Survival of irradiated recipient mice after transplantation of bone marrow from young, old and "early aging" mice.

abstract：:Despite improvements in surgical procedures and comprehensive therapies, pancreatic cancer remains one of the most aggressive and deadly human malignancies. It is therefore necessary to determine which cellular mediators associate with prognosis in pancreatic cancer so as to improve the treatment of this disease. In t...

journal_title：Aging

authors： Li Y,Kong R,Chen H,Zhao Z,Li L,Li J,Hu J,Zhang G,Pan S,Wang Y,Wang G,Chen H,Sun B

更新日期：2019-07-21 00:00:00

abstract：BACKGROUND:Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might i...

journal_title：Aging

authors： Wang ZL,Zhao Z,Wang Z,Zhang CB,Jiang T

更新日期：2019-02-02 00:00:00

abstract：:Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro- and macrovascular complications that increase the morbidity and mortality of patients. The risk of diabetic complications has a strong genetic component. To this end, we sought to evaluate the association of 40 single nucleotide polymorphism...

journal_title：Aging

authors： Montesanto A,Bonfigli AR,Crocco P,Garagnani P,De Luca M,Boemi M,Marasco E,Pirazzini C,Giuliani C,Franceschi C,Passarino G,Testa R,Olivieri F,Rose G

更新日期：2018-02-04 00:00:00

abstract：:Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...

journal_title：Aging

authors： Fu K,Hui B,Wang Q,Lu C,Shi W,Zhang Z,Rong D,Zhang B,Tian Z,Tang W,Cao H,Wang X,Chen Z

更新日期：2020-02-10 00:00:00

abstract：:Recent studies have demonstrated circular RNAs (circRNAs) to be widely expressed and to have important physiological functions. However, the expression, regulation, and function of circRNAs in neuroglial cells are unknown. Herein, we characterized the expression, regulation, and function of circRNAs in astrocytes. Ast...

journal_title：Aging

authors： Diling C,Yinrui G,Longkai Q,Xiaocui T,Yadi L,Xin Y,Guoyan H,Ou S,Tianqiao Y,Dongdong W,Yizhen X,Yang BB,Qingping W

更新日期：2019-12-20 00:00:00

abstract：:DNA methyltransferases (DNMTs) by regulating DNA methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia (AML). Accumulating investigations have identified the high incidence of DNMT3A mutation in AML, and it is correlated with poor prognosis. Although a few...

journal_title：Aging

authors： Zhang TJ,Zhang LC,Xu ZJ,Zhou JD

更新日期：2020-06-26 00:00:00

abstract：:Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a ...

journal_title：Aging

authors： Gao WQ,Hu XM,Zhang Q,Yang L,Lv XZ,Chen S,Wu P,Duan DW,Lang YH,Ning M,Lai KG,Zhang ZY,Liang B,Bao JY,Wu HD,Li T

更新日期：2020-12-19 00:00:00

abstract：:Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...

journal_title：Aging

authors： Zhu L,Zhong Q,Yang T,Xiao X

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:Gastric cancer is a common malignancy and had poor response to treatment due to its strong heterogeneity. This study aimed to identify essential genes associated with diffuse type gastric cancer and construct a powerful prognostic model. RESULTS:We conducted a weighted gene co-expression network analysis (W...

journal_title：Aging

authors： Zhou Q,Zhou LQ,Li SH,Yuan YW,Liu L,Wang JL,Wu DZ,Wu Y,Xin L

更新日期：2020-09-11 00:00:00

abstract：:There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recru...

journal_title：Aging

authors： Zarnani K,Nichols TE,Alfaro-Almagro F,Fagerlund B,Lauritzen M,Rostrup E,Smith SM

更新日期：2019-08-26 00:00:00

abstract：:FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we ...

journal_title：Aging

authors： Zhong L,Zhang Y,Li M,Song Y,Liu D,Yang X,Yang D,Qu H,Lai L,Wang Q,Chen Z

更新日期：2020-12-01 00:00:00

abstract：:Mesenchymal-to-endothelial transition (MEndT) is one of the mechanisms that influences cardiac fibrosis, which is a key process in cardiac remodeling. It has been reported that autophagy inhibits endothelial cell transition. However, whether autophagy could modulate MEndT in cardiac fibrosis has not yet been investiga...

journal_title：Aging

authors： Hu J,Kong S,Dong T,Lin Z,Zhang Q,Chen X,Gong Y,Fan X,He M,Zhou H

更新日期：2020-11-13 00:00:00

abstract：:Type 2 resistant starch (RS2) is a fermentable dietary fiber conferring health benefits. We investigated the effects of RS2 on host, gut microbiota, and metabolites in aged mice on high-fat diet. In eighteen-month old mice randomly assigned to control, high-fat (HF), or high-fat+20% RS2 (HFRS) diet for 16 weeks, RS2 r...

journal_title：Aging

authors： Zhang Y,Chen L,Hu M,Kim JJ,Lin R,Xu J,Fan L,Qi Y,Wang L,Liu W,Deng Y,Si J,Chen S

更新日期：2020-05-25 00:00:00

abstract：:The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms. Previous studies have characterized the impact of circadian clock on tumorigenesis and specific immune cells. Here, by using multi-omics computation techniques, we systematically characterized the distinct ...

journal_title：Aging

authors： Yang Y,Yuan G,Xie H,Wei T,Zhu D,Cui J,Liu X,Shen R,Zhu Y,Yang X

更新日期：2019-12-23 00:00:00

abstract：:Few reports have investigated different genetic alterations according to age in various cancers. In total, 1749 GC patients receiving curative surgery were enrolled. The clinicopathological features, and prognoses were compared between younger (<65 years) and older (≥65 years) patients. Genetic mutations were analyzed...

