Abstract:
:Telomeres are a hotspot for sister chromatid exchange (T-SCE). Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence. This work strongly suggests that progressive telomere erosion is not the only determinant of replicative capacity; instead, T-SCE need to be considered as an independent factor controlling colony growth and senescence. Additionally high T-SCE rates have been observed in cells with deficiencies in WRN and BLM, the genes that are defective in Werner's and Bloom's syndromes, implying a connection to premature aging. In this Research Perspective we will explore some of the implications this recent work has for human health.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Blagoev KB,Goodwin EH,Bailey SMdoi
10.18632/aging.100206subject
Has Abstractpub_date
2010-10-01 00:00:00pages
727-30issue
10issn
1945-4589pii
100206journal_volume
2pub_type
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