Can ovarian aging be delayed by pharmacological strategies?

Abstract:

:Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth, compared to other organs. Ovarian aging is considered as the pacemaker of female body aging, which drives the aging of multiple organs of the body. Hence, anti-ovarian aging has become a research topic broadly interesting to both biomedical scientists and pharmaceutical industry. A marked progress has been made in exploration of possible anti-ovarian agents or approaches, such as calorie restriction mimetics, antioxidants, autophagy inducers etc., over the past years. This review is attempted to discuss recent advances in the area of anti-ovarian aging pharmacology and to offer new insights into our better understanding of molecular mechanisms underlying ovarian aging, which might be informative for future prevention and treatment of ovarian aging and its related diseases.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Zhang J,Chen Q,Du D,Wu T,Wen J,Wu M,Zhang Y,Yan W,Zhou S,Li Y,Jin Y,Luo A,Wang S

doi

10.18632/aging.101784

subject

Has Abstract

pub_date

2019-01-23 00:00:00

pages

817-832

issue

2

issn

1945-4589

pii

101784

journal_volume

11

pub_type

杂志文章,评审

相关文献

Aging-US文献大全
  • Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression.

    abstract::Bladder cancer (BC) is one of the most commonly diagnosed urologic carcinomas, with high recurrence and death rates. Circular RNAs (circRNAs) are a class of noncoding RNAs which are anomalously expressed in cancers and involved in the progression of cancers. In this study, we found that circSEMA5A was upregulated in B...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103971

    authors: Wang L,Li H,Qiao Q,Ge Y,Ma L,Wang Q

    更新日期:2020-11-07 00:00:00

  • Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.

    abstract::Glomerulosclerosis and renal interstitial fibrosis occur with the aging kidney. In this study, we examined the expression of miR-21, peroxisome proliferator-activated receptor(PPARα), hypoxia-inducible factor(HIF-1α) in the kidney of 3-month-old rats fed ad libitum (YAL), 24-month-old rats fed ad libitum (OAL) and 24-...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103591

    authors: Liu JR,Cai GY,Ning YC,Wang JC,Lv Y,Guo YN,Fu B,Hong Q,Sun XF,Chen XM

    更新日期:2020-08-27 00:00:00

  • Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory.

    abstract::Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101256

    authors: Foscarin S,Raha-Chowdhury R,Fawcett JW,Kwok JCF

    更新日期:2017-06-28 00:00:00

  • ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy.

    abstract::As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical need. Italy has one of the highest numbers of SARS-CoV-2-related deaths and one of the highest mortality rates. Worldwide, a more severe course of COVID-19 is as...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103415

    authors: Asselta R,Paraboschi EM,Mantovani A,Duga S

    更新日期:2020-06-05 00:00:00

  • Urinary metabolite signature in bipolar disorder patients during depressive episode.

    abstract::The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101805

    authors: Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P

    更新日期:2019-02-05 00:00:00

  • Expression and prognosis analysis of TET family in acute myeloid leukemia.

    abstract::TET family members (TETs) encode proteins that represent crucial factors in the active DNA demethylation pathway. Evidence has proved that TET2 mutation is associated with leukemogenesis, drug response, and prognosis in acute myeloid leukemia (AML). However, few studies revealed the TETs expression and its clinical si...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102928

    authors: Zhang T,Zhao Y,Zhao Y,Zhou J

    更新日期:2020-03-25 00:00:00

  • LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264.

    abstract::Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103276

    authors: Zheng Z,Li X,You H,Zheng X,Ruan X

    更新日期:2020-05-21 00:00:00

  • BMAL1 knockdown triggers different colon carcinoma cell fates by altering the delicate equilibrium between AKT/mTOR and P53/P21 pathways.

    abstract::Dysregulation of the circadian timing system (CTS) frequently appears during colorectal cancer (CRC) progression. In order to better understand the role of the circadian clock in CRC progression, this study evaluated in vitro how knockdown of a core circadian protein BMAL1 (BMAL1-KD) influenced the behavior of two pri...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103124

    authors: Zhang Y,Devocelle A,Souza L,Foudi A,Tenreira Bento S,Desterke C,Sherrard R,Ballesta A,Adam R,Giron-Michel J,Chang Y

    更新日期:2020-05-10 00:00:00

  • Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of human bone marrow mesenchymal stem cells via H19/miR-675/APC axis.

