MicroRNA-141 suppresses growth and metastatic potential of head and neck squamous cell carcinoma.


:MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epidermal growth factor receptor (EGFR) were enhanced in tissues with low miR-141 expression but were reduced by miR-141 overexpression, and there was a significant negative correlation between EGFR and miR-141 levels in HNSCC tissues (P < 0.01). Luciferase assays confirmed that miR-141 targeted EGFR mRNA. In vitro, miR-141 inhibited the proliferation and migration of Cal-27 and FaDu HNSCC cells with corresponding decreases in CDK4 and MMP2. miR-141 also enhanced the incidence of apoptosis among the cells with a corresponding decrease in bcl-2. In BALB/c mice injected with FaDu HNSCC cells, miR-141 mitigated hepatic metastasis and inhibited expression of EGFR, CDK4, bcl-2 and MMP2. These results suggest that miR-141 functions as a tumor suppressor in HNSCC and that it suppresses tumor growth and metastasis by suppressing EGFR signaling. MiR-141 thus appears to be a potentially useful therapeutic target in the treatment of HNSCC.


Aging (Albany NY)




Zhao Z,Gao D,Ma T,Zhang L




Has Abstract


2019-02-08 00:00:00














  • Long-term environmental enrichment affects microglial morphology in middle age mice.

    abstract::Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors in the development of age-related neuroinflammation and microglial dysfunction. EE results in improvements ...


    pub_type: 杂志文章


    authors: Ali S,Liu X,Queen NJ,Patel RS,Wilkins RK,Mo X,Cao L

    更新日期:2019-04-29 00:00:00

  • Influence of human amylin on the membrane stability of rat primary hippocampal neurons.

    abstract::The two most common aging-related diseases, Alzheimer's disease and type 2 diabetes mellitus, are associated with accumulation of amyloid proteins (β-amyloid and amylin, respectively). This amylin aggregation is reportedly cytotoxic to neurons. We found that aggregation of human amylin (hAmylin) induced neuronal apopt...


    pub_type: 杂志文章


    authors: Zhang N,Xing Y,Yu Y,Liu C,Jin B,Huo L,Kong D,Yang Z,Zhang X,Zheng R,Jia Z,Kang L,Zhang W

    更新日期:2020-05-28 00:00:00

  • Circular RNA profiling in the oocyte and cumulus cells reveals that circARMC4 is essential for porcine oocyte maturation.

    abstract::Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression and function of circRNA during porcine oocyte meiotic maturation have been never examined. Here, we separately identified 7,067 and 637 circRNAs in both cumulus cells and oocyt...


    pub_type: 杂志文章


    authors: Cao Z,Gao D,Xu T,Zhang L,Tong X,Zhang D,Wang Y,Ning W,Qi X,Ma Y,Ji K,Yu T,Li Y,Zhang Y

    更新日期:2019-09-28 00:00:00

  • Matrix stiffness regulates myocardial differentiation of human umbilical cord mesenchymal stem cells.

    abstract::Myocardial infarction is a cardiovascular disease with high mortality. Human umbilical cord mesenchymal stem cells (hUC-MSCs) with strong self-renewal capacity and multipotency, provide the possibility of replacing injured cardiomyocytes. hUC-MSCs were cultured on polyacrylamide hydrogels with stiffnesses correspondin...


    pub_type: 杂志文章


    authors: Sun Y,Liu J,Xu Z,Lin X,Zhang X,Li L,Li Y

    更新日期:2020-12-09 00:00:00

  • CO2 lattice laser reverses skin aging caused by UVB.

    abstract::The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesi...


    pub_type: 杂志文章


    authors: Wang H,Guo B,Hui Q,Lin F,Tao K

    更新日期:2020-04-20 00:00:00

  • Proteomic profiling of mitochondria: what does it tell us about the ageing brain?

    abstract::Mitochondrial dysfunction is evident in numerous neurodegenerative and age-related disorders. It has also been linked to cellular ageing, however our current understanding of the mitochondrial changes that occur are unclear. Functional studies have made some progress reporting reduced respiration, dynamic structural m...


    pub_type: 杂志文章,评审


    authors: Ingram T,Chakrabarti L

    更新日期:2016-12-13 00:00:00

  • Association between immune-related adverse events and efficacy of PD-1 inhibitors in Chinese patients with advanced melanoma.

    abstract::Programmed cell death 1 (PD-1) checkpoint inhibitor therapy leads to immune-related adverse events (irAEs). We sought to evaluate whether the development of irAEs correlates with the treatment response in Chinese patients with advanced melanoma. In this study, we conducted a retrospective study of advanced melanoma pa...


    pub_type: 杂志文章


    authors: Zhao JJ,Wen XZ,Ding Y,Li DD,Zhu BY,Li JJ,Weng DS,Zhang X,Zhang XS

    更新日期:2020-06-08 00:00:00

  • Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.

    abstract::Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...


    pub_type: 杂志文章


    authors: Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV

    更新日期:2016-07-01 00:00:00

  • Role of apoptosis in disease.

    abstract::Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling...


