LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression.

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：:Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients' survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCG...

journal_title：Aging

authors： Yang Z,Wei X,Pan Y,Min Z,Xu J,Yu B

更新日期：2020-11-10 00:00:00

abstract：:The incidence of subarachnoid hemorrhage (SAH) and hazard ratio of death increase with age. Overactivation of microglia contributes to brain damage. This study aimed to investigate the effects of A3 adenosine receptors (A3R) activation on neurofunction and microglial phenotype polarization in the context of SAH in age...

journal_title：Aging

authors： Li P,Li X,Deng P,Wang D,Bai X,Li Y,Luo C,Belguise K,Wang X,Wei X,Xia Z,Yi B

更新日期：2020-11-30 00:00:00

abstract：:Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness...

journal_title：Aging

authors： Lee Y,Hwang W,Jung J,Park S,Cabatbat JJ,Kim PJ,Lee SJ

更新日期：2016-05-01 00:00:00

abstract：:Age can significantly affect human physiology and disease risk. Recent studies have shown that age may affect the composition and function of the gut microbiota, but the underlying mechanisms remain largely unknown. Non-human primates are an ideal model for uncovering how age shapes the gut microbiota, as their microb...

journal_title：Aging

authors： Duan J,Yin B,Li W,Chai T,Liang W,Huang Y,Tan X,Zheng P,Wu J,Li Y,Li Y,Zhou W,Xie P

更新日期：2019-12-14 00:00:00

abstract：:A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. W...

journal_title：Aging

authors： Hur JH,Cho J,Walker DW

更新日期：2010-01-26 00:00:00

abstract：:One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phospho...

journal_title：Aging

authors： Obukhova LA,Skulachev VP,Kolosova NG

更新日期：2009-04-22 00:00:00

abstract：:Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported t...

journal_title：Aging

authors： Huang JL,Yu C,Su M,Yang SM,Zhang F,Chen YY,Liu JY,Jiang YF,Zhong ZG,Wu DP

更新日期：2019-10-07 00:00:00

abstract：OBJECTIVE:Genome-wide association studies (GWAS) and the candidate gene based association studies have identified a panel of variants associated with atrial fibrillation (AF), however, most of the identified single nucleotide polymorphisms (SNPs) were found located within intergenic or intronic genomic regions, and whe...

journal_title：Aging

authors： Xu C,Zhang R,Xia Y,Xiong L,Yang W,Wang P

更新日期：2020-09-09 00:00:00

abstract：:Of all the major organ systems in the body, the ovaries of females are the first to exhibit impaired function with advancing age. Until recently, traditional thinking was that female mammals are provided with a non-renewable pool of oocyte-containing follicles at birth that are depleted during postnatal life to exhaus...

journal_title：Aging

authors： Niikura Y,Niikura T,Tilly JL

更新日期：2009-12-12 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common gynecologic malignancies. To identify potential prognostic biomarkers for EC, we analyzed the relationship between the EC tumor microenvironment and gene expression profiles. Using the ESTIMATE R tool, we found that immune and stromal scores correlated with clinical da...

journal_title：Aging

authors： Chen P,Yang Y,Zhang Y,Jiang S,Li X,Wan J

更新日期：2020-02-19 00:00:00

abstract：:Senescent cells accumulate in various tissues and organs with aging altering surrounding tissue due to an active secretome, and at least in mice their elimination extends healthy lifespan and ameliorates several chronic diseases. Whether all cell types senesce, including post-mitotic cells, has been poorly described m...

journal_title：Aging

authors： Moreno-Blas D,Gorostieta-Salas E,Pommer-Alba A,Muciño-Hernández G,Gerónimo-Olvera C,Maciel-Barón LA,Konigsberg M,Massieu L,Castro-Obregón S

更新日期：2019-08-30 00:00:00

abstract：:Combination treatment is a promising strategy to improve prognosis of hepatocellular carcinoma (HCC). Sorafenib is a traditional first-line agent approved for the treatment of advanced HCC, though with limited efficacy. Previously, we reported that lonafarnib, an orally bioavailable non-peptide inhibitor targeting far...

journal_title：Aging

authors： Wang J,Wei H,Huang Y,Chen D,Zeng G,Lian Y,Huang Y

更新日期：2019-08-13 00:00:00

abstract：:There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individua...

journal_title：Aging

authors： Hung PH,Lin CH,Hung KY,Muo CH,Chung MC,Chang CH,Chung CJ

更新日期：2020-02-24 00:00:00

abstract：:The Editorial Board of Aging reviews research papers published in 2009, which they believe have or will have significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote longevity in model organisms, DNA damage responses and telomeres, molecular mechani...

journal_title：Aging

authors： Blagosklonny MV,Campisi J,Sinclair DA,Bartke A,Blasco MA,Bonner WM,Bohr VA,Brosh RM Jr,Brunet A,Depinho RA,Donehower LA,Finch CE,Finkel T,Gorospe M,Gudkov AV,Hall MN,Hekimi S,Helfand SL,Karlseder J,Kenyon C,Kroeme

更新日期：2010-03-01 00:00:00

abstract：:Atg7, a critical component of autophagy machinery, is essential for counteracting hematopoietic aging. However, the non-autophagic role of Atg7 on hematopoietic cells remains fundamentally unclear. In this study, we found that loss of Atg7, but not Atg5, another autophagy-essential gene, in the hematopoietic system re...

journal_title：Aging

authors： Fang Y,Gu Y,Li L,Zhu L,Qian J,Zhao C,Xu L,Wei W,Du Y,Yuan N,Zhang S,Yuan Y,Xu Y,Jiang C,Wang J

