Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory.

abstract：:Esophageal adenocarcinoma (EAC) is one of the leading causes of cancer-related death worldwide, and the molecular biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs are dysregulated in a variety of cancers including EAC. In this study, siRNA mediated gene knockdown, W...

journal_title：Aging

authors： Su W,Wang L,Niu F,Zou L,Guo C,Wang Z,Yang X,Wu J,Lu Y,Zhang J,Beer DG,Yang Z,Chen G

更新日期：2019-05-13 00:00:00

abstract：:According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast ca...

journal_title：Aging

authors： Chen PS,Hsu HP,Phan NN,Yen MC,Chen FW,Liu YW,Lin FP,Feng SY,Cheng TL,Yeh PH,Omar HA,Sun Z,Jiang JZ,Chan YS,Lai MD,Wang CY,Hung JH

更新日期：2021-01-10 00:00:00

abstract：:Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (...

journal_title：Aging

authors： Zhang B,Lin L,Yuan F,Song G,Chang Q,Wu Z,Miao Z,Mo D,Huo X,Liu A

更新日期：2021-02-01 00:00:00

abstract：:Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...

journal_title：Aging

authors： Guo B,Zhang Q,Wang H,Chang P,Tao K

更新日期：2018-04-17 00:00:00

abstract：:Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...

journal_title：Aging

authors： Xu W,Song C,Wang X,Li Y,Bai X,Liang X,Wu J,Liu J

更新日期：2021-01-05 00:00:00

abstract：:Topoisomerase II (Top2) removes topological linkages between replicated chromosomes. Top2 inhibition leads to mitotic catastrophe (MC) when cells unsuccessfully try to split their genetic material between the two daughter cells. Herein, we have characterized the fate of these daughter cells in the budding yeast. Clono...

journal_title：Aging

authors： Ramos-Pérez C,Dominska M,Anaissi-Afonso L,Cazorla-Rivero S,Quevedo O,Lorenzo-Castrillejo I,Petes TD,Machín F

更新日期：2019-12-08 00:00:00

abstract：:Increasing attentions have been paid to the role of circRNAs in the etiology of triple-negative breast cancer (TNBC), and we strived to figure out the association of circRNA AKT3/miRNA axis with TNBC chemo-resistance. Altogether 207 BC patients were divided into TNBC group (n=83) and non-TNBC group (n=124), and MCF-10...

journal_title：Aging

authors： Li H,Xu W,Xia Z,Liu W,Pan G,Ding J,Li J,Wang J,Xie X,Jiang D

更新日期：2021-01-20 00:00:00

abstract：:We explored whether acute atorvastatin treatment would improve clinical outcomes and reduce the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage in elderly Chinese adults. Patients (60 to 90 years old) were admitted to intensive care units after surgery to clip or embolize their aneurysms. We a...

journal_title：Aging

authors： Chen J,Li M,Zhu X,Chen L,Yang S,Zhang C,Wu T,Feng X,Wang Y,Chen Q

更新日期：2020-02-07 00:00:00

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：:This study compares the longitudinal histological characteristics of proximal humeral implants with different spatial structures in rabbits. Thirty skeletally-mature male rabbits were divided into a trabecular structure group and regular hexahedron structure group according to the different spatial structures of a bio...

journal_title：Aging

authors： Xue Z,Pei Z,Zhang H,Tang C,Jia J,Zhang K,Zhang K,Wang L,Guan Z

更新日期：2021-01-20 00:00:00

abstract：:Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows ...

journal_title：Aging

authors： Del Campo A,Contreras-Hernández I,Castro-Sepúlveda M,Campos CA,Figueroa R,Tevy MF,Eisner V,Casas M,Jaimovich E

更新日期：2018-01-04 00:00:00

abstract：:Programmed cell death 1 (PD-1) checkpoint inhibitor therapy leads to immune-related adverse events (irAEs). We sought to evaluate whether the development of irAEs correlates with the treatment response in Chinese patients with advanced melanoma. In this study, we conducted a retrospective study of advanced melanoma pa...

journal_title：Aging

authors： Zhao JJ,Wen XZ,Ding Y,Li DD,Zhu BY,Li JJ,Weng DS,Zhang X,Zhang XS

更新日期：2020-06-08 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies worldwide with limited treatment options and distinct geographical distribution even in countries such as China. Genetic alterations during its carcinogenesis need urgent elucidation. In this study, we propose an intriguing hypothesis that the hepatitis B X-in...

journal_title：Aging

authors： Yang Z,Jiang X,Li D,Jiang X

更新日期：2020-10-13 00:00:00

abstract：:Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, ...

journal_title：Aging

authors： Sebastiani P,Bae H,Sun FX,Andersen SL,Daw EW,Malovini A,Kojima T,Hirose N,Schupf N,Puca A,Perls TT

更新日期：2013-09-01 00:00:00

abstract：:Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by analyzing The Cancer Genome Atlas cohort, we found that FAM84B amplification was ...

journal_title：Aging

authors： Zhang X,Xu J,Yan R,Zhang Y,Hu Z,Fu H,You Q,Cai Q,Yang D

更新日期：2020-04-14 00:00:00

abstract：:To investigate the relation of higher apolipoprotein B/apolipoprotein AI (apoB/AI) ratio with the risk of suffering intracranial atherosclerotic stenosis (ICAS) in both stroke and non-stroke population, we enrolled 1138 patients with acute ischemic stroke (359 with ICAS, 779 without ICAS) and 1072 non-stroke controls ...