    pub_type: 杂志文章,评审


    authors: Favaloro B,Allocati N,Graziano V,Di Ilio C,De Laurenzi V

    更新日期:2012-05-01 00:00:00

  • Expression and significance of miR - 20b in retinal photoreceptor cells exposed to PCB1254.

    abstract::Previous studies have shown that PCB1254 has an adverse effect on zebrafish retinal development, but the basic mechanism behind it is not clear. The purpose of this study was to investigate the molecular mechanisms of PCB-induced retinal dysplasia. RT-qPCR, immunoblotting, HE staining and immunofluorescence were adopt...


    pub_type: 杂志文章


    authors: Zhang X,Zhang Q,Jiang Y,Zhang S,Hong Q,Guo X,Chi X,Tong M

    更新日期:2019-10-16 00:00:00

  • TAp73 regulates ATP7A: possible implications for ageing-related diseases.

    abstract::The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...


    pub_type: 杂志文章


    authors: Lopriore P,Capitanio N,Panatta E,Di Daniele N,Gambacurta A,Melino G,Amelio I

    更新日期:2018-12-08 00:00:00

  • Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians.

    abstract::Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...


    pub_type: 杂志文章


    authors: Sgarbi G,Matarrese P,Pinti M,Lanzarini C,Ascione B,Gibellini L,Dika E,Patrizi A,Tommasino C,Capri M,Cossarizza A,Baracca A,Lenaz G,Solaini G,Franceschi C,Malorni W,Salvioli S

    更新日期:2014-04-01 00:00:00

  • Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy.

    abstract::Senescent cells accumulate in various tissues and organs with aging altering surrounding tissue due to an active secretome, and at least in mice their elimination extends healthy lifespan and ameliorates several chronic diseases. Whether all cell types senesce, including post-mitotic cells, has been poorly described m...


    pub_type: 杂志文章


    authors: Moreno-Blas D,Gorostieta-Salas E,Pommer-Alba A,Muciño-Hernández G,Gerónimo-Olvera C,Maciel-Barón LA,Konigsberg M,Massieu L,Castro-Obregón S

    更新日期:2019-08-30 00:00:00

  • IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of I...


    pub_type: 杂志文章


    authors: Wang M,Guo J,Zhao YQ,Wang JP

    更新日期:2020-08-28 00:00:00

  • Long noncoding RNA ARHGAP27P1 inhibits gastric cancer cell proliferation and cell cycle progression through epigenetically regulating p15 and p16.

    abstract::Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...


    pub_type: 杂志文章


    authors: Zhang G,Xu Y,Zou C,Tang Y,Lu J,Gong Z,Ma G,Zhang W,Jiang P

    更新日期:2019-10-30 00:00:00

  • NAC1 attenuates BCL6 negative autoregulation and functions as a BCL6 coactivator of FOXQ1 transcription in cancer cells.

    abstract:BACKGROUND:Nucleus accumbens-associated protein 1 (NAC1) has multifaceted roles in cancer pathogenesis and progression, including the development of drug resistance, promotion of cytokinesis, and maintenance of "stem cell-like" phenotypes. NAC1 is a transcriptional co-regulator belonging to the bric-a-brac tramtrack br...


    pub_type: 杂志文章


    authors: Gao M,Herlinger AL,Wu R,Wang TL,Shih IM,Kong B,Rangel LBA,Yang JM

    更新日期:2020-05-14 00:00:00

  • SNCA Rep1 microsatellite length influences non-motor symptoms in early Parkinson's disease.

    abstract::Long alpha-synuclein gene (SNCA) promoter (Rep1) allele-carriers are linked to higher risk for Parkinson's disease (PD) and faster motor progression. Non-motor symptoms including autonomic, neuropsychiatric, and sleep disorders are common in PD. However, the relationship between SNCA Rep1 microsatellite lengths and no...


    pub_type: 杂志文章


    authors: Yong AC,Tan YJ,Zhao Y,Lu Z,Ng EY,Ng SY,Chia NS,Choi X,Heng D,Neo S,Xu Z,Tay KY,Au WL,Tan EK,Tan LC,Ng AS

    更新日期:2020-10-20 00:00:00

  • Recent discoveries in the cycling, growing and aging of the p53 field.

    abstract::The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a...


    pub_type: 杂志文章,评审


    authors: McCubrey JA,Demidenko ZN

    更新日期:2012-12-01 00:00:00

  • Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma.

    abstract::Head and neck squamous cell carcinoma (HNSCC), a major histologic subtype of head and neck cancer, presents great mortality and morbidity worldwide. The aim of this study is to discover new potential biomarkers closely correlated with HNSCC progression. In this study, weighted gene co-expression network analysis was a...


    pub_type: 杂志文章


    authors: Xu W,Zou H,Wei Z,Song C,Tang C,Yin X,Wang Y,Han S,Cai Y,Han W

    更新日期:2019-06-06 00:00:00

  • Atorvastatin reduces cerebral vasospasm and infarction after aneurysmal subarachnoid hemorrhage in elderly Chinese adults.

    abstract::We explored whether acute atorvastatin treatment would improve clinical outcomes and reduce the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage in elderly Chinese adults. Patients (60 to 90 years old) were admitted to intensive care units after surgery to clip or embolize their aneurysms. We a...


