Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner.

Abstract:

:Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of three fibrates, pharmacologically established serum lipid-lowering drugs and ligands of the nuclear receptor PPARalpha in mammals, are capable of extending lifespan in a nematodal model organism for aging processes, the roundworm Caenorhabditis elegans. Adult C. elegans (wild-type N2 as well as two nhr-49-deficient strains, RB1716 and VC870) were maintained on agar plates and were fed E. coli strain OP50 bacteria. Bezafibrate, clofibrate, and fenofibrate were applied to the agar, respectively, to test whether they may promote longevity by quantifying survival in the presence and absence of the respective compounds. All three fibrates extended C. elegans N2 lifespan when applied at a concentration of 10 micromolar. Bezafibrate additionally extended C. elegans N2 lifespan at concentrations of 1 micromolar and 0.1 micromolar. In strains deficient for nhr-49, a functional orthologue of the mammalian peroxisome proliferator-activated receptor alpha (PPARalpha), all three compounds were incapable of extending lifespan. Taken together, fibrates promote C. elegans longevity in an NHR-49-dependent manner possibly by promoting mitohormesis and suggesting that these compounds may promote lifespan also in mammals.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Brandstädt S,Schmeisser K,Zarse K,Ristow M

doi

10.18632/aging.100548

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

270-5

issue

4

issn

1945-4589

pii

100548

journal_volume

5

pub_type

杂志文章

相关文献

Aging-US文献大全
  • lncRNA OGFRP1 functions as a ceRNA to promote the progression of prostate cancer by regulating SARM1 level via miR-124-3p.

    abstract::lncRNA can interact with miRNA as a ceRNA to participate in the regulation of target gene expression, thus playing an important role in the development of malignant tumors. In this research, we found that OGFRP1 was up-regulated in prostate cancer (PCa) clinical samples and cell lines. Additionally, OGFRP1 is signific...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103007

    authors: Yan K,Hou L,Liu T,Jiao W,Ma Q,Fang Z,Zhang S,Song D,Liu J,Gao X,Fan Y

    更新日期:2020-05-19 00:00:00

  • Caloric restriction effects on liver mTOR signaling are time-of-day dependent.

    abstract::The regulation of mechanistic target of rapamycin (mTOR) signaling contributes to the metabolic effects of a calorie restriction (CR) diet. We assayed the effect of CR on the activity of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) in the liver of mice at six different times across the day. CR effects on mTORC1...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101498

    authors: Tulsian R,Velingkaar N,Kondratov R

    更新日期:2018-07-16 00:00:00

  • FAM83A signaling induces epithelial-mesenchymal transition by the PI3K/AKT/Snail pathway in NSCLC.

    abstract::Family with sequence similarity 83, member A (FAM83A), as a potential tumor promoter, was reported to contribute to the progression of several malignant tumors. However, the significance of FAM83A in invasion and metastasis of non-small cell lung cancer (NSCLC) remains largely unknown. In this study, we found that FAM...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102163

    authors: Zhou F,Geng J,Xu S,Meng Q,Chen K,Liu F,Yang F,Pan B,Yu Y

    更新日期:2019-08-24 00:00:00

  • Single-cell RNA sequencing of immune cells in gastric cancer patients.

    abstract::Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102774

    authors: Fu K,Hui B,Wang Q,Lu C,Shi W,Zhang Z,Rong D,Zhang B,Tian Z,Tang W,Cao H,Wang X,Chen Z

    更新日期:2020-02-10 00:00:00

  • Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.

    abstract::Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102275

    authors: Li H,Wang X,Lu X,Zhu H,Li S,Duan S,Zhao X,Zhang F,Alterovitz G,Wang F,Li Q,Tian XL,Xu M

    更新日期:2019-09-12 00:00:00

  • Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers.

    abstract:INTRODUCTION:Circulating non-coding RNA is an ideal source to discover novel biomarkers for non-invasive screening. However, studies for the discovery of universal miRNAs in serum and exosomes for breast cancer early diagnosis are limited. METHODS:Based on bioinformatic analysis, in vitro and in vivo studies were perf...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202388

    authors: Liu D,Li B,Shi X,Zhang J,Chen AM,Xu J,Wang W,Huang K,Gao J,Zheng Z,Liu D,Wang H,Shi W,Chen L,Xu J

