Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.


:The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. In Alzheimer's Disease, T-cells were identified as important mediators of disease pathology. Since autophagy is a central regulator of cell activation and cytokine production, we investigated the influence of polyamines on T-cell activation, autophagy, and the release of Th1/Th2 cytokines from blood samples of patients (n=22) with cognitive impairment or dementia in comparison to healthy controls (n=12) ex vivo. We found that spermine downregulated all investigated cytokines in a dose-dependent manner. Spermidine led to an upregulation of some cytokines for lower dosages, while high dosages downregulated all cytokines apart from upregulated IL-17A. Autophagy and T-cell activation increased in a dose-dependent manner by incubation with either polyamine. Although effects in patients were seen in lower concentrations, alterations were similar to controls.We provide novel evidence that supplementation of polyamines alters the function of T-cells. Given their important role in dementia, these data indicate a possible mechanism by which polyamines would help to prevent structural and cognitive decline in aging.


Aging (Albany NY)




Fischer M,Ruhnau J,Schulze J,Obst D,Flöel A,Vogelgesang A




Has Abstract


2020-06-30 00:00:00














  • Subtype-specific risk models for accurately predicting the prognosis of breast cancer using differentially expressed autophagy-related genes.

    abstract::Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with the carcinogenesis and progression of breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, and Basal-like BRCA, four- (BIRC5, PARP1, ATG9B, and ...


    pub_type: 杂志文章


    authors: Han B,Zhang H,Zhu Y,Han X,Wang Z,Gao Z,Yuan Y,Tian R,Zhang F,Niu R

    更新日期:2020-07-10 00:00:00

  • SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray and public database ...


    pub_type: 杂志文章


    authors: Zhan YT,Li L,Zeng TT,Zhou NN,Guan XY,Li Y

    更新日期:2020-12-03 00:00:00

  • LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264.

    abstract::Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues...


    pub_type: 杂志文章


    authors: Zheng Z,Li X,You H,Zheng X,Ruan X

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  • BMAL1 knockdown triggers different colon carcinoma cell fates by altering the delicate equilibrium between AKT/mTOR and P53/P21 pathways.

    abstract::Dysregulation of the circadian timing system (CTS) frequently appears during colorectal cancer (CRC) progression. In order to better understand the role of the circadian clock in CRC progression, this study evaluated in vitro how knockdown of a core circadian protein BMAL1 (BMAL1-KD) influenced the behavior of two pri...


    pub_type: 杂志文章


    authors: Zhang Y,Devocelle A,Souza L,Foudi A,Tenreira Bento S,Desterke C,Sherrard R,Ballesta A,Adam R,Giron-Michel J,Chang Y

    更新日期:2020-05-10 00:00:00

  • Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates.

    abstract::Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...


    pub_type: 杂志文章


    authors: Djelti F,Dhenain M,Terrien J,Picq JL,Hardy I,Champeval D,Perret M,Schenker E,Epelbaum J,Aujard F

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  • Methylome-wide association study of whole blood DNA in the Norfolk Island isolate identifies robust loci associated with age.

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    pub_type: 杂志文章


    authors: Benton MC,Sutherland HG,Macartney-Coxson D,Haupt LM,Lea RA,Griffiths LR

    更新日期:2017-02-28 00:00:00

  • One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin.

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    pub_type: 杂志文章


    authors: Menendez JA,Joven J

    更新日期:2012-12-01 00:00:00

  • Circular RNAs in leukemia.

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    pub_type: 杂志文章,评审


    authors: Wu Z,Sun H,Li J,Jin H

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  • Immune senescence and immune activation in elderly colorectal cancer patients.

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    pub_type: 杂志文章


    authors: Giunco S,Petrara MR,Bergamo F,Del Bianco P,Zanchetta M,Carmona F,Zagonel V,De Rossi A,Lonardi S

    更新日期:2019-06-13 00:00:00

  • Meta‐analysis of genetic variants associated with human exceptional longevity.

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    pub_type: 杂志文章,meta分析


    authors: Sebastiani P,Bae H,Sun FX,Andersen SL,Daw EW,Malovini A,Kojima T,Hirose N,Schupf N,Puca A,Perls TT

    更新日期:2013-09-01 00:00:00

  • Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3.

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    pub_type: 杂志文章


    authors: Halicka HD,Zhao H,Li J,Traganos F,Studzinski GP,Darzynkiewicz Z

    更新日期:2012-04-01 00:00:00

  • Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age.

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    pub_type: 杂志文章


    authors: Mehdipour M,Etienne J,Chen CC,Gathwala R,Rehman M,Kato C,Liu C,Liu Y,Zuo Y,Conboy MJ,Conboy IM

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  • DNA methylation perturbations may link altered development and aging in the lung.

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    pub_type: 杂志文章


    authors: Kachroo P,Morrow JD,Vyhlidal CA,Gaedigk R,Silverman EK,Weiss ST,Tantisira KG,DeMeo DL

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  • Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet.

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    pub_type: 杂志文章


    authors: Zhang Y,Chen L,Hu M,Kim JJ,Lin R,Xu J,Fan L,Qi Y,Wang L,Liu W,Deng Y,Si J,Chen S

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  • Inducing cellular senescence in vitro by using genetically encoded photosensitizers.