    pub_type: 杂志文章,随机对照试验


    authors: Chen J,Li M,Zhu X,Chen L,Yang S,Zhang C,Wu T,Feng X,Wang Y,Chen Q

    更新日期:2020-02-07 00:00:00

  • Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1.

    abstract::Most muscle pathologies are characterized by the progressive loss of muscle tissue due to chronic degeneration combined with the inability of regeneration machinery to replace the damaged muscle. These pathological changes, known as muscle wasting, can be attributed to the activation of several proteolytic systems, su...


    pub_type: 杂志文章


    authors: Scicchitano BM,Rizzuto E,Musarò A

    更新日期:2009-05-13 00:00:00

  • Deep biomarkers of aging and longevity: from research to applications.

    abstract::Multiple recent advances in machine learning enabled computer systems to exceed human performance in many tasks including voice, text, and speech recognition and complex strategy games. Aging is a complex multifactorial process driven by and resulting in the many minute changes transpiring at every level of the human ...


    pub_type: 杂志文章,评审


    authors: Zhavoronkov A,Li R,Ma C,Mamoshina P

    更新日期:2019-11-25 00:00:00

  • E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis.

    abstract::Cardiomyocyte apoptosis is a major cause of myocardial ischemia/reperfusion (MI/R) injury, in which the activation of the signal transducer and activator of transcription 1 (STAT1) plays an important role. The E3-ubiquitin ligase TRIM6 has been implicated in regulating STAT1 activity, however, whether it is associated...


    pub_type: 杂志文章


    authors: Zeng G,Lian C,Yang P,Zheng M,Ren H,Wang H

    更新日期:2019-06-06 00:00:00

  • Identifying hub genes of clear cell renal cell carcinoma associated with the proportion of regulatory T cells by weighted gene co-expression network analysis.

    abstract:BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...


    pub_type: 杂志文章


    authors: Chen YH,Chen SH,Hou J,Ke ZB,Wu YP,Lin TT,Wei Y,Xue XY,Zheng QS,Huang JB,Xu N

    更新日期:2019-10-31 00:00:00

  • Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway.

    abstract::Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...


    pub_type: 杂志文章


    authors: Yao Y,Wang X,Zhou D,Li H,Qian H,Zhang J,Jiang L,Wang B,Lin Q,Zhu X

    更新日期:2020-07-02 00:00:00

  • Apolipoprotein B/AI ratio as an independent risk factor for intracranial atherosclerotic stenosis.

    abstract::To investigate the relation of higher apolipoprotein B/apolipoprotein AI (apoB/AI) ratio with the risk of suffering intracranial atherosclerotic stenosis (ICAS) in both stroke and non-stroke population, we enrolled 1138 patients with acute ischemic stroke (359 with ICAS, 779 without ICAS) and 1072 non-stroke controls ...


    pub_type: 杂志文章


    authors: Sun Y,Hou XH,Wang DD,Ma YH,Tan CC,Sun FR,Cui M,Dong Q,Tan L,Yu JT

    更新日期:2019-09-03 00:00:00

  • RWR-algorithm-based dissection of microRNA-506-3p and microRNA-140-5p as radiosensitive biomarkers in colorectal cancer.

    abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...


    pub_type: 杂志文章


    authors: Liao F,Chen X,Peng P,Dong W

    更新日期:2020-10-08 00:00:00

  • Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells.

    abstract::Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature senescence under sublethal oxidative stress, however underlying mechanism remains unknown. Here, we showed that exogenous H2O2 induces a rapid phosphorylation and co-localization of ATM, H2A.X, 53BP1 leading to DNA damage response (DDR) acti...


    pub_type: 杂志文章


    authors: Borodkina A,Shatrova A,Abushik P,Nikolsky N,Burova E

    更新日期:2014-06-01 00:00:00

  • Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency.

    abstract::Topoisomerase II (Top2) removes topological linkages between replicated chromosomes. Top2 inhibition leads to mitotic catastrophe (MC) when cells unsuccessfully try to split their genetic material between the two daughter cells. Herein, we have characterized the fate of these daughter cells in the budding yeast. Clono...


    pub_type: 杂志文章


    authors: Ramos-Pérez C,Dominska M,Anaissi-Afonso L,Cazorla-Rivero S,Quevedo O,Lorenzo-Castrillejo I,Petes TD,Machín F

    更新日期:2019-12-08 00:00:00

  • CircRNA CDR1as promotes hepatoblastoma proliferation and stemness by acting as a miR-7-5p sponge to upregulate KLF4 expression.

    abstract::Hepatoblastoma (HB) is a malignant embryonal tumor of the liver that consists of heterogenous populations of stem/progenitor cells. Although circular RNAs (circRNAs) play an essential role in tumor development, the effects of circRNA on the proliferation of HB cells, especially cancer stem cells (CSCs), remain unclear...


    pub_type: 杂志文章


    authors: Chen L,Shi J,Wu Y,Qiu R,Zeng L,Lou L,Su J,Liao M,Deng X

    更新日期:2020-10-14 00:00:00