Association of KRAS and NRAS gene polymorphisms with Wilms tumor risk: a four-center case-control study.


:Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose individuals to Wilms tumor. Four SNPs in RAS were genotyped in 355 Wilms tumor cases and 1070 controls. The SNPs included rs12587 G>T, rs7973450 A>G and rs7312175 G>A in KRAS, and rs2273267 A>T in NRAS. Individuals harboring the rs12587 GT genotype were more likely to develop Wilms tumor than those carrying the GG genotype (adjusted odds ratio [OR]=1.30, 95% confidence interval [CI]=1.004-1.68, P=0.046). However, the other three SNPs seemed not to influence the risk for Wilms tumor. Compared to individuals without a risk genotype, those harboring one to three KRAS risk genotypes had an adjusted OR of 1.28 for developing Wilms tumor (95% CI=1.002-1.64, P=0.048). Stratification analysis revealed that rs12587 GT/TT was associated with Wilms tumor risk in children >18 months old (adjusted OR=1.39, 95% CI=1.02-1.89, P=0.037). Our findings indicate that the rs12587 G>T polymorphism in KRAS is associated with increased Wilms tumor susceptibility.


Aging (Albany NY)




Fu W,Zhuo Z,Hua RX,Fu K,Jia W,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,He J,Liu G




Has Abstract


2019-03-12 00:00:00














  • Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore.

    abstract::How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...


    pub_type: 杂志文章


    authors: Yu R,Sun Y,Ye KX,Feng Q,Lim SL,Mahendran R,Cheah IK,Foo RSY,Chua RY,Gwee X,Loh M,Sarmugam R,Khine WWT,Chao YX,Larbi A,Lee YK,Kumar AP,Kennedy BK,Kua EH,Feng L

    更新日期:2020-11-18 00:00:00

  • Correlates of change in accelerometer-assessed total sedentary time and prolonged sedentary bouts among older English adults: results from five-year follow-up in the EPIC-Norfolk cohort.

    abstract:BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...


    pub_type: 杂志文章


    authors: Yerrakalva D,Hajna S,Wijndaele K,Westgate K,Khaw KT,Wareham N,Griffin SJ,Brage S

    更新日期:2021-01-11 00:00:00

  • Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p.

    abstract::Long non-coding RNA (lncRNA) Ewing sarcoma associated transcript 1 (EWSAT1) has been identified as an oncogene, and its dysregulation is closed corrected with tumor progression in Ewing sarcoma. Recently, high-through put analysis reveals that EWSAT1 is also highly expressed in human nasopharyngeal carcinoma (NPC). Ho...


    pub_type: 杂志文章


    authors: Song P,Yin SC

    更新日期:2016-11-03 00:00:00

  • Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly rats.

    abstract::The incidence of subarachnoid hemorrhage (SAH) and hazard ratio of death increase with age. Overactivation of microglia contributes to brain damage. This study aimed to investigate the effects of A3 adenosine receptors (A3R) activation on neurofunction and microglial phenotype polarization in the context of SAH in age...


    pub_type: 杂志文章


    authors: Li P,Li X,Deng P,Wang D,Bai X,Li Y,Luo C,Belguise K,Wang X,Wei X,Xia Z,Yi B

    更新日期:2020-11-30 00:00:00

  • Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study.

    abstract::Patients with end-stage renal disease (ESRD) display phenotypic features of premature biological aging, characterized by disproportionately high morbidity and mortality at a younger age. Nuclear factor erythroid 2-related factor 2 (Nrf2) activity, a master regulator of antioxidative responses, declines with age and is...


    pub_type: 杂志文章


    authors: Sumida K,Han Z,Dashputre AA,Potukuchi PK,Kovesdy CP

    更新日期:2020-07-13 00:00:00

  • Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinoma.

