HBXIP promotes gastric cancer via METTL3-mediated MYC mRNA m6A modification.

abstract：:Spermatogenesis is a complex process producing haploid spermatozoa, and the formation of lipid droplets (LDs) within Sertoli cells is critical to maintaining normal spermatogenesis. However, the utilization of LDs within Sertoli cells is still largely unknown. In the present study, proliferation of spermatogonial cell...

journal_title：Aging

authors： Ahmed N,Liu Y,Chen H,Yang P,Waqas Y,Liu T,Gandahi JA,Huang Y,Wang L,Song X,Rajput IR,Wang T,Chen Q

更新日期：2016-10-16 00:00:00

abstract：:Epigenetic regulation of various genomic functions, including gene expression, provide mechanisms whereby an organism can dynamically respond to changes in its environment and modify gene expression accordingly. One epigenetic mechanism implicated in human aging and age-related disorders is DNA methylation. Isolated p...

journal_title：Aging

authors： Benton MC,Sutherland HG,Macartney-Coxson D,Haupt LM,Lea RA,Griffiths LR

更新日期：2017-02-28 00:00:00

abstract：:Qigesan (QGS) has been used to effectively treat esophageal cancer (EC) for decades in China, but the mechanism by which it suppresses EC metastasis remains unknown. In this study, we examined the effects of QGS on EC cell mobility. Using immunohistochemistry and immunofluorescence, expression of Gas6 and Axl, which p...

journal_title：Aging

authors： Kong L,Lu X,Chen X,Wu Y,Zhang Y,Shi H,Li J

更新日期：2020-05-20 00:00:00

abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...

journal_title：Aging

authors： Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

更新日期：2019-12-19 00:00:00

abstract：:Of all the major organ systems in the body, the ovaries of females are the first to exhibit impaired function with advancing age. Until recently, traditional thinking was that female mammals are provided with a non-renewable pool of oocyte-containing follicles at birth that are depleted during postnatal life to exhaus...

journal_title：Aging

authors： Niikura Y,Niikura T,Tilly JL

更新日期：2009-12-12 00:00:00

abstract：:Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA...

journal_title：Aging

authors： Chen K,Huang X,Xie D,Shen M,Lin H,Zhu Y,Ma S,Zheng C,Chen L,Liu Y,Liao W,Bin J,Liao Y

更新日期：2021-01-20 00:00:00

abstract：:The flavonoids in Ageratum conyzoides L. have been used in traditional medicine due to its anti-inflammatory and antibacterial properties. However, the specific mechanism of its antibacterial effect, and the potential therapeutic effect on vaginitis have not been well explained. The growth curves of E. coli, S. aurues...

journal_title：Aging

authors： Lin Z,Lin Y,Zhang Z,Shen J,Yang C,Jiang M,Hou Y

更新日期：2020-04-09 00:00:00

abstract：:FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we ...

journal_title：Aging

authors： Zhong L,Zhang Y,Li M,Song Y,Liu D,Yang X,Yang D,Qu H,Lai L,Wang Q,Chen Z

更新日期：2020-12-01 00:00:00

abstract：:Myocardial infarction is a cardiovascular disease with high mortality. Human umbilical cord mesenchymal stem cells (hUC-MSCs) with strong self-renewal capacity and multipotency, provide the possibility of replacing injured cardiomyocytes. hUC-MSCs were cultured on polyacrylamide hydrogels with stiffnesses correspondin...

journal_title：Aging

authors： Sun Y,Liu J,Xu Z,Lin X,Zhang X,Li L,Li Y

更新日期：2020-12-09 00:00:00

abstract：:Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with the carcinogenesis and progression of breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, and Basal-like BRCA, four- (BIRC5, PARP1, ATG9B, and ...

journal_title：Aging

authors： Han B,Zhang H,Zhu Y,Han X,Wang Z,Gao Z,Yuan Y,Tian R,Zhang F,Niu R

更新日期：2020-07-10 00:00:00

abstract：:The two most common aging-related diseases, Alzheimer's disease and type 2 diabetes mellitus, are associated with accumulation of amyloid proteins (β-amyloid and amylin, respectively). This amylin aggregation is reportedly cytotoxic to neurons. We found that aggregation of human amylin (hAmylin) induced neuronal apopt...

journal_title：Aging

authors： Zhang N,Xing Y,Yu Y,Liu C,Jin B,Huo L,Kong D,Yang Z,Zhang X,Zheng R,Jia Z,Kang L,Zhang W

更新日期：2020-05-28 00:00:00

abstract：:A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in the secretome of senescent cultures a catalase, termed PaCATB, was identified. Genetic modulation...

journal_title：Aging

authors： Zintel S,Bernhardt D,Rogowska-Wrzesinska A,Osiewacz HD

更新日期：2011-08-01 00:00:00

abstract：:This study compares the longitudinal histological characteristics of proximal humeral implants with different spatial structures in rabbits. Thirty skeletally-mature male rabbits were divided into a trabecular structure group and regular hexahedron structure group according to the different spatial structures of a bio...

journal_title：Aging

authors： Xue Z,Pei Z,Zhang H,Tang C,Jia J,Zhang K,Zhang K,Wang L,Guan Z

更新日期：2021-01-20 00:00:00

abstract：:In this study, we used murine chondrocytes as an in vitro model and mice exhibiting destabilization of the medial meniscus (DMM) as an in vivo model to investigate the mechanisms through which S-allyl cysteine (SAC) alleviates osteoarthritis (OA). SAC significantly reduced apoptosis and senescence and maintained homeo...

