Can ovarian aging be delayed by pharmacological strategies?

Abstract:

:Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth, compared to other organs. Ovarian aging is considered as the pacemaker of female body aging, which drives the aging of multiple organs of the body. Hence, anti-ovarian aging has become a research topic broadly interesting to both biomedical scientists and pharmaceutical industry. A marked progress has been made in exploration of possible anti-ovarian agents or approaches, such as calorie restriction mimetics, antioxidants, autophagy inducers etc., over the past years. This review is attempted to discuss recent advances in the area of anti-ovarian aging pharmacology and to offer new insights into our better understanding of molecular mechanisms underlying ovarian aging, which might be informative for future prevention and treatment of ovarian aging and its related diseases.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Zhang J,Chen Q,Du D,Wu T,Wen J,Wu M,Zhang Y,Yan W,Zhou S,Li Y,Jin Y,Luo A,Wang S

doi

10.18632/aging.101784

subject

Has Abstract

pub_date

2019-01-23 00:00:00

pages

817-832

issue

2

issn

1945-4589

pii

101784

journal_volume

11

pub_type

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