Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age.

abstract：:Mounting studies have shown that long noncoding RNAs (lncRNAs) play important roles in the development and occurrence of several human diseases. However, the role of LINC00461 in osteoarthritis (OA) remains obscure. A CCK-8 assay was performed to detect cell viability, and qRT-PCR analysis was used to measure mRNA exp...

journal_title：Aging

authors： Zhang Y,Ma L,Wang C,Wang L,Guo Y,Wang G

更新日期：2020-03-10 00:00:00

abstract：:Aging is associated with the accumulation of DNA damage. High expression of DNA repair genes has been suggested to contribute to prolonged lifespan in several organisms. However, the crucial DNA repair genes contributing to longevity remain unknown. Termite kings have an extraordinary long lifespan compared with that ...

journal_title：Aging

authors： Tasaki E,Mitaka Y,Nozaki T,Kobayashi K,Matsuura K,Iuchi Y

更新日期：2018-10-11 00:00:00

abstract：:The incidence of subarachnoid hemorrhage (SAH) and hazard ratio of death increase with age. Overactivation of microglia contributes to brain damage. This study aimed to investigate the effects of A3 adenosine receptors (A3R) activation on neurofunction and microglial phenotype polarization in the context of SAH in age...

journal_title：Aging

authors： Li P,Li X,Deng P,Wang D,Bai X,Li Y,Luo C,Belguise K,Wang X,Wei X,Xia Z,Yi B

更新日期：2020-11-30 00:00:00

abstract：:The study was aimed at evaluation of the role of secondary oxidative stress in the stress-induced premature senescence (SIPS) of human fibroblasts induced by H2O2. Two fibroblast lines were used: lung MRC-5 and ear H8F2p25LM fibroblasts. The lines differed considerably in sensitivity to H2O2 (IC50 of 528 and 33.5 μM, ...

journal_title：Aging

authors： Pieńkowska N,Bartosz G,Pichla M,Grzesik-Pietrasiewicz M,Gruchala M,Sadowska-Bartosz I

更新日期：2020-01-21 00:00:00

abstract：:As of May 5, 2020, the number of confirmed coronavirus disease (COVID-19) cases has been more than 3.5 million with 243,540 deaths. We aimed to determine the associations between ageing population, median age, life expectancy at birth and COVID-19 mortality. The numbers of COVID-19 cases and deaths in the European reg...

journal_title：Aging

authors： Wang XQ,Song G,Yang Z,Chen RJ,Zheng YL,Hu HY,Su X,Chen PJ

更新日期：2020-11-24 00:00:00

abstract：OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...

journal_title：Aging

authors： Ma X,Yu X,Zhou Q

更新日期：2020-02-15 00:00:00

abstract：:Histones and their variants are subjected to several post-translational modifications (PTMs). Histones PTMs play an important role in the regulation of gene expression and are critical for the development and progression of many types of cancer, including breast cancer. In this study, we used two-dimensional TAU/SDS e...

journal_title：Aging

authors： Perri AM,Agosti V,Olivo E,Concolino A,Angelis M,Tammè L,Fiumara CV,Cuda G,Scumaci D

更新日期：2019-12-08 00:00:00

abstract：:We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of the patients at ad...

journal_title：Aging

authors： Zhang C,Xu G,Xu Y,Wu H,Guo X,Mao M,Baklaushev VP,Chekhonin VP,Peltzer K,Bai Y,Wang G,Ma W,Wang X

更新日期：2020-08-27 00:00:00

abstract：:Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...

journal_title：Aging

authors： Cui L,Xue H,Wen Z,Lu Z,Liu Y,Zhang Y

更新日期：2020-11-12 00:00:00

abstract：:Morbidity and mortality of coronavirus disease 2019 (COVID-19) is age-dependent. It remains unclear whether vertical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs during pregnancy and how such infection will affect fetal development. Here, we performed single-cell transcriptomic analysis of place...

journal_title：Aging

authors： Lü M,Qiu L,Jia G,Guo R,Leng Q

更新日期：2020-10-26 00:00:00

abstract：:According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast ca...

journal_title：Aging

authors： Chen PS,Hsu HP,Phan NN,Yen MC,Chen FW,Liu YW,Lin FP,Feng SY,Cheng TL,Yeh PH,Omar HA,Sun Z,Jiang JZ,Chan YS,Lai MD,Wang CY,Hung JH

更新日期：2021-01-10 00:00:00

abstract：:We examined the effects of coronary heart disease (CHD), hypertension and diabetes on the development of severe COVID-19. We performed a comprehensive, systematic literature search for studies published between December 2019 and July 5, 2020 in five databases. The prevalence of severe COVID-19 in patients with CHD, hy...

journal_title：Aging

authors： Meng M,Zhao Q,Kumar R,Bai C,Deng Y,Wan B

更新日期：2020-11-16 00:00:00

abstract：:Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues...

journal_title：Aging

authors： Zheng Z,Li X,You H,Zheng X,Ruan X

更新日期：2020-05-21 00:00:00

abstract：OBJECTIVE:Genome-wide association studies (GWAS) and the candidate gene based association studies have identified a panel of variants associated with atrial fibrillation (AF), however, most of the identified single nucleotide polymorphisms (SNPs) were found located within intergenic or intronic genomic regions, and whe...

