PaCATB, a secreted catalase protecting Podospora anserina against exogenous oxidative stress.

Abstract:

:A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in the secretome of senescent cultures a catalase, termed PaCATB, was identified. Genetic modulation of the abundance of PaCATB identified differential effects on the phenotype of the corresponding strains. Deletion of PaCatB resulted in decreased resistance, over-expression in increased resistance against hydrogen peroxide. While the lifespan of the genetically modified strains was found to be unaffected under standard growth conditions, increased exogenous hydrogen peroxide stress in the growth medium markedly reduced the lifespan of the PaCatB deletion strain but extended the lifespan of PaCatB over-expressors. Overall our data identify a component of the secretome of P. anserina as a new effective factor to cope with environmental stress, stress that under natural conditions is constantly applied on organisms and influences aging processes.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Zintel S,Bernhardt D,Rogowska-Wrzesinska A,Osiewacz HD

doi

10.18632/aging.100360

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

768-81

issue

8

issn

1945-4589

pii

100360

journal_volume

3

pub_type

杂志文章

相关文献

Aging-US文献大全
  • XRCC1 gene polymorphisms and risk of neuroblastoma in Chinese children.

    abstract::Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...

    journal_title:Aging

    pub_type: 杂志文章,多中心研究

    doi:10.18632/aging.101601

    authors: Zhang J,Zhuo Z,Li W,Zhu J,He J,Su J

    更新日期:2018-10-25 00:00:00

  • Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy.

    abstract::Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrate...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101231

    authors: Wong RCB,Lim SY,Hung SSC,Jackson S,Khan S,Van Bergen NJ,De Smit E,Liang HH,Kearns LS,Clarke L,Mackey DA,Hewitt AW,Trounce IA,Pébay A

    更新日期:2017-04-01 00:00:00

  • MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.

    abstract::Acute ischemic stroke (AIS) is a major public health problem in China. Impaired angiogenesis plays crucial roles in the development of ischemic cerebral injury. Recent studies have identified that microRNAs (miRNAs) are important regulators of angiogenesis, but little is known the exact effects of angiogenesis-associa...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101948

    authors: Du K,Zhao C,Wang L,Wang Y,Zhang KZ,Shen XY,Sun HX,Gao W,Lu X

    更新日期:2019-05-07 00:00:00

  • One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin.

    abstract::The gerosuppressant metformin operates as an efficient inhibitor of the mTOR/S6K1 gerogenic pathway due to its ability to ultimately activate the energy-sensor AMPK. If an aging-related decline in the AMPK sensitivity to cellular stress is a crucial event for mTOR-driven aging and aging-related diseases, including can...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100523

    authors: Menendez JA,Joven J

    更新日期:2012-12-01 00:00:00

  • KCNQ1OT1 promotes melanoma growth and metastasis.

    abstract::Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101418

    authors: Guo B,Zhang Q,Wang H,Chang P,Tao K

    更新日期:2018-04-17 00:00:00

  • Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation.

    abstract::Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102324

    authors: Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

    更新日期:2019-10-06 00:00:00

  • A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer.

    abstract::N6-methyladenosine (m6A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators. However, the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 cen...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103811

    authors: Fan L,Lin Y,Lei H,Shu G,He L,Yan Z,Rihan H,Yin G

    更新日期:2020-09-20 00:00:00

  • Identification of polymorphisms in cancer patients that differentially affect survival with age.

    abstract::The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101305

    authors: Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

    更新日期:2017-10-20 00:00:00

  • Relationship between the expression of oestrogen receptor and progesterone receptor and 18F-FDG uptake in endometrial cancer.

    abstract:BACKGROUND:Progestogens have been widely used for the treatment of inoperable endometrial cancer or younger patients with endometrial cancer. Identifying markers that are predictive of a response to progestogens is critical for successful therapy. Molecular imaging with 18F-fluorodeoxyglucose positron emission tomograp...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103352

    authors: Wu C,Chen R,Xu L,Chen Y,Wang Y,Huang G,Liu J

    更新日期:2020-07-08 00:00:00

  • S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.

