Immune profile of the tumor microenvironment and the identification of a four-gene signature for lung adenocarcinoma.

abstract：:The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell surface-associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perle...

journal_title：Aging

authors： Dos Santos M,Michopoulou A,André-Frei V,Boulesteix S,Guicher C,Dayan G,Whitelock J,Damour O,Rousselle P

更新日期：2016-04-01 00:00:00

abstract：:We examined the effects of coronary heart disease (CHD), hypertension and diabetes on the development of severe COVID-19. We performed a comprehensive, systematic literature search for studies published between December 2019 and July 5, 2020 in five databases. The prevalence of severe COVID-19 in patients with CHD, hy...

journal_title：Aging

authors： Meng M,Zhao Q,Kumar R,Bai C,Deng Y,Wan B

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might i...

journal_title：Aging

authors： Wang ZL,Zhao Z,Wang Z,Zhang CB,Jiang T

更新日期：2019-02-02 00:00:00

abstract：:Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT may disturb the integrity of the epigenetic system. Here, we used a PC...

journal_title：Aging

authors： Park M,Min B,Jeon K,Cho S,Park JS,Kim J,Jeon J,Song J,Kim S,Jeong S,Seo H,Kang YK

更新日期：2017-03-12 00:00:00

abstract：:Adipose-derived stem cells (ASCs) have a demonstrative therapeutic potential in aging-associated facial nerve regeneration, in which ASCs work as a source of Schwann cells therapy as an alternative to autologous nerve grafts. However, the transplantation of ASCs may induce local fibrosis, which causes inferior outcome...

journal_title：Aging

authors： Tan J,Xu Y,Han F,Ye X

更新日期：2019-02-06 00:00:00

abstract：:The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...

journal_title：Aging

authors： Zheng HX,Zhao Y,Xu Y,Zhang ZJ,Zhu JJ,Fan YF,Lin N

更新日期：2019-06-19 00:00:00

abstract：:Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significa...

journal_title：Aging

authors： Chi J,Yang Q,Xie XF,Yang XZ,Zhang MY,Wang HY,Xu GL

更新日期：2016-09-28 00:00:00

abstract：:A poor outcome for pancreatic ductal adenocarcinoma (PDAC) patients is still a challenge worldwide. The aim of our study is to investigate the potential of key laminin subunits for being used both as a diagnostic and prognostic biomarker for PDAC patients. We evaluated the mRNA expression and prognostic value of lamin...

journal_title：Aging

authors： Yang C,Liu Z,Zeng X,Wu Q,Liao X,Wang X,Han C,Yu T,Zhu G,Qin W,Peng T

更新日期：2019-06-10 00:00:00

abstract：:The mechanism underlying the association between age and depletion of the human ovarian follicle reserves remains uncertain. Many identified that impaired DNA polymerase β (Pol β)-mediated DNA base-excision repair (BER) drives to mouse oocyte aging. With aging, DNA lesions accumulate in primordial follicles. However, ...

journal_title：Aging

authors： Hua K,Wang L,Sun J,Zhou N,Zhang Y,Ji F,Jing L,Yang Y,Xia W,Hu Z,Pan F,Chen X,Yao B,Guo Z

更新日期：2020-11-20 00:00:00

abstract：:Our goal was to examine whether multicomponent exercise performed by older adults with mild cognitive impairment or dementia as group-based exercise in community have beneficial effects on cognition and brain-derived neurotrophic factor. Eight studies were identified through Emabase, Medline, PubMed. Searches combined...

journal_title：Aging

authors： Wang X,Wang H,Ye Z,Ding G,Li F,Ma J,Hua W

更新日期：2020-03-19 00:00:00

abstract：:Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...

journal_title：Aging

authors： Zhu L,Zhong Q,Yang T,Xiao X

更新日期：2019-12-21 00:00:00

abstract：:Age can significantly affect human physiology and disease risk. Recent studies have shown that age may affect the composition and function of the gut microbiota, but the underlying mechanisms remain largely unknown. Non-human primates are an ideal model for uncovering how age shapes the gut microbiota, as their microb...

journal_title：Aging

authors： Duan J,Yin B,Li W,Chai T,Liang W,Huang Y,Tan X,Zheng P,Wu J,Li Y,Li Y,Zhou W,Xie P

更新日期：2019-12-14 00:00:00

abstract：:Di (2-ethylhexyl) phthalate (DEHP), an estrogen-like compound that is a ubiquitous environmental contaminant, has been reported to adversely affect human and mammalian reproduction. Many studies have found that exposure to DEHP during pregnancy perturbs female germ cell meiosis and is detrimental to oogenesis. Previou...

journal_title：Aging

authors： Sun ZY,Zhang P,Wang JJ,Liu JC,Li L,Shen W,Zhai QY

更新日期：2018-12-26 00:00:00

abstract：:The lack of a univocal definition of frailty, a condition frequently found in the elderly population which is correlated with an increased risk of mortality, has prompted the search for clinical and laboratory parameters associated with this condition. Whereas OPG is a protein involved in different pathophysiological ...