    abstract::Bone volume inadequacy is an emerging clinical problem impairing the feasibility and longevity of dental implants. Human bone marrow mesenchymal stem cells (HBMSCs) have been widely used in bone remodeling and regeneration. This study examined the effect of long noncoding RNAs (lncRNAs)-H19 on the human amnion-derived...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103277

    authors: Ma X,Bian Y,Yuan H,Chen N,Pan Y,Zhou W,Gao S,Du X,Hao S,Yan Z,Li X,Liu K,Xu F,Wang Y,Du Y

    更新日期:2020-05-20 00:00:00

  • Insulin sensitivity in long-lived growth hormone-releasing hormone knockout mice.

    abstract::Our previous studies showed that loss-of-function mutation of growth hormone releasing hormone (GHRH) results in increased longevity and enhanced insulin sensitivity in mice. However, the details of improved insulin action and tissue-specific insulin signaling are largely unknown in this healthy-aging mouse model. We ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103588

    authors: Zhang F,Icyuz M,Liu Z,Fitch M,Sun LY

    更新日期:2020-10-06 00:00:00

  • Fish oil supplements, longevity and aging.

    abstract::Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...

    journal_title:Aging

    pub_type: 评论,杂志文章

    doi:10.18632/aging.101021

    authors: de Magalhães JP,Müller M,Rainger GE,Steegenga W

    更新日期:2016-08-01 00:00:00

  • TNFAIP3 ameliorates the degeneration of inflammatory human nucleus pulposus cells by inhibiting mTOR signaling and promoting autophagy.

    abstract::Autophagy is involved in degenerative diseases such as osteoarthritis and disc degeneration. Although, tumor necrosis factor α-induced protein 3 (TNFAIP3) is well-known as a key regulator of inflammation and autophagy, it is still not clear whether TNFAIP3 regulates autophagy to protect from human disc cells degenerat...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104160

    authors: Chen J,Ma Y,Yang Z,Lan H,Liu G,Zhang Y,Xia H,Wang X,Han F,Tu X,Liu B

    更新日期:2020-11-20 00:00:00

  • Assessment of ERBB2 and TOP2α gene status and expression profile in feline mammary tumors: findings and guidelines.

    abstract::In humans, the ERBB2 gene amplification and overexpression are biomarkers for invasive breast cancer and a therapeutic target. Also, TOP2α gene aberrations predict the response to anthracycline-based adjuvant chemotherapy. Although feline mammary tumors (FMTs) are good models in comparative oncology, scarce data is av...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102079

    authors: Ferreira D,Soares M,Correia J,Adega F,Ferreira F,Chaves R

    更新日期:2019-07-12 00:00:00

  • GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12).

    abstract::Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103005

    authors: Chen Y,Fu D,Zhao H,Cheng W,Xu F

    更新日期:2020-05-21 00:00:00

  • COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway.

    abstract::The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA....

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102300

    authors: Long R,Liu Z,Li J,Yu H

    更新日期:2019-10-17 00:00:00

  • Effect of antioxidants on the H2O2-induced premature senescence of human fibroblasts.

    abstract::The study was aimed at evaluation of the role of secondary oxidative stress in the stress-induced premature senescence (SIPS) of human fibroblasts induced by H2O2. Two fibroblast lines were used: lung MRC-5 and ear H8F2p25LM fibroblasts. The lines differed considerably in sensitivity to H2O2 (IC50 of 528 and 33.5 μM, ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102730

    authors: Pieńkowska N,Bartosz G,Pichla M,Grzesik-Pietrasiewicz M,Gruchala M,Sadowska-Bartosz I

    更新日期:2020-01-21 00:00:00

  • Predicting chromosome 1p/19q codeletion by RNA expression profile: a comparison of current prediction models.

    abstract:BACKGROUND:Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might i...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101795

    authors: Wang ZL,Zhao Z,Wang Z,Zhang CB,Jiang T

    更新日期:2019-02-02 00:00:00

  • Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway.

    abstract::Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression corr...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102423

    authors: Tsai HC,Cheng SP,Han CK,Huang YL,Wang SW,Lee JJ,Lai CT,Fong YC,Tang CH

    更新日期:2019-11-13 00:00:00

  • LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2.

    abstract::In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) FAM181A-AS1 in human gliomas. TCGA, GTEx and CGGA database analyses showed that high FAM181A-AS1 expression correlates with advanced tumor stage and poor survival of glioma patients. FAM181A-AS1 expression is hi...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103391

    authors: Jiang X,Chen D

    更新日期:2020-10-20 00:00:00

  • Identification of polymorphisms in cancer patients that differentially affect survival with age.

