Risk factors and prediction of second primary cancer in primary female non-metastatic breast cancer survivors.


:This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology and End Results (SEER) database. Subdistribution proportional hazard model and competing-risk nomogram were used to explore the risk factors of second primary BC and non-BC, and to predict the 5- and 10-year probabilities of second primary BC. Model performance was evaluated via calibration curves and decision curve analysis. The overall 3-, 5-, and 10-year cumulative incidences for second primary BC were 0.9%, 1.6% and 4.4%, and for second primary non-BC were 2.3%, 3.9%, and 7.8%, respectively. Age over 70 years at diagnosis, black race, tumor size over 2 cm, negative hormone receptor, mixed histology, localized tumor, lumpectomy alone, and surgeries plus radiotherapy were significantly associated with increased risk of second BC. The risk of second non-BC was only related to age, race and tumor size. The proposed risk model as well as its nomogram was clinically beneficial to identify patients at high risk of developing second primary breast cancer.


Aging (Albany NY)




Qian X,Jia H,Zhang Y,Ma B,Qin G,Wu Z




Has Abstract


2020-10-13 00:00:00














  • A nomogram combining long non-coding RNA expression profiles and clinical factors predicts survival in patients with bladder cancer.

    abstract::Bladder cancer (BCa) is a heterogeneous disease with various tumorigenic mechanisms and clinical behaviors. The current tumor-node-metastasis (TNM) staging system is inadequate to predict overall survival (OS) in BCa patients. We developed a BCa-specific, long-non-coding-RNA (lncRNA)-based nomogram to improve survival...


    pub_type: 杂志文章


    authors: Wang Y,Du L,Yang X,Li J,Li P,Zhao Y,Duan W,Chen Y,Wang Y,Mao H,Wang C

    更新日期:2020-02-12 00:00:00

  • Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis.

    abstract::Macromitophagy controls mitochondrial quality and quantity. It involves the sequestration of dysfunctional or excessive mitochondria within double-membrane autophagosomes, which then fuse with the vacuole/lysosome to deliver these mitochondria for degradation. To investigate a physiological role of macromitophagy in y...


    pub_type: 杂志文章


    authors: Richard VR,Leonov A,Beach A,Burstein MT,Koupaki O,Gomez-Perez A,Levy S,Pluska L,Mattie S,Rafesh R,Iouk T,Sheibani S,Greenwood M,Vali H,Titorenko VI

    更新日期:2013-04-01 00:00:00

  • Histological characteristics of bone in-growth of proximal humeral implants with different spatial structures.

    abstract::This study compares the longitudinal histological characteristics of proximal humeral implants with different spatial structures in rabbits. Thirty skeletally-mature male rabbits were divided into a trabecular structure group and regular hexahedron structure group according to the different spatial structures of a bio...


    pub_type: 杂志文章


    authors: Xue Z,Pei Z,Zhang H,Tang C,Jia J,Zhang K,Zhang K,Wang L,Guan Z

    更新日期:2021-01-20 00:00:00

  • Identification of survival-associated alternative splicing events and signatures in adrenocortical carcinoma based on TCGA SpliceSeq data.

    abstract:OBJECTIVE:To explore the correlations among alternative splicing (AS), splicing factors (SF) and survival outcome in adrenocortical carcinoma (ACC) patients. RESULTS:A total of 92 ACC patients were included. Univariate analysis identified 3919 AS events significantly associated with overall survival. Lasso method foll...


    pub_type: 杂志文章


    authors: Xu N,Ke ZB,Lin XD,Lin F,Chen SH,Wu YP,Chen YH,Wei Y,Zheng QS

    更新日期:2020-03-26 00:00:00

  • Acetylation-mediated degradation of HSD17B4 regulates the progression of prostate cancer.

    abstract::Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that the expression of HSD...


    pub_type: 杂志文章


    authors: Huang H,Liu R,Huang Y,Feng Y,Fu Y,Chen L,Chen Z,Cai Y,Zhang Y,Chen Y

    更新日期:2020-07-17 00:00:00

  • Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia.

    abstract::Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embr...


    pub_type: 杂志文章


    authors: Lu YJ,Jan YJ,Ko BS,Liang SM,Chen L,Wu CC,Chin CH,Kuo CC,Yet SF,Liou JY

    更新日期:2020-04-24 00:00:00

  • Osteoprotegerin as a biomarker of geriatric frailty syndrome.

    abstract::The lack of a univocal definition of frailty, a condition frequently found in the elderly population which is correlated with an increased risk of mortality, has prompted the search for clinical and laboratory parameters associated with this condition. Whereas OPG is a protein involved in different pathophysiological ...


    pub_type: 杂志文章


    authors: Valentini A,Cianfarani MA,Tarantino U,Di Daniele N,Bertoli A

    更新日期:2019-07-17 00:00:00

  • Cystathionine beta synthase modulates senescence of human endothelial cells.

    abstract::Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood. In eukaryotic cells, methionine can be converted to cysteine thr...


    pub_type: 杂志文章


    authors: Albertini E,Kozieł R,Dürr A,Neuhaus M,Jansen-Dürr P

    更新日期:2012-10-01 00:00:00

  • Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma.

