Genome-wide analyses of the prognosis-related mRNA alternative splicing landscape and novel splicing factors based on large-scale low grade glioma cohort.

abstract：:Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, ...

journal_title：Aging

authors： Sebastiani P,Bae H,Sun FX,Andersen SL,Daw EW,Malovini A,Kojima T,Hirose N,Schupf N,Puca A,Perls TT

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma. RESULTS:We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to...

journal_title：Aging

authors： Zhou J,Wu G,Tong Z,Sun J,Su J,Cao Z,Luo Y,Wang W

更新日期：2020-12-30 00:00:00

abstract：:Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness...

journal_title：Aging

authors： Lee Y,Hwang W,Jung J,Park S,Cabatbat JJ,Kim PJ,Lee SJ

更新日期：2016-05-01 00:00:00

abstract：:Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...

journal_title：Aging

authors： Wen C,Xie T,Pan K,Deng Y,Zhao Z,Li N,Bian J,Deng X,Zha Y

更新日期：2020-02-26 00:00:00

abstract：:Skeletal muscle mass and power decrease with age, leading to impairment of mobility and metabolism in the elderly. Ca2+ signaling is crucial for myoblast differentiation as well as muscle contraction through activation of transcription factors and Ca2+-dependent kinases and phosphatases. Ca2+ channels, such as dihydro...

journal_title：Aging

authors： Choi JY,Hwang CY,Lee B,Lee SM,Bahn YJ,Lee KP,Kang M,Kim YS,Woo SH,Lim JY,Kim E,Kwon KS

更新日期：2016-09-21 00:00:00

abstract：:TET family members (TETs) encode proteins that represent crucial factors in the active DNA demethylation pathway. Evidence has proved that TET2 mutation is associated with leukemogenesis, drug response, and prognosis in acute myeloid leukemia (AML). However, few studies revealed the TETs expression and its clinical si...

journal_title：Aging

authors： Zhang T,Zhao Y,Zhao Y,Zhou J

更新日期：2020-03-25 00:00:00

abstract：:Blood brain barrier (BBB) disruption is a crucial factor contributing to secondary brain injury after intracerebral hemorrhage (ICH). Heat shock protein B8 (HSPB8) has been recently reported to confer neuroprotection against against ischaemic stroke through maintaining BBB integrity. However, the role of HSPB8 in ICH ...

journal_title：Aging

authors： Hou Y,Hu Z,Gong X,Yang B

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:MiRNA can be involved in regulating tumor genesis and development through regulating the major genes expression and regulating corresponding pathways. Here, we investigated the function and mechanisms of miR-483-3p in glioma progression. RESULTS:We found that miR-483-3p was increased in glioma cells and tis...

journal_title：Aging

authors： Xu D,Chi G,Xu D

更新日期：2020-11-04 00:00:00

abstract：:Leptin signaling influences osteoblastogenesis and modulates the fate of mesenchymal stem cells (MSCs) during bone and cartilage regeneration. Although MSCs abound in the osteosarcoma (OS) microenvironment, and leptin exhibits pro-tumorigenic properties, leptin's influence on OS progression and chemoresistant signalin...

journal_title：Aging

authors： Feng H,Zhang Q,Zhao Y,Zhao L,Shan B

更新日期：2020-04-14 00:00:00

abstract：AIMS:We identified an autosomal dominant non‐sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC‐CMs) from an affected patient...

journal_title：Aging

authors： Siu CW,Lee YK,Ho JC,Lai WH,Chan YC,Ng KM,Wong LY,Au KW,Lau YM,Zhang J,Lay KW,Colman A,Tse HF

更新日期：2012-11-01 00:00:00

abstract：:Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatit...

journal_title：Aging

authors： Jin D,Zhang R,Chen H,Li C

更新日期：2020-06-13 00:00:00

abstract：:Glomerulosclerosis and renal interstitial fibrosis occur with the aging kidney. In this study, we examined the expression of miR-21, peroxisome proliferator-activated receptor(PPARα), hypoxia-inducible factor(HIF-1α) in the kidney of 3-month-old rats fed ad libitum (YAL), 24-month-old rats fed ad libitum (OAL) and 24-...

journal_title：Aging

authors： Liu JR,Cai GY,Ning YC,Wang JC,Lv Y,Guo YN,Fu B,Hong Q,Sun XF,Chen XM

更新日期：2020-08-27 00:00:00

abstract：:Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and strength in old rats following disuse-induced atrophy. Adult (9 month) ...

journal_title：Aging

authors： Baehr LM,West DW,Marcotte G,Marshall AG,De Sousa LG,Baar K,Bodine SC

更新日期：2016-01-01 00:00:00

abstract：:FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we ...

journal_title：Aging

authors： Zhong L,Zhang Y,Li M,Song Y,Liu D,Yang X,Yang D,Qu H,Lai L,Wang Q,Chen Z

更新日期：2020-12-01 00:00:00

abstract：:Dietary interventions, including a low-protein diet (LPD) and methionine (Met) restriction, have shown longevity, anti-aging and metabolic health effects. We previously reported that the LPD has a renoprotective effect against diabetic kidney disease (DKD) in rats with type 2 diabetes and obesity. However, it is uncle...

journal_title：Aging

authors： Kitada M,Ogura Y,Monno I,Xu J,Koya D

更新日期：2020-03-06 00:00:00

abstract：:Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...

