Novel cellular evidence of lipophagy within the Sertoli cells during spermatogenesis in the turtle.

abstract：:The solute carrier (SLC) family is the largest group of membrane transporters, but their functions in ovarian cancer (OV) remain unclear. We analyzed SLC family members with amino acids-transporting functions in OV. The mRNA expression levels and prognostic values of SLCs in OV were analyzed in the Gene Expression Pro...

journal_title：Aging

authors： Sun T,Bi F,Liu Z,Yang Q

更新日期：2020-07-09 00:00:00

abstract：:Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Relative risks an...

journal_title：Aging

authors： Zhang D,Dai C,Zhou L,Li Y,Liu K,Deng YJ,Li N,Zheng Y,Hao Q,Yang S,Song D,Wu Y,Zhai Z,Cao S,Dai Z

更新日期：2020-06-02 00:00:00

abstract：:Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embr...

journal_title：Aging

authors： Lu YJ,Jan YJ,Ko BS,Liang SM,Chen L,Wu CC,Chin CH,Kuo CC,Yet SF,Liou JY

更新日期：2020-04-24 00:00:00

abstract：:DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more ...

journal_title：Aging

authors： Blagosklonny MV

更新日期：2011-02-01 00:00:00

abstract：:The mechanism underlying the association between age and depletion of the human ovarian follicle reserves remains uncertain. Many identified that impaired DNA polymerase β (Pol β)-mediated DNA base-excision repair (BER) drives to mouse oocyte aging. With aging, DNA lesions accumulate in primordial follicles. However, ...

journal_title：Aging

authors： Hua K,Wang L,Sun J,Zhou N,Zhang Y,Ji F,Jing L,Yang Y,Xia W,Hu Z,Pan F,Chen X,Yao B,Guo Z

更新日期：2020-11-20 00:00:00

abstract：:Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...

journal_title：Aging

authors： de Magalhães JP,Müller M,Rainger GE,Steegenga W

更新日期：2016-08-01 00:00:00

abstract：:Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions in arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles in the regulation of lipid metabolism and the inflammatory response. However, little is kn...

journal_title：Aging

authors： Yin M,Lu J,Guo Z,Zhang Y,Liu J,Wu T,Guo K,Luo T,Guo Z

更新日期：2021-01-10 00:00:00

abstract：UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovati...

journal_title：Aging

authors： Vitale G,Brugts MP,Ogliari G,Castaldi D,Fatti LM,Varewijck AJ,Lamberts SW,Monti D,Bucci L,Cevenini E,Cavagnini F,Franceschi C,Hofland LJ,Mari D,Janssen J

更新日期：2012-09-01 00:00:00

abstract：:A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in the secretome of senescent cultures a catalase, termed PaCATB, was identified. Genetic modulation...

journal_title：Aging

authors： Zintel S,Bernhardt D,Rogowska-Wrzesinska A,Osiewacz HD

更新日期：2011-08-01 00:00:00

abstract：:Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...

journal_title：Aging

authors： Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

更新日期：2019-10-06 00:00:00

abstract：:Elderly patients with coronavirus disease 2019 (COVID-19) are more likely to develop severe or critical pneumonia, with a high fatality rate. To date, there is no model to predict the severity of COVID-19 in elderly patients. In this study, patients who maintained a non-severe condition and patients who progressed to ...

journal_title：Aging

authors： Zeng F,Deng G,Cui Y,Zhang Y,Dai M,Chen L,Han D,Li W,Guo K,Chen X,Shen M,Pan P

更新日期：2020-11-10 00:00:00

abstract：:Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...

journal_title：Aging

authors： Djelti F,Dhenain M,Terrien J,Picq JL,Hardy I,Champeval D,Perret M,Schenker E,Epelbaum J,Aujard F

更新日期：2016-12-28 00:00:00

abstract：:SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulate...

journal_title：Aging

authors： Liu A,Zhang S,Li W,Xu B,Lei R,Zhu S

更新日期：2020-01-11 00:00:00

abstract：:The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversib...

journal_title：Aging

authors： Galluzzi L,Kepp O,Kroemer G

更新日期：2010-09-01 00:00:00

abstract：:Renal dysfunction is a risk factor for morbidity and mortality in cardiac surgery patients. Serum Cystatin C (sCysC) is a well-recognized marker of early renal dysfunction but few reports evaluate its prognostic cardio-vascular role. The aim of the study is to consider the prognostic value of sCysC for cardiovascular ...

journal_title：Aging

authors： Rovella V,Marrone G,Dessì M,Ferrannini M,Toschi N,Pellegrino A,Casasco M,Di Daniele N,Noce A

更新日期：2018-03-27 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a highly malignant tumor. Many circular RNAs (circRNAs) are reportedly in regulating the progression of NSCLC. To identify potential therapeutic targets for NSCLC, we conducted a bioinformatics analysis of circRNAs differentially expressed between NSCLC tissues and adjacent normal...

