Silencing hTERT attenuates cancer stem cell-like characteristics and radioresistance in the radioresistant nasopharyngeal carcinoma cell line CNE-2R.

abstract：:For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...

journal_title：Aging

authors： Zhu Q,Ren H,Li X,Qian B,Fan S,Hu F,Xu L,Zhai B

更新日期：2020-11-16 00:00:00

abstract：:Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary ...

journal_title：Aging

authors： Niu H,Niu W,Yu T,Dong F,Huang K,Duan R,Qumu S,Lu M,Li Y,Yang T,Wang C

更新日期：2019-05-29 00:00:00

abstract：:A recently discovered satiety molecule, nesfatin-1, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances, corticotropin-releasing hormone (CRH), oxytocin, proopiomelanocortin, noradrenaline (NA) and 5-hydroxytryptamine (5-HT). Intracerebroventricular (icv) administr...

journal_title：Aging

authors： Yoshida N,Maejima Y,Sedbazar U,Ando A,Kurita H,Damdindorj B,Takano E,Gantulga D,Iwasaki Y,Kurashina T,Onaka T,Dezaki K,Nakata M,Mori M,Yada T

更新日期：2010-11-01 00:00:00

abstract：:A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative ...

journal_title：Aging

authors： Pretorius E,Swanepoel AC,Buys AV,Vermeulen N,Duim W,Kell DB

更新日期：2014-10-01 00:00:00

abstract：:N6-methyladenosine (m6A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators. However, the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 cen...

journal_title：Aging

authors： Fan L,Lin Y,Lei H,Shu G,He L,Yan Z,Rihan H,Yin G

更新日期：2020-09-20 00:00:00

abstract：:Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...

journal_title：Aging

authors： Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

更新日期：2019-10-06 00:00:00

abstract：:Multiple recent advances in machine learning enabled computer systems to exceed human performance in many tasks including voice, text, and speech recognition and complex strategy games. Aging is a complex multifactorial process driven by and resulting in the many minute changes transpiring at every level of the human ...

journal_title：Aging

authors： Zhavoronkov A,Li R,Ma C,Mamoshina P

更新日期：2019-11-25 00:00:00

abstract：:Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...

journal_title：Aging

authors： Li H,Wang X,Lu X,Zhu H,Li S,Duan S,Zhao X,Zhang F,Alterovitz G,Wang F,Li Q,Tian XL,Xu M

更新日期：2019-09-12 00:00:00

abstract：:Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...

journal_title：Aging

authors： de Magalhães JP,Müller M,Rainger GE,Steegenga W

更新日期：2016-08-01 00:00:00

abstract：:Bladder cancer (BCa) is a heterogeneous disease with various tumorigenic mechanisms and clinical behaviors. The current tumor-node-metastasis (TNM) staging system is inadequate to predict overall survival (OS) in BCa patients. We developed a BCa-specific, long-non-coding-RNA (lncRNA)-based nomogram to improve survival...

journal_title：Aging

authors： Wang Y,Du L,Yang X,Li J,Li P,Zhao Y,Duan W,Chen Y,Wang Y,Mao H,Wang C

更新日期：2020-02-12 00:00:00

abstract：:The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...

journal_title：Aging

authors： Lopriore P,Capitanio N,Panatta E,Di Daniele N,Gambacurta A,Melino G,Amelio I

更新日期：2018-12-08 00:00:00

abstract：:Reducing the expression of the Indy (I'm Not Dead Yet) gene in lower organisms extends life span by mechanisms resembling caloric restriction. Similarly, deletion of the mammalian homolog, mIndy (Slc13a5), encoding for a plasma membrane tricarboxylate transporter, protects from aging- and diet-induced adiposity and in...

journal_title：Aging

authors： Pesta DH,Perry RJ,Guebre-Egziabher F,Zhang D,Jurczak M,Fischer-Rosinsky A,Daniels MA,Willmes DM,Bhanot S,Bornstein SR,Knauf F,Samuel VT,Shulman GI,Birkenfeld AL

更新日期：2015-12-01 00:00:00

abstract：:Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...

journal_title：Aging

authors： Guo B,Zhang Q,Wang H,Chang P,Tao K

更新日期：2018-04-17 00:00:00

abstract：:Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Relative risks an...

journal_title：Aging

authors： Zhang D,Dai C,Zhou L,Li Y,Liu K,Deng YJ,Li N,Zheng Y,Hao Q,Yang S,Song D,Wu Y,Zhai Z,Cao S,Dai Z

更新日期：2020-06-02 00:00:00

abstract：INTRODUCTION:Circulating non-coding RNA is an ideal source to discover novel biomarkers for non-invasive screening. However, studies for the discovery of universal miRNAs in serum and exosomes for breast cancer early diagnosis are limited. METHODS:Based on bioinformatic analysis, in vitro and in vivo studies were perf...

journal_title：Aging

authors： Liu D,Li B,Shi X,Zhang J,Chen AM,Xu J,Wang W,Huang K,Gao J,Zheng Z,Liu D,Wang H,Shi W,Chen L,Xu J

更新日期：2021-01-20 00:00:00

abstract：:Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression corr...

journal_title：Aging

authors： Tsai HC,Cheng SP,Han CK,Huang YL,Wang SW,Lee JJ,Lai CT,Fong YC,Tang CH

更新日期：2019-11-13 00:00:00

abstract：:In humans, the ERBB2 gene amplification and overexpression are biomarkers for invasive breast cancer and a therapeutic target. Also, TOP2α gene aberrations predict the response to anthracycline-based adjuvant chemotherapy. Although feline mammary tumors (FMTs) are good models in comparative oncology, scarce data is av...

