Abstract:
:We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment of innate immune activation. Our observations have possible implications for mechanisms of therapeutic resistance to targeted oncogene inactivation.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Kearney AY,Anchang B,Plevritis S,Felsher DWdoi
10.18632/aging.100813subject
Has Abstractpub_date
2015-09-01 00:00:00pages
613-5issue
9issn
1945-4589pii
100813journal_volume
7pub_type
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