journal_title：Aging

authors： Chen S,Lu S,Yao Y,Chen J,Yang G,Tu L,Zhang Z,Zhang J,Chen L

更新日期：2020-07-18 00:00:00

abstract：:lncRNA can interact with miRNA as a ceRNA to participate in the regulation of target gene expression, thus playing an important role in the development of malignant tumors. In this research, we found that OGFRP1 was up-regulated in prostate cancer (PCa) clinical samples and cell lines. Additionally, OGFRP1 is signific...

journal_title：Aging

authors： Yan K,Hou L,Liu T,Jiao W,Ma Q,Fang Z,Zhang S,Song D,Liu J,Gao X,Fan Y

更新日期：2020-05-19 00:00:00

abstract：:Commensal microbes have mutualistic relationships with their host and mainly live in the host intestine. There are many studies on the relationships between commensal microbes and host physiology. However, there are inconsistent results on the effects of commensal microbes on host lifespan. To clarify this controversy...

journal_title：Aging

authors： Lee HY,Lee SH,Lee JH,Lee WJ,Min KJ

更新日期：2019-07-12 00:00:00

abstract：:Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth...

journal_title：Aging

authors： Zhang J,Chen Q,Du D,Wu T,Wen J,Wu M,Zhang Y,Yan W,Zhou S,Li Y,Jin Y,Luo A,Wang S

更新日期：2019-01-23 00:00:00

abstract：:Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...

journal_title：Aging

authors： Yin L,Yao J,Deng G,Wang X,Cai W,Shen J

更新日期：2020-05-11 00:00:00

abstract：OBJECTIVE:This study aimed to explore the effect of silencing hTERT on the CSC-like characteristics and radioresistance of CNE-2R cells. RESULTS:Silencing hTERT suppressed CNE-2R cell proliferation and increased the cell apoptosis rate and radiosensitivity in vitro. Moreover, it could also inhibit the growth of xenogr...

journal_title：Aging

authors： Chen K,Li L,Qu S,Pan X,Sun Y,Wan F,Yu B,Zhou L,Zhu X

更新日期：2020-11-24 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies worldwide with limited treatment options and distinct geographical distribution even in countries such as China. Genetic alterations during its carcinogenesis need urgent elucidation. In this study, we propose an intriguing hypothesis that the hepatitis B X-in...

journal_title：Aging

authors： Yang Z,Jiang X,Li D,Jiang X

更新日期：2020-10-13 00:00:00

abstract：:Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrate...

journal_title：Aging

authors： Wong RCB,Lim SY,Hung SSC,Jackson S,Khan S,Van Bergen NJ,De Smit E,Liang HH,Kearns LS,Clarke L,Mackey DA,Hewitt AW,Trounce IA,Pébay A

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because pat...

journal_title：Aging

authors： Pérez-Martínez L,Romero L,Muñoz-Galván S,Verdugo-Sivianes EM,Rubio-Mediavilla S,Oteo JA,Carnero A,Blanco JR

更新日期：2020-04-30 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem cell-derived exosomes have exhibited promising therapeutic effects. In this study, we performed intracerebroventricular microinject...

journal_title：Aging

authors： Chen Y,Li J,Ma B,Li N,Wang S,Sun Z,Xue C,Han Q,Wei J,Zhao RC

更新日期：2020-09-23 00:00:00

abstract：:Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...

journal_title：Aging

authors： Yang Y,Jia Y,Sun Q,Dong H,Zhao R

更新日期：2019-03-28 00:00:00

abstract：:Myocardial infarction is a cardiovascular disease with high mortality. Human umbilical cord mesenchymal stem cells (hUC-MSCs) with strong self-renewal capacity and multipotency, provide the possibility of replacing injured cardiomyocytes. hUC-MSCs were cultured on polyacrylamide hydrogels with stiffnesses correspondin...

journal_title：Aging

authors： Sun Y,Liu J,Xu Z,Lin X,Zhang X,Li L,Li Y

更新日期：2020-12-09 00:00:00

abstract：:The Editorial Board of Aging reviews research papers published in 2009, which they believe have or will have significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote longevity in model organisms, DNA damage responses and telomeres, molecular mechani...

journal_title：Aging

authors： Blagosklonny MV,Campisi J,Sinclair DA,Bartke A,Blasco MA,Bonner WM,Bohr VA,Brosh RM Jr,Brunet A,Depinho RA,Donehower LA,Finch CE,Finkel T,Gorospe M,Gudkov AV,Hall MN,Hekimi S,Helfand SL,Karlseder J,Kenyon C,Kroeme

更新日期：2010-03-01 00:00:00

abstract：:Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...

journal_title：Aging

authors： Tian Y,Yang J,Lan M,Zou T

更新日期：2020-12-26 00:00:00

abstract：:In our previous study, we found that low thymic output and short telomere length were associated with a higher risk of tumor in elderly cancer patients. Here, we aimed to examine in depth the impact of immunological and biological senescence and immune activation on disease outcome in elderly patients with colorectal ...

journal_title：Aging

authors： Giunco S,Petrara MR,Bergamo F,Del Bianco P,Zanchetta M,Carmona F,Zagonel V,De Rossi A,Lonardi S

更新日期：2019-06-13 00:00:00