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    pub_type: 杂志文章


    authors: Petrova NV,Luzhin AV,Serebrovskaya EO,Ryumina AP,Velichko AK,Razin SV,Kantidze OL

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  • Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats.

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    pub_type: 杂志文章


    authors: Obukhova LA,Skulachev VP,Kolosova NG

    更新日期:2009-04-22 00:00:00

  • Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin.

    abstract::The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell surface-associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perle...


    pub_type: 杂志文章


    authors: Dos Santos M,Michopoulou A,André-Frei V,Boulesteix S,Guicher C,Dayan G,Whitelock J,Damour O,Rousselle P

    更新日期:2016-04-01 00:00:00

  • Association of VAMP5 and MCC genetic polymorphisms with increased risk of Hirschsprung disease susceptibility in Southern Chinese children.

    abstract::Hirschsprung disease (HSCR) is a genetic disorder characterized by the absence of neural crest cells in parts of the intestine. This study aims to investigate the association of vesicle-associated membrane protein 5 (VAMP5) and mutated in colorectal cancer (MCC) genetic polymorphisms and their correlated risks with HS...


    pub_type: 杂志文章


    authors: Zhao J,Xie X,Yao Y,He Q,Zhang R,Xia H,Zhang Y

    更新日期:2018-04-25 00:00:00

  • Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.

    abstract::Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...


    pub_type: 杂志文章


    authors: Li H,Wang X,Lu X,Zhu H,Li S,Duan S,Zhao X,Zhang F,Alterovitz G,Wang F,Li Q,Tian XL,Xu M

    更新日期:2019-09-12 00:00:00

  • COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway.

    abstract::The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth and metastasis in pituitary adenoma (PA) was determined. COL6A6 was downregulated in PA tissues and cell lines, which was negatively associated with the expression of prolyl-4-hydroxylase alpha polypeptide III (P4HA3) in the progression of PA....


    pub_type: 杂志文章


    authors: Long R,Liu Z,Li J,Yu H

    更新日期:2019-10-17 00:00:00

  • Signatures of photo-aging and intrinsic aging in skin were revealed by transcriptome network analysis.

    abstract::There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...


    pub_type: 杂志文章


    authors: Cho BA,Yoo SK,Seo JS

    更新日期:2018-07-18 00:00:00

  • p21 can be a barrier to ferroptosis independent of p53.

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    pub_type: 杂志文章


    authors: Venkatesh D,Stockwell BR,Prives C

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  • Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study.

    abstract::Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD). Diverse studies have shown a bidirectional relationship between Klotho and inflammation, a risk factor for the development of CVD. In this work we aimed to evaluate the association between Klotho and inflammatory cytoki...


    pub_type: 杂志文章


    authors: Martín-Núñez E,Donate-Correa J,Ferri C,López-Castillo Á,Delgado-Molinos A,Hernández-Carballo C,Pérez-Delgado N,Rodríguez-Ramos S,Cerro-López P,Tagua VG,Mora-Fernández C,Navarro-González JF

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  • Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation.

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    pub_type: 杂志文章


    authors: Zheng HX,Zhao Y,Xu Y,Zhang ZJ,Zhu JJ,Fan YF,Lin N

    更新日期:2019-06-19 00:00:00

  • Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.

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    pub_type: 杂志文章


    authors: Liu JR,Cai GY,Ning YC,Wang JC,Lv Y,Guo YN,Fu B,Hong Q,Sun XF,Chen XM

    更新日期:2020-08-27 00:00:00

  • Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes.

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    pub_type: 杂志文章


    authors: Wang Y,Yang Q,Shen S,Zhang L,Xiang Y,Weng X

    更新日期:2020-07-21 00:00:00

  • RWR-algorithm-based dissection of microRNA-506-3p and microRNA-140-5p as radiosensitive biomarkers in colorectal cancer.

    abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...


    pub_type: 杂志文章


    authors: Liao F,Chen X,Peng P,Dong W

    更新日期:2020-10-08 00:00:00

  • A nomogram combining long non-coding RNA expression profiles and clinical factors predicts survival in patients with bladder cancer.

    abstract::Bladder cancer (BCa) is a heterogeneous disease with various tumorigenic mechanisms and clinical behaviors. The current tumor-node-metastasis (TNM) staging system is inadequate to predict overall survival (OS) in BCa patients. We developed a BCa-specific, long-non-coding-RNA (lncRNA)-based nomogram to improve survival...


    pub_type: 杂志文章


    authors: Wang Y,Du L,Yang X,Li J,Li P,Zhao Y,Duan W,Chen Y,Wang Y,Mao H,Wang C

    更新日期:2020-02-12 00:00:00

  • CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1.

    abstract:BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...


    pub_type: 杂志文章


    authors: Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

    更新日期:2019-12-19 00:00:00

  • Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells.

    abstract::Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6 and α-tubulin were...


    pub_type: 杂志文章


    authors: Li J,Zhou Y,Yan Y,Zheng Z,Hu Y,Wu W

    更新日期:2020-08-29 00:00:00