Abstract:
BACKGROUND:SARS-CoV-2 has raged around the world since March, 2020. We aim to describe the clinical characteristics and risk factors of severe patients with COVID-19 in Guangzhou. RESULTS:The severity and mortality of COVID-19 was 10.4% and 0.3% respectively. And each 1-year increase in age (OR, 1.057; 95% CI, 1.018-1.098; P=0.004), Wuhan exposure history greater than 2 weeks (OR, 2.765; 95% CI, 1.040-7.355; P=0.042), diarrhea (OR, 24.349; 95% CI, 3.580-165.609; P=0.001), chronic kidney disease (OR, 6.966; 95% CI, 1.310-37.058; P = 0.023), myoglobin higher than 106 μg/L (OR, 8.910; 95% CI, 1.225-64.816; P=0.031), white blood cell higher than 10×109/L (OR, 5.776; 95% CI, 1.052-31.722; P=0.044), and C-reactive protein higher than 10 mg/L (OR, 5.362; 95% CI, 1.631-17.626; P=0.006) were risk factors for severe cases. CONCLUSION:Older age, Wuhan exposure history, diarrhea, chronic kidney disease, elevated myoglobin, elevated white blood cell and C-reactive protein were independent risk factors for severe patients with COVID-19 in Guangzhou. METHODS:We included 288 adult patients with COVID-19 and compared the data between severe and non-severe group. We used univariate and multivariate logistic regression methods to explore risk factors of severe cases.
journal_name
Aging (Albany NY)journal_title
Agingauthors
He F,Luo Q,Lei M,Fan L,Shao X,Huang G,Zeng J,Zhao Z,Qin S,Yang Z,Yu N,Yang L,Cao Jdoi
10.18632/aging.103803subject
Has Abstractpub_date
2020-08-15 00:00:00pages
15730-15740issue
15issn
1945-4589pii
103803journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::Although the influenza virus only infects the respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults are more likely to develop disability following influenza infection; however, this relationship is understudied. We hypothesized...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100882
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...
journal_title:Aging
pub_type: 杂志文章,meta分析
doi:10.18632/aging.202195
更新日期:2020-12-15 00:00:00
abstract::Salivary gland dysfunction is a common symptom that occurs after menopause. This study was performed to investigate the mechanism of salivary gland dysfunction to confirm the relationship between ferroptosis and salivary gland dysfunction by ovariectomy. Forty-eight female rats were randomly divided into four groups (...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103882
更新日期:2020-11-05 00:00:00
abstract::Growing evidence highlighted the tumor mutational burden (TMB) as an important feature of carcinogenesis and therapeutic efficacy in esophageal cancer (EC). Our study aimed to explore the genomic landscape and the correlation between TMB and immune cell infiltration in EC patients with or without radiotherapy. The EC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102917
更新日期:2020-03-12 00:00:00
abstract::How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104051
更新日期:2020-11-18 00:00:00
abstract::To investigate the relation of higher apolipoprotein B/apolipoprotein AI (apoB/AI) ratio with the risk of suffering intracranial atherosclerotic stenosis (ICAS) in both stroke and non-stroke population, we enrolled 1138 patients with acute ischemic stroke (359 with ICAS, 779 without ICAS) and 1072 non-stroke controls ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102216
更新日期:2019-09-03 00:00:00
abstract::Personality and self-rated health have been linked previously to cognitive outcome in late life. However, these associations have not been shown among the oldest old. This study examined relationships between personality, self-rated health, and cognitive function in a selected sample of Ashkenazi Jewish centenarians (...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100545
更新日期:2013-03-01 00:00:00
abstract::Programmed death-1 (PD-1) polymorphisms have been associated with esophageal cancer risk. Here, the aims of this case-control study were to explore whether three PD-1 polymorphisms (rs10204525, rs7421861, and rs36084323) were related with the risk and clinical features of esophageal cancer in Chinese Han subjects (n =...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102845
更新日期:2020-02-21 00:00:00
abstract::This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103939
更新日期:2020-10-13 00:00:00
abstract::Larger dog breeds live shorter than the smaller ones, opposite of the mass-lifespan relationship observed across mammalian species. Here we use data from 90 dog breeds and a theoretical model based on the first principles of energy conservation and life history tradeoffs to explain the negative correlation between lon...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101081
更新日期:2016-12-08 00:00:00
abstract::Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202445
更新日期:2021-02-01 00:00:00
abstract::Impaired quality of life (QOL) is common in hepatocellular carcinoma (HCC) patients. In this study, we used a large hospital-based multiethnic HCC patient cohort to systematically identify factors associated with QOL and investigate the prognostic value of QOL.The Short Form-12 questionnaire was used to assess QOL. Th...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102889
更新日期:2020-03-07 00:00:00
abstract::Despite improvements in surgical procedures and comprehensive therapies, pancreatic cancer remains one of the most aggressive and deadly human malignancies. It is therefore necessary to determine which cellular mediators associate with prognosis in pancreatic cancer so as to improve the treatment of this disease. In t...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102096
更新日期:2019-07-21 00:00:00
abstract::In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) FAM181A-AS1 in human gliomas. TCGA, GTEx and CGGA database analyses showed that high FAM181A-AS1 expression correlates with advanced tumor stage and poor survival of glioma patients. FAM181A-AS1 expression is hi...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103391
更新日期:2020-10-20 00:00:00
abstract::Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that the expression of HSD...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103530
更新日期:2020-07-17 00:00:00
abstract::Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. The association between METH gene polymorphisms and prostate cancer susceptibility remains ambiguous. Thus, we performed an updated meta-analysis of METH single-nuc...
