Abstract:
OBJECTIVE:To assess the value of real-time three-dimensional echocardiography (RT-3DE) in evaluating changes in left atrial volume and function in type 2 diabetes mellitus (DM) and type 2 diabetic nephropathy (DN) patients. METHOD:104 control subjects, 109 DN patients, and 111 DM patients were recruited and underwent RT-3DE. Data pertaining to the left atrium were analyzed using the 3DQA software in order to determine left atrial maximum volume index (LAVImax), left atrial pre-systolic volume index (LAVIp), left atrial minimum volume index (LAVImin), total left atrial ejection fraction (LAEFt), passive left atrial ejection fraction (LAEFp), and active left atrial ejection fraction (LAEFa). Differences between these three groups and correlations between individual index values and E/e' ratios were additionally assessed. RESULT:LAVImax, LAVIp, and LAVImin were higher in the DN and DM groups relative to controls, whereas LAEFt and LAEFp were higher in controls relative to DM and DN patients (P < 0.05). LAVImax, LAVIp, and LAVImin in the DN group were significantly higher than those in the DM group, while LAEFt, LAEFp were higher in DM patients relative to DN patients (P < 0.05). The E/e' ratio was also found to be significantly correlated with LAVImax, LAVIp, and LAVImin. CONCLUSION:Our results indicate that RT-3DE can be used to assess changes in left atrial volume and function in patients with diabetes and can be used to monitor disease progression-related damage to such left atrial functionality.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Li X,Dong Y,Zheng C,Wang P,Xu M,Zou C,Wang Ldoi
10.18632/aging.202218subject
Has Abstractpub_date
2020-12-03 00:00:00pages
991-1000issue
1issn
1945-4589pii
202218journal_volume
13pub_type
杂志文章相关文献
Aging-US文献大全abstract:BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202497
更新日期:2021-01-11 00:00:00
abstract::The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesi...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103063
更新日期:2020-04-20 00:00:00
abstract:OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102804
更新日期:2020-02-15 00:00:00
abstract::Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increas...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102678
更新日期:2020-01-09 00:00:00
abstract::The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102110
更新日期:2019-07-22 00:00:00
abstract:PURPOSE:This study aimed to validate the newly proposed American Joint Committee on Cancer (AJCC) pathological prognostic staging system for young breast cancer patients (aged ≤40 years). RESULTS:We included 12811 women in this study. Overall, 52.8% of patients in the 7th AJCC stages were restaged to the 8th AJCC path...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103111
更新日期:2020-04-22 00:00:00
abstract::Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101878
更新日期:2019-03-28 00:00:00
abstract::Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101148
更新日期:2016-12-28 00:00:00
abstract::The development and progression of hepatocellular carcinoma (HCC) is accompanied with persistent oxidative stress, but the molecular basis is not well defined. Superoxide dismutase 2 (SOD2) is an important mitochondrial antioxidant and a key aging factor. Here we investigated the expression and clinical significance o...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100967
更新日期:2016-06-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a common cancer with very poor survival due to lack of reliable biomarker for early diagnosis. In this study, we investigated microRNA (miRNA) profile of whole blood with a custom microarray containing probes for 1849 miRNA species in a total 213 successive subjects who were divided i...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101253
更新日期:2017-06-27 00:00:00
abstract::Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by analyzing The Cancer Genome Atlas cohort, we found that FAM84B amplification was ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103044
更新日期:2020-04-14 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (LncRNAs) have been associated with several types of cancer. However, little is known about their role in lung adenocarcinoma (LUAD). RESULTS:LINC00968 was significantly differentially expressed in LUAD tissues. Downregulated LINC00968 was associated with clinicopathological features of...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104011
更新日期:2020-11-04 00:00:00
abstract::Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem cell-derived exosomes have exhibited promising therapeutic effects. In this study, we performed intracerebroventricular microinject...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103692
更新日期:2020-09-23 00:00:00
abstract::Aging and age-related diseases occur in almost all organisms. Recently, it was discovered that the inhibition of target of rapamycin complex 1 (TORC1), a conserved complex that mediates nutrient status and cell metabolism, can extend an individual's lifespan and inhibit age-related diseases in many model organisms. Ho...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102428
更新日期:2019-11-11 00:00:00
abstract::Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. ...
journal_title:Aging
pub_type: 杂志文章,随机对照试验
doi:10.18632/aging.100597
更新日期:2014-02-01 00:00:00
abstract::In this study, we analyzed the role of circular RNAs in the growth and progression of bladder cancer. Direct Sanger sequencing and quantitative RT-PCR analysis showed that circ_0006332 was significantly upregulated in bladder cancer tissues. Sequencing analysis showed that circ_0006332 is generated from splicing of ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102481
更新日期:2019-11-22 00:00:00
abstract::Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102774
更新日期:2020-02-10 00:00:00
abstract::Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a re...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202453
更新日期:2020-12-29 00:00:00
abstract::Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. Since strong consensus regarding commonly altered MRs in hepatocellular carcinoma (HCC) is lacking, we generated a compendium of HCC datasets from 21 studies and identified a c...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102579
更新日期:2019-12-18 00:00:00
abstract::Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and d...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101022
更新日期:2016-08-29 00:00:00
abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202302
更新日期:2020-12-03 00:00:00
abstract::Post-myocardial infarction (MI), overactive inflammation is the hallmark of aging, however, the mechanism is unclear. We hypothesized that excess influx of omega 6 fatty acids may impair resolution, thus impacting the cardiosplenic and cardiorenal network post-MI. Young and aging mice were fed on standard lab chow (LC...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101077
更新日期:2016-10-18 00:00:00
abstract::Few reports have investigated different genetic alterations according to age in various cancers. In total, 1749 GC patients receiving curative surgery were enrolled. The clinicopathological features, and prognoses were compared between younger (<65 years) and older (≥65 years) patients. Genetic mutations were analyzed...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103627
更新日期:2020-08-18 00:00:00
abstract::The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102035
更新日期:2019-06-19 00:00:00
abstract::As an emerging technology, artificial intelligence has been applied to identify various physical disorders. Here, we developed a three-layer diagnosis system for lung cancer, in which three machine learning approaches including decision tree C5.0, artificial neural network (ANN) and support vector machine (SVM) were i...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103249
更新日期:2020-05-23 00:00:00
abstract::Long intergenic nonprotein-coding RNA 00514 (LINC00514) is upregulated in papillary thyroid cancer and contributes to its aggressiveness. In this study, we thoroughly explored the expression profile, specific functions, and relevant molecular mechanism of LINC00514 in osteosarcoma (OS). Herein, LINC00514 was significa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103043
更新日期:2020-04-23 00:00:00
abstract::Metabolic syndrome, a network of medical disorders that greatly increase the risk for developing metabolic and cardiovascular diseases, has reached epidemic levels in many areas of today's world. Despite this alarming medicare situation, scientific understandings on the root mechanisms of metabolic syndrome are still ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100431
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Gastric cancer is a common malignancy and had poor response to treatment due to its strong heterogeneity. This study aimed to identify essential genes associated with diffuse type gastric cancer and construct a powerful prognostic model. RESULTS:We conducted a weighted gene co-expression network analysis (W...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103743
更新日期:2020-09-11 00:00:00
abstract::Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100960
更新日期:2016-05-01 00:00:00
abstract::Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mas...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103286
更新日期:2020-06-05 00:00:00