Abstract:
:Renal dysfunction is a risk factor for morbidity and mortality in cardiac surgery patients. Serum Cystatin C (sCysC) is a well-recognized marker of early renal dysfunction but few reports evaluate its prognostic cardio-vascular role. The aim of the study is to consider the prognostic value of sCysC for cardiovascular mortality. Four hundred twenty-four cardiac-surgery patients (264 men and 160 women) were enrolled. At admission, all patients were tested for renal function and inflammatory status. Patients were subdivided in subgroups according to the values of the following variables: sCysC, serum Creatinine (sCrea), age, high sensitivity-C Reactive Protein, fibrinogen, surgical procedures and Kaplan-Meier cumulative survival curves were plotted. The primary end-point was cardiovascular mortality. In order to evaluate the simultaneous independent impact of all measured variables on survival we fitted a multivariate Cox-Proportional Hazard Model (CPHM). In Kaplan-Meier analysis 124 patients (29.4%) reached the end-point. In multivariate CPHM, the only significant predictors of mortality were sCysC (p<0.00001, risk ratio: 1.529, CI: 1.29-1.80) and age (p=0.039, risk ratio: 1.019, CI: 1.001-1.037). When replacing sCysC with sCrea, the only significant predictor of mortality was sCrea (p=0.0026; risk ratio 1.20; CI: 1.06-1.36). Increased levels of sCysC can be considered a useful biomarker of cardiovascular mortality in cardiac-surgery patients.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Rovella V,Marrone G,Dessì M,Ferrannini M,Toschi N,Pellegrino A,Casasco M,Di Daniele N,Noce Adoi
10.18632/aging.101403subject
Has Abstractpub_date
2018-03-27 00:00:00pages
425-433issue
3issn
1945-4589pii
101403journal_volume
10pub_type
杂志文章相关文献
Aging-US文献大全abstract::Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100958
更新日期:2016-05-01 00:00:00
abstract::The gerosuppressant metformin operates as an efficient inhibitor of the mTOR/S6K1 gerogenic pathway due to its ability to ultimately activate the energy-sensor AMPK. If an aging-related decline in the AMPK sensitivity to cellular stress is a crucial event for mTOR-driven aging and aging-related diseases, including can...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100523
更新日期:2012-12-01 00:00:00
abstract::Spermatogenesis is a complex process producing haploid spermatozoa, and the formation of lipid droplets (LDs) within Sertoli cells is critical to maintaining normal spermatogenesis. However, the utilization of LDs within Sertoli cells is still largely unknown. In the present study, proliferation of spermatogonial cell...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101070
更新日期:2016-10-16 00:00:00
abstract::Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102856
更新日期:2020-02-26 00:00:00
abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202302
更新日期:2020-12-03 00:00:00
abstract::Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported t...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102337
更新日期:2019-10-07 00:00:00
abstract::Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100991
更新日期:2016-07-01 00:00:00
abstract::The lack of a univocal definition of frailty, a condition frequently found in the elderly population which is correlated with an increased risk of mortality, has prompted the search for clinical and laboratory parameters associated with this condition. Whereas OPG is a protein involved in different pathophysiological ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102083
更新日期:2019-07-17 00:00:00
abstract::As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical need. Italy has one of the highest numbers of SARS-CoV-2-related deaths and one of the highest mortality rates. Worldwide, a more severe course of COVID-19 is as...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103415
更新日期:2020-06-05 00:00:00
abstract::Esophageal adenocarcinoma (EAC) is one of the leading causes of cancer-related death worldwide, and the molecular biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs are dysregulated in a variety of cancers including EAC. In this study, siRNA mediated gene knockdown, W...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101953
更新日期:2019-05-13 00:00:00
abstract::Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101878
更新日期:2019-03-28 00:00:00
abstract::Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101280
更新日期:2017-08-31 00:00:00
abstract::Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro- and macrovascular complications that increase the morbidity and mortality of patients. The risk of diabetic complications has a strong genetic component. To this end, we sought to evaluate the association of 40 single nucleotide polymorphism...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101375
更新日期:2018-02-04 00:00:00