    abstract::For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...


    pub_type: 杂志文章


    authors: Zhu Q,Ren H,Li X,Qian B,Fan S,Hu F,Xu L,Zhai B

    更新日期:2020-11-16 00:00:00

  • The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells.

    abstract::Combination treatment is a promising strategy to improve prognosis of hepatocellular carcinoma (HCC). Sorafenib is a traditional first-line agent approved for the treatment of advanced HCC, though with limited efficacy. Previously, we reported that lonafarnib, an orally bioavailable non-peptide inhibitor targeting far...


    pub_type: 杂志文章


    authors: Wang J,Wei H,Huang Y,Chen D,Zeng G,Lian Y,Huang Y

    更新日期:2019-08-13 00:00:00

  • Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology.

    abstract::Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...


    pub_type: 杂志文章


    authors: Chen CC,Wong TY,Chin TY,Lee WH,Kuo CY,Hsu YC

    更新日期:2020-08-05 00:00:00

  • NEAT1/miR-200b-3p/SMAD2 axis promotes progression of melanoma.

    abstract::Melanoma is a skin malignancy with a high mutation frequency of genetic alterations. MicroRNA (miR)-200b-3p is involved in various cancers, while in melanoma its bio-function remains unknown. In this study, we found that miR-200b-3p was down-regulated in melanoma tissues and cell lines compared to benign nevus cells. ...


    pub_type: 杂志文章


    authors: Zhou WJ,Wang HY,Zhang J,Dai HY,Yao ZX,Zheng Z,Meng-Yan S,Wu K

    更新日期:2020-11-16 00:00:00

  • In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma.

    abstract::Proteasome inhibition demonstrates highly effective impact on multiple myeloma (MM) treatment. Here, we aimed to examine anti-tumor efficiency and underlying mechanisms of a novel well tolerated orally applicable proteasome inhibitor NNU546 and its hydrolyzed pharmacologically active form NNU219. NNU219 showed more se...


    pub_type: 杂志文章


    authors: Zhou H,Lei M,Wang W,Guo M,Wang J,Zhang H,Qiao L,Feng H,Liu Z,Chen L,Hou J,Wang X,Gu C,Zhao B,Izumchenko E,Yang Y,Zhu Y

    更新日期:2020-11-16 00:00:00

  • Overexpression of CBS and CSE genes affects lifespan, stress resistance and locomotor activity in Drosophila melanogaster.

    abstract::Recent experimental studies highlighted the role of hydrogen sulfide (H2S) in aging and longevity. The cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) are the key enzymes responsible for H2S production. Here we investigated the geroprotective effects of CSE and CBS overexpression in Drosophila. Overexpr...


    pub_type: 杂志文章


    authors: Shaposhnikov M,Proshkina E,Koval L,Zemskaya N,Zhavoronkov A,Moskalev A

    更新日期:2018-11-08 00:00:00

  • Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells.

    abstract::Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6 and α-tubulin were...


    pub_type: 杂志文章


    authors: Li J,Zhou Y,Yan Y,Zheng Z,Hu Y,Wu W

    更新日期:2020-08-29 00:00:00

  • Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma.

    abstract::Head and neck squamous cell carcinoma (HNSCC), a major histologic subtype of head and neck cancer, presents great mortality and morbidity worldwide. The aim of this study is to discover new potential biomarkers closely correlated with HNSCC progression. In this study, weighted gene co-expression network analysis was a...


    pub_type: 杂志文章


    authors: Xu W,Zou H,Wei Z,Song C,Tang C,Yin X,Wang Y,Han S,Cai Y,Han W

    更新日期:2019-06-06 00:00:00

  • KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma.

    abstract::Proliferating cell nuclear antigen binding factor (encoded by KIAA0101/PCLAF) regulates DNA synthesis and cell cycle progression; however, whether the level of KIAA0101 mRNA in lung adenocarcinoma is related to prognosis and tumor immune infiltration is unknown. In patients with lung adenocarcinoma, the differential e...


    pub_type: 杂志文章


    authors: Hu S,Zeng W,Zhang W,Xu J,Yu D,Peng J,Wei Y

    更新日期:2020-11-20 00:00:00

  • miR-345-5p regulates adipogenesis via targeting VEGF-B.

    abstract::Adipocyte differentiation involves a series of highly synergistic processes, including clone amplification, proliferation arrest, and terminal differentiation. However, the mechanisms that control these different steps remain unclear. Emerging studies support that miRNAs play an important role in regulating adipogenes...


    pub_type: 杂志文章


    authors: Liu X,He Y,Feng Z,Sheng J,Dong A,Zhang M,Cao L

    更新日期:2020-09-14 00:00:00

  • Downregulation of interleukin-6 and C-reactive protein underlies a novel inhibitory role of microRNA-136-5p in acute lower extremity deep vein thrombosis.

    abstract::Deep vein thrombosis (DVT) comprises a critical and common health condition with high incidence, mortality, and long-term adverse sequelae. Several differentially expressed microRNAs (miRNAs) have emerged as promising prognostic markers in DVT. The present study intended to explore the functional relevance of miR-136-...


