Elevated systemic inflammatory responses, factors associated with physical and mental quality of life, and prognosis of hepatocellular carcinoma.

abstract：:MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epide...

journal_title：Aging

authors： Zhao Z,Gao D,Ma T,Zhang L

更新日期：2019-02-08 00:00:00

abstract：:Mitochondrial dysfunction is evident in numerous neurodegenerative and age-related disorders. It has also been linked to cellular ageing, however our current understanding of the mitochondrial changes that occur are unclear. Functional studies have made some progress reporting reduced respiration, dynamic structural m...

journal_title：Aging

authors： Ingram T,Chakrabarti L

更新日期：2016-12-13 00:00:00

abstract：:Exosomes play important roles in proliferation and microenvironment modulation of many types of cancers, including colorectal cancer (CRC). However, the inhibitory effect of CRC cells-derived exosomes in angiogenesis has not been fully discussed. In this study, the roles of microRNA-183-5p (miR-183-5p) in abundant in ...

journal_title：Aging

authors： Shang A,Wang X,Gu C,Liu W,Sun J,Zeng B,Chen C,Ji P,Wu J,Quan W,Yao Y,Wang W,Sun Z,Li D

更新日期：2020-05-03 00:00:00

abstract：:Chronic inflammation, increased reactivity to self-antigens and incidences of cancer are hallmarks of aging. However, the underlying mechanisms are not well understood. Age-associated alterations in the DNA either due to oxidative damage, defects in DNA repair or epigenetic modifications such as methylation that lead ...

journal_title：Aging

authors： Agrawal A,Tay J,Yang GE,Agrawal S,Gupta S

更新日期：2010-03-20 00:00:00

abstract：:This study compares the longitudinal histological characteristics of proximal humeral implants with different spatial structures in rabbits. Thirty skeletally-mature male rabbits were divided into a trabecular structure group and regular hexahedron structure group according to the different spatial structures of a bio...

journal_title：Aging

authors： Xue Z,Pei Z,Zhang H,Tang C,Jia J,Zhang K,Zhang K,Wang L,Guan Z

更新日期：2021-01-20 00:00:00

abstract：:Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phy...

journal_title：Aging

authors： Whittemore K,Martínez-Nevado E,Blasco MA

更新日期：2019-11-15 00:00:00

abstract：:Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. Since strong consensus regarding commonly altered MRs in hepatocellular carcinoma (HCC) is lacking, we generated a compendium of HCC datasets from 21 studies and identified a c...

journal_title：Aging

authors： Li Z,Lou Y,Tian G,Wu J,Lu A,Chen J,Xu B,Shi J,Yang J

更新日期：2019-12-18 00:00:00

abstract：:Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...

journal_title：Aging

authors： Tian Y,Yang J,Lan M,Zou T

更新日期：2020-12-26 00:00:00

abstract：:Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling...

journal_title：Aging

authors： Favaloro B,Allocati N,Graziano V,Di Ilio C,De Laurenzi V

更新日期：2012-05-01 00:00:00

abstract：:Metabolic syndrome, a network of medical disorders that greatly increase the risk for developing metabolic and cardiovascular diseases, has reached epidemic levels in many areas of today's world. Despite this alarming medicare situation, scientific understandings on the root mechanisms of metabolic syndrome are still ...

journal_title：Aging

authors： Cai D,Liu T

更新日期：2012-02-01 00:00:00

abstract：:Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...

journal_title：Aging

authors： Cui L,Xue H,Wen Z,Lu Z,Liu Y,Zhang Y

更新日期：2020-11-12 00:00:00

abstract：:Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...

journal_title：Aging

authors： Chen Y,Fu D,Zhao H,Cheng W,Xu F

更新日期：2020-05-21 00:00:00

abstract：:In this study, we analyzed the role of circular RNAs in the growth and progression of bladder cancer. Direct Sanger sequencing and quantitative RT-PCR analysis showed that circ_0006332 was significantly upregulated in bladder cancer tissues. Sequencing analysis showed that circ_0006332 is generated from splicing of ex...

journal_title：Aging

authors： Li M,Liu Y,Liu J,Li W,Li N,Xue D,Zhang X,Wang P

更新日期：2019-11-22 00:00:00

abstract：:Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...

journal_title：Aging

authors： Patrick A,Seluanov M,Hwang C,Tam J,Khan T,Morgenstern A,Wiener L,Vazquez JM,Zafar H,Wen R,Muratkalyeva M,Doerig K,Zagorulya M,Cole L,Catalano S,Lobo Ladd AA,Coppi AA,Coşkun Y,Tian X,Ablaeva J,Nevo E,Gladyshev VN

更新日期：2016-05-01 00:00:00

abstract：:The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent e...

journal_title：Aging

authors： van der Velden YU,Haramis AP

更新日期：2011-04-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, and immune-related genes (IRGs) are key contributors to its development. In this study, the gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database and the...

journal_title：Aging

authors： Wan B,Liu B,Huang Y,Yu G,Lv C

更新日期：2019-12-10 00:00:00

abstract：:Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose indivi...

journal_title：Aging

authors： Fu W,Zhuo Z,Hua RX,Fu K,Jia W,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,He J,Liu G

