Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring.

Abstract:

UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p〈0.01), total IGF-I (p〈0.01) and the IGF-I/IGFBP-3 molar ratio (p〈0.001) were significantly lower in centenarians' offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians' offspring IGF-I bioactivity was inversely associated to insulin sensitivity. IN CONCLUSION:1) centenarians' offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians' offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Vitale G,Brugts MP,Ogliari G,Castaldi D,Fatti LM,Varewijck AJ,Lamberts SW,Monti D,Bucci L,Cevenini E,Cavagnini F,Franceschi C,Hofland LJ,Mari D,Janssen J

doi

10.18632/aging.100484

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

580-9

issue

9

issn

1945-4589

pii

100484

journal_volume

4

pub_type

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