IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.


:Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of IBD. Therefore, exploring the mechanism is very important to clarify the pathogenesis of IBD. In our research, we provided evidence of IL-21 function in IBD. The junction complex protein claudin-5 may be a downstream gene of the IL-21. Anti-IL-21 administrated prevented DSS-simulative colitis via recovering claudin-5 expression in the human colonic epithelial cells. Meanwhile, we described that miR-423-5p could be involved in IL-21/ claudin-5 pathway by regulating NF-κB/MAPKs/JNK signaling pathway, which may provide a new therapeutic target for IBD.


Aging (Albany NY)




Wang M,Guo J,Zhao YQ,Wang JP




Has Abstract


2020-08-28 00:00:00














  • miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression.

    abstract::Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain a...


    pub_type: 杂志文章


    authors: Wang Y,Song Y,Pang Y,Yu Z,Hua W,Gu Y,Qi J,Wu H

    更新日期:2020-06-29 00:00:00

  • One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin.

    abstract::The gerosuppressant metformin operates as an efficient inhibitor of the mTOR/S6K1 gerogenic pathway due to its ability to ultimately activate the energy-sensor AMPK. If an aging-related decline in the AMPK sensitivity to cellular stress is a crucial event for mTOR-driven aging and aging-related diseases, including can...


    pub_type: 杂志文章


    authors: Menendez JA,Joven J

    更新日期:2012-12-01 00:00:00

  • Calreticulin increases growth and progression of natural killer/T-cell lymphoma.

    abstract::In this study, we investigated the role of calreticulin (CALR) in the pathogenesis of natural killer/T-cell lymphoma (NKTCL). CALR expression was significantly higher in the NKTCL tissues than normal control tissues in the GSE80632 dataset. High CALR expression correlated with poorer overall survival of NKTCL patients...


    pub_type: 杂志文章


    authors: Zheng Y,Li C,Xin P,Peng Q,Zhang W,Liu S,Zhu X

    更新日期:2020-11-18 00:00:00

  • Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss.

    abstract::Amyotrophic lateral sclerosis (ALS) is one of the most common motoneuronal disease, characterized by motoneuronal loss and progressive paralysis. Despite research efforts, ALS remains a fatal disease, with a survival of 2-5 years after disease onset. Numerous gene mutations have been correlated with both sporadic (sAL...


    pub_type: 杂志文章


    authors: Spitale FM,Vicario N,Rosa MD,Tibullo D,Vecchio M,Gulino R,Parenti R

    更新日期:2020-06-24 00:00:00

  • Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.

    abstract::Glomerulosclerosis and renal interstitial fibrosis occur with the aging kidney. In this study, we examined the expression of miR-21, peroxisome proliferator-activated receptor(PPARα), hypoxia-inducible factor(HIF-1α) in the kidney of 3-month-old rats fed ad libitum (YAL), 24-month-old rats fed ad libitum (OAL) and 24-...


    pub_type: 杂志文章


    authors: Liu JR,Cai GY,Ning YC,Wang JC,Lv Y,Guo YN,Fu B,Hong Q,Sun XF,Chen XM

    更新日期:2020-08-27 00:00:00

  • Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p.

    abstract::Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...


    pub_type: 杂志文章


    authors: Zhu L,Zhong Q,Yang T,Xiao X

    更新日期:2019-12-21 00:00:00

  • KCNQ1OT1 promotes melanoma growth and metastasis.

    abstract::Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...


    pub_type: 杂志文章


    authors: Guo B,Zhang Q,Wang H,Chang P,Tao K

    更新日期:2018-04-17 00:00:00

  • Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects.

    abstract::Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP ...


    pub_type: 杂志文章


    authors: Honkonen M,Vääräniemi K,Saijonmaa O,Nyman A,Tikkakoski AJ,Koskela J,Lehtimäki T,Kähönen M,Mustonen J,Fyhrquist F,Pörsti I

    更新日期:2020-06-23 00:00:00

  • Subgroup analysis of proinsulin and insulin levels reveals novel correlations to metabolic indicators of type 2 diabetes.

    abstract::Proinsulin, insulin and proinsulin/insulin (P/I) ratio have been reported to be correlated with fasting plasma glucose (FPG) and Hemoglobin A1c (HbA1c) in whole population study therefore sensitive predictors of T2D progression. However, by analyzing data collected from 2018-2019 from a cohort of 1579 East Asian indiv...