    abstract::The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101305

    authors: Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

    更新日期:2017-10-20 00:00:00

  • Cumulus cell-released tumor necrosis factor (TNF)-α promotes post-ovulatory aging of mouse oocytes.

    abstract::Although previous studies indicated that cumulus cells (CCs) accelerate oocyte aging by releasing soluble factors, the factors have yet to be characterized. While demonstrating that CCs promoted oocyte aging by releasing soluble Fas ligand (sFasL), our recent study suggested that CCs might secrete other factors to med...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101507

    authors: Kong QQ,Wang J,Xiao B,Lin FH,Zhu J,Sun GY,Luo MJ,Tan JH

    更新日期:2018-07-26 00:00:00

  • Identifying hub genes of clear cell renal cell carcinoma associated with the proportion of regulatory T cells by weighted gene co-expression network analysis.

    abstract:BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102397

    authors: Chen YH,Chen SH,Hou J,Ke ZB,Wu YP,Lin TT,Wei Y,Xue XY,Zheng QS,Huang JB,Xu N

    更新日期:2019-10-31 00:00:00

  • Survival of irradiated recipient mice after transplantation of bone marrow from young, old and "early aging" mice.

    abstract::Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100867

    authors: Guest I,Ilic Z,Scrable H,Sell S

    更新日期:2015-12-01 00:00:00

  • Risk factors and prediction of second primary cancer in primary female non-metastatic breast cancer survivors.

    abstract::This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103939

    authors: Qian X,Jia H,Zhang Y,Ma B,Qin G,Wu Z

    更新日期:2020-10-13 00:00:00

  • Skin aging: are adipocytes the next target?

    abstract::Dermal white adipose tissue (dWAT) is increasingly appreciated as a special fat depot. The adipocytes in this depot exert a variety of unique effects on their surrounding cells and can undergo massive phenotypic changes. Significant modulation of dWAT content can be observed both in intrinsically and extrinsically age...

    journal_title:Aging

    pub_type: 杂志文章,评审

    doi:10.18632/aging.100999

    authors: Kruglikov IL,Scherer PE

    更新日期:2016-07-01 00:00:00

  • LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.

    abstract::Recently, over-expression of LAIR-1 has been found in some solid cancers, including ovarian cancer. The role of LAIR-1 in cancer progression needs further investigation. In this study, we identified the LAIR-1 cDNA sequence of the ovarian cancer cells HO8910. Using SKOV3 cells, we confirmed the finding from our previo...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103589

    authors: Liu Y,Ma L,Shangguan F,Zhao X,Wang W,Gao Z,Zhou H,Qu G,Huang Y,An J,Xue J,Yang S,Cao Q

    更新日期:2020-09-05 00:00:00

  • Evaluation of the diagnostic ability of laminin gene family for pancreatic ductal adenocarcinoma.

    abstract::A poor outcome for pancreatic ductal adenocarcinoma (PDAC) patients is still a challenge worldwide. The aim of our study is to investigate the potential of key laminin subunits for being used both as a diagnostic and prognostic biomarker for PDAC patients. We evaluated the mRNA expression and prognostic value of lamin...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102007

    authors: Yang C,Liu Z,Zeng X,Wu Q,Liao X,Wang X,Han C,Yu T,Zhu G,Qin W,Peng T

    更新日期:2019-06-10 00:00:00

  • Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.

    abstract::Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a re...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202453

    authors: Chen X,Amorim JA,Moustafa GA,Lee JJ,Yu Z,Ishihara K,Iesato Y,Barbisan P,Ueta T,Togka KA,Lu L,Sinclair DA,Vavvas DG

    更新日期:2020-12-29 00:00:00

  • A novel six-microRNA-based model to improve prognosis prediction of breast cancer.

    abstract::Current tumor-node-metastasis (TNM) stage is unable to accurately predict the overall survival (OS) in breast cancer (BC) patients. This study aimed to construct a microRNA (miRNA)-based model to improve survival prediction of BC. We confirmed 99 differentially expressed miRNAs (DEMs) in 1044 BC samples compared to 10...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101767

    authors: Lai J,Wang H,Pan Z,Su F

    更新日期:2019-01-30 00:00:00

  • IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of I...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103566

    authors: Wang M,Guo J,Zhao YQ,Wang JP

    更新日期:2020-08-28 00:00:00