journal_title：Aging

authors： Wu CW,Chen MH,Huang KH,Chang SC,Fang WL,Lin CH,Chao Y,Lo SS,Li AF,Shyr YM

更新日期：2020-08-18 00:00:00

abstract：:Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and strength in old rats following disuse-induced atrophy. Adult (9 month) ...

journal_title：Aging

authors： Baehr LM,West DW,Marcotte G,Marshall AG,De Sousa LG,Baar K,Bodine SC

更新日期：2016-01-01 00:00:00

abstract：:To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA ...

journal_title：Aging

authors： Ko CH,Wu SJ,Wang ST,Chang YF,Chang CS,Kuan TS,Chuang HY,Chang CM,Chou W,Wu CH

更新日期：2020-07-26 00:00:00

abstract：:Human tumors and cultured cells contain elevated levels of endogenous DNA damage resulting from telomere dysfunction, replication and transcription errors, reactive oxygen species, and genome instability. However, the contribution of telomere-associated versus telomere-independent endogenous DNA lesions to this damage...

journal_title：Aging

authors： Nakamura AJ,Redon CE,Bonner WM,Sedelnikova OA

更新日期：2009-02-04 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery smooth muscle cell (PASMC) dysfunction. However, the underlying mechanisms of PASMC dysfunction remain largely unknown. Here, we show that mitochondrial fragmentation contributes to PASMC dysfunction through enhancement of endoplasmic reticulum...

journal_title：Aging

authors： Zhuan B,Wang X,Wang MD,Li ZC,Yuan Q,Xie J,Yang Z

更新日期：2020-11-18 00:00:00

abstract：:Dysregulation of α(1,6)-fucosyltransferase (FUT8) plays significant roles in development of a variety of malignant tumor types. We collected as many relevant articles and microarray datasets as possible to assess the prognostic value of FUT8 expression in malignant tumors. For this purpose, we systematically searched ...

journal_title：Aging

authors： Ma M,Han G,Wang Y,Zhao Z,Guan F,Li X

更新日期：2020-12-11 00:00:00

abstract：:Telomeres are a hotspot for sister chromatid exchange (T-SCE). Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence. This work strongly suggests that progressive telomere erosion ...

journal_title：Aging

authors： Blagoev KB,Goodwin EH,Bailey SM

更新日期：2010-10-01 00:00:00

abstract：:Glomerulosclerosis and renal interstitial fibrosis occur with the aging kidney. In this study, we examined the expression of miR-21, peroxisome proliferator-activated receptor(PPARα), hypoxia-inducible factor(HIF-1α) in the kidney of 3-month-old rats fed ad libitum (YAL), 24-month-old rats fed ad libitum (OAL) and 24-...

journal_title：Aging

authors： Liu JR,Cai GY,Ning YC,Wang JC,Lv Y,Guo YN,Fu B,Hong Q,Sun XF,Chen XM

更新日期：2020-08-27 00:00:00

abstract：:Liver fibrosis biomarker, Type IV collagen, may function as hepatocarcinogenesis niche. However, among the six isoforms, the isoforms providing tumor microenvironment and their regulatory network are still unclarified. Based on bioinformatics analysis of hundreds of HCC transcriptome datasets from public databases, we...

journal_title：Aging

authors： Liu Y,Zhang J,Chen Y,Sohel H,Ke X,Chen J,Li YX

更新日期：2020-01-05 00:00:00

abstract：:The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a...

journal_title：Aging

authors： McCubrey JA,Demidenko ZN

更新日期：2012-12-01 00:00:00

abstract：:Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers ...

journal_title：Aging

authors： Peto MV,De la Guardia C,Winslow K,Ho A,Fortney K,Morgen E

更新日期：2017-08-31 00:00:00

abstract：:In this study, we constructed a model using a Cox proportional hazards model based on the expression of eight immune-related genes that were associated with prognosis in prostate cancer: EDNRB, ANGPTL2, TNFSF15, TNFRSF10D, EDN2, BMP2, NLRP14, and PLK1. We then identified associations between risk scores calculated wit...

journal_title：Aging

authors： Liu Z,Zhong J,Cai C,Lu J,Wu W,Zeng G

更新日期：2020-11-10 00:00:00

abstract：:Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embr...

journal_title：Aging

authors： Lu YJ,Jan YJ,Ko BS,Liang SM,Chen L,Wu CC,Chin CH,Kuo CC,Yet SF,Liou JY

更新日期：2020-04-24 00:00:00

abstract：OBJECTIVE:To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma. RESULTS:We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to...

journal_title：Aging

authors： Zhou J,Wu G,Tong Z,Sun J,Su J,Cao Z,Luo Y,Wang W

更新日期：2020-12-30 00:00:00

abstract：:Our objectives were to evaluate: 1) the associations of cognitive frailty with various health outcomes including disability, hospitalization, and death; 2) whether the associations differed by multimorbidity. We included data of 5113 Chinese older adults (aged 60+ years) who had baseline cognition and physical frailty...

journal_title：Aging

authors： Chen C,Park J,Wu C,Xue Q,Agogo G,Han L,Hoogendijk EO,Liu Z,Wu Z

更新日期：2020-11-18 00:00:00

abstract：:How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...

journal_title：Aging

authors： Yu R,Sun Y,Ye KX,Feng Q,Lim SL,Mahendran R,Cheah IK,Foo RSY,Chua RY,Gwee X,Loh M,Sarmugam R,Khine WWT,Chao YX,Larbi A,Lee YK,Kumar AP,Kennedy BK,Kua EH,Feng L

更新日期：2020-11-18 00:00:00