Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet.

abstract：:The loss of regenerative capacity of tissues is one of the major characteristics of aging. Liver represents a powerful system for investigations of mechanisms by which aging reduces regenerative capacity of tissues. The studies within last five years revealed critical role of epigenetic silencing in the inhibition of ...

journal_title：Aging

authors： Jin J,Wang GL,Timchenko L,Timchenko NA

更新日期：2009-06-22 00:00:00

abstract：:Autophagy is involved in degenerative diseases such as osteoarthritis and disc degeneration. Although, tumor necrosis factor α-induced protein 3 (TNFAIP3) is well-known as a key regulator of inflammation and autophagy, it is still not clear whether TNFAIP3 regulates autophagy to protect from human disc cells degenerat...

journal_title：Aging

authors： Chen J,Ma Y,Yang Z,Lan H,Liu G,Zhang Y,Xia H,Wang X,Han F,Tu X,Liu B

更新日期：2020-11-20 00:00:00

abstract：:Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and d...

journal_title：Aging

authors： Valentini E,Zampieri M,Malavolta M,Bacalini MG,Calabrese R,Guastafierro T,Reale A,Franceschi C,Hervonen A,Koller B,Bernhardt J,Slagboom PE,Toussaint O,Sikora E,Gonos ES,Breusing N,Grune T,Jansen E,Dollé ME,Moreno-Vi

更新日期：2016-08-29 00:00:00

abstract：:According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast ca...

journal_title：Aging

authors： Chen PS,Hsu HP,Phan NN,Yen MC,Chen FW,Liu YW,Lin FP,Feng SY,Cheng TL,Yeh PH,Omar HA,Sun Z,Jiang JZ,Chan YS,Lai MD,Wang CY,Hung JH

更新日期：2021-01-10 00:00:00

abstract：:The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...

journal_title：Aging

authors： Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

更新日期：2017-10-20 00:00:00

abstract：:Circular RNAs (circRNAs) play important roles in cancer progression. hsa_circRNA6448-14 originates from exon 5 to exon 11 of the TGFBI gene. We investigated the roles of hsa_circRNA6448-14 in esophageal squamous cell carcinoma (ESCC) with microarrays and quantitative real-time polymerase chain reaction (qRT-PCR), Kapl...

journal_title：Aging

authors： Zhang Y,Yuan X,Yue N,Wang L,Liu J,Dai N,Yang H,Fan R,Zhou F

更新日期：2020-08-15 00:00:00

abstract：:Proinsulin, insulin and proinsulin/insulin (P/I) ratio have been reported to be correlated with fasting plasma glucose (FPG) and Hemoglobin A1c (HbA1c) in whole population study therefore sensitive predictors of T2D progression. However, by analyzing data collected from 2018-2019 from a cohort of 1579 East Asian indiv...

journal_title：Aging

authors： Li T,Quan H,Zhang H,Lin L,Lin L,Ou Q,Chen K

更新日期：2020-06-12 00:00:00

abstract：:The flavonoids in Ageratum conyzoides L. have been used in traditional medicine due to its anti-inflammatory and antibacterial properties. However, the specific mechanism of its antibacterial effect, and the potential therapeutic effect on vaginitis have not been well explained. The growth curves of E. coli, S. aurues...

journal_title：Aging

authors： Lin Z,Lin Y,Zhang Z,Shen J,Yang C,Jiang M,Hou Y

更新日期：2020-04-09 00:00:00

abstract：:A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative ...

journal_title：Aging

authors： Pretorius E,Swanepoel AC,Buys AV,Vermeulen N,Duim W,Kell DB

更新日期：2014-10-01 00:00:00

abstract：:Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...

journal_title：Aging

authors： Djelti F,Dhenain M,Terrien J,Picq JL,Hardy I,Champeval D,Perret M,Schenker E,Epelbaum J,Aujard F

更新日期：2016-12-28 00:00:00

abstract：:We examined the effects of coronary heart disease (CHD), hypertension and diabetes on the development of severe COVID-19. We performed a comprehensive, systematic literature search for studies published between December 2019 and July 5, 2020 in five databases. The prevalence of severe COVID-19 in patients with CHD, hy...

journal_title：Aging

authors： Meng M,Zhao Q,Kumar R,Bai C,Deng Y,Wan B

更新日期：2020-11-16 00:00:00

abstract：:Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by analyzing The Cancer Genome Atlas cohort, we found that FAM84B amplification was ...

journal_title：Aging

authors： Zhang X,Xu J,Yan R,Zhang Y,Hu Z,Fu H,You Q,Cai Q,Yang D

更新日期：2020-04-14 00:00:00

abstract：:Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mas...

journal_title：Aging

authors： Cao W,Zheng D,Wang G,Zhang J,Ge S,Singh M,Wang H,Song M,Li D,Wang W,Xu X,Wang Y

更新日期：2020-06-05 00:00:00

abstract：:MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epide...

journal_title：Aging

authors： Zhao Z,Gao D,Ma T,Zhang L

更新日期：2019-02-08 00:00:00

abstract：:Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 orthologue) transcriptionally-regulated 20S proteasome degrades damaged proteins ...

journal_title：Aging

authors： Pomatto LCD,Wong S,Carney C,Shen B,Tower J,Davies KJA

更新日期：2017-04-01 00:00:00

abstract：:As of May 5, 2020, the number of confirmed coronavirus disease (COVID-19) cases has been more than 3.5 million with 243,540 deaths. We aimed to determine the associations between ageing population, median age, life expectancy at birth and COVID-19 mortality. The numbers of COVID-19 cases and deaths in the European reg...

