Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology.

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：:Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...

journal_title：Aging

authors： Sgarbi G,Matarrese P,Pinti M,Lanzarini C,Ascione B,Gibellini L,Dika E,Patrizi A,Tommasino C,Capri M,Cossarizza A,Baracca A,Lenaz G,Solaini G,Franceschi C,Malorni W,Salvioli S

更新日期：2014-04-01 00:00:00

abstract：:Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by analyzing The Cancer Genome Atlas cohort, we found that FAM84B amplification was ...

journal_title：Aging

authors： Zhang X,Xu J,Yan R,Zhang Y,Hu Z,Fu H,You Q,Cai Q,Yang D

更新日期：2020-04-14 00:00:00

abstract：:Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients' survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCG...

journal_title：Aging

authors： Yang Z,Wei X,Pan Y,Min Z,Xu J,Yu B

更新日期：2020-11-10 00:00:00

abstract：:Spermatogenesis is a complex process producing haploid spermatozoa, and the formation of lipid droplets (LDs) within Sertoli cells is critical to maintaining normal spermatogenesis. However, the utilization of LDs within Sertoli cells is still largely unknown. In the present study, proliferation of spermatogonial cell...

journal_title：Aging

authors： Ahmed N,Liu Y,Chen H,Yang P,Waqas Y,Liu T,Gandahi JA,Huang Y,Wang L,Song X,Rajput IR,Wang T,Chen Q

更新日期：2016-10-16 00:00:00

abstract：:In this study, we investigated the mechanistic role and prognostic significance of the long coding RNA (lncRNA) KCNQ1OT1 in colorectal cancer (CRC). KCNQ1OT1 levels were significantly higher in CRC tissues than adjacent normal colorectal tissues (n=79). High KCNQ1OT1 expression correlated with poorer prognosis in CRC ...

journal_title：Aging

authors： Chen C,Wei M,Wang C,Sun D,Liu P,Zhong X,Yu W

更新日期：2020-06-21 00:00:00

abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...

journal_title：Aging

authors： Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

更新日期：2019-12-19 00:00:00

abstract：:Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and interstitial conditions ...

journal_title：Aging

authors： Yanagida K,Maejima Y,Santoso P,Otgon-Uul Z,Yang Y,Sakuma K,Shimomura K,Yada T

更新日期：2014-03-01 00:00:00

abstract：:Sarcopenia is a hallmark of aging. Inflammation due to increased generation of cytokines such as TNFα, IL-1β and IL-6 has been implicated in the pathogenesis of sarcopenia. In skeletal muscle of C57BL/6 mice from 12 until 28 months of age, we observed a progressive reduction of myofiber cross sectional area, loss of t...

journal_title：Aging

authors： Sciorati C,Gamberale R,Monno A,Citterio L,Lanzani C,De Lorenzo R,Ramirez GA,Esposito A,Manunta P,Manfredi AA,Rovere-Querini P

更新日期：2020-11-26 00:00:00

abstract：:Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. The association between METH gene polymorphisms and prostate cancer susceptibility remains ambiguous. Thus, we performed an updated meta-analysis of METH single-nuc...

journal_title：Aging

authors： Zhang X,Tang J,Shen N,Ren K

更新日期：2018-10-18 00:00:00

abstract：BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...

journal_title：Aging

authors： Wenjing L,Yuanzheng F,Li JY,Tang LV,Yu H

更新日期：2020-12-15 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem cell-derived exosomes have exhibited promising therapeutic effects. In this study, we performed intracerebroventricular microinject...

journal_title：Aging

authors： Chen Y,Li J,Ma B,Li N,Wang S,Sun Z,Xue C,Han Q,Wei J,Zhao RC

更新日期：2020-09-23 00:00:00

abstract：:Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrate...

journal_title：Aging

authors： Wong RCB,Lim SY,Hung SSC,Jackson S,Khan S,Van Bergen NJ,De Smit E,Liang HH,Kearns LS,Clarke L,Mackey DA,Hewitt AW,Trounce IA,Pébay A

更新日期：2017-04-01 00:00:00

abstract：:Bladder cancer (BCa) is a heterogeneous disease with various tumorigenic mechanisms and clinical behaviors. The current tumor-node-metastasis (TNM) staging system is inadequate to predict overall survival (OS) in BCa patients. We developed a BCa-specific, long-non-coding-RNA (lncRNA)-based nomogram to improve survival...

journal_title：Aging

authors： Wang Y,Du L,Yang X,Li J,Li P,Zhao Y,Duan W,Chen Y,Wang Y,Mao H,Wang C

更新日期：2020-02-12 00:00:00

abstract：:Studies in young mammals on the molecular effects of food restriction leading to prolong adult life are scares. Here, we used high-throughput quantitative proteomic analysis of whole rat livers to address the molecular basis for growth arrest and the apparent life-prolonging phenotype of the food restriction regimen. ...

journal_title：Aging

authors： Gat-Yablonski G,Finka A,Pinto G,Quadroni M,Shtaif B,Goloubinoff P

更新日期：2016-08-01 00:00:00

abstract：:The development and progression of hepatocellular carcinoma (HCC) is accompanied with persistent oxidative stress, but the molecular basis is not well defined. Superoxide dismutase 2 (SOD2) is an important mitochondrial antioxidant and a key aging factor. Here we investigated the expression and clinical significance o...

journal_title：Aging

authors： Wang R,Yin C,Li XX,Yang XZ,Yang Y,Zhang MY,Wang HY,Zheng XF

更新日期：2016-06-01 00:00:00

abstract：:Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in ...

