Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in.

abstract：:Endometrial cancer (EC) is one of the most common gynecologic malignancies. To identify potential prognostic biomarkers for EC, we analyzed the relationship between the EC tumor microenvironment and gene expression profiles. Using the ESTIMATE R tool, we found that immune and stromal scores correlated with clinical da...

journal_title：Aging

authors： Chen P,Yang Y,Zhang Y,Jiang S,Li X,Wan J

更新日期：2020-02-19 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies worldwide with limited treatment options and distinct geographical distribution even in countries such as China. Genetic alterations during its carcinogenesis need urgent elucidation. In this study, we propose an intriguing hypothesis that the hepatitis B X-in...

journal_title：Aging

authors： Yang Z,Jiang X,Li D,Jiang X

更新日期：2020-10-13 00:00:00

abstract：:Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...

journal_title：Aging

authors： Yin L,Yao J,Deng G,Wang X,Cai W,Shen J

更新日期：2020-05-11 00:00:00

abstract：:Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...

journal_title：Aging

authors： Patrick A,Seluanov M,Hwang C,Tam J,Khan T,Morgenstern A,Wiener L,Vazquez JM,Zafar H,Wen R,Muratkalyeva M,Doerig K,Zagorulya M,Cole L,Catalano S,Lobo Ladd AA,Coppi AA,Coşkun Y,Tian X,Ablaeva J,Nevo E,Gladyshev VN

更新日期：2016-05-01 00:00:00

abstract：:The broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear. We used the C. elegans nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. The lifespan, phenotype, pharyngeal pumping, mobility, lipofuscin a...

journal_title：Aging

authors： Qi Z,Ji H,Le M,Li H,Wieland A,Bauer S,Liu L,Wink M,Herr I

更新日期：2021-01-20 00:00:00

abstract：:Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...

journal_title：Aging

authors： Cui L,Xue H,Wen Z,Lu Z,Liu Y,Zhang Y

更新日期：2020-11-12 00:00:00

abstract：:The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesi...

journal_title：Aging

authors： Wang H,Guo B,Hui Q,Lin F,Tao K

更新日期：2020-04-20 00:00:00

abstract：:Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...

journal_title：Aging

authors： Guo B,Zhang Q,Wang H,Chang P,Tao K

更新日期：2018-04-17 00:00:00

abstract：:Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain a...

journal_title：Aging

authors： Wang Y,Song Y,Pang Y,Yu Z,Hua W,Gu Y,Qi J,Wu H

更新日期：2020-06-29 00:00:00

abstract：:Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated that miR-214-3p is abnormally expressed in various malignant tumors. However, the biological function it plays in CRC and the potential mechanism are unclear. Here, we demonstrated that miR-214-3p was obvi...

journal_title：Aging

authors： Zhou Z,Wu L,Liu Z,Zhang X,Han S,Zhao N,Bao H,Yuan W,Chen J,Ji J,Shu X

更新日期：2020-05-15 00:00:00

abstract：:The estrogen membrane receptor GPR30 (also known as G-protein coupled receptor 30) has recently been shown to be involved in the regulation of oocyte maturation and cumulus expansion. However, whether GPR30 expression is regulated by gonadotropin stimulation and how it participates in the regulation of the maturation ...

journal_title：Aging

authors： Liu J,Yao R,Lu S,Xu R,Zhang H,Wei J,Zhao C,Tang Y,Li C,Liu H,Zhao X,Wei Q,Ma B

更新日期：2020-10-28 00:00:00

abstract：:DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more ...

journal_title：Aging

authors： Blagosklonny MV

更新日期：2011-02-01 00:00:00

abstract：:Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with the carcinogenesis and progression of breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, and Basal-like BRCA, four- (BIRC5, PARP1, ATG9B, and ...

journal_title：Aging

authors： Han B,Zhang H,Zhu Y,Han X,Wang Z,Gao Z,Yuan Y,Tian R,Zhang F,Niu R

更新日期：2020-07-10 00:00:00

abstract：:Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues...

journal_title：Aging

authors： Zheng Z,Li X,You H,Zheng X,Ruan X

更新日期：2020-05-21 00:00:00

abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...

journal_title：Aging

authors： Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

更新日期：2019-12-19 00:00:00

abstract：:Programmed death-1 (PD-1) polymorphisms have been associated with esophageal cancer risk. Here, the aims of this case-control study were to explore whether three PD-1 polymorphisms (rs10204525, rs7421861, and rs36084323) were related with the risk and clinical features of esophageal cancer in Chinese Han subjects (n =...