journal_title：Aging

authors： Valentini A,Cianfarani MA,Tarantino U,Di Daniele N,Bertoli A

更新日期：2019-07-17 00:00:00

abstract：:Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...

journal_title：Aging

authors： de Magalhães JP,Müller M,Rainger GE,Steegenga W

更新日期：2016-08-01 00:00:00

abstract：:Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the fli...

journal_title：Aging

authors： Lin YR,Parikh H,Park Y

更新日期：2018-04-19 00:00:00

abstract：:Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a ...

journal_title：Aging

authors： Gao WQ,Hu XM,Zhang Q,Yang L,Lv XZ,Chen S,Wu P,Duan DW,Lang YH,Ning M,Lai KG,Zhang ZY,Liang B,Bao JY,Wu HD,Li T

更新日期：2020-12-19 00:00:00

abstract：:Acute ischemic stroke (AIS) is a major public health problem in China. Impaired angiogenesis plays crucial roles in the development of ischemic cerebral injury. Recent studies have identified that microRNAs (miRNAs) are important regulators of angiogenesis, but little is known the exact effects of angiogenesis-associa...

journal_title：Aging

authors： Du K,Zhao C,Wang L,Wang Y,Zhang KZ,Shen XY,Sun HX,Gao W,Lu X

更新日期：2019-05-07 00:00:00

abstract：:Aging and age-related diseases occur in almost all organisms. Recently, it was discovered that the inhibition of target of rapamycin complex 1 (TORC1), a conserved complex that mediates nutrient status and cell metabolism, can extend an individual's lifespan and inhibit age-related diseases in many model organisms. Ho...

journal_title：Aging

authors： Xi J,Cai J,Cheng Y,Fu Y,Wei W,Zhang Z,Zhuang Z,Hao Y,Lilly MA,Wei Y

更新日期：2019-11-11 00:00:00

abstract：:Recently epidemiological studies suggest females lose neuroprotection from neurodegenerative diseases as they go through menopause. It has been hypothesized that this neuroprotection is hormone-dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to pl...

journal_title：Aging

authors： Evola CM,Hudson TL,Huang L,Corbett AM,Mayes DA

更新日期：2018-08-31 00:00:00

abstract：:Stress responses are affected by aging. However, studies on stress-related changes in feeding patterns with aging subject are minimal. We investigated feeding patterns induced by two psychological stress models, revealing characteristics of stress-induced feeding patterns as "meal" and "bout" (defined as the minimum f...

journal_title：Aging

authors： Yamada C,Mogami S,Hattori T

更新日期：2017-11-09 00:00:00

abstract：:There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individua...

journal_title：Aging

authors： Hung PH,Lin CH,Hung KY,Muo CH,Chung MC,Chang CH,Chung CJ

更新日期：2020-02-24 00:00:00

abstract：:Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...

journal_title：Aging

authors： Wen C,Xie T,Pan K,Deng Y,Zhao Z,Li N,Bian J,Deng X,Zha Y

更新日期：2020-02-26 00:00:00

abstract：:Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. ...

journal_title：Aging

authors： Reifsnyder PC,Flurkey K,Te A,Harrison DE

更新日期：2016-11-30 00:00:00

abstract：:Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Relative risks an...

journal_title：Aging

authors： Zhang D,Dai C,Zhou L,Li Y,Liu K,Deng YJ,Li N,Zheng Y,Hao Q,Yang S,Song D,Wu Y,Zhai Z,Cao S,Dai Z

更新日期：2020-06-02 00:00:00

abstract：:Recent experimental studies highlighted the role of hydrogen sulfide (H2S) in aging and longevity. The cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) are the key enzymes responsible for H2S production. Here we investigated the geroprotective effects of CSE and CBS overexpression in Drosophila. Overexpr...

journal_title：Aging

authors： Shaposhnikov M,Proshkina E,Koval L,Zemskaya N,Zhavoronkov A,Moskalev A

更新日期：2018-11-08 00:00:00

abstract：:Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old m...

journal_title：Aging

authors： Dong Q,Gao H,Shi Y,Zhang F,Gu X,Wu A,Wang D,Chen Y,Bandyopadhyay A,Yeh IT,Daniel BJ,Chen Y,Zou Y,Rebel VL,Walter CA,Lu J,Huang C,Sun LZ

更新日期：2016-11-15 00:00:00

abstract：:PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...

journal_title：Aging

authors： Kunstmann B,Osiewacz HD

更新日期：2009-03-03 00:00:00

abstract：:Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is on...

journal_title：Aging

authors： Mara JN,Zhou LT,Larmore M,Johnson B,Ayiku R,Amargant F,Pritchard MT,Duncan FE

更新日期：2020-05-14 00:00:00

abstract：:FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we ...

journal_title：Aging

authors： Zhong L,Zhang Y,Li M,Song Y,Liu D,Yang X,Yang D,Qu H,Lai L,Wang Q,Chen Z

更新日期：2020-12-01 00:00:00