GSK3beta and aging liver.

abstract：:The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversib...

journal_title：Aging

authors： Galluzzi L,Kepp O,Kroemer G

更新日期：2010-09-01 00:00:00

abstract：:Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight junctions (TJs) remains unclear. In the present study, we found that high salt d...

journal_title：Aging

authors： Deng Z,Zhou L,Wang Y,Liao S,Huang Y,Shan Y,Tan S,Zeng Q,Peng L,Huang H,Lu Z

更新日期：2020-06-22 00:00:00

abstract：:One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phospho...

journal_title：Aging

authors： Obukhova LA,Skulachev VP,Kolosova NG

更新日期：2009-04-22 00:00:00

abstract：:Morbidity and mortality of coronavirus disease 2019 (COVID-19) is age-dependent. It remains unclear whether vertical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs during pregnancy and how such infection will affect fetal development. Here, we performed single-cell transcriptomic analysis of place...

journal_title：Aging

authors： Lü M,Qiu L,Jia G,Guo R,Leng Q

更新日期：2020-10-26 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common cancer with very poor survival due to lack of reliable biomarker for early diagnosis. In this study, we investigated microRNA (miRNA) profile of whole blood with a custom microarray containing probes for 1849 miRNA species in a total 213 successive subjects who were divided i...

journal_title：Aging

authors： Long XR,Zhang YJ,Zhang MY,Chen K,Zheng XFS,Wang HY

更新日期：2017-06-27 00:00:00

abstract：:Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar body following TubA treatment. However, a previous study demonstrated that homozygous Hdac6 knockout (KO) mice can be viable and fertile. Therefore, we asked wh...

journal_title：Aging

authors： Choi YJ,Kang MH,Hong K,Kim JH

更新日期：2019-03-26 00:00:00

abstract：BACKGROUND:MiRNA can be involved in regulating tumor genesis and development through regulating the major genes expression and regulating corresponding pathways. Here, we investigated the function and mechanisms of miR-483-3p in glioma progression. RESULTS:We found that miR-483-3p was increased in glioma cells and tis...

journal_title：Aging

authors： Xu D,Chi G,Xu D

更新日期：2020-11-04 00:00:00

abstract：:The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms. Previous studies have characterized the impact of circadian clock on tumorigenesis and specific immune cells. Here, by using multi-omics computation techniques, we systematically characterized the distinct ...

journal_title：Aging

authors： Yang Y,Yuan G,Xie H,Wei T,Zhu D,Cui J,Liu X,Shen R,Zhu Y,Yang X

更新日期：2019-12-23 00:00:00

abstract：:Proteasome inhibition demonstrates highly effective impact on multiple myeloma (MM) treatment. Here, we aimed to examine anti-tumor efficiency and underlying mechanisms of a novel well tolerated orally applicable proteasome inhibitor NNU546 and its hydrolyzed pharmacologically active form NNU219. NNU219 showed more se...

journal_title：Aging

authors： Zhou H,Lei M,Wang W,Guo M,Wang J,Zhang H,Qiao L,Feng H,Liu Z,Chen L,Hou J,Wang X,Gu C,Zhao B,Izumchenko E,Yang Y,Zhu Y

更新日期：2020-11-16 00:00:00

abstract：:The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent e...

journal_title：Aging

authors： van der Velden YU,Haramis AP

更新日期：2011-04-01 00:00:00

abstract：:Traditionally, the p21 protein has been viewed as limiting cancer progression and promoting aging. In contrast, there are reports that p21 can enhance cancer survival and limit tissue damage, depending on the tissue of origin and type of stressor involved. Here, we provide evidence to support these latter two roles of...

journal_title：Aging

authors： Venkatesh D,Stockwell BR,Prives C

更新日期：2020-09-24 00:00:00

abstract：:Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown proliferative restrictions of adult SCs forced to re-enter the cell cycle. By comparing juvenile and adult SCs in explant cultures, ...

journal_title：Aging

authors： Laos M,Anttonen T,Kirjavainen A,af Hällström T,Laiho M,Pirvola U

更新日期：2014-06-01 00:00:00

abstract：:Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study inv...

journal_title：Aging

authors： Rajapakse D,Chen M,Curtis TM,Xu H

更新日期：2017-10-09 00:00:00

abstract：OBJECTIVE:To assess the value of real-time three-dimensional echocardiography (RT-3DE) in evaluating changes in left atrial volume and function in type 2 diabetes mellitus (DM) and type 2 diabetic nephropathy (DN) patients. METHOD:104 control subjects, 109 DN patients, and 111 DM patients were recruited and underwent ...

journal_title：Aging

authors： Li X,Dong Y,Zheng C,Wang P,Xu M,Zou C,Wang L

更新日期：2020-12-03 00:00:00

abstract：:The lack of a univocal definition of frailty, a condition frequently found in the elderly population which is correlated with an increased risk of mortality, has prompted the search for clinical and laboratory parameters associated with this condition. Whereas OPG is a protein involved in different pathophysiological ...

journal_title：Aging

authors： Valentini A,Cianfarani MA,Tarantino U,Di Daniele N,Bertoli A

更新日期：2019-07-17 00:00:00

abstract：:As of May 5, 2020, the number of confirmed coronavirus disease (COVID-19) cases has been more than 3.5 million with 243,540 deaths. We aimed to determine the associations between ageing population, median age, life expectancy at birth and COVID-19 mortality. The numbers of COVID-19 cases and deaths in the European reg...