    更新日期:2021-01-20 00:00:00

  • E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc.

    abstract::FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202293

    authors: Zhong L,Zhang Y,Li M,Song Y,Liu D,Yang X,Yang D,Qu H,Lai L,Wang Q,Chen Z

    更新日期:2020-12-01 00:00:00

  • The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress.

    abstract::PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100029

    authors: Kunstmann B,Osiewacz HD

    更新日期:2009-03-03 00:00:00

  • CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1.

    abstract:BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102539

    authors: Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

    更新日期:2019-12-19 00:00:00

  • Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.

    abstract::Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100991

    authors: Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV

    更新日期:2016-07-01 00:00:00

  • Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells.

    abstract::Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6 and α-tubulin were...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103537

    authors: Li J,Zhou Y,Yan Y,Zheng Z,Hu Y,Wu W

    更新日期:2020-08-29 00:00:00

  • Inducing cellular senescence in vitro by using genetically encoded photosensitizers.

    abstract::Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101065

    authors: Petrova NV,Luzhin AV,Serebrovskaya EO,Ryumina AP,Velichko AK,Razin SV,Kantidze OL

    更新日期:2016-10-14 00:00:00

  • Age-associated chromatin relaxation is enhanced in Huntington's disease mice.

    abstract::Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT may disturb the integrity of the epigenetic system. Here, we used a PC...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101193

    authors: Park M,Min B,Jeon K,Cho S,Park JS,Kim J,Jeon J,Song J,Kim S,Jeong S,Seo H,Kang YK

    更新日期:2017-03-12 00:00:00

  • LINC00968 can inhibit the progression of lung adenocarcinoma through the miR-21-5p/SMAD7 signal axis.

    abstract:BACKGROUND:Long non-coding RNAs (LncRNAs) have been associated with several types of cancer. However, little is known about their role in lung adenocarcinoma (LUAD). RESULTS:LINC00968 was significantly differentially expressed in LUAD tissues. Downregulated LINC00968 was associated with clinicopathological features of...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104011

    authors: Zhu Y,Bo H,Chen Z,Li J,He D,Xiao M,Xiang L,Jin L,Zhou J,Gong L,Zhou Y,Zhou M,Xiong W,Xing X,Li R,Cao K

    更新日期:2020-11-04 00:00:00

  • Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology.

    abstract::Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103465

    authors: Chen CC,Wong TY,Chin TY,Lee WH,Kuo CY,Hsu YC

    更新日期:2020-08-05 00:00:00

  • PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation.

    abstract::Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study inv...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101299

    authors: Rajapakse D,Chen M,Curtis TM,Xu H

    更新日期:2017-10-09 00:00:00

  • MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.

    abstract::Acute ischemic stroke (AIS) is a major public health problem in China. Impaired angiogenesis plays crucial roles in the development of ischemic cerebral injury. Recent studies have identified that microRNAs (miRNAs) are important regulators of angiogenesis, but little is known the exact effects of angiogenesis-associa...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101948

    authors: Du K,Zhao C,Wang L,Wang Y,Zhang KZ,Shen XY,Sun HX,Gao W,Lu X

    更新日期:2019-05-07 00:00:00

  • Expression and prognosis analysis of TET family in acute myeloid leukemia.

    abstract::TET family members (TETs) encode proteins that represent crucial factors in the active DNA demethylation pathway. Evidence has proved that TET2 mutation is associated with leukemogenesis, drug response, and prognosis in acute myeloid leukemia (AML). However, few studies revealed the TETs expression and its clinical si...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102928

    authors: Zhang T,Zhao Y,Zhao Y,Zhou J

    更新日期:2020-03-25 00:00:00

  • Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells.

    abstract::Human tumors and cultured cells contain elevated levels of endogenous DNA damage resulting from telomere dysfunction, replication and transcription errors, reactive oxygen species, and genome instability. However, the contribution of telomere-associated versus telomere-independent endogenous DNA lesions to this damage...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100019

    authors: Nakamura AJ,Redon CE,Bonner WM,Sedelnikova OA

    更新日期:2009-02-04 00:00:00

  • miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression.

