NEAT1/miR-200b-3p/SMAD2 axis promotes progression of melanoma.

abstract：BACKGROUND:Mitochondrial dysfunction and oxidative stress are closely associated with the pathogenesis of Parkinson's disease. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α) is thought to play multiple roles in the regulation of mitochondrial biogenesis and cellular energy metabolism. We rece...

journal_title：Aging

authors： Wang Y,Chen C,Huang W,Huang M,Wang J,Chen X,Ye Q

更新日期：2019-10-21 00:00:00

abstract：:Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...

journal_title：Aging

authors： Ren W,Guan W,Zhang J,Wang F,Xu G

更新日期：2019-04-14 00:00:00

abstract：:Programmed cell death 1 (PD-1) checkpoint inhibitor therapy leads to immune-related adverse events (irAEs). We sought to evaluate whether the development of irAEs correlates with the treatment response in Chinese patients with advanced melanoma. In this study, we conducted a retrospective study of advanced melanoma pa...

journal_title：Aging

authors： Zhao JJ,Wen XZ,Ding Y,Li DD,Zhu BY,Li JJ,Weng DS,Zhang X,Zhang XS

更新日期：2020-06-08 00:00:00

abstract：:Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Ectopic expression o...

journal_title：Aging

authors： Yan L,You WQ,Sheng NQ,Gong JF,Hu LD,Tan GW,Chen HQ,Wang ZG

更新日期：2018-12-06 00:00:00

abstract：:Although previous studies indicated that cumulus cells (CCs) accelerate oocyte aging by releasing soluble factors, the factors have yet to be characterized. While demonstrating that CCs promoted oocyte aging by releasing soluble Fas ligand (sFasL), our recent study suggested that CCs might secrete other factors to med...

journal_title：Aging

authors： Kong QQ,Wang J,Xiao B,Lin FH,Zhu J,Sun GY,Luo MJ,Tan JH

更新日期：2018-07-26 00:00:00

abstract：:Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...

journal_title：Aging

authors： Hexiao T,Yuquan B,Lecai X,Yanhong W,Li S,Weidong H,Ming X,Xuefeng Z,Gaofeng P,Li Z,Minglin Z,Zheng T,Zetian Y,Xiao Z,Yi C,Lanuti M,Jinping Z

更新日期：2021-01-10 00:00:00

abstract：:Mounting studies have shown that long noncoding RNAs (lncRNAs) play important roles in the development and occurrence of several human diseases. However, the role of LINC00461 in osteoarthritis (OA) remains obscure. A CCK-8 assay was performed to detect cell viability, and qRT-PCR analysis was used to measure mRNA exp...

journal_title：Aging

authors： Zhang Y,Ma L,Wang C,Wang L,Guo Y,Wang G

更新日期：2020-03-10 00:00:00

abstract：:Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows ...

journal_title：Aging

authors： Del Campo A,Contreras-Hernández I,Castro-Sepúlveda M,Campos CA,Figueroa R,Tevy MF,Eisner V,Casas M,Jaimovich E

更新日期：2018-01-04 00:00:00

abstract：:MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epide...

journal_title：Aging

authors： Zhao Z,Gao D,Ma T,Zhang L

更新日期：2019-02-08 00:00:00

abstract：:Chondrocyte apoptosis and extracellular matrix (ECM) degeneration have been implicated in the pathogenesis of osteoarthritis (OA). Based on previously reported microarray analysis, HRAS (Harvey rat sarcoma viral oncogene homolog), a member of the RAS protein family, was chosen as a potential regulator of OA chondrocyt...

journal_title：Aging

authors： Lü G,Li L,Wang B,Kuang L

更新日期：2020-02-12 00:00:00

abstract：:Proliferating cell nuclear antigen binding factor (encoded by KIAA0101/PCLAF) regulates DNA synthesis and cell cycle progression; however, whether the level of KIAA0101 mRNA in lung adenocarcinoma is related to prognosis and tumor immune infiltration is unknown. In patients with lung adenocarcinoma, the differential e...

journal_title：Aging

authors： Hu S,Zeng W,Zhang W,Xu J,Yu D,Peng J,Wei Y

更新日期：2020-11-20 00:00:00

abstract：:Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains...

journal_title：Aging

authors： Foscarin S,Raha-Chowdhury R,Fawcett JW,Kwok JCF

更新日期：2017-06-28 00:00:00

abstract：:A recently discovered satiety molecule, nesfatin-1, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances, corticotropin-releasing hormone (CRH), oxytocin, proopiomelanocortin, noradrenaline (NA) and 5-hydroxytryptamine (5-HT). Intracerebroventricular (icv) administr...

journal_title：Aging

authors： Yoshida N,Maejima Y,Sedbazar U,Ando A,Kurita H,Damdindorj B,Takano E,Gantulga D,Iwasaki Y,Kurashina T,Onaka T,Dezaki K,Nakata M,Mori M,Yada T

更新日期：2010-11-01 00:00:00

abstract：:Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food ...

journal_title：Aging

authors： Suo S,Culotti JG,Van Tol HH

更新日期：2009-10-21 00:00:00

abstract：:The estrogen membrane receptor GPR30 (also known as G-protein coupled receptor 30) has recently been shown to be involved in the regulation of oocyte maturation and cumulus expansion. However, whether GPR30 expression is regulated by gonadotropin stimulation and how it participates in the regulation of the maturation ...

