Abstract:
:Inequalities in older adults' health rarely consider life-course aspects of socioeconomic status (SES). We examined the association between lifelong SES and old-age health trajectories, and explored the role of lifestyle factors and depressive symptoms in this association. We followed 2760 adults aged 60+ from the Swedish National Study on Care and Aging, Kungsholmen. SES groups were derived using latent class analysis incorporating seven socioeconomic measures spanning childhood, midlife, and late life. We measured health using the Health Assessment Tool, which combines gait speed, cognition, multimorbidity, and disability. Linear mixed models were used to estimate health trajectories. Four SES groups were identified: High (34.9%), Middle (40.2%), Low (21.2%), and Mixed (3.8%). The Mixed group reported greater financial difficulties in childhood and older age, but varying SES attainment in midlife. Baseline health scores indicated that Mixed SES experienced substantial cognitive and physical deficits 12 years earlier than the High SES group. Compared to the High SES group, the Mixed SES group had the fastest health deterioration (β×time=-0.07, 95% CI:-0.11,-0.02); other groups followed a gradient (High>Middle>Low). Lifestyle factors and depressive symptoms attenuated the gradient but did not explain Mixed group's health disadvantage. Life-long SES measures are crucial for understanding older adults' health inequalities.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Harber-Aschan L,Calderón-Larrañaga A,Darin-Mattson A,Hu X,Fratiglioni L,Dekhtyar Sdoi
10.18632/aging.202342subject
Has Abstractpub_date
2020-12-21 00:00:00pages
24693-24708issue
24issn
1945-4589pii
202342journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::Exposure to particulate matter (PM) is associated with increased incidence of respiratory diseases. The present study aimed to investigate the roles of fibroblast growth factor 10 (FGF10) in PM-induced lung injury. Mice were intratracheally instilled with FGF10 or phosphate-buffered saline at one hour before instillat...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102676
更新日期:2020-01-20 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102377
更新日期:2019-10-30 00:00:00
abstract::This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103939
更新日期:2020-10-13 00:00:00
abstract::Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101601
更新日期:2018-10-25 00:00:00
abstract::Our previous studies showed that loss-of-function mutation of growth hormone releasing hormone (GHRH) results in increased longevity and enhanced insulin sensitivity in mice. However, the details of improved insulin action and tissue-specific insulin signaling are largely unknown in this healthy-aging mouse model. We ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103588
更新日期:2020-10-06 00:00:00
abstract::Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...
journal_title:Aging
pub_type: 杂志文章,随机对照试验
doi:10.18632/aging.100597
更新日期:2014-02-01 00:00:00
abstract::Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose indivi...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101855
更新日期:2019-03-12 00:00:00
abstract::The two most common aging-related diseases, Alzheimer's disease and type 2 diabetes mellitus, are associated with accumulation of amyloid proteins (β-amyloid and amylin, respectively). This amylin aggregation is reportedly cytotoxic to neurons. We found that aggregation of human amylin (hAmylin) induced neuronal apopt...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103105
更新日期:2020-05-28 00:00:00
abstract::Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain a...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103343
更新日期:2020-06-29 00:00:00
abstract::Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101256
更新日期:2017-06-28 00:00:00
abstract::Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103005
更新日期:2020-05-21 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is a highly malignant tumor. Many circular RNAs (circRNAs) are reportedly in regulating the progression of NSCLC. To identify potential therapeutic targets for NSCLC, we conducted a bioinformatics analysis of circRNAs differentially expressed between NSCLC tissues and adjacent normal...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103472
更新日期:2020-07-18 00:00:00
abstract::Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101065
更新日期:2016-10-14 00:00:00
abstract::The lack of a univocal definition of frailty, a condition frequently found in the elderly population which is correlated with an increased risk of mortality, has prompted the search for clinical and laboratory parameters associated with this condition. Whereas OPG is a protein involved in different pathophysiological ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102083
更新日期:2019-07-17 00:00:00
abstract::Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100492
更新日期:2012-10-01 00:00:00
abstract::We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging. Investigating this has revealed a novel approach to rejuvenate multiple mammalian tissues by defined pharmacology. Specifically, we pursued the simultaneous youthful in vivo calibration of two determinan...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102148
更新日期:2019-08-15 00:00:00
abstract::Alterations in KEAP1/ NF-E2 p45-related factor 2 (NFE2L2/Nrf2) signaling pathway have been reported in 23% lung adenocarcinoma patients, suggesting that deregulation of the pathway is a major cancer driver. Here we report that mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) drives tumor growth and drug re...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102531
更新日期:2019-12-06 00:00:00
abstract::Traditionally, the p21 protein has been viewed as limiting cancer progression and promoting aging. In contrast, there are reports that p21 can enhance cancer survival and limit tissue damage, depending on the tissue of origin and type of stressor involved. Here, we provide evidence to support these latter two roles of...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103961
更新日期:2020-09-24 00:00:00
abstract::Long non-coding RNA (lncRNA) Ewing sarcoma associated transcript 1 (EWSAT1) has been identified as an oncogene, and its dysregulation is closed corrected with tumor progression in Ewing sarcoma. Recently, high-through put analysis reveals that EWSAT1 is also highly expressed in human nasopharyngeal carcinoma (NPC). Ho...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101103
更新日期:2016-11-03 00:00:00
abstract::Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...
journal_title:Aging
pub_type: 评论,杂志文章
doi:10.18632/aging.101021
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To assess the value of real-time three-dimensional echocardiography (RT-3DE) in evaluating changes in left atrial volume and function in type 2 diabetes mellitus (DM) and type 2 diabetic nephropathy (DN) patients. METHOD:104 control subjects, 109 DN patients, and 111 DM patients were recruited and underwent ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202218
更新日期:2020-12-03 00:00:00
abstract::Liver fibrosis biomarker, Type IV collagen, may function as hepatocarcinogenesis niche. However, among the six isoforms, the isoforms providing tumor microenvironment and their regulatory network are still unclarified. Based on bioinformatics analysis of hundreds of HCC transcriptome datasets from public databases, we...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102610
更新日期:2020-01-05 00:00:00
abstract::Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of three fibrates, pharmacologically established s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100548
更新日期:2013-04-01 00:00:00
abstract::Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101117
更新日期:2016-11-30 00:00:00
abstract::There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individua...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102858
更新日期:2020-02-24 00:00:00
abstract::Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is on...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103237
更新日期:2020-05-14 00:00:00
abstract::The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103931
更新日期:2020-10-14 00:00:00
abstract::Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that the expression of HSD...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103530
更新日期:2020-07-17 00:00:00
abstract::Metabolic syndrome, a network of medical disorders that greatly increase the risk for developing metabolic and cardiovascular diseases, has reached epidemic levels in many areas of today's world. Despite this alarming medicare situation, scientific understandings on the root mechanisms of metabolic syndrome are still ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100431
更新日期:2012-02-01 00:00:00
abstract::In this study, we constructed a model using a Cox proportional hazards model based on the expression of eight immune-related genes that were associated with prognosis in prostate cancer: EDNRB, ANGPTL2, TNFSF15, TNFRSF10D, EDN2, BMP2, NLRP14, and PLK1. We then identified associations between risk scores calculated wit...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103921
更新日期:2020-11-10 00:00:00