Inverse correlation between longevity and developmental rate among wild C. elegans strains.

Abstract:

:Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness in wild organisms remains inconclusive. Here, we determined the correlation between lifespan and fitness, developmental rate and brood size, by using 16 wild-derived C. elegans strains originated from various geographic areas. We found a negative correlation between lifespan and developmental rate. In contrast, we did not find such negative correlation between longevity and developmental rate among the individuals of C. elegans strains. These data imply that polymorphic genetic variants among wild isolates determine resource allocation to longevity and developmental rate.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Lee Y,Hwang W,Jung J,Park S,Cabatbat JJ,Kim PJ,Lee SJ

doi

10.18632/aging.100960

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

986-99

issue

5

issn

1945-4589

pii

100960

journal_volume

8

pub_type

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