Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia.

abstract：:To identify an immune-related prognostic signature based on long non-coding RNAs (lncRNAs) and find immunotherapeutic targets for bladder urothelial carcinoma, we downloaded RNA-sequencing data from The Cancer Genome Atlas (TCGA) dataset. Functional enrichment analysis demonstrated bladder urothelial carcinoma was rel...

journal_title：Aging

authors： Song Y,Jin D,Chen J,Luo Z,Chen G,Yang Y,Liu X

更新日期：2020-06-24 00:00:00

abstract：:Non-coding small RNAs of the micro-RNA class (miRNA) are conserved regulators of gene function with a broad impact on biological processes. We screened miRNA levels for age-related changes in individual worms and investigated their influence on the lifespan of the nematode C. elegans. We measured the abundance of 69 m...

journal_title：Aging

authors： Lucanic M,Graham J,Scott G,Bhaumik D,Benz CC,Hubbard A,Lithgow GJ,Melov S

更新日期：2013-06-01 00:00:00

abstract：:TET family members (TETs) encode proteins that represent crucial factors in the active DNA demethylation pathway. Evidence has proved that TET2 mutation is associated with leukemogenesis, drug response, and prognosis in acute myeloid leukemia (AML). However, few studies revealed the TETs expression and its clinical si...

journal_title：Aging

authors： Zhang T,Zhao Y,Zhao Y,Zhou J

更新日期：2020-03-25 00:00:00

abstract：BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...

journal_title：Aging

authors： Yerrakalva D,Hajna S,Wijndaele K,Westgate K,Khaw KT,Wareham N,Griffin SJ,Brage S

更新日期：2021-01-11 00:00:00

abstract：:Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of three fibrates, pharmacologically established s...

journal_title：Aging

authors： Brandstädt S,Schmeisser K,Zarse K,Ristow M

更新日期：2013-04-01 00:00:00

abstract：:This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...

journal_title：Aging

authors： Qian X,Jia H,Zhang Y,Ma B,Qin G,Wu Z

更新日期：2020-10-13 00:00:00

abstract：:Senescent cells accumulate in various tissues and organs with aging altering surrounding tissue due to an active secretome, and at least in mice their elimination extends healthy lifespan and ameliorates several chronic diseases. Whether all cell types senesce, including post-mitotic cells, has been poorly described m...

journal_title：Aging

authors： Moreno-Blas D,Gorostieta-Salas E,Pommer-Alba A,Muciño-Hernández G,Gerónimo-Olvera C,Maciel-Barón LA,Konigsberg M,Massieu L,Castro-Obregón S

更新日期：2019-08-30 00:00:00

abstract：:Recently, over-expression of LAIR-1 has been found in some solid cancers, including ovarian cancer. The role of LAIR-1 in cancer progression needs further investigation. In this study, we identified the LAIR-1 cDNA sequence of the ovarian cancer cells HO8910. Using SKOV3 cells, we confirmed the finding from our previo...

journal_title：Aging

authors： Liu Y,Ma L,Shangguan F,Zhao X,Wang W,Gao Z,Zhou H,Qu G,Huang Y,An J,Xue J,Yang S,Cao Q

更新日期：2020-09-05 00:00:00

abstract：:Stress responses are affected by aging. However, studies on stress-related changes in feeding patterns with aging subject are minimal. We investigated feeding patterns induced by two psychological stress models, revealing characteristics of stress-induced feeding patterns as "meal" and "bout" (defined as the minimum f...

journal_title：Aging

authors： Yamada C,Mogami S,Hattori T

更新日期：2017-11-09 00:00:00

abstract：:Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain a...

journal_title：Aging

authors： Wang Y,Song Y,Pang Y,Yu Z,Hua W,Gu Y,Qi J,Wu H

更新日期：2020-06-29 00:00:00

abstract：:Proinsulin, insulin and proinsulin/insulin (P/I) ratio have been reported to be correlated with fasting plasma glucose (FPG) and Hemoglobin A1c (HbA1c) in whole population study therefore sensitive predictors of T2D progression. However, by analyzing data collected from 2018-2019 from a cohort of 1579 East Asian indiv...

journal_title：Aging

authors： Li T,Quan H,Zhang H,Lin L,Lin L,Ou Q,Chen K

更新日期：2020-06-12 00:00:00

abstract：:The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...

journal_title：Aging

authors： Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P

更新日期：2019-02-05 00:00:00

abstract：:Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...

journal_title：Aging

authors： de Magalhães JP,Müller M,Rainger GE,Steegenga W

更新日期：2016-08-01 00:00:00

abstract：:Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...

journal_title：Aging

authors： Noren Hooten N,Fitzpatrick M,Kompaniez K,Jacob KD,Moore BR,Nagle J,Barnes J,Lohani A,Evans MK

更新日期：2012-10-01 00:00:00

abstract：:Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a re...

