A novel six-microRNA-based model to improve prognosis prediction of breast cancer.


:Current tumor-node-metastasis (TNM) stage is unable to accurately predict the overall survival (OS) in breast cancer (BC) patients. This study aimed to construct a microRNA (miRNA)-based model to improve survival prediction of BC. We confirmed 99 differentially expressed miRNAs (DEMs) in 1044 BC samples compared to 102 adjacent normal breast tissues from The Cancer Genome Atlas (TCGA) database. Prognostic DEMs were used to establish a miRNA-based nomogram via Cox regression model. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses (KEGG) were executed to analyze target genes of miRNAs. A six-miRNA signature was screened to effectively distinguish high-risk patients in the primary and validation cohort (all P<0.001). Furthermore, we established a novel prognostic model incorporating the six-miRNA signature and clinical risk factors to predict 5-year OS of BC. Time-dependent receiver operating characteristic analysis suggested that the predictive accuracy of the six-miRNA-based nomogram was distinctly higher than that of TNM stage (0.758 vs 0.650, P<0.001). GO and KEGG pathway analyses showed that the 39 target genes mainly enrichment in protein binding, cytoplasm and MAPK signaling pathway. Our six-miRNA-based model is a reliable prognostic tool for survival prediction and provides information for individualized treatment decisions in BC patients.


Aging (Albany NY)




Lai J,Wang H,Pan Z,Su F




Has Abstract


2019-01-30 00:00:00














  • Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.

    abstract::Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...


    pub_type: 杂志文章


    authors: Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV

    更新日期:2016-07-01 00:00:00

  • Development of a machine learning-based multimode diagnosis system for lung cancer.

    abstract::As an emerging technology, artificial intelligence has been applied to identify various physical disorders. Here, we developed a three-layer diagnosis system for lung cancer, in which three machine learning approaches including decision tree C5.0, artificial neural network (ANN) and support vector machine (SVM) were i...


    pub_type: 杂志文章


    authors: Duan S,Cao H,Liu H,Miao L,Wang J,Zhou X,Wang W,Hu P,Qu L,Wu Y

    更新日期:2020-05-23 00:00:00

  • One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin.

    abstract::The gerosuppressant metformin operates as an efficient inhibitor of the mTOR/S6K1 gerogenic pathway due to its ability to ultimately activate the energy-sensor AMPK. If an aging-related decline in the AMPK sensitivity to cellular stress is a crucial event for mTOR-driven aging and aging-related diseases, including can...


    pub_type: 杂志文章


    authors: Menendez JA,Joven J

    更新日期:2012-12-01 00:00:00

  • Fibroblast growth factor 10 alleviates particulate matter-induced lung injury by inhibiting the HMGB1-TLR4 pathway.

    abstract::Exposure to particulate matter (PM) is associated with increased incidence of respiratory diseases. The present study aimed to investigate the roles of fibroblast growth factor 10 (FGF10) in PM-induced lung injury. Mice were intratracheally instilled with FGF10 or phosphate-buffered saline at one hour before instillat...


    pub_type: 杂志文章


    authors: Liu L,Song C,Li J,Wang Q,Zhu M,Hu Y,Chen J,Chen C,Zhang JS,Dong N,Chen C

    更新日期:2020-01-20 00:00:00

  • Aging and circadian disruption: causes and effects.

    abstract::The relationship between aging and daily "circadian" behavior in humans is bidirectional: on the one hand, dysfunction of circadian clocks promotes age-related maladies; on the other, aging per se leads to changes and disruption in circadian behavior and physiology. For the latter case, recent research suggests that c...


    pub_type: 杂志文章


    authors: Brown SA,Schmitt K,Eckert A

    更新日期:2011-08-01 00:00:00

  • CO2 lattice laser reverses skin aging caused by UVB.

    abstract::The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesi...


    pub_type: 杂志文章


    authors: Wang H,Guo B,Hui Q,Lin F,Tao K

    更新日期:2020-04-20 00:00:00

  • Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose.

    abstract::Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and interstitial conditions ...


    pub_type: 杂志文章


    authors: Yanagida K,Maejima Y,Santoso P,Otgon-Uul Z,Yang Y,Sakuma K,Shimomura K,Yada T

    更新日期:2014-03-01 00:00:00

  • Identification of survival-associated alternative splicing events and signatures in adrenocortical carcinoma based on TCGA SpliceSeq data.

    abstract:OBJECTIVE:To explore the correlations among alternative splicing (AS), splicing factors (SF) and survival outcome in adrenocortical carcinoma (ACC) patients. RESULTS:A total of 92 ACC patients were included. Univariate analysis identified 3919 AS events significantly associated with overall survival. Lasso method foll...