    pub_type: 杂志文章


    authors: Ou M,Hao S,Chen J,Zhao S,Cui S,Tu J

    更新日期:2020-11-14 00:00:00

  • Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts.

    abstract::Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy. However, these changes in the metabolic profile of stromal cancer-associated fibroblasts and their imp...


    pub_type: 杂志文章


    authors: Peiris-Pagès M,Smith DL,Győrffy B,Sotgia F,Lisanti MP

    更新日期:2015-10-01 00:00:00

  • Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway.

    abstract::Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...


    pub_type: 杂志文章


    authors: Yao Y,Wang X,Zhou D,Li H,Qian H,Zhang J,Jiang L,Wang B,Lin Q,Zhu X

    更新日期:2020-07-02 00:00:00

  • SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray and public database ...


    pub_type: 杂志文章


    authors: Zhan YT,Li L,Zeng TT,Zhou NN,Guan XY,Li Y

    更新日期:2020-12-03 00:00:00

  • DNA methylation perturbations may link altered development and aging in the lung.

    abstract::Fetal perturbations in DNA methylation during lung development may reveal insights into the enduring impacts on adult lung health and disease during aging that have not been explored altogether before. We studied the association between genome-wide DNA-methylation and post-conception age in fetal-lung (n=78, 42 expose...


    pub_type: 杂志文章


    authors: Kachroo P,Morrow JD,Vyhlidal CA,Gaedigk R,Silverman EK,Weiss ST,Tantisira KG,DeMeo DL

    更新日期:2021-01-19 00:00:00

  • A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer.

    abstract::N6-methyladenosine (m6A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators. However, the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 cen...


    pub_type: 杂志文章


    authors: Fan L,Lin Y,Lei H,Shu G,He L,Yan Z,Rihan H,Yin G

    更新日期:2020-09-20 00:00:00

  • hsa_circRNA6448-14 promotes carcinogenesis in esophageal squamous cell carcinoma.

    abstract::Circular RNAs (circRNAs) play important roles in cancer progression. hsa_circRNA6448-14 originates from exon 5 to exon 11 of the TGFBI gene. We investigated the roles of hsa_circRNA6448-14 in esophageal squamous cell carcinoma (ESCC) with microarrays and quantitative real-time polymerase chain reaction (qRT-PCR), Kapl...


    pub_type: 杂志文章


    authors: Zhang Y,Yuan X,Yue N,Wang L,Liu J,Dai N,Yang H,Fan R,Zhou F

    更新日期:2020-08-15 00:00:00

  • CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age.

    abstract::Natural killer cells lacking expression of CD56 (CD56neg NK cells) have been described in chronic HIV and hepatitis C virus infection. Features and functions of CD56neg NK cells in the context of latent infection with CMV and / or EBV with age are not known. In a cohort of healthy donors >60 years of age, we found tha...


    pub_type: 杂志文章


    authors: Müller-Durovic B,Grählert J,Devine OP,Akbar AN,Hess C

    更新日期:2019-01-27 00:00:00

  • Expression and significance of miR - 20b in retinal photoreceptor cells exposed to PCB1254.

    abstract::Previous studies have shown that PCB1254 has an adverse effect on zebrafish retinal development, but the basic mechanism behind it is not clear. The purpose of this study was to investigate the molecular mechanisms of PCB-induced retinal dysplasia. RT-qPCR, immunoblotting, HE staining and immunofluorescence were adopt...


    pub_type: 杂志文章


    authors: Zhang X,Zhang Q,Jiang Y,Zhang S,Hong Q,Guo X,Chi X,Tong M

    更新日期:2019-10-16 00:00:00

  • Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.

    abstract::Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phy...


    pub_type: 杂志文章


    authors: Whittemore K,Martínez-Nevado E,Blasco MA

    更新日期:2019-11-15 00:00:00

  • Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis.

    abstract::A recently discovered satiety molecule, nesfatin-1, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances, corticotropin-releasing hormone (CRH), oxytocin, proopiomelanocortin, noradrenaline (NA) and 5-hydroxytryptamine (5-HT). Intracerebroventricular (icv) administr...


    pub_type: 杂志文章


    authors: Yoshida N,Maejima Y,Sedbazar U,Ando A,Kurita H,Damdindorj B,Takano E,Gantulga D,Iwasaki Y,Kurashina T,Onaka T,Dezaki K,Nakata M,Mori M,Yada T

    更新日期:2010-11-01 00:00:00

  • Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs).

    abstract::Bedaquiline (a.k.a., Sirturo) is an anti-microbial agent, which is approved by the FDA for the treatment of multi-drug resistant pulmonary tuberculosis (TB). Bedaquiline is a first-in-class diaryl-quinoline compound, that mechanistically inhibits the bacterial ATP-synthase, and shows potent activity against both drug-...


    pub_type: 杂志文章


    authors: Fiorillo M,Lamb R,Tanowitz HB,Cappello AR,Martinez-Outschoorn UE,Sotgia F,Lisanti MP

    更新日期:2016-08-01 00:00:00