Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions.

abstract：:Exposure to particulate matter (PM) is associated with increased incidence of respiratory diseases. The present study aimed to investigate the roles of fibroblast growth factor 10 (FGF10) in PM-induced lung injury. Mice were intratracheally instilled with FGF10 or phosphate-buffered saline at one hour before instillat...

journal_title：Aging

authors： Liu L,Song C,Li J,Wang Q,Zhu M,Hu Y,Chen J,Chen C,Zhang JS,Dong N,Chen C

更新日期：2020-01-20 00:00:00

abstract：:Despite improvements in surgical procedures and comprehensive therapies, pancreatic cancer remains one of the most aggressive and deadly human malignancies. It is therefore necessary to determine which cellular mediators associate with prognosis in pancreatic cancer so as to improve the treatment of this disease. In t...

journal_title：Aging

authors： Li Y,Kong R,Chen H,Zhao Z,Li L,Li J,Hu J,Zhang G,Pan S,Wang Y,Wang G,Chen H,Sun B

更新日期：2019-07-21 00:00:00

abstract：:Telomeres are a hotspot for sister chromatid exchange (T-SCE). Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence. This work strongly suggests that progressive telomere erosion ...

journal_title：Aging

authors： Blagoev KB,Goodwin EH,Bailey SM

更新日期：2010-10-01 00:00:00

abstract：:Oxidative stress and inflammation play vital roles in Parkinson's disease (PD) development. Thus, telomere length is expected to be shortened in this disease, but current data are inconclusive. We performed a case-control study of 261 patients with PD and 270 sex and age-matched healthy controls treated at the Peking ...

journal_title：Aging

authors： Wu Y,Pei Y,Yang Z,Li K,Lou X,Cui W

更新日期：2020-10-29 00:00:00

abstract：:Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a re...

journal_title：Aging

authors： Chen X,Amorim JA,Moustafa GA,Lee JJ,Yu Z,Ishihara K,Iesato Y,Barbisan P,Ueta T,Togka KA,Lu L,Sinclair DA,Vavvas DG

更新日期：2020-12-29 00:00:00

abstract：:Angiogenesis - the growth of new blood capillaries- is impaired in aging animals. Biophysical factors such as changes in cell size control endothelial cell (EC) proliferation and differentiation. However, the effects of aging on EC size and the mechanism by which changes in cell size control age-dependent decline in E...

journal_title：Aging

authors： Mammoto T,Torisawa YS,Muyleart M,Hendee K,Anugwom C,Gutterman D,Mammoto A

更新日期：2019-09-05 00:00:00

abstract：:Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...

journal_title：Aging

authors： Chen CC,Wong TY,Chin TY,Lee WH,Kuo CY,Hsu YC

更新日期：2020-08-05 00:00:00

abstract：:Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA...

journal_title：Aging

authors： Chen K,Huang X,Xie D,Shen M,Lin H,Zhu Y,Ma S,Zheng C,Chen L,Liu Y,Liao W,Bin J,Liao Y

更新日期：2021-01-20 00:00:00

abstract：:The frailty index (FI) is one of the most widespread tools used to predict poor, health-related outcomes in older persons. The selection of clinical and functional deficits to include in a FI is mostly based on the users' clinical experience. However, this approach may not be sufficiently accurate to predict health ou...

journal_title：Aging

authors： Zucchelli A,Marengoni A,Rizzuto D,Calderón-Larrañaga A,Zucchelli M,Bernabei R,Onder G,Fratiglioni L,Vetrano DL

更新日期：2020-04-28 00:00:00

abstract：:Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains...

journal_title：Aging

authors： Foscarin S,Raha-Chowdhury R,Fawcett JW,Kwok JCF

更新日期：2017-06-28 00:00:00

abstract：:Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows ...

journal_title：Aging

authors： Del Campo A,Contreras-Hernández I,Castro-Sepúlveda M,Campos CA,Figueroa R,Tevy MF,Eisner V,Casas M,Jaimovich E

更新日期：2018-01-04 00:00:00

abstract：:The broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear. We used the C. elegans nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. The lifespan, phenotype, pharyngeal pumping, mobility, lipofuscin a...

