Abstract:
:Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and ERβ was found in the nucleus of LUAD cells through immunofluorescence. We identified the nuclear protein CENPF and explored its relationship with the ER pathway. CENPF and ERβ2/5 were related with T stage and poor prognosis (P<0.05). CENPF knockout significantly inhibited LUAD cell growth, the tumor growth of mice and the expression of ERβ2/5 (P<0.05). The protein expression of CENPF and ERβ2/5 in the CENPF-Knockdown+Fulvestrant group was lower than CENPF- Negative Control +Fulvestrant group (P=0.002, 0.004, 0.001) in A549 cells. The tumor size and weight of the CENPF-Knockdown+Fulvestrant group were significantly lower than CENPF- Negative Control +Fulvestrant group (P=0.001, 0.039) in nude mice. All the results indicated that both CENPF and ERβ2/5 play important roles in the progression of LUAD, and knockdown CENPF can inhibit the progression of LUAD by inhibiting the expression of ER2/5. Thus, the development of inhibitors against ERβ2/5 and CENPF remained more effective in improving the therapeutic effect of LUAD.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Hexiao T,Yuquan B,Lecai X,Yanhong W,Li S,Weidong H,Ming X,Xuefeng Z,Gaofeng P,Li Z,Minglin Z,Zheng T,Zetian Y,Xiao Z,Yi C,Lanuti M,Jinping Zdoi
10.18632/aging.202303subject
Has Abstractpub_date
2021-01-10 00:00:00issn
1945-4589pii
202303journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::Topoisomerase II (Top2) removes topological linkages between replicated chromosomes. Top2 inhibition leads to mitotic catastrophe (MC) when cells unsuccessfully try to split their genetic material between the two daughter cells. Herein, we have characterized the fate of these daughter cells in the budding yeast. Clono...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102573
更新日期:2019-12-08 00:00:00
abstract::Senescence is a leading cause of age-related cataract (ARC). The current study indicated that the senescence-associated protein, p53, total laminin (LM), LMα4, and transforming growth factor-beta1 (TGF-β1) in the cataractous anterior lens capsules (ALCs) increase with the grades of ARC. In cataractous ALCs, patient ag...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101943
更新日期:2019-05-10 00:00:00
abstract::The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101305
更新日期:2017-10-20 00:00:00
abstract::The flavonoids in Ageratum conyzoides L. have been used in traditional medicine due to its anti-inflammatory and antibacterial properties. However, the specific mechanism of its antibacterial effect, and the potential therapeutic effect on vaginitis have not been well explained. The growth curves of E. coli, S. aurues...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103024
更新日期:2020-04-09 00:00:00
abstract::Our previous studies showed that loss-of-function mutation of growth hormone releasing hormone (GHRH) results in increased longevity and enhanced insulin sensitivity in mice. However, the details of improved insulin action and tissue-specific insulin signaling are largely unknown in this healthy-aging mouse model. We ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103588
更新日期:2020-10-06 00:00:00
abstract::In this study, we investigated the effects of G-protein coupled estrogen receptor (GPER) activation in the early phase of retinopathy of prematurity (ROP) and its association with endoplasmic reticulum (ER) stress using primary murine retinal microglia as an experimental model. Fluorescence microscopy results show tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103733
更新日期:2020-09-13 00:00:00
abstract:OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102804
更新日期:2020-02-15 00:00:00
abstract::Salivary gland dysfunction is a common symptom that occurs after menopause. This study was performed to investigate the mechanism of salivary gland dysfunction to confirm the relationship between ferroptosis and salivary gland dysfunction by ovariectomy. Forty-eight female rats were randomly divided into four groups (...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103882
更新日期:2020-11-05 00:00:00
abstract::To investigate the relation of higher apolipoprotein B/apolipoprotein AI (apoB/AI) ratio with the risk of suffering intracranial atherosclerotic stenosis (ICAS) in both stroke and non-stroke population, we enrolled 1138 patients with acute ischemic stroke (359 with ICAS, 779 without ICAS) and 1072 non-stroke controls ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102216
更新日期:2019-09-03 00:00:00
abstract::Growing evidence highlighted the tumor mutational burden (TMB) as an important feature of carcinogenesis and therapeutic efficacy in esophageal cancer (EC). Our study aimed to explore the genomic landscape and the correlation between TMB and immune cell infiltration in EC patients with or without radiotherapy. The EC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102917