    abstract::Epithelial-to-mesenchymal transition (EMT) is important in tumor invasiveness and metastasis. We aimed to determine prognostic value of six key EMT markers (CDH1, CDH2, SNAI1, SNAI2, VIM, TWIST1) in clear cell renal cell carcinoma (ccRCC). A total of 533 ccRCC patients with RNASeq data from The Cancer Genome Atlas (TC...


    pub_type: 杂志文章


    authors: Xu H,Xu WH,Ren F,Wang J,Wang HK,Cao DL,Shi GH,Qu YY,Zhang HL,Ye DW

    更新日期:2020-01-08 00:00:00

  • CircRNA CDR1as promotes hepatoblastoma proliferation and stemness by acting as a miR-7-5p sponge to upregulate KLF4 expression.

    abstract::Hepatoblastoma (HB) is a malignant embryonal tumor of the liver that consists of heterogenous populations of stem/progenitor cells. Although circular RNAs (circRNAs) play an essential role in tumor development, the effects of circRNA on the proliferation of HB cells, especially cancer stem cells (CSCs), remain unclear...


    pub_type: 杂志文章


    authors: Chen L,Shi J,Wu Y,Qiu R,Zeng L,Lou L,Su J,Liao M,Deng X

    更新日期:2020-10-14 00:00:00

  • A decline in female baboon hypothalamo-pituitary-adrenal axis activity anticipates aging.

    abstract::Stressors that disrupt homeostasis advance aging. Glucocorticoids regulate multiple processes that determine the aging trajectory. Debate exists regarding life-course circulating glucocorticoid concentrations. Rodent and nonhuman primate studies indicate circulating glucocorticoids fall from early life. We measured fa...


    pub_type: 杂志文章


    authors: Yang S,Gerow KG,Huber HF,Considine MM,Li C,Mattern V,Comuzzie AG,Ford SP,Nathanielsz PW

    更新日期:2017-05-09 00:00:00

  • Long-term environmental enrichment affects microglial morphology in middle age mice.

    abstract::Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors in the development of age-related neuroinflammation and microglial dysfunction. EE results in improvements ...


    pub_type: 杂志文章


    authors: Ali S,Liu X,Queen NJ,Patel RS,Wilkins RK,Mo X,Cao L

    更新日期:2019-04-29 00:00:00

  • BMAL1 knockdown triggers different colon carcinoma cell fates by altering the delicate equilibrium between AKT/mTOR and P53/P21 pathways.

    abstract::Dysregulation of the circadian timing system (CTS) frequently appears during colorectal cancer (CRC) progression. In order to better understand the role of the circadian clock in CRC progression, this study evaluated in vitro how knockdown of a core circadian protein BMAL1 (BMAL1-KD) influenced the behavior of two pri...


    pub_type: 杂志文章


    authors: Zhang Y,Devocelle A,Souza L,Foudi A,Tenreira Bento S,Desterke C,Sherrard R,Ballesta A,Adam R,Giron-Michel J,Chang Y

    更新日期:2020-05-10 00:00:00

  • Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates.

    abstract::Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...


    pub_type: 杂志文章


    authors: Djelti F,Dhenain M,Terrien J,Picq JL,Hardy I,Champeval D,Perret M,Schenker E,Epelbaum J,Aujard F

    更新日期:2016-12-28 00:00:00

  • Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner.

    abstract::Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of three fibrates, pharmacologically established s...


    pub_type: 杂志文章


    authors: Brandstädt S,Schmeisser K,Zarse K,Ristow M

    更新日期:2013-04-01 00:00:00

  • System level characterization of small molecule drugs and their affected long noncoding RNAs.

    abstract::Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...


    pub_type: 杂志文章


    authors: Yang H,Jiang Y,Zhang Y,Xu Y,Zhang C,Han J,Su F,Liu X,Mi K,Liu B,Shang D

    更新日期:2019-12-18 00:00:00

  • Circular RNA profiling in the oocyte and cumulus cells reveals that circARMC4 is essential for porcine oocyte maturation.

    abstract::Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression and function of circRNA during porcine oocyte meiotic maturation have been never examined. Here, we separately identified 7,067 and 637 circRNAs in both cumulus cells and oocyt...