    abstract::Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain a...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103343

    authors: Wang Y,Song Y,Pang Y,Yu Z,Hua W,Gu Y,Qi J,Wu H

    更新日期:2020-06-29 00:00:00

  • KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling pathway.

    abstract:BACKGROUND/AIMS:Kinesin family member 20A (KIF20A) is upregulated in multiple cancers and plays important roles in promoting malignant behavior, whereas its exact role in CRC remains unknown. RESULTS:Both genomic and protein expression levels showed that KIF20A was upregulated in CRC. Further functional analyses revea...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102505

    authors: Xiong M,Zhuang K,Luo Y,Lai Q,Luo X,Fang Y,Zhang Y,Li A,Liu S

    更新日期:2019-12-16 00:00:00

  • COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway.

    abstract::The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA....

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102300

    authors: Long R,Liu Z,Li J,Yu H

    更新日期:2019-10-17 00:00:00

  • Urinary metabolite signature in bipolar disorder patients during depressive episode.

    abstract::The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101805

    authors: Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P

    更新日期:2019-02-05 00:00:00

  • Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.

    abstract::Recent studies have demonstrated circular RNAs (circRNAs) to be widely expressed and to have important physiological functions. However, the expression, regulation, and function of circRNAs in neuroglial cells are unknown. Herein, we characterized the expression, regulation, and function of circRNAs in astrocytes. Ast...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102529

    authors: Diling C,Yinrui G,Longkai Q,Xiaocui T,Yadi L,Xin Y,Guoyan H,Ou S,Tianqiao Y,Dongdong W,Yizhen X,Yang BB,Qingping W

    更新日期:2019-12-20 00:00:00

  • Birth mass is the key to understanding the negative correlation between lifespan and body size in dogs.

    abstract::Larger dog breeds live shorter than the smaller ones, opposite of the mass-lifespan relationship observed across mammalian species. Here we use data from 90 dog breeds and a theoretical model based on the first principles of energy conservation and life history tradeoffs to explain the negative correlation between lon...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101081

    authors: Fan R,Olbricht G,Baker X,Hou C

    更新日期:2016-12-08 00:00:00

  • Prognostic values of GPNMB identified by mining TCGA database and STAD microenvironment.

    abstract::The survival rate of stomach adenocarcinoma patients with immune and stromal scores and different clinicopathological features obtained from the TCGA datasets was systematically compared. A list of genes that are correlated with stomach adenocarcinoma microenvironment were extracted using the TCGA database to predict ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103646

    authors: Yao K,Wei L,Zhang J,Wang C,Wang C,Qin C,Li S

    更新日期:2020-08-21 00:00:00

  • Knockdown of CENPF inhibits the progression of lung adenocarcinoma mediated by ERβ2/5 pathway.

    abstract::Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202303

    authors: Hexiao T,Yuquan B,Lecai X,Yanhong W,Li S,Weidong H,Ming X,Xuefeng Z,Gaofeng P,Li Z,Minglin Z,Zheng T,Zetian Y,Xiao Z,Yi C,Lanuti M,Jinping Z

    更新日期:2021-01-10 00:00:00

  • Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions.

    abstract::Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight junctions (TJs) remains unclear. In the present study, we found that high salt d...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103348

    authors: Deng Z,Zhou L,Wang Y,Liao S,Huang Y,Shan Y,Tan S,Zeng Q,Peng L,Huang H,Lu Z

    更新日期:2020-06-22 00:00:00

  • Association between immune-related adverse events and efficacy of PD-1 inhibitors in Chinese patients with advanced melanoma.

    abstract::Programmed cell death 1 (PD-1) checkpoint inhibitor therapy leads to immune-related adverse events (irAEs). We sought to evaluate whether the development of irAEs correlates with the treatment response in Chinese patients with advanced melanoma. In this study, we conducted a retrospective study of advanced melanoma pa...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103285

    authors: Zhao JJ,Wen XZ,Ding Y,Li DD,Zhu BY,Li JJ,Weng DS,Zhang X,Zhang XS

    更新日期:2020-06-08 00:00:00

  • Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese.

    abstract::Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101975

    authors: Niu H,Niu W,Yu T,Dong F,Huang K,Duan R,Qumu S,Lu M,Li Y,Yang T,Wang C

    更新日期:2019-05-29 00:00:00