ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas.

abstract：:Proteasome inhibition demonstrates highly effective impact on multiple myeloma (MM) treatment. Here, we aimed to examine anti-tumor efficiency and underlying mechanisms of a novel well tolerated orally applicable proteasome inhibitor NNU546 and its hydrolyzed pharmacologically active form NNU219. NNU219 showed more se...

journal_title：Aging

authors： Zhou H,Lei M,Wang W,Guo M,Wang J,Zhang H,Qiao L,Feng H,Liu Z,Chen L,Hou J,Wang X,Gu C,Zhao B,Izumchenko E,Yang Y,Zhu Y

更新日期：2020-11-16 00:00:00

abstract：:Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators. ...

journal_title：Aging

authors： Cantó C,Auwerx J

更新日期：2011-05-01 00:00:00

abstract：:Elderly patients with type 2 diabetes mellitus (T2DM) exhibit considerable periodontitis frequency, which causes tooth loss and poor quality of life. To investigate the impact of periodontitis on gut microbiota, we used 16S rRNA amplicon sequencing to characterize the composition and structure of gut microbiota among ...

journal_title：Aging

authors： Li J,Lu H,Wu H,Huang S,Chen L,Gui Q,Zhou W,Yang Y,Wu Y,Zhang H,Zhang Q,Yang Y

更新日期：2020-11-25 00:00:00

abstract：:Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients' survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCG...

journal_title：Aging

authors： Yang Z,Wei X,Pan Y,Min Z,Xu J,Yu B

更新日期：2020-11-10 00:00:00

abstract：:Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...

journal_title：Aging

authors： Hexiao T,Yuquan B,Lecai X,Yanhong W,Li S,Weidong H,Ming X,Xuefeng Z,Gaofeng P,Li Z,Minglin Z,Zheng T,Zetian Y,Xiao Z,Yi C,Lanuti M,Jinping Z

更新日期：2021-01-10 00:00:00

abstract：:Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6 and α-tubulin were...

journal_title：Aging

authors： Li J,Zhou Y,Yan Y,Zheng Z,Hu Y,Wu W

更新日期：2020-08-29 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray and public database ...

journal_title：Aging

authors： Zhan YT,Li L,Zeng TT,Zhou NN,Guan XY,Li Y

更新日期：2020-12-03 00:00:00

abstract：:Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD). Diverse studies have shown a bidirectional relationship between Klotho and inflammation, a risk factor for the development of CVD. In this work we aimed to evaluate the association between Klotho and inflammatory cytoki...

journal_title：Aging

authors： Martín-Núñez E,Donate-Correa J,Ferri C,López-Castillo Á,Delgado-Molinos A,Hernández-Carballo C,Pérez-Delgado N,Rodríguez-Ramos S,Cerro-López P,Tagua VG,Mora-Fernández C,Navarro-González JF

更新日期：2020-01-27 00:00:00

abstract：:Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth...

journal_title：Aging

authors： Zhang J,Chen Q,Du D,Wu T,Wen J,Wu M,Zhang Y,Yan W,Zhou S,Li Y,Jin Y,Luo A,Wang S

更新日期：2019-01-23 00:00:00

abstract：:Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...

journal_title：Aging

authors： Petrova NV,Luzhin AV,Serebrovskaya EO,Ryumina AP,Velichko AK,Razin SV,Kantidze OL

更新日期：2016-10-14 00:00:00

abstract：:Although previous studies indicated that cumulus cells (CCs) accelerate oocyte aging by releasing soluble factors, the factors have yet to be characterized. While demonstrating that CCs promoted oocyte aging by releasing soluble Fas ligand (sFasL), our recent study suggested that CCs might secrete other factors to med...

journal_title：Aging

authors： Kong QQ,Wang J,Xiao B,Lin FH,Zhu J,Sun GY,Luo MJ,Tan JH

更新日期：2018-07-26 00:00:00

abstract：:Circular RNAs (circRNAs) play important roles in cancer progression. hsa_circRNA6448-14 originates from exon 5 to exon 11 of the TGFBI gene. We investigated the roles of hsa_circRNA6448-14 in esophageal squamous cell carcinoma (ESCC) with microarrays and quantitative real-time polymerase chain reaction (qRT-PCR), Kapl...

journal_title：Aging

authors： Zhang Y,Yuan X,Yue N,Wang L,Liu J,Dai N,Yang H,Fan R,Zhou F

更新日期：2020-08-15 00:00:00

abstract：:Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...

journal_title：Aging

authors： Zhang J,Zhuo Z,Li W,Zhu J,He J,Su J

更新日期：2018-10-25 00:00:00

abstract：:One important process in liver cancer growth and progression is angiogenesis. Vascular endothelial growth factor (VEGF) has the significant role in liver cancer angiogenesis. sFlt1 (soluble Fms-like tyrosine kinase-1) is the promising inhibitor of VEGF and can be used as the new method of inhibiting angiogenesis. MSCs...

journal_title：Aging

authors： Niu J,Wang Y,Wang J,Bin L,Hu X

更新日期：2016-12-28 00:00:00

abstract：:lncRNA can interact with miRNA as a ceRNA to participate in the regulation of target gene expression, thus playing an important role in the development of malignant tumors. In this research, we found that OGFRP1 was up-regulated in prostate cancer (PCa) clinical samples and cell lines. Additionally, OGFRP1 is signific...

journal_title：Aging

authors： Yan K,Hou L,Liu T,Jiao W,Ma Q,Fang Z,Zhang S,Song D,Liu J,Gao X,Fan Y

更新日期：2020-05-19 00:00:00

abstract：:SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is decreased in atherosclerotic lesions from ApoE(-/-) mice and human patients. However, the role of SIRT6 in regulating vascular endothelia...