journal_title：Aging

authors： Qi Z,Ji H,Le M,Li H,Wieland A,Bauer S,Liu L,Wink M,Herr I

更新日期：2021-01-20 00:00:00

abstract：:Sarcopenia is a hallmark of aging. Inflammation due to increased generation of cytokines such as TNFα, IL-1β and IL-6 has been implicated in the pathogenesis of sarcopenia. In skeletal muscle of C57BL/6 mice from 12 until 28 months of age, we observed a progressive reduction of myofiber cross sectional area, loss of t...

journal_title：Aging

authors： Sciorati C,Gamberale R,Monno A,Citterio L,Lanzani C,De Lorenzo R,Ramirez GA,Esposito A,Manunta P,Manfredi AA,Rovere-Querini P

更新日期：2020-11-26 00:00:00

abstract：:The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...

journal_title：Aging

authors： Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P

更新日期：2019-02-05 00:00:00

abstract：:DNA repair mechanisms play a crucial role in maintaining genome integrity. However, the increased frequency of DNA double-strand breaks (DSBs) and genome rearrangements in aged individuals suggests an age-associated DNA repair deficiency. Previous work from our group revealed a delayed firing of the DNA damage respons...

journal_title：Aging

authors： Anglada T,Genescà A,Martín M

更新日期：2020-12-27 00:00:00

abstract：:Little is known on how well senescence markers in vitro and in situ correlate within individual donors. We studied correlations between the same and different in vitro markers. Furthermore, we tested correlations between in vitro markers with in situ p16INK4a positivity.From 100 donors (20-91 years), cultured dermal f...

journal_title：Aging

authors： Waaijer MEC,Gunn DA,van Heemst D,Slagboom PE,Sedivy JM,Dirks RW,Tanke HJ,Westendorp RGJ,Maier AB

更新日期：2018-02-28 00:00:00

abstract：:N6-methyladenosine (m6A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators. However, the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 cen...

journal_title：Aging

authors： Fan L,Lin Y,Lei H,Shu G,He L,Yan Z,Rihan H,Yin G

更新日期：2020-09-20 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common gynecologic malignancies. To identify potential prognostic biomarkers for EC, we analyzed the relationship between the EC tumor microenvironment and gene expression profiles. Using the ESTIMATE R tool, we found that immune and stromal scores correlated with clinical da...

journal_title：Aging

authors： Chen P,Yang Y,Zhang Y,Jiang S,Li X,Wan J

更新日期：2020-02-19 00:00:00

abstract：:How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...

journal_title：Aging

authors： Yu R,Sun Y,Ye KX,Feng Q,Lim SL,Mahendran R,Cheah IK,Foo RSY,Chua RY,Gwee X,Loh M,Sarmugam R,Khine WWT,Chao YX,Larbi A,Lee YK,Kumar AP,Kennedy BK,Kua EH,Feng L

更新日期：2020-11-18 00:00:00

abstract：:Inequalities in older adults' health rarely consider life-course aspects of socioeconomic status (SES). We examined the association between lifelong SES and old-age health trajectories, and explored the role of lifestyle factors and depressive symptoms in this association. We followed 2760 adults aged 60+ from the Swe...

journal_title：Aging

authors： Harber-Aschan L,Calderón-Larrañaga A,Darin-Mattson A,Hu X,Fratiglioni L,Dekhtyar S

更新日期：2020-12-21 00:00:00

abstract：:Cardiomyocyte apoptosis is a major cause of myocardial ischemia/reperfusion (MI/R) injury, in which the activation of the signal transducer and activator of transcription 1 (STAT1) plays an important role. The E3-ubiquitin ligase TRIM6 has been implicated in regulating STAT1 activity, however, whether it is associated...

journal_title：Aging

authors： Zeng G,Lian C,Yang P,Zheng M,Ren H,Wang H

更新日期：2019-06-06 00:00:00

abstract：:In this study, we investigated the role of macrophage stimulating 1 (Mst1) and the AMPK-Sirt1 signaling pathway in the oxidative stress-induced mitochondrial dysfunction and apoptosis seen in rheumatoid arthritis-related fibroblast-like synoviocytes (RA-FLSs). Mst1 mRNA and protein expression was significantly higher ...

