,Gao W,Lu X

更新日期：2019-05-07 00:00:00

abstract：:There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recru...

journal_title：Aging

authors： Zarnani K,Nichols TE,Alfaro-Almagro F,Fagerlund B,Lauritzen M,Rostrup E,Smith SM

更新日期：2019-08-26 00:00:00

abstract：:Cardiomyocyte apoptosis is a major cause of myocardial ischemia/reperfusion (MI/R) injury, in which the activation of the signal transducer and activator of transcription 1 (STAT1) plays an important role. The E3-ubiquitin ligase TRIM6 has been implicated in regulating STAT1 activity, however, whether it is associated...

journal_title：Aging

authors： Zeng G,Lian C,Yang P,Zheng M,Ren H,Wang H

更新日期：2019-06-06 00:00:00

abstract：:Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression corr...

journal_title：Aging

authors： Tsai HC,Cheng SP,Han CK,Huang YL,Wang SW,Lee JJ,Lai CT,Fong YC,Tang CH

更新日期：2019-11-13 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC), a major histologic subtype of head and neck cancer, presents great mortality and morbidity worldwide. The aim of this study is to discover new potential biomarkers closely correlated with HNSCC progression. In this study, weighted gene co-expression network analysis was a...

journal_title：Aging

authors： Xu W,Zou H,Wei Z,Song C,Tang C,Yin X,Wang Y,Han S,Cai Y,Han W

更新日期：2019-06-06 00:00:00

abstract：:Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight junctions (TJs) remains unclear. In the present study, we found that high salt d...

journal_title：Aging

authors： Deng Z,Zhou L,Wang Y,Liao S,Huang Y,Shan Y,Tan S,Zeng Q,Peng L,Huang H,Lu Z

更新日期：2020-06-22 00:00:00

abstract：:Osteosarcoma (OS) is the most common bone tumor in children and adolescents and is characterized by high metastatic and recurrence rates. In the past, it has been shown that microRNAs may play critical roles in hypoxia-related OS proliferation and invasion. However, the mechanisms by which OS cells acquire this malign...

journal_title：Aging

authors： Chen G,Gu H,Fang T,Zhou K,Xu J,Yin X

更新日期：2020-04-17 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...

journal_title：Aging

authors： Zhang G,Xu Y,Zou C,Tang Y,Lu J,Gong Z,Ma G,Zhang W,Jiang P

更新日期：2019-10-30 00:00:00

abstract：:One important process in liver cancer growth and progression is angiogenesis. Vascular endothelial growth factor (VEGF) has the significant role in liver cancer angiogenesis. sFlt1 (soluble Fms-like tyrosine kinase-1) is the promising inhibitor of VEGF and can be used as the new method of inhibiting angiogenesis. MSCs...

journal_title：Aging

authors： Niu J,Wang Y,Wang J,Bin L,Hu X

更新日期：2016-12-28 00:00:00

abstract：:Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...

journal_title：Aging

authors： de Magalhães JP,Müller M,Rainger GE,Steegenga W

更新日期：2016-08-01 00:00:00

abstract：:Epigenetic regulation of various genomic functions, including gene expression, provide mechanisms whereby an organism can dynamically respond to changes in its environment and modify gene expression accordingly. One epigenetic mechanism implicated in human aging and age-related disorders is DNA methylation. Isolated p...

journal_title：Aging

authors： Benton MC,Sutherland HG,Macartney-Coxson D,Haupt LM,Lea RA,Griffiths LR

更新日期：2017-02-28 00:00:00

abstract：:MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epide...

journal_title：Aging

authors： Zhao Z,Gao D,Ma T,Zhang L

更新日期：2019-02-08 00:00:00

abstract：:As an emerging technology, artificial intelligence has been applied to identify various physical disorders. Here, we developed a three-layer diagnosis system for lung cancer, in which three machine learning approaches including decision tree C5.0, artificial neural network (ANN) and support vector machine (SVM) were i...

journal_title：Aging

authors： Duan S,Cao H,Liu H,Miao L,Wang J,Zhou X,Wang W,Hu P,Qu L,Wu Y

更新日期：2020-05-23 00:00:00

abstract：:The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...

journal_title：Aging

authors： Lopriore P,Capitanio N,Panatta E,Di Daniele N,Gambacurta A,Melino G,Amelio I

更新日期：2018-12-08 00:00:00

abstract：:Although the influenza virus only infects the respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults are more likely to develop disability following influenza infection; however, this relationship is understudied. We hypothesized...

journal_title：Aging

authors： Bartley JM,Pan SJ,Keilich SR,Hopkins JW,Al-Naggar IM,Kuchel GA,Haynes L

更新日期：2016-04-01 00:00:00