journal_title：Aging

authors： Fu K,Hui B,Wang Q,Lu C,Shi W,Zhang Z,Rong D,Zhang B,Tian Z,Tang W,Cao H,Wang X,Chen Z

更新日期：2020-02-10 00:00:00

abstract：PURPOSE:To develop a decision tree algorithm-based classification system for personalized management of hepatocellular carcinoma (HCC) patients with macroscopic vascular invasion. RESULTS:The HVTT-PVTT score could differentiate two groups of patients (< 3 and ≥ 3 points) with different survival outcomes (7.4 vs 4.6 mo...

journal_title：Aging

authors： Cao F,Shen L,Qi H,Xie L,Song Z,Chen S,Fan W

更新日期：2019-11-03 00:00:00

abstract：:Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...

journal_title：Aging

authors： Xu W,Song C,Wang X,Li Y,Bai X,Liang X,Wu J,Liu J

更新日期：2021-01-05 00:00:00

abstract：:Spermatogenesis is a complex process producing haploid spermatozoa, and the formation of lipid droplets (LDs) within Sertoli cells is critical to maintaining normal spermatogenesis. However, the utilization of LDs within Sertoli cells is still largely unknown. In the present study, proliferation of spermatogonial cell...

journal_title：Aging

authors： Ahmed N,Liu Y,Chen H,Yang P,Waqas Y,Liu T,Gandahi JA,Huang Y,Wang L,Song X,Rajput IR,Wang T,Chen Q

更新日期：2016-10-16 00:00:00

abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...

journal_title：Aging

authors： Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

更新日期：2019-12-19 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is important in tumor invasiveness and metastasis. We aimed to determine prognostic value of six key EMT markers (CDH1, CDH2, SNAI1, SNAI2, VIM, TWIST1) in clear cell renal cell carcinoma (ccRCC). A total of 533 ccRCC patients with RNASeq data from The Cancer Genome Atlas (TC...

journal_title：Aging

authors： Xu H,Xu WH,Ren F,Wang J,Wang HK,Cao DL,Shi GH,Qu YY,Zhang HL,Ye DW

更新日期：2020-01-08 00:00:00

abstract：:In pace with the development of gene sequencing technology and transcriptome research, it has been found that 70 to 90% of the human genome is transcribed into RNAs, while only 2% of RNAs encode proteins. This implies that non-coding RNAs (ncRNAs) may exert vital biological functions and a full analysis of non-coding ...

journal_title：Aging

authors： Wu Z,Sun H,Li J,Jin H

更新日期：2019-07-15 00:00:00

abstract：:The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...

journal_title：Aging

authors： Lopriore P,Capitanio N,Panatta E,Di Daniele N,Gambacurta A,Melino G,Amelio I

更新日期：2018-12-08 00:00:00

abstract：:Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old m...

journal_title：Aging

authors： Dong Q,Gao H,Shi Y,Zhang F,Gu X,Wu A,Wang D,Chen Y,Bandyopadhyay A,Yeh IT,Daniel BJ,Chen Y,Zou Y,Rebel VL,Walter CA,Lu J,Huang C,Sun LZ

更新日期：2016-11-15 00:00:00

abstract：:As of May 5, 2020, the number of confirmed coronavirus disease (COVID-19) cases has been more than 3.5 million with 243,540 deaths. We aimed to determine the associations between ageing population, median age, life expectancy at birth and COVID-19 mortality. The numbers of COVID-19 cases and deaths in the European reg...

journal_title：Aging

authors： Wang XQ,Song G,Yang Z,Chen RJ,Zheng YL,Hu HY,Su X,Chen PJ

更新日期：2020-11-24 00:00:00

abstract：:There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recru...

journal_title：Aging

authors： Zarnani K,Nichols TE,Alfaro-Almagro F,Fagerlund B,Lauritzen M,Rostrup E,Smith SM

更新日期：2019-08-26 00:00:00

abstract：:Despite improvements in surgical procedures and comprehensive therapies, pancreatic cancer remains one of the most aggressive and deadly human malignancies. It is therefore necessary to determine which cellular mediators associate with prognosis in pancreatic cancer so as to improve the treatment of this disease. In t...

journal_title：Aging

authors： Li Y,Kong R,Chen H,Zhao Z,Li L,Li J,Hu J,Zhang G,Pan S,Wang Y,Wang G,Chen H,Sun B

更新日期：2019-07-21 00:00:00

abstract：PURPOSE:This study aimed to validate the newly proposed American Joint Committee on Cancer (AJCC) pathological prognostic staging system for young breast cancer patients (aged ≤40 years). RESULTS:We included 12811 women in this study. Overall, 52.8% of patients in the 7th AJCC stages were restaged to the 8th AJCC path...

journal_title：Aging

authors： Zhou J,Lei J,Wang J,Lian CL,Hua L,Yang LC,Wu SG

更新日期：2020-04-22 00:00:00

abstract：:Current tumor-node-metastasis (TNM) stage is unable to accurately predict the overall survival (OS) in breast cancer (BC) patients. This study aimed to construct a microRNA (miRNA)-based model to improve survival prediction of BC. We confirmed 99 differentially expressed miRNAs (DEMs) in 1044 BC samples compared to 10...

journal_title：Aging

authors： Lai J,Wang H,Pan Z,Su F

更新日期：2019-01-30 00:00:00

abstract：:Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling...

journal_title：Aging

authors： Favaloro B,Allocati N,Graziano V,Di Ilio C,De Laurenzi V

更新日期：2012-05-01 00:00:00