Abstract:
:Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. The association between METH gene polymorphisms and prostate cancer susceptibility remains ambiguous. Thus, we performed an updated meta-analysis of METH single-nucleotide polymorphism rs1805087 involving 12 independent case-control studies comprising 9986 prostate cancer patients and 40134 controls. The odds ratio and 95% confidence intervals were applied to evaluate the relation of this single-nucleotide polymorphism with prostate cancer. Statistical analysis was performed in STATA 11.0. A significant association was found between rs1805087 and increased prostate cancer risk, overall and with Hardy-Weinberg equilibrium. In subgroup analyses (based on ethnicity, source of control, genotyping methods, or publication status), similar associations were observed (e.g., genotype GA vs. AA: odds ratio 1.19, 95% confidence interval 1.01-1.40 among whites; G allele vs. A allele: odds ratio 1.14, 95% confidence interval 1.02-1.28 among hospital-based controls). Thus, the common polymorphism (rs1805087) of METH may be associated with increased prostate cancer risk. Further studies with a larger sample size and detailed gene-environment interactions should be conducted to identify the role of METH polymorphisms in prostate cancer susceptibility.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Zhang X,Tang J,Shen N,Ren Kdoi
10.18632/aging.101584subject
Has Abstractpub_date
2018-10-18 00:00:00pages
2741-2754issue
10issn
1945-4589pii
101584journal_volume
10pub_type
杂志文章,meta分析,评审相关文献
Aging-US文献大全abstract::One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phospho...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100043
更新日期:2009-04-22 00:00:00
abstract::Numerous studies have investigated the differences in the mean functional connectivity (FC) strength between amnestic mild cognitive impairment (aMCI) patients and normal subjects using resting-state functional magnetic resonance imaging. However, whether the mean FC is increased, decreased or unchanged in aMCI patien...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102986
更新日期:2020-04-01 00:00:00
abstract::The estrogen membrane receptor GPR30 (also known as G-protein coupled receptor 30) has recently been shown to be involved in the regulation of oocyte maturation and cumulus expansion. However, whether GPR30 expression is regulated by gonadotropin stimulation and how it participates in the regulation of the maturation ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104029
更新日期:2020-10-28 00:00:00
abstract::Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, complete cardiac regeneration has been demonstrated in fish and newborn mice following resection of the cardiac apex. However, it remained entirely unclear...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100526
更新日期:2012-12-01 00:00:00
abstract::In this study, we used murine chondrocytes as an in vitro model and mice exhibiting destabilization of the medial meniscus (DMM) as an in vivo model to investigate the mechanisms through which S-allyl cysteine (SAC) alleviates osteoarthritis (OA). SAC significantly reduced apoptosis and senescence and maintained homeo...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103757
更新日期:2020-10-07 00:00:00
abstract::Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202385
更新日期:2021-01-20 00:00:00
abstract::Detecting low-abundance mutations is very important for cancer diagnosis and treatment. Here we describe an improved targeted sequencing analysis that dramatically increases sequencing depth. Seven colorectal cancer (CRC) patients and seven healthy adults were enrolled in this study. We examined genetic mutations in t...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102657
更新日期:2020-01-12 00:00:00
abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103907
更新日期:2020-10-08 00:00:00
abstract::Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown proliferative restrictions of adult SCs forced to re-enter the cell cycle. By comparing juvenile and adult SCs in explant cultures, ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100668
更新日期:2014-06-01 00:00:00
abstract::Inhalation anesthetics have been demonstrated to have protective effects against myocardial ischemia reperfusion injury (MIRI). O-linked GlcNAcylation (O-GlcNAc) modifications have been shown to protect against MIRI. This study aimed to investigate whether O-GlcNAcylation and necroptosis signaling were important for s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104146
更新日期:2020-11-20 00:00:00
abstract::SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulate...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102663
更新日期:2020-01-11 00:00:00
abstract::Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101148
更新日期:2016-12-28 00:00:00
abstract::The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms. Previous studies have characterized the impact of circadian clock on tumorigenesis and specific immune cells. Here, by using multi-omics computation techniques, we systematically characterized the distinct ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102450