journal_title：Aging

authors： Xu Y,Chen T,Li X,Qu YK,An JN,Zheng HX,Zhang ZJ,Lin N

更新日期：2016-12-20 00:00:00

abstract：:Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...

journal_title：Aging

authors： Ren W,Guan W,Zhang J,Wang F,Xu G

更新日期：2019-04-14 00:00:00

abstract：:Histones and their variants are subjected to several post-translational modifications (PTMs). Histones PTMs play an important role in the regulation of gene expression and are critical for the development and progression of many types of cancer, including breast cancer. In this study, we used two-dimensional TAU/SDS e...

journal_title：Aging

authors： Perri AM,Agosti V,Olivo E,Concolino A,Angelis M,Tammè L,Fiumara CV,Cuda G,Scumaci D

更新日期：2019-12-08 00:00:00

abstract：:Previous studies have shown that PCB1254 has an adverse effect on zebrafish retinal development, but the basic mechanism behind it is not clear. The purpose of this study was to investigate the molecular mechanisms of PCB-induced retinal dysplasia. RT-qPCR, immunoblotting, HE staining and immunofluorescence were adopt...

journal_title：Aging

authors： Zhang X,Zhang Q,Jiang Y,Zhang S,Hong Q,Guo X,Chi X,Tong M

更新日期：2019-10-16 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC), a major histologic subtype of head and neck cancer, presents great mortality and morbidity worldwide. The aim of this study is to discover new potential biomarkers closely correlated with HNSCC progression. In this study, weighted gene co-expression network analysis was a...

journal_title：Aging

authors： Xu W,Zou H,Wei Z,Song C,Tang C,Yin X,Wang Y,Han S,Cai Y,Han W

更新日期：2019-06-06 00:00:00

abstract：:The incidence of subarachnoid hemorrhage (SAH) and hazard ratio of death increase with age. Overactivation of microglia contributes to brain damage. This study aimed to investigate the effects of A3 adenosine receptors (A3R) activation on neurofunction and microglial phenotype polarization in the context of SAH in age...

journal_title：Aging

authors： Li P,Li X,Deng P,Wang D,Bai X,Li Y,Luo C,Belguise K,Wang X,Wei X,Xia Z,Yi B

更新日期：2020-11-30 00:00:00

abstract：:Hepatoblastoma (HB) is a malignant embryonal tumor of the liver that consists of heterogenous populations of stem/progenitor cells. Although circular RNAs (circRNAs) play an essential role in tumor development, the effects of circRNA on the proliferation of HB cells, especially cancer stem cells (CSCs), remain unclear...

journal_title：Aging

authors： Chen L,Shi J,Wu Y,Qiu R,Zeng L,Lou L,Su J,Liao M,Deng X

更新日期：2020-10-14 00:00:00

abstract：:The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...

journal_title：Aging

authors： Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P

更新日期：2019-02-05 00:00:00

abstract：:Senescence is a leading cause of age-related cataract (ARC). The current study indicated that the senescence-associated protein, p53, total laminin (LM), LMα4, and transforming growth factor-beta1 (TGF-β1) in the cataractous anterior lens capsules (ALCs) increase with the grades of ARC. In cataractous ALCs, patient ag...

journal_title：Aging

authors： Yan Y,Yu H,Sun L,Liu H,Wang C,Wei X,Song F,Li H,Ge H,Qian H,Li X,Tang X,Liu P

更新日期：2019-05-10 00:00:00

abstract：:Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Ectopic expression o...

journal_title：Aging

authors： Yan L,You WQ,Sheng NQ,Gong JF,Hu LD,Tan GW,Chen HQ,Wang ZG

更新日期：2018-12-06 00:00:00

abstract：:Personality and self-rated health have been linked previously to cognitive outcome in late life. However, these associations have not been shown among the oldest old. This study examined relationships between personality, self-rated health, and cognitive function in a selected sample of Ashkenazi Jewish centenarians (...

journal_title：Aging

authors： Kato K,Zweig R,Schechter CB,Verghese J,Barzilai N,Atzmon G

更新日期：2013-03-01 00:00:00

abstract：:Blood brain barrier (BBB) disruption is a crucial factor contributing to secondary brain injury after intracerebral hemorrhage (ICH). Heat shock protein B8 (HSPB8) has been recently reported to confer neuroprotection against against ischaemic stroke through maintaining BBB integrity. However, the role of HSPB8 in ICH ...

journal_title：Aging

authors： Hou Y,Hu Z,Gong X,Yang B

更新日期：2020-09-04 00:00:00

abstract：:Osteoporosis is a metabolic disease characterized by reduced osteoblast differentiation and proliferation. Oxidative stress plays a role in the pathogenesis of osteoporosis. Aucubin (AU), an iridoid glycoside, was previously shown to promote osteoblast differentiation. We investigated the effects of AU on MG63 human o...

journal_title：Aging

authors： Li Y,Zhang Y,Zhang X,Lu W,Liu X,Hu M,Wang D

更新日期：2020-02-05 00:00:00

abstract：:The composition and relative abundances of immune cells in the tumor microenvironment are key factors affecting the progression of lung adenocarcinomas (LUADs) and the efficacy of immunotherapy. Using the cancer gene expression dataset from The Cancer Genome Atlas (TCGA) program, we scored stromal and immune cells for...

journal_title：Aging

authors： Fan T,Zhu M,Wang L,Liu Y,Tian H,Zheng Y,Tan F,Sun N,Li C,He J

更新日期：2020-12-09 00:00:00