    abstract::In this study, we used murine chondrocytes as an in vitro model and mice exhibiting destabilization of the medial meniscus (DMM) as an in vivo model to investigate the mechanisms through which S-allyl cysteine (SAC) alleviates osteoarthritis (OA). SAC significantly reduced apoptosis and senescence and maintained homeo...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103757

    authors: Shao Z,Pan Z,Lin J,Zhao Q,Wang Y,Ni L,Feng S,Tian N,Wu Y,Sun L,Gao W,Zhou Y,Zhang X,Wang X

    更新日期:2020-10-07 00:00:00

  • Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation.

    abstract::The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102035

    authors: Zheng HX,Zhao Y,Xu Y,Zhang ZJ,Zhu JJ,Fan YF,Lin N

    更新日期:2019-06-19 00:00:00

  • Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development.

    abstract::Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101908

    authors: Ren W,Guan W,Zhang J,Wang F,Xu G

    更新日期:2019-04-14 00:00:00

  • Annotation of susceptibility SNPs associated with atrial fibrillation.

    abstract:OBJECTIVE:Genome-wide association studies (GWAS) and the candidate gene based association studies have identified a panel of variants associated with atrial fibrillation (AF), however, most of the identified single nucleotide polymorphisms (SNPs) were found located within intergenic or intronic genomic regions, and whe...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103615

    authors: Xu C,Zhang R,Xia Y,Xiong L,Yang W,Wang P

    更新日期:2020-09-09 00:00:00

  • Age-associated deficient recruitment of 53BP1 in G1 cells directs DNA double-strand break repair to BRCA1/CtIP-mediated DNA-end resection.

    abstract::DNA repair mechanisms play a crucial role in maintaining genome integrity. However, the increased frequency of DNA double-strand breaks (DSBs) and genome rearrangements in aged individuals suggests an age-associated DNA repair deficiency. Previous work from our group revealed a delayed firing of the DNA damage respons...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202419

    authors: Anglada T,Genescà A,Martín M

    更新日期:2020-12-27 00:00:00

  • Colon cancer combined with obesity indicates improved survival- research on relevant mechanism.

    abstract::Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients' survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCG...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103972

    authors: Yang Z,Wei X,Pan Y,Min Z,Xu J,Yu B

    更新日期:2020-11-10 00:00:00

  • Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia.

    abstract::Circular RNAs (circRNAs) have been reported to be involved in many diseases. But there is no report on circRNAs in non-obstructive azoospermia (NOA). The purpose of this paper is to explore the circular RNA expression profile and potential functions of circRNAs in NOA patients. We first preformed circRNA expression pr...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102765

    authors: Bo H,Liu Z,Tang R,Gong G,Wang X,Zhang H,Zhu F,Zhou D,Zhu W,Tan Y,Fan L

    更新日期:2020-02-06 00:00:00

  • A systematic review and network meta-analysis of single nucleotide polymorphisms associated with pancreatic cancer risk.

    abstract::In this meta-analysis, we systematically investigated the correlation between single nucleotide polymorphisms (SNPs) and pancreatic cancer (PC) risk. We searched PubMed, Network Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), an...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104128

    authors: Ye ZM,Li LJ,Luo MB,Qing HY,Zheng JH,Zhang C,Lu YX,Tang YM

    更新日期:2020-11-20 00:00:00

  • Development of a machine learning-based multimode diagnosis system for lung cancer.

    abstract::As an emerging technology, artificial intelligence has been applied to identify various physical disorders. Here, we developed a three-layer diagnosis system for lung cancer, in which three machine learning approaches including decision tree C5.0, artificial neural network (ANN) and support vector machine (SVM) were i...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103249

    authors: Duan S,Cao H,Liu H,Miao L,Wang J,Zhou X,Wang W,Hu P,Qu L,Wu Y

    更新日期:2020-05-23 00:00:00

  • Tubastatin A inhibits HDAC and Sirtuin activity rather than being a HDAC6-specific inhibitor in mouse oocytes.

    abstract::Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar body following TubA treatment. However, a previous study demonstrated that homozygous Hdac6 knockout (KO) mice can be viable and fertile. Therefore, we asked wh...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101867

    authors: Choi YJ,Kang MH,Hong K,Kim JH

    更新日期:2019-03-26 00:00:00

  • FAM84B, amplified in pancreatic ductal adenocarcinoma, promotes tumorigenesis through the Wnt/β-catenin pathway.