    pub_type: 杂志文章


    authors: Xu N,Ke ZB,Lin XD,Lin F,Chen SH,Wu YP,Chen YH,Wei Y,Zheng QS

    更新日期:2020-03-26 00:00:00

  • Estrogen regulation of germline stem cell differentiation as a mechanism contributing to female reproductive aging.

    abstract::Progressive loss of ovarian estrogen (E2) production is a hallmark feature of, if not a driving force behind, reproductive aging and the menopause. Recent genetic studies in mice have shown that female germline or oogonial stem cells (OSCs) contribute to maintenance of adult ovarian function and fertility under physio...


    pub_type: 杂志文章


    authors: Satirapod C,Wang N,MacDonald JA,Sun M,Woods DC,Tilly JL

    更新日期:2020-04-17 00:00:00

  • Knockdown of CENPF inhibits the progression of lung adenocarcinoma mediated by ERβ2/5 pathway.

    abstract::Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...


    pub_type: 杂志文章


    authors: Hexiao T,Yuquan B,Lecai X,Yanhong W,Li S,Weidong H,Ming X,Xuefeng Z,Gaofeng P,Li Z,Minglin Z,Zheng T,Zetian Y,Xiao Z,Yi C,Lanuti M,Jinping Z

    更新日期:2021-01-10 00:00:00

  • FX5 as a non-steroidal GR antagonist improved glucose homeostasis in type 2 diabetic mice via GR/HNF4α/miR-122-5p pathway.

    abstract::Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...


    pub_type: 杂志文章


    authors: Xu X,Chen Y,Zhu D,Zhao T,Xu R,Wang J,Hu L,Shen X

    更新日期:2020-12-09 00:00:00

  • A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer.

    abstract::N6-methyladenosine (m6A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators. However, the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 cen...


    pub_type: 杂志文章


    authors: Fan L,Lin Y,Lei H,Shu G,He L,Yan Z,Rihan H,Yin G

    更新日期:2020-09-20 00:00:00

  • Insulin sensitivity in long-lived growth hormone-releasing hormone knockout mice.

    abstract::Our previous studies showed that loss-of-function mutation of growth hormone releasing hormone (GHRH) results in increased longevity and enhanced insulin sensitivity in mice. However, the details of improved insulin action and tissue-specific insulin signaling are largely unknown in this healthy-aging mouse model. We ...


    pub_type: 杂志文章


    authors: Zhang F,Icyuz M,Liu Z,Fitch M,Sun LY

    更新日期:2020-10-06 00:00:00

  • Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.

    abstract::The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. In Alzheimer's Disease, T-cells were identified as important...


    pub_type: 杂志文章


    authors: Fischer M,Ruhnau J,Schulze J,Obst D,Flöel A,Vogelgesang A

    更新日期:2020-06-30 00:00:00

  • Genome-wide analyses of the prognosis-related mRNA alternative splicing landscape and novel splicing factors based on large-scale low grade glioma cohort.

    abstract::Alternative splicing (AS) changes are considered to be critical in predicting treatment response. Our study aimed to investigate differential splicing patterns and to elucidate the role of splicing factor (SF) as prognostic markers of low-grade glioma (LGG). We downloaded RNA-seq data from a cohort of 516 LGG tumors i...


    pub_type: 杂志文章


    authors: Liu WR,Li CY,Xu WH,Liu XJ,Tang HD,Huang HN

    更新日期:2020-07-13 00:00:00

  • Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling.

    abstract::Increasing attentions have been paid to the role of circRNAs in the etiology of triple-negative breast cancer (TNBC), and we strived to figure out the association of circRNA AKT3/miRNA axis with TNBC chemo-resistance. Altogether 207 BC patients were divided into TNBC group (n=83) and non-TNBC group (n=124), and MCF-10...


    pub_type: 杂志文章


    authors: Li H,Xu W,Xia Z,Liu W,Pan G,Ding J,Li J,Wang J,Xie X,Jiang D

    更新日期:2021-01-20 00:00:00

  • Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway.

    abstract::Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression corr...


    pub_type: 杂志文章


    authors: Tsai HC,Cheng SP,Han CK,Huang YL,Wang SW,Lee JJ,Lai CT,Fong YC,Tang CH

    更新日期:2019-11-13 00:00:00

  • IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of I...


    pub_type: 杂志文章


    authors: Wang M,Guo J,Zhao YQ,Wang JP

    更新日期:2020-08-28 00:00:00

  • Single-cell RNA sequencing of immune cells in gastric cancer patients.

    abstract::Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...


    pub_type: 杂志文章


    authors: Fu K,Hui B,Wang Q,Lu C,Shi W,Zhang Z,Rong D,Zhang B,Tian Z,Tang W,Cao H,Wang X,Chen Z

