Abstract:
:The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progression commonly neglects to account for the ageing process. Herein is the first systematic analysis that combines a large longitudinal data set with a targeted candidate gene approach to examine the effect of genetic variation on survival as a function of age in cancer patients. Survival was significantly decreased in individuals with heterozygote or rare homozygote (i.e. variant) genotypes compared to those with a common homozygote genotype (i.e. wild type) for two single nucleotide polymorphisms (rs11574358 and rs4147918), one gene (SIRT3) and one pathway (FoxO signalling) in an age-dependent manner. All identified genes and pathways have previously been associated with ageing and cancer. These observations demonstrate that there are ageing-related genetic elements that differentially affect mortality in cancer patients in an age-dependent manner. Understanding the genetic determinants affecting prognosis differently with age will be invaluable to develop age-specific prognostic biomarkers and personalized therapies that may improve clinical outcomes for older individuals.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães Jdoi
10.18632/aging.101305subject
Has Abstractpub_date
2017-10-20 00:00:00pages
2117-2136issue
10issn
1945-4589pii
101305journal_volume
9pub_type
杂志文章相关文献
Aging-US文献大全abstract::The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102110
更新日期:2019-07-22 00:00:00
abstract::In this study, we investigated the effects of G-protein coupled estrogen receptor (GPER) activation in the early phase of retinopathy of prematurity (ROP) and its association with endoplasmic reticulum (ER) stress using primary murine retinal microglia as an experimental model. Fluorescence microscopy results show tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103733
更新日期:2020-09-13 00:00:00
abstract::This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103939
更新日期:2020-10-13 00:00:00
abstract::DNA repair mechanisms play a crucial role in maintaining genome integrity. However, the increased frequency of DNA double-strand breaks (DSBs) and genome rearrangements in aged individuals suggests an age-associated DNA repair deficiency. Previous work from our group revealed a delayed firing of the DNA damage respons...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202419
更新日期:2020-12-27 00:00:00
abstract::The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100529
更新日期:2012-12-01 00:00:00
abstract::SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is decreased in atherosclerotic lesions from ApoE(-/-) mice and human patients. However, the role of SIRT6 in regulating vascular endothelia...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100975
更新日期:2016-05-01 00:00:00
abstract::Stress responses are affected by aging. However, studies on stress-related changes in feeding patterns with aging subject are minimal. We investigated feeding patterns induced by two psychological stress models, revealing characteristics of stress-induced feeding patterns as "meal" and "bout" (defined as the minimum f...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101320
更新日期:2017-11-09 00:00:00
abstract::Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain a...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103343
更新日期:2020-06-29 00:00:00
abstract::Nucleic acid sequence analyses are fundamental to all aspects of biological research, spanning aging, mitochondrial DNA (mtDNA) and cancer, as well as microbial and viral evolution. Over the past several years, significant improvements in DNA sequencing, including consensus sequence analysis, have proven invaluable fo...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103171
更新日期:2020-04-28 00:00:00
abstract::The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA....
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102300
更新日期:2019-10-17 00:00:00
abstract::Natural killer cells lacking expression of CD56 (CD56neg NK cells) have been described in chronic HIV and hepatitis C virus infection. Features and functions of CD56neg NK cells in the context of latent infection with CMV and / or EBV with age are not known. In a cohort of healthy donors >60 years of age, we found tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101774
更新日期:2019-01-27 00:00:00
abstract:BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202497
更新日期:2021-01-11 00:00:00
abstract::As of May 5, 2020, the number of confirmed coronavirus disease (COVID-19) cases has been more than 3.5 million with 243,540 deaths. We aimed to determine the associations between ageing population, median age, life expectancy at birth and COVID-19 mortality. The numbers of COVID-19 cases and deaths in the European reg...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104193
更新日期:2020-11-24 00:00:00
abstract::Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101358
更新日期:2018-01-04 00:00:00
abstract::The Mitochondrial Free Radical Theory of Aging (MFRTA) is currently one of the most widely accepted theories used to explain aging. From MFRTA three basic predictions can be made: long-lived individuals or species should produce fewer mitochondrial Reactive Oxygen Species (mtROS) than short-lived individuals or specie...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100137
更新日期:2010-04-01 00:00:00
abstract::A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in the secretome of senescent cultures a catalase, termed PaCATB, was identified. Genetic modulation...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100360
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102397
更新日期:2019-10-31 00:00:00
abstract::Many studies have investigated how aging decreases human strength and endurance. However, understanding the effect of aging on human motor ability requires more than knowledge of the separate temporal profile of individual motor function because the structure of human motor ability is multi-dimensional. We address the...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102126
更新日期:2019-07-30 00:00:00
abstract::Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phy...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102430
更新日期:2019-11-15 00:00:00
abstract::Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100097
更新日期:2009-10-21 00:00:00
abstract:BACKGROUND:As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because pat...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103167
更新日期:2020-04-30 00:00:00
abstract::Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrate...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101231
更新日期:2017-04-01 00:00:00
abstract::Our goal was to examine whether multicomponent exercise performed by older adults with mild cognitive impairment or dementia as group-based exercise in community have beneficial effects on cognition and brain-derived neurotrophic factor. Eight studies were identified through Emabase, Medline, PubMed. Searches combined...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102918
更新日期:2020-03-19 00:00:00
abstract::The survival rate of stomach adenocarcinoma patients with immune and stromal scores and different clinicopathological features obtained from the TCGA datasets was systematically compared. A list of genes that are correlated with stomach adenocarcinoma microenvironment were extracted using the TCGA database to predict ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103646
更新日期:2020-08-21 00:00:00
abstract::Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101037
更新日期:2016-09-28 00:00:00
abstract::There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101496
更新日期:2018-07-18 00:00:00
abstract::Aging and age-related diseases occur in almost all organisms. Recently, it was discovered that the inhibition of target of rapamycin complex 1 (TORC1), a conserved complex that mediates nutrient status and cell metabolism, can extend an individual's lifespan and inhibit age-related diseases in many model organisms. Ho...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102428
更新日期:2019-11-11 00:00:00
abstract::Aging is associated with impaired angiogenesis and lung alveolar regeneration, which contributes to the increased susceptibility to chronic lung diseases (CLD). We have reported that the Wnt ligand co-receptor, low-density lipoprotein receptor-related protein 5 (LRP5), stimulates angiogenesis and lung alveolar regener...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101722
更新日期:2019-01-05 00:00:00
abstract::We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging. Investigating this has revealed a novel approach to rejuvenate multiple mammalian tissues by defined pharmacology. Specifically, we pursued the simultaneous youthful in vivo calibration of two determinan...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102148
更新日期:2019-08-15 00:00:00
abstract::The Editorial Board of Aging reviews research papers published in 2009, which they believe have or will have significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote longevity in model organisms, DNA damage responses and telomeres, molecular mechani...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100132
更新日期:2010-03-01 00:00:00