journal_title：Aging

authors： Zang B,Chen C,Zhao JQ

更新日期：2020-02-21 00:00:00

abstract：:Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression and function of circRNA during porcine oocyte meiotic maturation have been never examined. Here, we separately identified 7,067 and 637 circRNAs in both cumulus cells and oocyt...

journal_title：Aging

authors： Cao Z,Gao D,Xu T,Zhang L,Tong X,Zhang D,Wang Y,Ning W,Qi X,Ma Y,Ji K,Yu T,Li Y,Zhang Y

更新日期：2019-09-28 00:00:00

abstract：:The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...

journal_title：Aging

authors： Bai Y,Xie F,Miao F,Long J,Huang S,Huang H,Lin J,Wang D,Yang X,Bian J,Mao J,Wang X,Mao Y,Sang X,Zhao H

更新日期：2019-07-22 00:00:00

abstract：:The composition and relative abundances of immune cells in the tumor microenvironment are key factors affecting the progression of lung adenocarcinomas (LUADs) and the efficacy of immunotherapy. Using the cancer gene expression dataset from The Cancer Genome Atlas (TCGA) program, we scored stromal and immune cells for...

journal_title：Aging

authors： Fan T,Zhu M,Wang L,Liu Y,Tian H,Zheng Y,Tan F,Sun N,Li C,He J

更新日期：2020-12-09 00:00:00

abstract：:Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and interstitial conditions ...

journal_title：Aging

authors： Yanagida K,Maejima Y,Santoso P,Otgon-Uul Z,Yang Y,Sakuma K,Shimomura K,Yada T

更新日期：2014-03-01 00:00:00

abstract：:Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth...

journal_title：Aging

authors： Zhang J,Chen Q,Du D,Wu T,Wen J,Wu M,Zhang Y,Yan W,Zhou S,Li Y,Jin Y,Luo A,Wang S

更新日期：2019-01-23 00:00:00

abstract：:Despite the accumulating evidence from in vitro and animal experiments supporting the role of kynurenine (a tryptophan metabolite) in a number of degenerative age-related changes, the relationship between kynurenine and frailty in older adults is not well understood. We collected blood samples from 73 participants who...

journal_title：Aging

authors： Jang IY,Park JH,Kim JH,Lee S,Lee E,Lee JY,Park SJ,Kim DA,Hamrick MW,Kim BJ

更新日期：2020-11-13 00:00:00

abstract：:In this study, we investigated the effects of G-protein coupled estrogen receptor (GPER) activation in the early phase of retinopathy of prematurity (ROP) and its association with endoplasmic reticulum (ER) stress using primary murine retinal microglia as an experimental model. Fluorescence microscopy results show tha...

journal_title：Aging

authors： Li R,Wang Y,Chen P,Meng J,Zhang H

更新日期：2020-09-13 00:00:00

abstract：BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...

journal_title：Aging

authors： Yerrakalva D,Hajna S,Wijndaele K,Westgate K,Khaw KT,Wareham N,Griffin SJ,Brage S

更新日期：2021-01-11 00:00:00

abstract：:Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrate...

journal_title：Aging

authors： Wong RCB,Lim SY,Hung SSC,Jackson S,Khan S,Van Bergen NJ,De Smit E,Liang HH,Kearns LS,Clarke L,Mackey DA,Hewitt AW,Trounce IA,Pébay A

更新日期：2017-04-01 00:00:00

abstract：:The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...

journal_title：Aging

authors： Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

更新日期：2017-10-20 00:00:00

abstract：:Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 orthologue) transcriptionally-regulated 20S proteasome degrades damaged proteins ...

journal_title：Aging

authors： Pomatto LCD,Wong S,Carney C,Shen B,Tower J,Davies KJA

更新日期：2017-04-01 00:00:00

abstract：AIMS:We identified an autosomal dominant non‐sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC‐CMs) from an affected patient...

journal_title：Aging

authors： Siu CW,Lee YK,Ho JC,Lai WH,Chan YC,Ng KM,Wong LY,Au KW,Lau YM,Zhang J,Lay KW,Colman A,Tse HF

更新日期：2012-11-01 00:00:00

abstract：:Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown proliferative restrictions of adult SCs forced to re-enter the cell cycle. By comparing juvenile and adult SCs in explant cultures, ...

journal_title：Aging

authors： Laos M,Anttonen T,Kirjavainen A,af Hällström T,Laiho M,Pirvola U

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inope...

journal_title：Aging

authors： Chen D,Feng X,Lv Z,Xu X,Lu Y,Wu W,Wu H,Liu H,Cao L,Ye S,Chen J,Wu J

更新日期：2019-10-25 00:00:00