journal_title：Aging

authors： Xu S,Yin M,Koroleva M,Mastrangelo MA,Zhang W,Bai P,Little PJ,Jin ZG

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (LncRNAs) have been associated with several types of cancer. However, little is known about their role in lung adenocarcinoma (LUAD). RESULTS:LINC00968 was significantly differentially expressed in LUAD tissues. Downregulated LINC00968 was associated with clinicopathological features of...

journal_title：Aging

authors： Zhu Y,Bo H,Chen Z,Li J,He D,Xiao M,Xiang L,Jin L,Zhou J,Gong L,Zhou Y,Zhou M,Xiong W,Xing X,Li R,Cao K

更新日期：2020-11-04 00:00:00

abstract：:New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1) are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs, exposure to the dietary polyphenol resveratrol (RSV) revealed its differential capacity to generate a distinct P...

journal_title：Aging

authors： Verdura S,Cuyàs E,Cortada E,Brunet J,Lopez-Bonet E,Martin-Castillo B,Bosch-Barrera J,Encinar JA,Menendez JA

更新日期：2020-01-04 00:00:00

abstract：PURPOSE:To develop a decision tree algorithm-based classification system for personalized management of hepatocellular carcinoma (HCC) patients with macroscopic vascular invasion. RESULTS:The HVTT-PVTT score could differentiate two groups of patients (< 3 and ≥ 3 points) with different survival outcomes (7.4 vs 4.6 mo...

journal_title：Aging

authors： Cao F,Shen L,Qi H,Xie L,Song Z,Chen S,Fan W

更新日期：2019-11-03 00:00:00

abstract：:The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...

journal_title：Aging

authors： Bai Y,Xie F,Miao F,Long J,Huang S,Huang H,Lin J,Wang D,Yang X,Bian J,Mao J,Wang X,Mao Y,Sang X,Zhao H

更新日期：2019-07-22 00:00:00

abstract：:Numerous studies have investigated the differences in the mean functional connectivity (FC) strength between amnestic mild cognitive impairment (aMCI) patients and normal subjects using resting-state functional magnetic resonance imaging. However, whether the mean FC is increased, decreased or unchanged in aMCI patien...

journal_title：Aging

authors： Liang J,Li Y,Liu H,Zhang S,Wang M,Chu Y,Ye J,Xi Q,Zhao X

更新日期：2020-04-01 00:00:00

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：:Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR impairs immunity against certain pathogens. However, little is known about the effects of long-term moderate CR on immune function in humans. In this multi-center, randomized cli...

journal_title：Aging

authors： Meydani SN,Das SK,Pieper CF,Lewis MR,Klein S,Dixit VD,Gupta AK,Villareal DT,Bhapkar M,Huang M,Fuss PJ,Roberts SB,Holloszy JO,Fontana L

更新日期：2016-07-01 00:00:00

abstract：:Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and interstitial conditions ...

journal_title：Aging

authors： Yanagida K,Maejima Y,Santoso P,Otgon-Uul Z,Yang Y,Sakuma K,Shimomura K,Yada T

更新日期：2014-03-01 00:00:00

abstract：:Larger dog breeds live shorter than the smaller ones, opposite of the mass-lifespan relationship observed across mammalian species. Here we use data from 90 dog breeds and a theoretical model based on the first principles of energy conservation and life history tradeoffs to explain the negative correlation between lon...

journal_title：Aging

authors： Fan R,Olbricht G,Baker X,Hou C

更新日期：2016-12-08 00:00:00

abstract：:The solute carrier (SLC) family is the largest group of membrane transporters, but their functions in ovarian cancer (OV) remain unclear. We analyzed SLC family members with amino acids-transporting functions in OV. The mRNA expression levels and prognostic values of SLCs in OV were analyzed in the Gene Expression Pro...

journal_title：Aging

authors： Sun T,Bi F,Liu Z,Yang Q

更新日期：2020-07-09 00:00:00

abstract：:Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression and function of circRNA during porcine oocyte meiotic maturation have been never examined. Here, we separately identified 7,067 and 637 circRNAs in both cumulus cells and oocyt...

journal_title：Aging

authors： Cao Z,Gao D,Xu T,Zhang L,Tong X,Zhang D,Wang Y,Ning W,Qi X,Ma Y,Ji K,Yu T,Li Y,Zhang Y

更新日期：2019-09-28 00:00:00

abstract：:Autophagy is involved in degenerative diseases such as osteoarthritis and disc degeneration. Although, tumor necrosis factor α-induced protein 3 (TNFAIP3) is well-known as a key regulator of inflammation and autophagy, it is still not clear whether TNFAIP3 regulates autophagy to protect from human disc cells degenerat...

journal_title：Aging

authors： Chen J,Ma Y,Yang Z,Lan H,Liu G,Zhang Y,Xia H,Wang X,Han F,Tu X,Liu B

更新日期：2020-11-20 00:00:00

abstract：:Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...

journal_title：Aging

authors： Sgarbi G,Matarrese P,Pinti M,Lanzarini C,Ascione B,Gibellini L,Dika E,Patrizi A,Tommasino C,Capri M,Cossarizza A,Baracca A,Lenaz G,Solaini G,Franceschi C,Malorni W,Salvioli S

更新日期：2014-04-01 00:00:00

abstract：:Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...

journal_title：Aging

authors： Soare A,Weiss EP,Holloszy JO,Fontana L

更新日期：2014-02-01 00:00:00