更新日期：2019-03-12 00:00:00

abstract：:Adipose-derived stem cells (ASCs) have a demonstrative therapeutic potential in aging-associated facial nerve regeneration, in which ASCs work as a source of Schwann cells therapy as an alternative to autologous nerve grafts. However, the transplantation of ASCs may induce local fibrosis, which causes inferior outcome...

journal_title：Aging

authors： Tan J,Xu Y,Han F,Ye X

更新日期：2019-02-06 00:00:00

abstract：:Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT may disturb the integrity of the epigenetic system. Here, we used a PC...

journal_title：Aging

authors： Park M,Min B,Jeon K,Cho S,Park JS,Kim J,Jeon J,Song J,Kim S,Jeong S,Seo H,Kang YK

更新日期：2017-03-12 00:00:00

abstract：:Recently epidemiological studies suggest females lose neuroprotection from neurodegenerative diseases as they go through menopause. It has been hypothesized that this neuroprotection is hormone-dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to pl...

journal_title：Aging

authors： Evola CM,Hudson TL,Huang L,Corbett AM,Mayes DA

更新日期：2018-08-31 00:00:00

abstract：:Proteasome inhibition demonstrates highly effective impact on multiple myeloma (MM) treatment. Here, we aimed to examine anti-tumor efficiency and underlying mechanisms of a novel well tolerated orally applicable proteasome inhibitor NNU546 and its hydrolyzed pharmacologically active form NNU219. NNU219 showed more se...

journal_title：Aging

authors： Zhou H,Lei M,Wang W,Guo M,Wang J,Zhang H,Qiao L,Feng H,Liu Z,Chen L,Hou J,Wang X,Gu C,Zhao B,Izumchenko E,Yang Y,Zhu Y

更新日期：2020-11-16 00:00:00

abstract：:Hepatoblastoma (HB) is a malignant embryonal tumor of the liver that consists of heterogenous populations of stem/progenitor cells. Although circular RNAs (circRNAs) play an essential role in tumor development, the effects of circRNA on the proliferation of HB cells, especially cancer stem cells (CSCs), remain unclear...

journal_title：Aging

authors： Chen L,Shi J,Wu Y,Qiu R,Zeng L,Lou L,Su J,Liao M,Deng X

更新日期：2020-10-14 00:00:00

abstract：:New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1) are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs, exposure to the dietary polyphenol resveratrol (RSV) revealed its differential capacity to generate a distinct P...

journal_title：Aging

authors： Verdura S,Cuyàs E,Cortada E,Brunet J,Lopez-Bonet E,Martin-Castillo B,Bosch-Barrera J,Encinar JA,Menendez JA

更新日期：2020-01-04 00:00:00

abstract：:Aging is associated with the accumulation of DNA damage. High expression of DNA repair genes has been suggested to contribute to prolonged lifespan in several organisms. However, the crucial DNA repair genes contributing to longevity remain unknown. Termite kings have an extraordinary long lifespan compared with that ...

journal_title：Aging

authors： Tasaki E,Mitaka Y,Nozaki T,Kobayashi K,Matsuura K,Iuchi Y

更新日期：2018-10-11 00:00:00

abstract：:Personality and self-rated health have been linked previously to cognitive outcome in late life. However, these associations have not been shown among the oldest old. This study examined relationships between personality, self-rated health, and cognitive function in a selected sample of Ashkenazi Jewish centenarians (...

journal_title：Aging

authors： Kato K,Zweig R,Schechter CB,Verghese J,Barzilai N,Atzmon G

更新日期：2013-03-01 00:00:00

abstract：:Post-myocardial infarction (MI), overactive inflammation is the hallmark of aging, however, the mechanism is unclear. We hypothesized that excess influx of omega 6 fatty acids may impair resolution, thus impacting the cardiosplenic and cardiorenal network post-MI. Young and aging mice were fed on standard lab chow (LC...

journal_title：Aging

authors： Halade GV,Kain V,Black LM,Prabhu SD,Ingle KA

更新日期：2016-10-18 00:00:00

abstract：:The survival rate of stomach adenocarcinoma patients with immune and stromal scores and different clinicopathological features obtained from the TCGA datasets was systematically compared. A list of genes that are correlated with stomach adenocarcinoma microenvironment were extracted using the TCGA database to predict ...

journal_title：Aging

authors： Yao K,Wei L,Zhang J,Wang C,Wang C,Qin C,Li S

更新日期：2020-08-21 00:00:00

abstract：:Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with the carcinogenesis and progression of breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, and Basal-like BRCA, four- (BIRC5, PARP1, ATG9B, and ...

journal_title：Aging

authors： Han B,Zhang H,Zhu Y,Han X,Wang Z,Gao Z,Yuan Y,Tian R,Zhang F,Niu R

更新日期：2020-07-10 00:00:00

abstract：:Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...

journal_title：Aging

authors： Xu W,Song C,Wang X,Li Y,Bai X,Liang X,Wu J,Liu J

更新日期：2021-01-05 00:00:00

abstract：:Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food ...

journal_title：Aging

authors： Suo S,Culotti JG,Van Tol HH

更新日期：2009-10-21 00:00:00