    pub_type: 杂志文章


    authors: Cao Z,Gao D,Xu T,Zhang L,Tong X,Zhang D,Wang Y,Ning W,Qi X,Ma Y,Ji K,Yu T,Li Y,Zhang Y

    更新日期:2019-09-28 00:00:00

  • RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome.

    abstract::Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA...


    pub_type: 杂志文章


    authors: Chen K,Huang X,Xie D,Shen M,Lin H,Zhu Y,Ma S,Zheng C,Chen L,Liu Y,Liao W,Bin J,Liao Y

    更新日期:2021-01-20 00:00:00

  • Eryptosis as a marker of Parkinson's disease.

    abstract::A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative ...


    pub_type: 杂志文章


    authors: Pretorius E,Swanepoel AC,Buys AV,Vermeulen N,Duim W,Kell DB

    更新日期:2014-10-01 00:00:00

  • MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.

    abstract::Acute ischemic stroke (AIS) is a major public health problem in China. Impaired angiogenesis plays crucial roles in the development of ischemic cerebral injury. Recent studies have identified that microRNAs (miRNAs) are important regulators of angiogenesis, but little is known the exact effects of angiogenesis-associa...


    pub_type: 杂志文章


    authors: Du K,Zhao C,Wang L,Wang Y,Zhang KZ,Shen XY,Sun HX,Gao W,Lu X

    更新日期:2019-05-07 00:00:00

  • LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression.

    abstract::Long intergenic nonprotein-coding RNA 00514 (LINC00514) is upregulated in papillary thyroid cancer and contributes to its aggressiveness. In this study, we thoroughly explored the expression profile, specific functions, and relevant molecular mechanism of LINC00514 in osteosarcoma (OS). Herein, LINC00514 was significa...


    pub_type: 杂志文章


    authors: Yu D,Xu X,Li S,Zhang K

    更新日期:2020-04-23 00:00:00

  • miR-345-5p regulates adipogenesis via targeting VEGF-B.

    abstract::Adipocyte differentiation involves a series of highly synergistic processes, including clone amplification, proliferation arrest, and terminal differentiation. However, the mechanisms that control these different steps remain unclear. Emerging studies support that miRNAs play an important role in regulating adipogenes...


    pub_type: 杂志文章


    authors: Liu X,He Y,Feng Z,Sheng J,Dong A,Zhang M,Cao L

    更新日期:2020-09-14 00:00:00

  • The association of circulating kynurenine, a tryptophan metabolite, with frailty in older adults.

    abstract::Despite the accumulating evidence from in vitro and animal experiments supporting the role of kynurenine (a tryptophan metabolite) in a number of degenerative age-related changes, the relationship between kynurenine and frailty in older adults is not well understood. We collected blood samples from 73 participants who...


    pub_type: 杂志文章


    authors: Jang IY,Park JH,Kim JH,Lee S,Lee E,Lee JY,Park SJ,Kim DA,Hamrick MW,Kim BJ

    更新日期:2020-11-13 00:00:00

  • Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p.

    abstract::Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...


    pub_type: 杂志文章


    authors: Zhu L,Zhong Q,Yang T,Xiao X

    更新日期:2019-12-21 00:00:00

  • Skin aging: are adipocytes the next target?

    abstract::Dermal white adipose tissue (dWAT) is increasingly appreciated as a special fat depot. The adipocytes in this depot exert a variety of unique effects on their surrounding cells and can undergo massive phenotypic changes. Significant modulation of dWAT content can be observed both in intrinsically and extrinsically age...


    pub_type: 杂志文章,评审


    authors: Kruglikov IL,Scherer PE

    更新日期:2016-07-01 00:00:00

  • TAp73 regulates ATP7A: possible implications for ageing-related diseases.

    abstract::The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...


    pub_type: 杂志文章


    authors: Lopriore P,Capitanio N,Panatta E,Di Daniele N,Gambacurta A,Melino G,Amelio I