    pub_type: 杂志文章


    authors: Li T,Quan H,Zhang H,Lin L,Lin L,Ou Q,Chen K

    更新日期:2020-06-12 00:00:00

  • Survival of irradiated recipient mice after transplantation of bone marrow from young, old and "early aging" mice.

    abstract::Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...


    pub_type: 杂志文章


    authors: Guest I,Ilic Z,Scrable H,Sell S

    更新日期:2015-12-01 00:00:00

  • HSPB8 overexpression prevents disruption of blood-brain barrier after intracerebral hemorrhage in rats through Akt/GSK3β/β-catenin signaling pathway.

    abstract::Blood brain barrier (BBB) disruption is a crucial factor contributing to secondary brain injury after intracerebral hemorrhage (ICH). Heat shock protein B8 (HSPB8) has been recently reported to confer neuroprotection against against ischaemic stroke through maintaining BBB integrity. However, the role of HSPB8 in ICH ...


    pub_type: 杂志文章


    authors: Hou Y,Hu Z,Gong X,Yang B

    更新日期:2020-09-04 00:00:00

  • Identification of polymorphisms in cancer patients that differentially affect survival with age.

    abstract::The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...


    pub_type: 杂志文章


    authors: Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

    更新日期:2017-10-20 00:00:00

  • Interference between PARPs and SIRT1: a novel approach to healthy ageing?

    abstract::Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators. ...


    pub_type: 杂志文章


    authors: Cantó C,Auwerx J

    更新日期:2011-05-01 00:00:00

  • Inducing cellular senescence in vitro by using genetically encoded photosensitizers.

    abstract::Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...


    pub_type: 杂志文章


    authors: Petrova NV,Luzhin AV,Serebrovskaya EO,Ryumina AP,Velichko AK,Razin SV,Kantidze OL

    更新日期:2016-10-14 00:00:00

  • Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans.

    abstract::N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects ...


    pub_type: 杂志文章


    authors: Shaposhnikov MV,Zemskaya NV,Koval LA,Schegoleva EV,Zhavoronkov A,Moskalev AA

    更新日期:2018-09-20 00:00:00

  • Modelling biological age based on plasma peptides in Han Chinese adults.

    abstract::Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mas...


    pub_type: 杂志文章


    authors: Cao W,Zheng D,Wang G,Zhang J,Ge S,Singh M,Wang H,Song M,Li D,Wang W,Xu X,Wang Y

    更新日期:2020-06-05 00:00:00

  • Telomere sister chromatid exchange and the process of aging.

    abstract::Telomeres are a hotspot for sister chromatid exchange (T-SCE). Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence. This work strongly suggests that progressive telomere erosion ...


    pub_type: 杂志文章


    authors: Blagoev KB,Goodwin EH,Bailey SM

    更新日期:2010-10-01 00:00:00

  • Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.

    abstract::Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a re...


    pub_type: 杂志文章


    authors: Chen X,Amorim JA,Moustafa GA,Lee JJ,Yu Z,Ishihara K,Iesato Y,Barbisan P,Ueta T,Togka KA,Lu L,Sinclair DA,Vavvas DG

    更新日期:2020-12-29 00:00:00

  • DR region specific antibody ameliorated but ouabain worsened renal injury in nephrectomized rats through regulating Na,K-ATPase mediated signaling pathways.

    abstract::Reduced Na+-K+-ATPase function is reported in various renal diseases. This implies that increase of Na+-K+-ATPase function may be a new target in treatment of renal injury. We previously reported that Na+-K+-ATPase was stabilized by DRm217, a specific antibody against DR region of Na+-K+-ATPase. In this study, we comp...


    pub_type: 杂志文章


    authors: Wang J,Ullah SH,Li M,Zhang M,Zhang F,Zheng J,Yan X

    更新日期:2019-02-26 00:00:00

  • The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress.

    abstract::PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...


    pub_type: 杂志文章


    authors: Kunstmann B,Osiewacz HD

    更新日期:2009-03-03 00:00:00

  • LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.