更新日期:2020-03-12 00:00:00
abstract::Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression corr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102423
更新日期:2019-11-13 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC), a major histologic subtype of head and neck cancer, presents great mortality and morbidity worldwide. The aim of this study is to discover new potential biomarkers closely correlated with HNSCC progression. In this study, weighted gene co-expression network analysis was a...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102000
更新日期:2019-06-06 00:00:00
abstract::The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103931
更新日期:2020-10-14 00:00:00
abstract::Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.101784
更新日期:2019-01-23 00:00:00
abstract::Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions in arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles in the regulation of lipid metabolism and the inflammatory response. However, little is kn...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202273
更新日期:2021-01-10 00:00:00
abstract::How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104051
更新日期:2020-11-18 00:00:00
abstract::Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phy...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102430
更新日期:2019-11-15 00:00:00
abstract::Current tumor-node-metastasis (TNM) stage is unable to accurately predict the overall survival (OS) in breast cancer (BC) patients. This study aimed to construct a microRNA (miRNA)-based model to improve survival prediction of BC. We confirmed 99 differentially expressed miRNAs (DEMs) in 1044 BC samples compared to 10...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101767
更新日期:2019-01-30 00:00:00
abstract::A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in the secretome of senescent cultures a catalase, termed PaCATB, was identified. Genetic modulation...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100360
更新日期:2011-08-01 00:00:00
abstract::Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of I...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103566
更新日期:2020-08-28 00:00:00
abstract::Bladder cancer (BCa) is a heterogeneous disease with various tumorigenic mechanisms and clinical behaviors. The current tumor-node-metastasis (TNM) staging system is inadequate to predict overall survival (OS) in BCa patients. We developed a BCa-specific, long-non-coding-RNA (lncRNA)-based nomogram to improve survival...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102782
更新日期:2020-02-12 00:00:00
abstract::Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cel...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103321
更新日期:2020-06-10 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (LncRNAs) have been associated with several types of cancer. However, little is known about their role in lung adenocarcinoma (LUAD). RESULTS:LINC00968 was significantly differentially expressed in LUAD tissues. Downregulated LINC00968 was associated with clinicopathological features of...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104011
更新日期:2020-11-04 00:00:00
abstract::Proliferating cell nuclear antigen binding factor (encoded by KIAA0101/PCLAF) regulates DNA synthesis and cell cycle progression; however, whether the level of KIAA0101 mRNA in lung adenocarcinoma is related to prognosis and tumor immune infiltration is unknown. In patients with lung adenocarcinoma, the differential e...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104144
更新日期:2020-11-20 00:00:00
abstract::Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study inv...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101299
更新日期:2017-10-09 00:00:00
abstract:BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...
journal_title:Aging
pub_type: 杂志文章,meta分析
doi:10.18632/aging.202195
更新日期:2020-12-15 00:00:00
abstract::Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...
journal_title:Aging
pub_type: 杂志文章,随机对照试验
doi:10.18632/aging.100597
更新日期:2014-02-01 00:00:00
abstract::Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103137
更新日期:2020-05-11 00:00:00
abstract::Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated that miR-214-3p is abnormally expressed in various malignant tumors. However, the biological function it plays in CRC and the potential mechanism are unclear. Here, we demonstrated that miR-214-3p was obvi...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103233
更新日期:2020-05-15 00:00:00
abstract::Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101418
更新日期:2018-04-17 00:00:00