    abstract::Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by analyzing The Cancer Genome Atlas cohort, we found that FAM84B amplification was ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103044

    authors: Zhang X,Xu J,Yan R,Zhang Y,Hu Z,Fu H,You Q,Cai Q,Yang D

    更新日期:2020-04-14 00:00:00

  • Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages.

    abstract::Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions in arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles in the regulation of lipid metabolism and the inflammatory response. However, little is kn...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202273

    authors: Yin M,Lu J,Guo Z,Zhang Y,Liu J,Wu T,Guo K,Luo T,Guo Z

    更新日期:2021-01-10 00:00:00

  • Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in.

    abstract::The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent e...

    journal_title:Aging

    pub_type: 杂志文章,评审

    doi:10.18632/aging.100319

    authors: van der Velden YU,Haramis AP

    更新日期:2011-04-01 00:00:00

  • Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2.

    abstract::Genome stability of human embryonic stem cells (hESC) is an important issue because even minor genetic alterations can negatively impact cell functionality and safety. The incorrect repair of DNA double-stranded breaks (DSBs) is the ultimate cause of the formation of chromosomal aberrations. Using G2 radiosensitivity ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100336

    authors: Bogomazova AN,Lagarkova MA,Tskhovrebova LV,Shutova MV,Kiselev SL

    更新日期:2011-06-01 00:00:00

  • Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion.

    abstract::An intriguing area of research has demonstrated the ability of extracellular vesicles (EVs) as biological vehicles for microRNAs (miRNAs) transfer. Mesenchymal stem cells (MSCs) produce large amounts of EVs. Rat models of ischemia/reperfusion (I/R) were established to explore the expression profile of thioredoxin-inte...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102792

    authors: Ou H,Teng H,Qin Y,Luo X,Yang P,Zhang W,Chen W,Lv D,Tang H

    更新日期:2020-07-13 00:00:00

  • KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma.

    abstract::Proliferating cell nuclear antigen binding factor (encoded by KIAA0101/PCLAF) regulates DNA synthesis and cell cycle progression; however, whether the level of KIAA0101 mRNA in lung adenocarcinoma is related to prognosis and tumor immune infiltration is unknown. In patients with lung adenocarcinoma, the differential e...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104144

    authors: Hu S,Zeng W,Zhang W,Xu J,Yu D,Peng J,Wei Y

    更新日期:2020-11-20 00:00:00

  • LINC00623/miR-101/HRAS axis modulates IL-1β-mediated ECM degradation, apoptosis and senescence of osteoarthritis chondrocytes.

    abstract::Chondrocyte apoptosis and extracellular matrix (ECM) degeneration have been implicated in the pathogenesis of osteoarthritis (OA). Based on previously reported microarray analysis, HRAS (Harvey rat sarcoma viral oncogene homolog), a member of the RAS protein family, was chosen as a potential regulator of OA chondrocyt...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102801

    authors: Lü G,Li L,Wang B,Kuang L

    更新日期:2020-02-12 00:00:00

  • Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis.

    abstract::Interleukin 18 (IL-18) promotes inflammation and apoptosis in chondrocytes, thereby contributing to the development and progression of osteoarthritis (OA). Here, we investigated the effects of IL-18 treatment and inhibition in rat chondrocytes in vitro and in vivo. We used RT-PCR and Western blotting to measure the mR...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102937

    authors: Bao J,Chen Z,Xu L,Wu L,Xiong Y

    更新日期:2020-03-17 00:00:00

  • CO2 lattice laser reverses skin aging caused by UVB.

    abstract::The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesi...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103063

    authors: Wang H,Guo B,Hui Q,Lin F,Tao K

    更新日期:2020-04-20 00:00:00

  • Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling.

    abstract::Increasing attentions have been paid to the role of circRNAs in the etiology of triple-negative breast cancer (TNBC), and we strived to figure out the association of circRNA AKT3/miRNA axis with TNBC chemo-resistance. Altogether 207 BC patients were divided into TNBC group (n=83) and non-TNBC group (n=124), and MCF-10...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202415

    authors: Li H,Xu W,Xia Z,Liu W,Pan G,Ding J,Li J,Wang J,Xie X,Jiang D

    更新日期:2021-01-20 00:00:00

  • Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis.

    abstract::Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103669

    authors: Xu W,Song C,Wang X,Li Y,Bai X,Liang X,Wu J,Liu J

    更新日期:2021-01-05 00:00:00