更新日期：2020-11-24 00:00:00

abstract：:Reducing the expression of the Indy (I'm Not Dead Yet) gene in lower organisms extends life span by mechanisms resembling caloric restriction. Similarly, deletion of the mammalian homolog, mIndy (Slc13a5), encoding for a plasma membrane tricarboxylate transporter, protects from aging- and diet-induced adiposity and in...

journal_title：Aging

authors： Pesta DH,Perry RJ,Guebre-Egziabher F,Zhang D,Jurczak M,Fischer-Rosinsky A,Daniels MA,Willmes DM,Bhanot S,Bornstein SR,Knauf F,Samuel VT,Shulman GI,Birkenfeld AL

更新日期：2015-12-01 00:00:00

abstract：:Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and d...

journal_title：Aging

authors： Valentini E,Zampieri M,Malavolta M,Bacalini MG,Calabrese R,Guastafierro T,Reale A,Franceschi C,Hervonen A,Koller B,Bernhardt J,Slagboom PE,Toussaint O,Sikora E,Gonos ES,Breusing N,Grune T,Jansen E,Dollé ME,Moreno-Vi

更新日期：2016-08-29 00:00:00

abstract：:Salivary gland dysfunction is a common symptom that occurs after menopause. This study was performed to investigate the mechanism of salivary gland dysfunction to confirm the relationship between ferroptosis and salivary gland dysfunction by ovariectomy. Forty-eight female rats were randomly divided into four groups (...

journal_title：Aging

authors： Kwon HK,Kim JM,Shin SC,Sung ES,Kim HS,Park GC,Cheon YI,Lee JC,Lee BJ

更新日期：2020-11-05 00:00:00

abstract：:Histones and their variants are subjected to several post-translational modifications (PTMs). Histones PTMs play an important role in the regulation of gene expression and are critical for the development and progression of many types of cancer, including breast cancer. In this study, we used two-dimensional TAU/SDS e...

journal_title：Aging

authors： Perri AM,Agosti V,Olivo E,Concolino A,Angelis M,Tammè L,Fiumara CV,Cuda G,Scumaci D

更新日期：2019-12-08 00:00:00

abstract：OBJECTIVE:We analyzed clinical parameters and risk factors for coronavirus disease 2019 (COVID-19)-related liver damage. RESULTS:Of the 332 COVID-19 patients, 306 and 26 were included in the non-critical and critical groups, respectively. The median time from onset to admission was 4.0 (2.0-8.0) days. Of the 332 COVID...

journal_title：Aging

authors： Guo H,Zhang Z,Zhang Y,Liu Y,Wang J,Qian Z,Zou Y,Lu H

更新日期：2020-10-01 00:00:00

abstract：:Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and strength in old rats following disuse-induced atrophy. Adult (9 month) ...

journal_title：Aging

authors： Baehr LM,West DW,Marcotte G,Marshall AG,De Sousa LG,Baar K,Bodine SC

更新日期：2016-01-01 00:00:00

abstract：:Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression and function of circRNA during porcine oocyte meiotic maturation have been never examined. Here, we separately identified 7,067 and 637 circRNAs in both cumulus cells and oocyt...

journal_title：Aging

authors： Cao Z,Gao D,Xu T,Zhang L,Tong X,Zhang D,Wang Y,Ning W,Qi X,Ma Y,Ji K,Yu T,Li Y,Zhang Y

更新日期：2019-09-28 00:00:00

abstract：:Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the fli...

journal_title：Aging

authors： Lin YR,Parikh H,Park Y

更新日期：2018-04-19 00:00:00

abstract：:Uveal melanoma (UM) is the most common primary intraocular tumour in adults. The most accurate prognostic factor of UM is classification by gene expression profiling. Currently, the role of epigenetics is much less defined compared to genetic mechanisms. We recently showed a strong prognostic role of the expression le...

journal_title：Aging

authors： Giallongo S,Di Rosa M,Caltabiano R,Longhitano L,Reibaldi M,Distefano A,Lo Re O,Amorini AM,Puzzo L,Salvatorelli L,Palmucci S,Tibullo D,Russo A,Longo A,Lazzarino G,Li Volti G,Vinciguerra M

更新日期：2020-05-12 00:00:00

abstract：:Cognitive dysfunction caused by chronic cerebral hypoperfusion is a common underlying cause of many cognition-related neurodegenerative diseases. The mechanisms of cognitive dysfunction caused by CCH are not clear. Long non-coding RNA is involved in synaptic plasticity and cognitive function, but whether lncRNA is inv...

journal_title：Aging

authors： Yao ZH,Wang J,Shen BZ,Li YT,Yao XL,Zhang SF,Zhang Y,Hu JC,Xie YC

更新日期：2020-10-11 00:00:00

abstract：:Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...

journal_title：Aging

authors： Zhang J,Zhuo Z,Li W,Zhu J,He J,Su J

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:MiRNA can be involved in regulating tumor genesis and development through regulating the major genes expression and regulating corresponding pathways. Here, we investigated the function and mechanisms of miR-483-3p in glioma progression. RESULTS:We found that miR-483-3p was increased in glioma cells and tis...

journal_title：Aging

authors： Xu D,Chi G,Xu D

更新日期：2020-11-04 00:00:00

abstract：:Cellular senescence is considered a stress response imposing a stable cell cycle arrest to restrict the growth of damaged cells. More recently however, cellular senescence was identified during mouse embryo development at particular structures during specific periods of time. This programmed cell senescence has been p...

journal_title：Aging

authors： Da Silva-Álvarez S,Guerra-Varela J,Sobrido-Cameán D,Quelle A,Barreiro-Iglesias A,Sánchez L,Collado M

更新日期：2020-09-29 00:00:00

abstract：:Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...

journal_title：Aging

authors： Darst BF,Koscik RL,Hogan KJ,Johnson SC,Engelman CD

更新日期：2019-02-24 00:00:00