abstract::Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100867
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (LncRNAs) have been associated with several types of cancer. However, little is known about their role in lung adenocarcinoma (LUAD). RESULTS:LINC00968 was significantly differentially expressed in LUAD tissues. Downregulated LINC00968 was associated with clinicopathological features of...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104011
更新日期:2020-11-04 00:00:00
abstract::Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202303
更新日期:2021-01-10 00:00:00
abstract::Angiogenesis - the growth of new blood capillaries- is impaired in aging animals. Biophysical factors such as changes in cell size control endothelial cell (EC) proliferation and differentiation. However, the effects of aging on EC size and the mechanism by which changes in cell size control age-dependent decline in E...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102236
更新日期:2019-09-05 00:00:00
abstract:BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102397
更新日期:2019-10-31 00:00:00
abstract::Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by analyzing The Cancer Genome Atlas cohort, we found that FAM84B amplification was ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103044
更新日期:2020-04-14 00:00:00
abstract::Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. The association between METH gene polymorphisms and prostate cancer susceptibility remains ambiguous. Thus, we performed an updated meta-analysis of METH single-nuc...
journal_title:Aging
pub_type: 杂志文章,meta分析,评审
doi:10.18632/aging.101584
更新日期:2018-10-18 00:00:00
abstract::Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors in the development of age-related neuroinflammation and microglial dysfunction. EE results in improvements ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101923
更新日期:2019-04-29 00:00:00
abstract::We examined the effects of coronary heart disease (CHD), hypertension and diabetes on the development of severe COVID-19. We performed a comprehensive, systematic literature search for studies published between December 2019 and July 5, 2020 in five databases. The prevalence of severe COVID-19 in patients with CHD, hy...
journal_title:Aging
pub_type: 杂志文章,meta分析
doi:10.18632/aging.103991
更新日期:2020-11-16 00:00:00
abstract::Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions in arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles in the regulation of lipid metabolism and the inflammatory response. However, little is kn...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202273
更新日期:2021-01-10 00:00:00
abstract::Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with the carcinogenesis and progression of breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, and Basal-like BRCA, four- (BIRC5, PARP1, ATG9B, and ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103437
更新日期:2020-07-10 00:00:00
abstract::Macromitophagy controls mitochondrial quality and quantity. It involves the sequestration of dysfunctional or excessive mitochondria within double-membrane autophagosomes, which then fuse with the vacuole/lysosome to deliver these mitochondria for degradation. To investigate a physiological role of macromitophagy in y...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100547
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because pat...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103167
更新日期:2020-04-30 00:00:00
abstract::Caveolae are vesicular invaginations of the plasma membrane. Caveolin-1 is the structural protein component of caveolae. Caveolin-1 participates in signal transduction processes by acting as a scaffolding protein that concentrates, organizes and functional regulates signaling molecules within caveolar membranes. Cigar...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100079
更新日期:2009-08-10 00:00:00
abstract:BACKGROUND:Gastric cancer is a common malignancy and had poor response to treatment due to its strong heterogeneity. This study aimed to identify essential genes associated with diffuse type gastric cancer and construct a powerful prognostic model. RESULTS:We conducted a weighted gene co-expression network analysis (W...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103743
更新日期:2020-09-11 00:00:00
abstract::Treatment of thoracic tumors with radiotherapy can lead to severe cardiac injury. We investigated the effects of dexrazoxane, a USFDA-approved cardioprotective drug administered with chemotherapy, on radiation-induced heart disease (RIHD) in a rat model. Male Sprague-Dawley rats were irradiated with a single dose of 2...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202332
更新日期:2021-01-02 00:00:00
abstract::Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103669
更新日期:2021-01-05 00:00:00