Abstract:
:Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phylogenetically distinct species from birds to mammals was lacking. Here, we demonstrate that the rate of accumulation of DNA damage as measured by the DNA damage marker γH2AX correlates with species longevity in dolphins, goats, reindeer, American flamingos, and griffon vultures. In particular, we find that species that show slower rates of accumulation of the DNA damage marker γH2AX also live longer.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Whittemore K,Martínez-Nevado E,Blasco MAdoi
10.18632/aging.102430subject
Has Abstractpub_date
2019-11-15 00:00:00pages
9829-9845issue
21issn
1945-4589pii
102430journal_volume
11pub_type
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