journal_title：Aging

authors： Chen X,Amorim JA,Moustafa GA,Lee JJ,Yu Z,Ishihara K,Iesato Y,Barbisan P,Ueta T,Togka KA,Lu L,Sinclair DA,Vavvas DG

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might i...

journal_title：Aging

authors： Wang ZL,Zhao Z,Wang Z,Zhang CB,Jiang T

更新日期：2019-02-02 00:00:00

abstract：:Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and d...

journal_title：Aging

authors： Valentini E,Zampieri M,Malavolta M,Bacalini MG,Calabrese R,Guastafierro T,Reale A,Franceschi C,Hervonen A,Koller B,Bernhardt J,Slagboom PE,Toussaint O,Sikora E,Gonos ES,Breusing N,Grune T,Jansen E,Dollé ME,Moreno-Vi

更新日期：2016-08-29 00:00:00

abstract：:Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains...

journal_title：Aging

authors： Foscarin S,Raha-Chowdhury R,Fawcett JW,Kwok JCF

更新日期：2017-06-28 00:00:00

abstract：:The ventral hypothalamus (VHT) integrates several physiological cues to maintain glucose homeostasis and energy balance. Aging is associated with increased glucose intolerance but the underlying mechanisms responsible for age-related metabolic decline, including neuronal signaling in the VHT, remain elusive. We have s...

journal_title：Aging

authors： Sato K,Idelevich A,Nagano K,Rowe GC,Gori F,Baron R

更新日期：2017-01-20 00:00:00

abstract：OBJECTIVE:This study aimed to explore the effect of silencing hTERT on the CSC-like characteristics and radioresistance of CNE-2R cells. RESULTS:Silencing hTERT suppressed CNE-2R cell proliferation and increased the cell apoptosis rate and radiosensitivity in vitro. Moreover, it could also inhibit the growth of xenogr...

journal_title：Aging

authors： Chen K,Li L,Qu S,Pan X,Sun Y,Wan F,Yu B,Zhou L,Zhu X

更新日期：2020-11-24 00:00:00

abstract：:Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness...

journal_title：Aging

authors： Lee Y,Hwang W,Jung J,Park S,Cabatbat JJ,Kim PJ,Lee SJ

更新日期：2016-05-01 00:00:00

abstract：:The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...

journal_title：Aging

authors： Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

更新日期：2017-10-20 00:00:00

abstract：:Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...

journal_title：Aging

authors： Yin L,Yao J,Deng G,Wang X,Cai W,Shen J

更新日期：2020-05-11 00:00:00

abstract：:Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mas...

journal_title：Aging

authors： Cao W,Zheng D,Wang G,Zhang J,Ge S,Singh M,Wang H,Song M,Li D,Wang W,Xu X,Wang Y

更新日期：2020-06-05 00:00:00

abstract：:Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported t...

journal_title：Aging

authors： Huang JL,Yu C,Su M,Yang SM,Zhang F,Chen YY,Liu JY,Jiang YF,Zhong ZG,Wu DP

更新日期：2019-10-07 00:00:00

abstract：:Osteoarthritis is a common joint disease that disrupts the lives of millions of people worldwide. To date, a safe and reliable treatment has not yet been announced. Excessive production of pro-inflammatory cytokines such as TNF-α plays an important role in the pathological development of OA. Dehydrocostus lactone (DHC...

journal_title：Aging

authors： Wang L,Yang M,Zhang C,Huang F

更新日期：2020-09-14 00:00:00

abstract：:Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in ...

journal_title：Aging

authors： Xu Y,Chen T,Li X,Qu YK,An JN,Zheng HX,Zhang ZJ,Lin N

更新日期：2016-12-20 00:00:00

abstract：:Recent studies have confirmed that both cancer-associated bone marrow mesenchymal stem cells (BM-MSCs, MSCs) and glioma stem-like cells (GSCs) contribute to malignant progression of gliomas through their mutual interactions within the tumor microenvironment. However, the exact ways and relevant mechanisms involved in ...

journal_title：Aging

authors： Wang H,Tan L,Dong X,Liu L,Jiang Q,Li H,Shi J,Yang X,Dai X,Qian Z,Dong J

更新日期：2020-07-06 00:00:00

abstract：:The regulation of mechanistic target of rapamycin (mTOR) signaling contributes to the metabolic effects of a calorie restriction (CR) diet. We assayed the effect of CR on the activity of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) in the liver of mice at six different times across the day. CR effects on mTORC1...

journal_title：Aging

authors： Tulsian R,Velingkaar N,Kondratov R

更新日期：2018-07-16 00:00:00

abstract：:Oxidative stress and inflammation play vital roles in Parkinson's disease (PD) development. Thus, telomere length is expected to be shortened in this disease, but current data are inconclusive. We performed a case-control study of 261 patients with PD and 270 sex and age-matched healthy controls treated at the Peking ...

journal_title：Aging

authors： Wu Y,Pei Y,Yang Z,Li K,Lou X,Cui W

更新日期：2020-10-29 00:00:00