更新日期:2019-12-23 00:00:00
abstract::There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recru...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102151
更新日期:2019-08-26 00:00:00
abstract::Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a sense ncmtRNA (SncmtRNA), which seems to be required for cell proliferation, and two antisense transcripts referred ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101711
更新日期:2018-12-30 00:00:00
abstract::Myocardial infarction is characterized by sudden ischemia and cardiomyocyte death. Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain damage under ischemic conditions. Mitophagy is a mechanism by which damaged mitochondria are removed by autophagy to maintain mitochondrial structure...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102899
更新日期:2020-03-10 00:00:00
abstract::Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increas...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102678
更新日期:2020-01-09 00:00:00
abstract::A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in the secretome of senescent cultures a catalase, termed PaCATB, was identified. Genetic modulation...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100360
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202497
更新日期:2021-01-11 00:00:00
abstract::Telomeres are a hotspot for sister chromatid exchange (T-SCE). Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence. This work strongly suggests that progressive telomere erosion ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100206
更新日期:2010-10-01 00:00:00
abstract::Our previous studies showed that loss-of-function mutation of growth hormone releasing hormone (GHRH) results in increased longevity and enhanced insulin sensitivity in mice. However, the details of improved insulin action and tissue-specific insulin signaling are largely unknown in this healthy-aging mouse model. We ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103588
更新日期:2020-10-06 00:00:00
abstract::Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100459
更新日期:2012-05-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102581
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND/AIMS:Kinesin family member 20A (KIF20A) is upregulated in multiple cancers and plays important roles in promoting malignant behavior, whereas its exact role in CRC remains unknown. RESULTS:Both genomic and protein expression levels showed that KIF20A was upregulated in CRC. Further functional analyses revea...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102505
更新日期:2019-12-16 00:00:00
abstract::Long non-coding RNA (lncRNA) Ewing sarcoma associated transcript 1 (EWSAT1) has been identified as an oncogene, and its dysregulation is closed corrected with tumor progression in Ewing sarcoma. Recently, high-through put analysis reveals that EWSAT1 is also highly expressed in human nasopharyngeal carcinoma (NPC). Ho...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101103
更新日期:2016-11-03 00:00:00
abstract::Traditionally, the p21 protein has been viewed as limiting cancer progression and promoting aging. In contrast, there are reports that p21 can enhance cancer survival and limit tissue damage, depending on the tissue of origin and type of stressor involved. Here, we provide evidence to support these latter two roles of...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103961
更新日期:2020-09-24 00:00:00
abstract::Type 2 resistant starch (RS2) is a fermentable dietary fiber conferring health benefits. We investigated the effects of RS2 on host, gut microbiota, and metabolites in aged mice on high-fat diet. In eighteen-month old mice randomly assigned to control, high-fat (HF), or high-fat+20% RS2 (HFRS) diet for 16 weeks, RS2 r...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103187
更新日期:2020-05-25 00:00:00
abstract::Long intergenic nonprotein-coding RNA 00514 (LINC00514) is upregulated in papillary thyroid cancer and contributes to its aggressiveness. In this study, we thoroughly explored the expression profile, specific functions, and relevant molecular mechanism of LINC00514 in osteosarcoma (OS). Herein, LINC00514 was significa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103043
更新日期:2020-04-23 00:00:00
abstract::Progressive loss of ovarian estrogen (E2) production is a hallmark feature of, if not a driving force behind, reproductive aging and the menopause. Recent genetic studies in mice have shown that female germline or oogonial stem cells (OSCs) contribute to maintenance of adult ovarian function and fertility under physio...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103080
更新日期:2020-04-17 00:00:00
abstract::Growing evidence highlighted the tumor mutational burden (TMB) as an important feature of carcinogenesis and therapeutic efficacy in esophageal cancer (EC). Our study aimed to explore the genomic landscape and the correlation between TMB and immune cell infiltration in EC patients with or without radiotherapy. The EC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102917
更新日期:2020-03-12 00:00:00