journal_title：Aging

authors： Sun Y,Hou XH,Wang DD,Ma YH,Tan CC,Sun FR,Cui M,Dong Q,Tan L,Yu JT

更新日期：2019-09-03 00:00:00

abstract：:Aging is associated with the accumulation of DNA damage. High expression of DNA repair genes has been suggested to contribute to prolonged lifespan in several organisms. However, the crucial DNA repair genes contributing to longevity remain unknown. Termite kings have an extraordinary long lifespan compared with that ...

journal_title：Aging

authors： Tasaki E,Mitaka Y,Nozaki T,Kobayashi K,Matsuura K,Iuchi Y

更新日期：2018-10-11 00:00:00

abstract：:Aged subjects display increased susceptibility to mucosal diseases. Retinoic Acid (RA) plays a major role in inducing tolerance in the mucosa. RA acts on Dendritic cells (DCs) to induce mucosal tolerance. Here we compared the response of DCs from aged and young individuals to RA with a view to understand the role of D...

journal_title：Aging

authors： Agrawal S,Ganguly S,Tran A,Sundaram P,Agrawal A

更新日期：2016-06-01 00:00:00

abstract：:Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old m...

journal_title：Aging

authors： Dong Q,Gao H,Shi Y,Zhang F,Gu X,Wu A,Wang D,Chen Y,Bandyopadhyay A,Yeh IT,Daniel BJ,Chen Y,Zou Y,Rebel VL,Walter CA,Lu J,Huang C,Sun LZ

更新日期：2016-11-15 00:00:00

abstract：:The loss of regenerative capacity of tissues is one of the major characteristics of aging. Liver represents a powerful system for investigations of mechanisms by which aging reduces regenerative capacity of tissues. The studies within last five years revealed critical role of epigenetic silencing in the inhibition of ...

journal_title：Aging

authors： Jin J,Wang GL,Timchenko L,Timchenko NA

更新日期：2009-06-22 00:00:00

abstract：:The main aspects of severe COVID-19 disease pathogenesis include hyper-induction of proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory distress syndrome (ARDS) and often leads to death. COVID-19 patients often suffer from lung fibrosis, a serious and untreatable condition. There...

journal_title：Aging

authors： Kovalchuk A,Wang B,Li D,Rodriguez-Juarez R,Ilnytskyy S,Kovalchuk I,Kovalchuk O

更新日期：2021-01-19 00:00:00

abstract：:Upregulated ubiquitin-conjugating enzyme E2M (UBE2M) is associated with poor prognosis in malignancies; However, the phenotype and mechanism of action of UBE2M in hepatocellular carcinoma (HCC) remain elusive. Here, we report that UBE2M is overexpressed and correlated with poor prognosis in HCC patients. The UBE2M lev...

journal_title：Aging

authors： Zhang GC,Yu XN,Sun JL,Xiong J,Yang YJ,Jiang XM,Zhu JM

更新日期：2020-02-03 00:00:00

abstract：:Adipocyte differentiation involves a series of highly synergistic processes, including clone amplification, proliferation arrest, and terminal differentiation. However, the mechanisms that control these different steps remain unclear. Emerging studies support that miRNAs play an important role in regulating adipogenes...

journal_title：Aging

authors： Liu X,He Y,Feng Z,Sheng J,Dong A,Zhang M,Cao L

更新日期：2020-09-14 00:00:00

abstract：OBJECTIVE:Genome-wide association studies (GWAS) and the candidate gene based association studies have identified a panel of variants associated with atrial fibrillation (AF), however, most of the identified single nucleotide polymorphisms (SNPs) were found located within intergenic or intronic genomic regions, and whe...

journal_title：Aging

authors： Xu C,Zhang R,Xia Y,Xiong L,Yang W,Wang P

更新日期：2020-09-09 00:00:00

abstract：:There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individua...

journal_title：Aging

authors： Hung PH,Lin CH,Hung KY,Muo CH,Chung MC,Chang CH,Chung CJ

更新日期：2020-02-24 00:00:00

abstract：:Multiple recent advances in machine learning enabled computer systems to exceed human performance in many tasks including voice, text, and speech recognition and complex strategy games. Aging is a complex multifactorial process driven by and resulting in the many minute changes transpiring at every level of the human ...

journal_title：Aging

authors： Zhavoronkov A,Li R,Ma C,Mamoshina P

更新日期：2019-11-25 00:00:00

abstract：:Qigesan (QGS) has been used to effectively treat esophageal cancer (EC) for decades in China, but the mechanism by which it suppresses EC metastasis remains unknown. In this study, we examined the effects of QGS on EC cell mobility. Using immunohistochemistry and immunofluorescence, expression of Gas6 and Axl, which p...

journal_title：Aging

authors： Kong L,Lu X,Chen X,Wu Y,Zhang Y,Shi H,Li J

更新日期：2020-05-20 00:00:00

abstract：:The Mitochondrial Free Radical Theory of Aging (MFRTA) is currently one of the most widely accepted theories used to explain aging. From MFRTA three basic predictions can be made: long-lived individuals or species should produce fewer mitochondrial Reactive Oxygen Species (mtROS) than short-lived individuals or specie...

journal_title：Aging

authors： Sanz A,Fernández-Ayala DJ,Stefanatos RK,Jacobs HT

更新日期：2010-04-01 00:00:00

abstract：:Mitochondrial dysfunction is evident in numerous neurodegenerative and age-related disorders. It has also been linked to cellular ageing, however our current understanding of the mitochondrial changes that occur are unclear. Functional studies have made some progress reporting reduced respiration, dynamic structural m...

journal_title：Aging

authors： Ingram T,Chakrabarti L

更新日期：2016-12-13 00:00:00

abstract：:Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported t...

journal_title：Aging

authors： Huang JL,Yu C,Su M,Yang SM,Zhang F,Chen YY,Liu JY,Jiang YF,Zhong ZG,Wu DP

更新日期：2019-10-07 00:00:00