    更新日期:2018-12-08 00:00:00

  • Aging and circadian disruption: causes and effects.

    abstract::The relationship between aging and daily "circadian" behavior in humans is bidirectional: on the one hand, dysfunction of circadian clocks promotes age-related maladies; on the other, aging per se leads to changes and disruption in circadian behavior and physiology. For the latter case, recent research suggests that c...


    pub_type: 杂志文章


    authors: Brown SA,Schmitt K,Eckert A

    更新日期:2011-08-01 00:00:00

  • Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.

    abstract::Angiogenesis - the growth of new blood capillaries- is impaired in aging animals. Biophysical factors such as changes in cell size control endothelial cell (EC) proliferation and differentiation. However, the effects of aging on EC size and the mechanism by which changes in cell size control age-dependent decline in E...


    pub_type: 杂志文章


    authors: Mammoto T,Torisawa YS,Muyleart M,Hendee K,Anugwom C,Gutterman D,Mammoto A

    更新日期:2019-09-05 00:00:00

  • Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of human bone marrow mesenchymal stem cells via H19/miR-675/APC axis.

    abstract::Bone volume inadequacy is an emerging clinical problem impairing the feasibility and longevity of dental implants. Human bone marrow mesenchymal stem cells (HBMSCs) have been widely used in bone remodeling and regeneration. This study examined the effect of long noncoding RNAs (lncRNAs)-H19 on the human amnion-derived...


    pub_type: 杂志文章


    authors: Ma X,Bian Y,Yuan H,Chen N,Pan Y,Zhou W,Gao S,Du X,Hao S,Yan Z,Li X,Liu K,Xu F,Wang Y,Du Y

    更新日期:2020-05-20 00:00:00

  • Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila.

    abstract::Accumulating evidence suggests that early-life diet may program one's health status by causing permanent alternations in specific organs, tissues, or metabolic or homeostatic pathways, and such programming effects may propagate across generations through heritable epigenetic modifications. However, it remains uninvest...


    pub_type: 杂志文章


    authors: Xia B,de Belle JS

    更新日期:2016-05-01 00:00:00

  • Low-abundance mutations in colorectal cancer patients and healthy adults.

    abstract::Detecting low-abundance mutations is very important for cancer diagnosis and treatment. Here we describe an improved targeted sequencing analysis that dramatically increases sequencing depth. Seven colorectal cancer (CRC) patients and seven healthy adults were enrolled in this study. We examined genetic mutations in t...


    pub_type: 杂志文章


    authors: Li Y,Dai Z,Huang G,Jin Y,Ning Z,Shen J

    更新日期:2020-01-12 00:00:00

  • CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer.

    abstract::Lung cancer remains the most lethal cancer worldwide because of its high metastasis potential. Epithelial-mesenchymal transition (EMT) is known as the first step of the metastasis cascade, but the potential regulatory mechanisms of EMT have not been clearly established. In this study, we first found that low CUEDC1 ex...


    pub_type: 杂志文章


    authors: Cui Y,Song Y,Yan S,Cao M,Huang J,Jia D,Liu Y,Zhang S,Fan W,Cai L,Li C,Xing Y

    更新日期:2020-10-25 00:00:00

  • SNCA Rep1 microsatellite length influences non-motor symptoms in early Parkinson's disease.

    abstract::Long alpha-synuclein gene (SNCA) promoter (Rep1) allele-carriers are linked to higher risk for Parkinson's disease (PD) and faster motor progression. Non-motor symptoms including autonomic, neuropsychiatric, and sleep disorders are common in PD. However, the relationship between SNCA Rep1 microsatellite lengths and no...


    pub_type: 杂志文章


    authors: Yong AC,Tan YJ,Zhao Y,Lu Z,Ng EY,Ng SY,Chia NS,Choi X,Heng D,Neo S,Xu Z,Tay KY,Au WL,Tan EK,Tan LC,Ng AS

    更新日期:2020-10-20 00:00:00