journal_title：Aging

authors： Wang XQ,Song G,Yang Z,Chen RJ,Zheng YL,Hu HY,Su X,Chen PJ

更新日期：2020-11-24 00:00:00

abstract：:Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...

journal_title：Aging

authors： Xu W,Song C,Wang X,Li Y,Bai X,Liang X,Wu J,Liu J

更新日期：2021-01-05 00:00:00

abstract：:Recent studies have confirmed that both cancer-associated bone marrow mesenchymal stem cells (BM-MSCs, MSCs) and glioma stem-like cells (GSCs) contribute to malignant progression of gliomas through their mutual interactions within the tumor microenvironment. However, the exact ways and relevant mechanisms involved in ...

journal_title：Aging

authors： Wang H,Tan L,Dong X,Liu L,Jiang Q,Li H,Shi J,Yang X,Dai X,Qian Z,Dong J

更新日期：2020-07-06 00:00:00

abstract：:DNA repair mechanisms play a crucial role in maintaining genome integrity. However, the increased frequency of DNA double-strand breaks (DSBs) and genome rearrangements in aged individuals suggests an age-associated DNA repair deficiency. Previous work from our group revealed a delayed firing of the DNA damage respons...

journal_title：Aging

authors： Anglada T,Genescà A,Martín M

更新日期：2020-12-27 00:00:00

abstract：:Deep vein thrombosis (DVT) comprises a critical and common health condition with high incidence, mortality, and long-term adverse sequelae. Several differentially expressed microRNAs (miRNAs) have emerged as promising prognostic markers in DVT. The present study intended to explore the functional relevance of miR-136-...

journal_title：Aging

authors： Ou M,Hao S,Chen J,Zhao S,Cui S,Tu J

更新日期：2020-11-14 00:00:00

abstract：:This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...

journal_title：Aging

authors： Qian X,Jia H,Zhang Y,Ma B,Qin G,Wu Z

更新日期：2020-10-13 00:00:00

abstract：:The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms. Previous studies have characterized the impact of circadian clock on tumorigenesis and specific immune cells. Here, by using multi-omics computation techniques, we systematically characterized the distinct ...

journal_title：Aging

authors： Yang Y,Yuan G,Xie H,Wei T,Zhu D,Cui J,Liu X,Shen R,Zhu Y,Yang X

更新日期：2019-12-23 00:00:00

abstract：:A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. W...

journal_title：Aging

authors： Hur JH,Cho J,Walker DW

更新日期：2010-01-26 00:00:00

abstract：:To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. BMSCs from mice 2 months of age were isolated, and their cellular age determined (over 80% Scal-1+ C...

journal_title：Aging

authors： Xu F,Zhang Q,Wang H

更新日期：2020-07-25 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...

journal_title：Aging

authors： Xu X,Chen Y,Zhu D,Zhao T,Xu R,Wang J,Hu L,Shen X

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:SARS-CoV-2 has raged around the world since March, 2020. We aim to describe the clinical characteristics and risk factors of severe patients with COVID-19 in Guangzhou. RESULTS:The severity and mortality of COVID-19 was 10.4% and 0.3% respectively. And each 1-year increase in age (OR, 1.057; 95% CI, 1.018-1...

journal_title：Aging

authors： He F,Luo Q,Lei M,Fan L,Shao X,Huang G,Zeng J,Zhao Z,Qin S,Yang Z,Yu N,Yang L,Cao J

更新日期：2020-08-15 00:00:00

abstract：:Proteasome inhibition demonstrates highly effective impact on multiple myeloma (MM) treatment. Here, we aimed to examine anti-tumor efficiency and underlying mechanisms of a novel well tolerated orally applicable proteasome inhibitor NNU546 and its hydrolyzed pharmacologically active form NNU219. NNU219 showed more se...

journal_title：Aging

authors： Zhou H,Lei M,Wang W,Guo M,Wang J,Zhang H,Qiao L,Feng H,Liu Z,Chen L,Hou J,Wang X,Gu C,Zhao B,Izumchenko E,Yang Y,Zhu Y

更新日期：2020-11-16 00:00:00

abstract：:The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA....

journal_title：Aging

authors： Long R,Liu Z,Li J,Yu H

更新日期：2019-10-17 00:00:00

abstract：:Hirschsprung disease (HSCR) is a genetic disorder characterized by the absence of neural crest cells in parts of the intestine. This study aims to investigate the association of vesicle-associated membrane protein 5 (VAMP5) and mutated in colorectal cancer (MCC) genetic polymorphisms and their correlated risks with HS...

journal_title：Aging

authors： Zhao J,Xie X,Yao Y,He Q,Zhang R,Xia H,Zhang Y

更新日期：2018-04-25 00:00:00

abstract：:Upregulated ubiquitin-conjugating enzyme E2M (UBE2M) is associated with poor prognosis in malignancies; However, the phenotype and mechanism of action of UBE2M in hepatocellular carcinoma (HCC) remain elusive. Here, we report that UBE2M is overexpressed and correlated with poor prognosis in HCC patients. The UBE2M lev...

journal_title：Aging

authors： Zhang GC,Yu XN,Sun JL,Xiong J,Yang YJ,Jiang XM,Zhu JM

更新日期：2020-02-03 00:00:00