journal_title：Aging

authors： Wang Y,Yang Q,Shen S,Zhang L,Xiang Y,Weng X

更新日期：2020-07-21 00:00:00

abstract：:Uveal melanoma (UM) is the most common primary intraocular tumour in adults. The most accurate prognostic factor of UM is classification by gene expression profiling. Currently, the role of epigenetics is much less defined compared to genetic mechanisms. We recently showed a strong prognostic role of the expression le...

journal_title：Aging

authors： Giallongo S,Di Rosa M,Caltabiano R,Longhitano L,Reibaldi M,Distefano A,Lo Re O,Amorini AM,Puzzo L,Salvatorelli L,Palmucci S,Tibullo D,Russo A,Longo A,Lazzarino G,Li Volti G,Vinciguerra M

更新日期：2020-05-12 00:00:00

abstract：:Despite the accumulating evidence from in vitro and animal experiments supporting the role of kynurenine (a tryptophan metabolite) in a number of degenerative age-related changes, the relationship between kynurenine and frailty in older adults is not well understood. We collected blood samples from 73 participants who...

journal_title：Aging

authors： Jang IY,Park JH,Kim JH,Lee S,Lee E,Lee JY,Park SJ,Kim DA,Hamrick MW,Kim BJ

更新日期：2020-11-13 00:00:00

abstract：PURPOSE:To develop a decision tree algorithm-based classification system for personalized management of hepatocellular carcinoma (HCC) patients with macroscopic vascular invasion. RESULTS:The HVTT-PVTT score could differentiate two groups of patients (< 3 and ≥ 3 points) with different survival outcomes (7.4 vs 4.6 mo...

journal_title：Aging

authors： Cao F,Shen L,Qi H,Xie L,Song Z,Chen S,Fan W

更新日期：2019-11-03 00:00:00

abstract：:Hirschsprung disease (HSCR) is a genetic disorder characterized by the absence of neural crest cells in parts of the intestine. This study aims to investigate the association of vesicle-associated membrane protein 5 (VAMP5) and mutated in colorectal cancer (MCC) genetic polymorphisms and their correlated risks with HS...

journal_title：Aging

authors： Zhao J,Xie X,Yao Y,He Q,Zhang R,Xia H,Zhang Y

更新日期：2018-04-25 00:00:00

abstract：BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...

journal_title：Aging

authors： Wenjing L,Yuanzheng F,Li JY,Tang LV,Yu H

更新日期：2020-12-15 00:00:00

abstract：OBJECTIVE:We analyzed clinical parameters and risk factors for coronavirus disease 2019 (COVID-19)-related liver damage. RESULTS:Of the 332 COVID-19 patients, 306 and 26 were included in the non-critical and critical groups, respectively. The median time from onset to admission was 4.0 (2.0-8.0) days. Of the 332 COVID...

journal_title：Aging

authors： Guo H,Zhang Z,Zhang Y,Liu Y,Wang J,Qian Z,Zou Y,Lu H

更新日期：2020-10-01 00:00:00

abstract：:Macromitophagy controls mitochondrial quality and quantity. It involves the sequestration of dysfunctional or excessive mitochondria within double-membrane autophagosomes, which then fuse with the vacuole/lysosome to deliver these mitochondria for degradation. To investigate a physiological role of macromitophagy in y...

journal_title：Aging

authors： Richard VR,Leonov A,Beach A,Burstein MT,Koupaki O,Gomez-Perez A,Levy S,Pluska L,Mattie S,Rafesh R,Iouk T,Sheibani S,Greenwood M,Vali H,Titorenko VI

更新日期：2013-04-01 00:00:00

abstract：:We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of the patients at ad...

journal_title：Aging

authors： Zhang C,Xu G,Xu Y,Wu H,Guo X,Mao M,Baklaushev VP,Chekhonin VP,Peltzer K,Bai Y,Wang G,Ma W,Wang X

更新日期：2020-08-27 00:00:00