journal_title：Aging

authors： Xu C,Zhang R,Xia Y,Xiong L,Yang W,Wang P

更新日期：2020-09-09 00:00:00

abstract：:Hutchinson-Gilford Progeria (HGPS) and Werner syndromes are diseases that clinically resemble some aspects of accelerated aging. HGPS is caused by mutations in theLMNA gene resulting in post-translational processing defects that trigger Progeria in children. Werner syndrome, arising from mutations in the WRN helicase ...

journal_title：Aging

authors： Dreesen O,Stewart CL

更新日期：2011-09-01 00:00:00

abstract：:Myocardial infarction is a cardiovascular disease with high mortality. Human umbilical cord mesenchymal stem cells (hUC-MSCs) with strong self-renewal capacity and multipotency, provide the possibility of replacing injured cardiomyocytes. hUC-MSCs were cultured on polyacrylamide hydrogels with stiffnesses correspondin...

journal_title：Aging

authors： Sun Y,Liu J,Xu Z,Lin X,Zhang X,Li L,Li Y

更新日期：2020-12-09 00:00:00

abstract：:Autophagy is involved in degenerative diseases such as osteoarthritis and disc degeneration. Although, tumor necrosis factor α-induced protein 3 (TNFAIP3) is well-known as a key regulator of inflammation and autophagy, it is still not clear whether TNFAIP3 regulates autophagy to protect from human disc cells degenerat...

journal_title：Aging

authors： Chen J,Ma Y,Yang Z,Lan H,Liu G,Zhang Y,Xia H,Wang X,Han F,Tu X,Liu B

更新日期：2020-11-20 00:00:00

abstract：:N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects ...

journal_title：Aging

authors： Shaposhnikov MV,Zemskaya NV,Koval LA,Schegoleva EV,Zhavoronkov A,Moskalev AA

更新日期：2018-09-20 00:00:00

abstract：:Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy. However, these changes in the metabolic profile of stromal cancer-associated fibroblasts and their imp...

journal_title：Aging

authors： Peiris-Pagès M,Smith DL,Győrffy B,Sotgia F,Lisanti MP

更新日期：2015-10-01 00:00:00

abstract：:Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that the expression of HSD...

journal_title：Aging

authors： Huang H,Liu R,Huang Y,Feng Y,Fu Y,Chen L,Chen Z,Cai Y,Zhang Y,Chen Y

更新日期：2020-07-17 00:00:00

abstract：:Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...

journal_title：Aging

authors： Wen C,Xie T,Pan K,Deng Y,Zhao Z,Li N,Bian J,Deng X,Zha Y

更新日期：2020-02-26 00:00:00

abstract：:In this meta-analysis, we systematically investigated the correlation between single nucleotide polymorphisms (SNPs) and pancreatic cancer (PC) risk. We searched PubMed, Network Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), an...

journal_title：Aging

authors： Ye ZM,Li LJ,Luo MB,Qing HY,Zheng JH,Zhang C,Lu YX,Tang YM

更新日期：2020-11-20 00:00:00

abstract：:Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling...

journal_title：Aging

authors： Favaloro B,Allocati N,Graziano V,Di Ilio C,De Laurenzi V

更新日期：2012-05-01 00:00:00

abstract：:Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary ...

journal_title：Aging

authors： Niu H,Niu W,Yu T,Dong F,Huang K,Duan R,Qumu S,Lu M,Li Y,Yang T,Wang C

更新日期：2019-05-29 00:00:00

abstract：:Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old m...

journal_title：Aging

authors： Dong Q,Gao H,Shi Y,Zhang F,Gu X,Wu A,Wang D,Chen Y,Bandyopadhyay A,Yeh IT,Daniel BJ,Chen Y,Zou Y,Rebel VL,Walter CA,Lu J,Huang C,Sun LZ

更新日期：2016-11-15 00:00:00

abstract：:Kidney clear cell carcinoma (KIRC) is the most prevalent kidney malignancy. Accumulating evidence shows that high expression of TIP-B1 correlates with development of tumor progression. However, the detailed functions of TIP-B1 in the KIRC remain to be further elucidated. Here, we firstly found TIP-B1 expression was si...

journal_title：Aging

authors： Yin L,Gao S,Shi H,Wang K,Yang H,Peng B

更新日期：2019-09-27 00:00:00

abstract：:Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar body following TubA treatment. However, a previous study demonstrated that homozygous Hdac6 knockout (KO) mice can be viable and fertile. Therefore, we asked wh...

journal_title：Aging

authors： Choi YJ,Kang MH,Hong K,Kim JH

更新日期：2019-03-26 00:00:00

abstract：:Inhalation anesthetics have been demonstrated to have protective effects against myocardial ischemia reperfusion injury (MIRI). O-linked GlcNAcylation (O-GlcNAc) modifications have been shown to protect against MIRI. This study aimed to investigate whether O-GlcNAcylation and necroptosis signaling were important for s...

journal_title：Aging

authors： Zhang J,Yu P,Hua F,Hu Y,Xiao F,Liu Q,Huang D,Deng F,Wei G,Deng W,Ma J,Zhu W,Zhang J,Yu S

更新日期：2020-11-20 00:00:00

abstract：:Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significa...

journal_title：Aging

authors： Chi J,Yang Q,Xie XF,Yang XZ,Zhang MY,Wang HY,Xu GL

更新日期：2016-09-28 00:00:00

abstract：:Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...

journal_title：Aging

authors： Petrova NV,Luzhin AV,Serebrovskaya EO,Ryumina AP,Velichko AK,Razin SV,Kantidze OL

更新日期：2016-10-14 00:00:00