    abstract::Recently, over-expression of LAIR-1 has been found in some solid cancers, including ovarian cancer. The role of LAIR-1 in cancer progression needs further investigation. In this study, we identified the LAIR-1 cDNA sequence of the ovarian cancer cells HO8910. Using SKOV3 cells, we confirmed the finding from our previo...


    pub_type: 杂志文章


    authors: Liu Y,Ma L,Shangguan F,Zhao X,Wang W,Gao Z,Zhou H,Qu G,Huang Y,An J,Xue J,Yang S,Cao Q

    更新日期:2020-09-05 00:00:00

  • Longitudinal plasma metabolomics of aging and sex.

    abstract::Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...


    pub_type: 杂志文章


    authors: Darst BF,Koscik RL,Hogan KJ,Johnson SC,Engelman CD

    更新日期:2019-02-24 00:00:00

  • RWR-algorithm-based dissection of microRNA-506-3p and microRNA-140-5p as radiosensitive biomarkers in colorectal cancer.

    abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...


    pub_type: 杂志文章


    authors: Liao F,Chen X,Peng P,Dong W

    更新日期:2020-10-08 00:00:00

  • PaCATB, a secreted catalase protecting Podospora anserina against exogenous oxidative stress.

    abstract::A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in the secretome of senescent cultures a catalase, termed PaCATB, was identified. Genetic modulation...


    pub_type: 杂志文章


    authors: Zintel S,Bernhardt D,Rogowska-Wrzesinska A,Osiewacz HD

    更新日期:2011-08-01 00:00:00

  • Biomarkers of aging and lung function in the normative aging study.

    abstract::Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis ...


    pub_type: 杂志文章


    authors: Wang C,Just A,Heiss J,Coull BA,Hou L,Zheng Y,Sparrow D,Vokonas PS,Baccarelli A,Schwartz J

    更新日期:2020-06-19 00:00:00

  • Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion.

    abstract::An intriguing area of research has demonstrated the ability of extracellular vesicles (EVs) as biological vehicles for microRNAs (miRNAs) transfer. Mesenchymal stem cells (MSCs) produce large amounts of EVs. Rat models of ischemia/reperfusion (I/R) were established to explore the expression profile of thioredoxin-inte...


    pub_type: 杂志文章


    authors: Ou H,Teng H,Qin Y,Luo X,Yang P,Zhang W,Chen W,Lv D,Tang H

    更新日期:2020-07-13 00:00:00

  • The correlation and role analysis of COL4A1 and COL4A2 in hepatocarcinogenesis.

    abstract::Liver fibrosis biomarker, Type IV collagen, may function as hepatocarcinogenesis niche. However, among the six isoforms, the isoforms providing tumor microenvironment and their regulatory network are still unclarified. Based on bioinformatics analysis of hundreds of HCC transcriptome datasets from public databases, we...


    pub_type: 杂志文章


    authors: Liu Y,Zhang J,Chen Y,Sohel H,Ke X,Chen J,Li YX

    更新日期:2020-01-05 00:00:00

  • Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age.

    abstract::Aged subjects display increased susceptibility to mucosal diseases. Retinoic Acid (RA) plays a major role in inducing tolerance in the mucosa. RA acts on Dendritic cells (DCs) to induce mucosal tolerance. Here we compared the response of DCs from aged and young individuals to RA with a view to understand the role of D...


    pub_type: 杂志文章


    authors: Agrawal S,Ganguly S,Tran A,Sundaram P,Agrawal A

    更新日期:2016-06-01 00:00:00

  • Downregulation of interleukin-6 and C-reactive protein underlies a novel inhibitory role of microRNA-136-5p in acute lower extremity deep vein thrombosis.

    abstract::Deep vein thrombosis (DVT) comprises a critical and common health condition with high incidence, mortality, and long-term adverse sequelae. Several differentially expressed microRNAs (miRNAs) have emerged as promising prognostic markers in DVT. The present study intended to explore the functional relevance of miR-136-...


    pub_type: 杂志文章


    authors: Ou M,Hao S,Chen J,Zhao S,Cui S,Tu J

    更新日期:2020-11-14 00:00:00

  • White light emitting diode induces autophagy in hippocampal neuron cells through GSK-3-mediated GR and RORα pathways.

    abstract::Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...


    pub_type: 杂志文章


    authors: Yang Y,Jia Y,Sun Q,Dong H,Zhao R

    更新日期:2019-03-28 00:00:00