    更新日期:2020-02-10 00:00:00

  • Multiple dietary supplements do not affect metabolic and cardio-vascular health.

    abstract::Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...


    pub_type: 杂志文章,随机对照试验


    authors: Soare A,Weiss EP,Holloszy JO,Fontana L

    更新日期:2014-02-01 00:00:00

  • Association of KRAS and NRAS gene polymorphisms with Wilms tumor risk: a four-center case-control study.

    abstract::Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose indivi...


    pub_type: 杂志文章,多中心研究


    authors: Fu W,Zhuo Z,Hua RX,Fu K,Jia W,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,He J,Liu G

    更新日期:2019-03-12 00:00:00

  • Laminin α4 overexpression in the anterior lens capsule may contribute to the senescence of human lens epithelial cells in age-related cataract.

    abstract::Senescence is a leading cause of age-related cataract (ARC). The current study indicated that the senescence-associated protein, p53, total laminin (LM), LMα4, and transforming growth factor-beta1 (TGF-β1) in the cataractous anterior lens capsules (ALCs) increase with the grades of ARC. In cataractous ALCs, patient ag...


    pub_type: 杂志文章


    authors: Yan Y,Yu H,Sun L,Liu H,Wang C,Wei X,Song F,Li H,Ge H,Qian H,Li X,Tang X,Liu P

    更新日期:2019-05-10 00:00:00

  • NAC1 attenuates BCL6 negative autoregulation and functions as a BCL6 coactivator of FOXQ1 transcription in cancer cells.

    abstract:BACKGROUND:Nucleus accumbens-associated protein 1 (NAC1) has multifaceted roles in cancer pathogenesis and progression, including the development of drug resistance, promotion of cytokinesis, and maintenance of "stem cell-like" phenotypes. NAC1 is a transcriptional co-regulator belonging to the bric-a-brac tramtrack br...


    pub_type: 杂志文章


    authors: Gao M,Herlinger AL,Wu R,Wang TL,Shih IM,Kong B,Rangel LBA,Yang JM

    更新日期:2020-05-14 00:00:00

  • HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes.

    abstract::Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a sense ncmtRNA (SncmtRNA), which seems to be required for cell proliferation, and two antisense transcripts referred ...


    pub_type: 杂志文章


    authors: Villota C,Varas-Godoy M,Jeldes E,Campos A,Villegas J,Borgna V,Burzio LO,Burzio VA

    更新日期:2018-12-30 00:00:00

  • Risk factors and prediction of second primary cancer in primary female non-metastatic breast cancer survivors.

    abstract::This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...


    pub_type: 杂志文章


    authors: Qian X,Jia H,Zhang Y,Ma B,Qin G,Wu Z

    更新日期:2020-10-13 00:00:00

  • A model integrating donor gene polymorphisms predicts fibrosis after liver transplantation.

    abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...


    pub_type: 杂志文章


    authors: Wang C,Zhang X,Ling Q,Zheng S,Xu X

    更新日期:2020-12-03 00:00:00

  • Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation.

    abstract::Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...


    pub_type: 杂志文章


    authors: Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

    更新日期:2019-10-06 00:00:00

  • miR-345-5p regulates adipogenesis via targeting VEGF-B.

    abstract::Adipocyte differentiation involves a series of highly synergistic processes, including clone amplification, proliferation arrest, and terminal differentiation. However, the mechanisms that control these different steps remain unclear. Emerging studies support that miRNAs play an important role in regulating adipogenes...


    pub_type: 杂志文章


    authors: Liu X,He Y,Feng Z,Sheng J,Dong A,Zhang M,Cao L

    更新日期:2020-09-14 00:00:00

  • Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila.

    abstract::Accumulating evidence suggests that early-life diet may program one's health status by causing permanent alternations in specific organs, tissues, or metabolic or homeostatic pathways, and such programming effects may propagate across generations through heritable epigenetic modifications. However, it remains uninvest...


    pub_type: 杂志文章


    authors: Xia B,de Belle JS

    更新日期:2016-05-01 00:00:00

  • TNFAIP3 ameliorates the degeneration of inflammatory human nucleus pulposus cells by inhibiting mTOR signaling and promoting autophagy.

    abstract::Autophagy is involved in degenerative diseases such as osteoarthritis and disc degeneration. Although, tumor necrosis factor α-induced protein 3 (TNFAIP3) is well-known as a key regulator of inflammation and autophagy, it is still not clear whether TNFAIP3 regulates autophagy to protect from human disc cells degenerat...


    pub_type: 杂志文章


    authors: Chen J,Ma Y,Yang Z,Lan H,Liu G,Zhang Y,Xia H,Wang X,Han F,Tu X,Liu B

    更新日期:2020-11-20 00:00:00