journal_title：Aging

authors： Liu J,Yao R,Lu S,Xu R,Zhang H,Wei J,Zhao C,Tang Y,Li C,Liu H,Zhao X,Wei Q,Ma B

更新日期：2020-10-28 00:00:00

abstract：:Reducing the expression of the Indy (I'm Not Dead Yet) gene in lower organisms extends life span by mechanisms resembling caloric restriction. Similarly, deletion of the mammalian homolog, mIndy (Slc13a5), encoding for a plasma membrane tricarboxylate transporter, protects from aging- and diet-induced adiposity and in...

journal_title：Aging

authors： Pesta DH,Perry RJ,Guebre-Egziabher F,Zhang D,Jurczak M,Fischer-Rosinsky A,Daniels MA,Willmes DM,Bhanot S,Bornstein SR,Knauf F,Samuel VT,Shulman GI,Birkenfeld AL

更新日期：2015-12-01 00:00:00

abstract：:To investigate the association of homocysteine concentration with intracranial atherosclerotic stenosis (ICAS), we assessed 933 acute ischemic stroke patients (346 with ICAS, 587 without ICAS) and 798 non-stroke controls (175 with ICAS, 623 without ICAS) with magnetic resonance angiography (MRA). Homocysteine concentr...

journal_title：Aging

authors： Liu Y,Song JH,Hou XH,Ma YH,Shen XN,Xu W,Sun FR,Dong Q,Yu JT,Tan L,Chi S

更新日期：2019-06-12 00:00:00

abstract：:The survival rate of stomach adenocarcinoma patients with immune and stromal scores and different clinicopathological features obtained from the TCGA datasets was systematically compared. A list of genes that are correlated with stomach adenocarcinoma microenvironment were extracted using the TCGA database to predict ...

journal_title：Aging

authors： Yao K,Wei L,Zhang J,Wang C,Wang C,Qin C,Li S

更新日期：2020-08-21 00:00:00

abstract：:Alterations in KEAP1/ NF-E2 p45-related factor 2 (NFE2L2/Nrf2) signaling pathway have been reported in 23% lung adenocarcinoma patients, suggesting that deregulation of the pathway is a major cancer driver. Here we report that mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) drives tumor growth and drug re...

journal_title：Aging

authors： Wang H,Liu K,Chi Z,Zhou X,Ren G,Zhou R,Li Y,Tang X,Wang XJ

更新日期：2019-12-06 00:00:00

abstract：:The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a...

journal_title：Aging

authors： McCubrey JA,Demidenko ZN

更新日期：2012-12-01 00:00:00

abstract：:Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...

journal_title：Aging

authors： Zhang J,Zhuo Z,Li W,Zhu J,He J,Su J

更新日期：2018-10-25 00:00:00

abstract：OBJECTIVE:To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma. RESULTS:We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to...

journal_title：Aging

authors： Zhou J,Wu G,Tong Z,Sun J,Su J,Cao Z,Luo Y,Wang W

更新日期：2020-12-30 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray and public database ...

journal_title：Aging

authors： Zhan YT,Li L,Zeng TT,Zhou NN,Guan XY,Li Y

更新日期：2020-12-03 00:00:00

abstract：:Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...

journal_title：Aging

authors： Yang Y,Jia Y,Sun Q,Dong H,Zhao R

更新日期：2019-03-28 00:00:00

abstract：:Stress responses are affected by aging. However, studies on stress-related changes in feeding patterns with aging subject are minimal. We investigated feeding patterns induced by two psychological stress models, revealing characteristics of stress-induced feeding patterns as "meal" and "bout" (defined as the minimum f...

journal_title：Aging

authors： Yamada C,Mogami S,Hattori T

更新日期：2017-11-09 00:00:00

abstract：:Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...

journal_title：Aging

authors： Wen C,Xie T,Pan K,Deng Y,Zhao Z,Li N,Bian J,Deng X,Zha Y

更新日期：2020-02-26 00:00:00

abstract：:Salivary gland dysfunction is a common symptom that occurs after menopause. This study was performed to investigate the mechanism of salivary gland dysfunction to confirm the relationship between ferroptosis and salivary gland dysfunction by ovariectomy. Forty-eight female rats were randomly divided into four groups (...

journal_title：Aging

authors： Kwon HK,Kim JM,Shin SC,Sung ES,Kim HS,Park GC,Cheon YI,Lee JC,Lee BJ

更新日期：2020-11-05 00:00:00

abstract：:Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...

journal_title：Aging

authors： Guo B,Zhang Q,Wang H,Chang P,Tao K

更新日期：2018-04-17 00:00:00

abstract：:Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and interstitial conditions ...

journal_title：Aging

authors： Yanagida K,Maejima Y,Santoso P,Otgon-Uul Z,Yang Y,Sakuma K,Shimomura K,Yada T

更新日期：2014-03-01 00:00:00

abstract：:Blood brain barrier (BBB) disruption is a crucial factor contributing to secondary brain injury after intracerebral hemorrhage (ICH). Heat shock protein B8 (HSPB8) has been recently reported to confer neuroprotection against against ischaemic stroke through maintaining BBB integrity. However, the role of HSPB8 in ICH ...

journal_title：Aging

authors： Hou Y,Hu Z,Gong X,Yang B

更新日期：2020-09-04 00:00:00