journal_title：Aging

authors： Wang XQ,Song G,Yang Z,Chen RJ,Zheng YL,Hu HY,Su X,Chen PJ

更新日期：2020-11-24 00:00:00

abstract：:Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...

journal_title：Aging

authors： Guest I,Ilic Z,Scrable H,Sell S

更新日期：2015-12-01 00:00:00

abstract：:Dysregulation of the circadian timing system (CTS) frequently appears during colorectal cancer (CRC) progression. In order to better understand the role of the circadian clock in CRC progression, this study evaluated in vitro how knockdown of a core circadian protein BMAL1 (BMAL1-KD) influenced the behavior of two pri...

journal_title：Aging

authors： Zhang Y,Devocelle A,Souza L,Foudi A,Tenreira Bento S,Desterke C,Sherrard R,Ballesta A,Adam R,Giron-Michel J,Chang Y

更新日期：2020-05-10 00:00:00

abstract：:Senescence is a leading cause of age-related cataract (ARC). The current study indicated that the senescence-associated protein, p53, total laminin (LM), LMα4, and transforming growth factor-beta1 (TGF-β1) in the cataractous anterior lens capsules (ALCs) increase with the grades of ARC. In cataractous ALCs, patient ag...

journal_title：Aging

authors： Yan Y,Yu H,Sun L,Liu H,Wang C,Wei X,Song F,Li H,Ge H,Qian H,Li X,Tang X,Liu P

更新日期：2019-05-10 00:00:00

abstract：:Uveal melanoma (UM) is the most common primary intraocular tumour in adults. The most accurate prognostic factor of UM is classification by gene expression profiling. Currently, the role of epigenetics is much less defined compared to genetic mechanisms. We recently showed a strong prognostic role of the expression le...

journal_title：Aging

authors： Giallongo S,Di Rosa M,Caltabiano R,Longhitano L,Reibaldi M,Distefano A,Lo Re O,Amorini AM,Puzzo L,Salvatorelli L,Palmucci S,Tibullo D,Russo A,Longo A,Lazzarino G,Li Volti G,Vinciguerra M

更新日期：2020-05-12 00:00:00

abstract：:The solute carrier (SLC) family is the largest group of membrane transporters, but their functions in ovarian cancer (OV) remain unclear. We analyzed SLC family members with amino acids-transporting functions in OV. The mRNA expression levels and prognostic values of SLCs in OV were analyzed in the Gene Expression Pro...

journal_title：Aging

authors： Sun T,Bi F,Liu Z,Yang Q

更新日期：2020-07-09 00:00:00

abstract：OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...

journal_title：Aging

authors： Ma X,Yu X,Zhou Q

更新日期：2020-02-15 00:00:00

abstract：:The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell surface-associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perle...

journal_title：Aging

authors： Dos Santos M,Michopoulou A,André-Frei V,Boulesteix S,Guicher C,Dayan G,Whitelock J,Damour O,Rousselle P

更新日期：2016-04-01 00:00:00

abstract：:Inhalation anesthetics have been demonstrated to have protective effects against myocardial ischemia reperfusion injury (MIRI). O-linked GlcNAcylation (O-GlcNAc) modifications have been shown to protect against MIRI. This study aimed to investigate whether O-GlcNAcylation and necroptosis signaling were important for s...

journal_title：Aging

authors： Zhang J,Yu P,Hua F,Hu Y,Xiao F,Liu Q,Huang D,Deng F,Wei G,Deng W,Ma J,Zhu W,Zhang J,Yu S

更新日期：2020-11-20 00:00:00

abstract：:Recent studies have confirmed that both cancer-associated bone marrow mesenchymal stem cells (BM-MSCs, MSCs) and glioma stem-like cells (GSCs) contribute to malignant progression of gliomas through their mutual interactions within the tumor microenvironment. However, the exact ways and relevant mechanisms involved in ...

journal_title：Aging

authors： Wang H,Tan L,Dong X,Liu L,Jiang Q,Li H,Shi J,Yang X,Dai X,Qian Z,Dong J

更新日期：2020-07-06 00:00:00

abstract：:One important process in liver cancer growth and progression is angiogenesis. Vascular endothelial growth factor (VEGF) has the significant role in liver cancer angiogenesis. sFlt1 (soluble Fms-like tyrosine kinase-1) is the promising inhibitor of VEGF and can be used as the new method of inhibiting angiogenesis. MSCs...

journal_title：Aging

authors： Niu J,Wang Y,Wang J,Bin L,Hu X

更新日期：2016-12-28 00:00:00

abstract：:Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a ...

journal_title：Aging

authors： Gao WQ,Hu XM,Zhang Q,Yang L,Lv XZ,Chen S,Wu P,Duan DW,Lang YH,Ning M,Lai KG,Zhang ZY,Liang B,Bao JY,Wu HD,Li T

更新日期：2020-12-19 00:00:00

abstract：:Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. ...

journal_title：Aging

authors： Reifsnyder PC,Flurkey K,Te A,Harrison DE

更新日期：2016-11-30 00:00:00

abstract：:MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epide...

journal_title：Aging

authors： Zhao Z,Gao D,Ma T,Zhang L

更新日期：2019-02-08 00:00:00

abstract：:Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT may disturb the integrity of the epigenetic system. Here, we used a PC...

journal_title：Aging

authors： Park M,Min B,Jeon K,Cho S,Park JS,Kim J,Jeon J,Song J,Kim S,Jeong S,Seo H,Kang YK

更新日期：2017-03-12 00:00:00