journal_title：Aging

authors： Ferreira D,Soares M,Correia J,Adega F,Ferreira F,Chaves R

更新日期：2019-07-12 00:00:00

abstract：:Increased activation of catabolic pathways, including apoptosis causes sarcopenia. However, the precise molecular mechanism that initiates apoptosis during aging is not well understood. Here, we report that aging alters miRNA expression profile in mouse skeletal muscle as evidenced by miRNA microarray and real-time PC...

journal_title：Aging

authors： Pardo PS,Hajira A,Boriek AM,Mohamed JS

更新日期：2017-03-22 00:00:00

abstract：:Melanoma is a skin malignancy with a high mutation frequency of genetic alterations. MicroRNA (miR)-200b-3p is involved in various cancers, while in melanoma its bio-function remains unknown. In this study, we found that miR-200b-3p was down-regulated in melanoma tissues and cell lines compared to benign nevus cells. ...

journal_title：Aging

authors： Zhou WJ,Wang HY,Zhang J,Dai HY,Yao ZX,Zheng Z,Meng-Yan S,Wu K

更新日期：2020-11-16 00:00:00

abstract：:Few reports have investigated different genetic alterations according to age in various cancers. In total, 1749 GC patients receiving curative surgery were enrolled. The clinicopathological features, and prognoses were compared between younger (<65 years) and older (≥65 years) patients. Genetic mutations were analyzed...

journal_title：Aging

authors： Wu CW,Chen MH,Huang KH,Chang SC,Fang WL,Lin CH,Chao Y,Lo SS,Li AF,Shyr YM

更新日期：2020-08-18 00:00:00

abstract：:We explored whether acute atorvastatin treatment would improve clinical outcomes and reduce the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage in elderly Chinese adults. Patients (60 to 90 years old) were admitted to intensive care units after surgery to clip or embolize their aneurysms. We a...

journal_title：Aging

authors： Chen J,Li M,Zhu X,Chen L,Yang S,Zhang C,Wu T,Feng X,Wang Y,Chen Q

更新日期：2020-02-07 00:00:00

abstract：:Neural stem cell (NSC) transplantation has prevailed as a promising protective strategy for cardiac arrest (CA)-induced brain damage. Surprisingly, the poor survival of neuronal cells in severe hypoxic condition restricts the utilization of this cell-based therapy. Extracellular vesicles (EVs) transfer microRNAs (miRN...

journal_title：Aging

authors： Li F,Zhang J,Chen A,Liao R,Duan Y,Xu Y,Tao L

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...

journal_title：Aging

authors： Wenjing L,Yuanzheng F,Li JY,Tang LV,Yu H

更新日期：2020-12-15 00:00:00

abstract：:Recent experimental studies highlighted the role of hydrogen sulfide (H2S) in aging and longevity. The cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) are the key enzymes responsible for H2S production. Here we investigated the geroprotective effects of CSE and CBS overexpression in Drosophila. Overexpr...

journal_title：Aging

authors： Shaposhnikov M,Proshkina E,Koval L,Zemskaya N,Zhavoronkov A,Moskalev A

更新日期：2018-11-08 00:00:00

abstract：:The incidence of subarachnoid hemorrhage (SAH) and hazard ratio of death increase with age. Overactivation of microglia contributes to brain damage. This study aimed to investigate the effects of A3 adenosine receptors (A3R) activation on neurofunction and microglial phenotype polarization in the context of SAH in age...

journal_title：Aging

authors： Li P,Li X,Deng P,Wang D,Bai X,Li Y,Luo C,Belguise K,Wang X,Wei X,Xia Z,Yi B

更新日期：2020-11-30 00:00:00

abstract：:In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted brain magnetic resonance imaging data were analyzed from 45 adults with NSCLP after palatoplasty: 24 subjects were assessed before AR ...

journal_title：Aging

authors： Li Z,Zhang W,Li C,Wang M,Wang S,Chen R,Zhang X

更新日期：2020-07-03 00:00:00

abstract：:Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...

journal_title：Aging

authors： Patrick A,Seluanov M,Hwang C,Tam J,Khan T,Morgenstern A,Wiener L,Vazquez JM,Zafar H,Wen R,Muratkalyeva M,Doerig K,Zagorulya M,Cole L,Catalano S,Lobo Ladd AA,Coppi AA,Coşkun Y,Tian X,Ablaeva J,Nevo E,Gladyshev VN

更新日期：2016-05-01 00:00:00

abstract：:Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain a...

journal_title：Aging

authors： Wang Y,Song Y,Pang Y,Yu Z,Hua W,Gu Y,Qi J,Wu H

更新日期：2020-06-29 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery smooth muscle cell (PASMC) dysfunction. However, the underlying mechanisms of PASMC dysfunction remain largely unknown. Here, we show that mitochondrial fragmentation contributes to PASMC dysfunction through enhancement of endoplasmic reticulum...

journal_title：Aging

authors： Zhuan B,Wang X,Wang MD,Li ZC,Yuan Q,Xie J,Yang Z

更新日期：2020-11-18 00:00:00

abstract：:Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...

journal_title：Aging

authors： Yin L,Yao J,Deng G,Wang X,Cai W,Shen J

更新日期：2020-05-11 00:00:00