Abstract:
:A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. We performed an RNAi screen to probe the role of ETC components in modulating lifespan in the fruit fly Drosophila melanogaster. In this Research Perspective, we discuss our findings and how they may relate to similar studies in worms and mice.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Hur JH,Cho J,Walker DWdoi
10.18632/aging.100118subject
Has Abstractpub_date
2010-01-26 00:00:00pages
69-73issue
1issn
1945-4589journal_volume
2pub_type
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