journal_title：Aging

authors： Shao Z,Pan Z,Lin J,Zhao Q,Wang Y,Ni L,Feng S,Tian N,Wu Y,Sun L,Gao W,Zhou Y,Zhang X,Wang X

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:Mitochondrial dysfunction and oxidative stress are closely associated with the pathogenesis of Parkinson's disease. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α) is thought to play multiple roles in the regulation of mitochondrial biogenesis and cellular energy metabolism. We rece...

journal_title：Aging

authors： Wang Y,Chen C,Huang W,Huang M,Wang J,Chen X,Ye Q

更新日期：2019-10-21 00:00:00

abstract：:Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...

journal_title：Aging

authors： Sgarbi G,Matarrese P,Pinti M,Lanzarini C,Ascione B,Gibellini L,Dika E,Patrizi A,Tommasino C,Capri M,Cossarizza A,Baracca A,Lenaz G,Solaini G,Franceschi C,Malorni W,Salvioli S

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma. RESULTS:We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to...

journal_title：Aging

authors： Zhou J,Wu G,Tong Z,Sun J,Su J,Cao Z,Luo Y,Wang W

更新日期：2020-12-30 00:00:00

abstract：:Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. ...

journal_title：Aging

authors： Reifsnyder PC,Flurkey K,Te A,Harrison DE

更新日期：2016-11-30 00:00:00

abstract：:Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the fli...

journal_title：Aging

authors： Lin YR,Parikh H,Park Y

更新日期：2018-04-19 00:00:00

abstract：:Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. Since strong consensus regarding commonly altered MRs in hepatocellular carcinoma (HCC) is lacking, we generated a compendium of HCC datasets from 21 studies and identified a c...

journal_title：Aging

authors： Li Z,Lou Y,Tian G,Wu J,Lu A,Chen J,Xu B,Shi J,Yang J

更新日期：2019-12-18 00:00:00

abstract：:Mounting studies have shown that long noncoding RNAs (lncRNAs) play important roles in the development and occurrence of several human diseases. However, the role of LINC00461 in osteoarthritis (OA) remains obscure. A CCK-8 assay was performed to detect cell viability, and qRT-PCR analysis was used to measure mRNA exp...

journal_title：Aging

authors： Zhang Y,Ma L,Wang C,Wang L,Guo Y,Wang G

更新日期：2020-03-10 00:00:00

abstract：:Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and strength in old rats following disuse-induced atrophy. Adult (9 month) ...

journal_title：Aging

authors： Baehr LM,West DW,Marcotte G,Marshall AG,De Sousa LG,Baar K,Bodine SC

更新日期：2016-01-01 00:00:00

abstract：:Many studies have investigated how aging decreases human strength and endurance. However, understanding the effect of aging on human motor ability requires more than knowledge of the separate temporal profile of individual motor function because the structure of human motor ability is multi-dimensional. We address the...

journal_title：Aging

authors： Panday SB,Pathak P,Moon J,Ahn J

更新日期：2019-07-30 00:00:00

abstract：:Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embr...

journal_title：Aging

authors： Lu YJ,Jan YJ,Ko BS,Liang SM,Chen L,Wu CC,Chin CH,Kuo CC,Yet SF,Liou JY

更新日期：2020-04-24 00:00:00

abstract：:PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...

journal_title：Aging

authors： Kunstmann B,Osiewacz HD

更新日期：2009-03-03 00:00:00

abstract：:The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...

journal_title：Aging

authors： Zheng HX,Zhao Y,Xu Y,Zhang ZJ,Zhu JJ,Fan YF,Lin N

更新日期：2019-06-19 00:00:00

abstract：:Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is on...

journal_title：Aging

authors： Mara JN,Zhou LT,Larmore M,Johnson B,Ayiku R,Amargant F,Pritchard MT,Duncan FE

更新日期：2020-05-14 00:00:00

abstract：:Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. The association between METH gene polymorphisms and prostate cancer susceptibility remains ambiguous. Thus, we performed an updated meta-analysis of METH single-nuc...

journal_title：Aging

authors： Zhang X,Tang J,Shen N,Ren K

更新日期：2018-10-18 00:00:00

abstract：:Melanoma is a skin malignancy with a high mutation frequency of genetic alterations. MicroRNA (miR)-200b-3p is involved in various cancers, while in melanoma its bio-function remains unknown. In this study, we found that miR-200b-3p was down-regulated in melanoma tissues and cell lines compared to benign nevus cells. ...

journal_title：Aging

authors： Zhou WJ,Wang HY,Zhang J,Dai HY,Yao ZX,Zheng Z,Meng-Yan S,Wu K

更新日期：2020-11-16 00:00:00

abstract：:Combination treatment is a promising strategy to improve prognosis of hepatocellular carcinoma (HCC). Sorafenib is a traditional first-line agent approved for the treatment of advanced HCC, though with limited efficacy. Previously, we reported that lonafarnib, an orally bioavailable non-peptide inhibitor targeting far...

journal_title：Aging

authors： Wang J,Wei H,Huang Y,Chen D,Zeng G,Lian Y,Huang Y

更新日期：2019-08-13 00:00:00