Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.

Abstract:

:The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. In Alzheimer's Disease, T-cells were identified as important mediators of disease pathology. Since autophagy is a central regulator of cell activation and cytokine production, we investigated the influence of polyamines on T-cell activation, autophagy, and the release of Th1/Th2 cytokines from blood samples of patients (n=22) with cognitive impairment or dementia in comparison to healthy controls (n=12) ex vivo. We found that spermine downregulated all investigated cytokines in a dose-dependent manner. Spermidine led to an upregulation of some cytokines for lower dosages, while high dosages downregulated all cytokines apart from upregulated IL-17A. Autophagy and T-cell activation increased in a dose-dependent manner by incubation with either polyamine. Although effects in patients were seen in lower concentrations, alterations were similar to controls.We provide novel evidence that supplementation of polyamines alters the function of T-cells. Given their important role in dementia, these data indicate a possible mechanism by which polyamines would help to prevent structural and cognitive decline in aging.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Fischer M,Ruhnau J,Schulze J,Obst D,Flöel A,Vogelgesang A

doi

10.18632/aging.103527

subject

Has Abstract

pub_date

2020-06-30 00:00:00

pages

13716-13739

issue

13

issn

1945-4589

pii

103527

journal_volume

12

pub_type

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