journal_title:Aging
pub_type: 杂志文章,meta分析,评审
doi:10.18632/aging.101584
更新日期:2018-10-18 00:00:00
abstract::The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversib...
journal_title:Aging
pub_type: 社论
doi:10.18632/aging.100202
更新日期:2010-09-01 00:00:00
abstract::Angiogenesis - the growth of new blood capillaries- is impaired in aging animals. Biophysical factors such as changes in cell size control endothelial cell (EC) proliferation and differentiation. However, the effects of aging on EC size and the mechanism by which changes in cell size control age-dependent decline in E...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102236
更新日期:2019-09-05 00:00:00
abstract::Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of three fibrates, pharmacologically established s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100548
更新日期:2013-04-01 00:00:00
abstract::As of May 5, 2020, the number of confirmed coronavirus disease (COVID-19) cases has been more than 3.5 million with 243,540 deaths. We aimed to determine the associations between ageing population, median age, life expectancy at birth and COVID-19 mortality. The numbers of COVID-19 cases and deaths in the European reg...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104193
更新日期:2020-11-24 00:00:00
abstract::Hepatoblastoma (HB) is a malignant embryonal tumor of the liver that consists of heterogenous populations of stem/progenitor cells. Although circular RNAs (circRNAs) play an essential role in tumor development, the effects of circRNA on the proliferation of HB cells, especially cancer stem cells (CSCs), remain unclear...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103748
更新日期:2020-10-14 00:00:00
abstract::Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported t...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102337
更新日期:2019-10-07 00:00:00
abstract::Metabolic syndrome, a network of medical disorders that greatly increase the risk for developing metabolic and cardiovascular diseases, has reached epidemic levels in many areas of today's world. Despite this alarming medicare situation, scientific understandings on the root mechanisms of metabolic syndrome are still ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100431
更新日期:2012-02-01 00:00:00
abstract::In addition to its traditional role in the regulation of calcium homeostasis and bone metabolism, vitamin D also exhibits immunomodulatory, anti-proliferative and cancer preventive activities. Molecular mechanisms that confer the chemo-preventive properties to vitamin D are poorly understood. We previously reported th...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100450
更新日期:2012-04-01 00:00:00
abstract::In this study, we analyzed the role of circular RNAs in the growth and progression of bladder cancer. Direct Sanger sequencing and quantitative RT-PCR analysis showed that circ_0006332 was significantly upregulated in bladder cancer tissues. Sequencing analysis showed that circ_0006332 is generated from splicing of ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102481
更新日期:2019-11-22 00:00:00
abstract::Alternative splicing (AS) changes are considered to be critical in predicting treatment response. Our study aimed to investigate differential splicing patterns and to elucidate the role of splicing factor (SF) as prognostic markers of low-grade glioma (LGG). We downloaded RNA-seq data from a cohort of 516 LGG tumors i...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103491
更新日期:2020-07-13 00:00:00
abstract::In this meta-analysis, we systematically investigated the correlation between single nucleotide polymorphisms (SNPs) and pancreatic cancer (PC) risk. We searched PubMed, Network Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), an...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104128
更新日期:2020-11-20 00:00:00
abstract::Recent studies have demonstrated circular RNAs (circRNAs) to be widely expressed and to have important physiological functions. However, the expression, regulation, and function of circRNAs in neuroglial cells are unknown. Herein, we characterized the expression, regulation, and function of circRNAs in astrocytes. Ast...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102529
更新日期:2019-12-20 00:00:00
abstract::The study was aimed at evaluation of the role of secondary oxidative stress in the stress-induced premature senescence (SIPS) of human fibroblasts induced by H2O2. Two fibroblast lines were used: lung MRC-5 and ear H8F2p25LM fibroblasts. The lines differed considerably in sensitivity to H2O2 (IC50 of 528 and 33.5 μM, ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102730
更新日期:2020-01-21 00:00:00
abstract::N6-methyladenosine (m6A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators. However, the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 cen...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103811
更新日期:2020-09-20 00:00:00