Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers.

abstract：:Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...

journal_title：Aging

authors： Liao F,Chen X,Peng P,Dong W

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:Mitochondrial dysfunction and oxidative stress are closely associated with the pathogenesis of Parkinson's disease. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α) is thought to play multiple roles in the regulation of mitochondrial biogenesis and cellular energy metabolism. We rece...

journal_title：Aging

authors： Wang Y,Chen C,Huang W,Huang M,Wang J,Chen X,Ye Q

更新日期：2019-10-21 00:00:00

abstract：:Proteasome inhibition demonstrates highly effective impact on multiple myeloma (MM) treatment. Here, we aimed to examine anti-tumor efficiency and underlying mechanisms of a novel well tolerated orally applicable proteasome inhibitor NNU546 and its hydrolyzed pharmacologically active form NNU219. NNU219 showed more se...

journal_title：Aging

authors： Zhou H,Lei M,Wang W,Guo M,Wang J,Zhang H,Qiao L,Feng H,Liu Z,Chen L,Hou J,Wang X,Gu C,Zhao B,Izumchenko E,Yang Y,Zhu Y

更新日期：2020-11-16 00:00:00

abstract：:Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows ...

journal_title：Aging

authors： Del Campo A,Contreras-Hernández I,Castro-Sepúlveda M,Campos CA,Figueroa R,Tevy MF,Eisner V,Casas M,Jaimovich E

更新日期：2018-01-04 00:00:00

abstract：:Age can significantly affect human physiology and disease risk. Recent studies have shown that age may affect the composition and function of the gut microbiota, but the underlying mechanisms remain largely unknown. Non-human primates are an ideal model for uncovering how age shapes the gut microbiota, as their microb...

journal_title：Aging

authors： Duan J,Yin B,Li W,Chai T,Liang W,Huang Y,Tan X,Zheng P,Wu J,Li Y,Li Y,Zhou W,Xie P

更新日期：2019-12-14 00:00:00

abstract：:Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness...

journal_title：Aging

authors： Lee Y,Hwang W,Jung J,Park S,Cabatbat JJ,Kim PJ,Lee SJ

更新日期：2016-05-01 00:00:00

abstract：:Growing evidence highlighted the tumor mutational burden (TMB) as an important feature of carcinogenesis and therapeutic efficacy in esophageal cancer (EC). Our study aimed to explore the genomic landscape and the correlation between TMB and immune cell infiltration in EC patients with or without radiotherapy. The EC ...

journal_title：Aging

authors： Yuan C,Xiang L,Cao K,Zhang J,Luo Y,Sun W,Zhang N,Ren J,Zhang J,Gong Y,Xie C

更新日期：2020-03-12 00:00:00

abstract：:Aging and age-related diseases occur in almost all organisms. Recently, it was discovered that the inhibition of target of rapamycin complex 1 (TORC1), a conserved complex that mediates nutrient status and cell metabolism, can extend an individual's lifespan and inhibit age-related diseases in many model organisms. Ho...

journal_title：Aging

authors： Xi J,Cai J,Cheng Y,Fu Y,Wei W,Zhang Z,Zhuang Z,Hao Y,Lilly MA,Wei Y

更新日期：2019-11-11 00:00:00

abstract：:Studies in young mammals on the molecular effects of food restriction leading to prolong adult life are scares. Here, we used high-throughput quantitative proteomic analysis of whole rat livers to address the molecular basis for growth arrest and the apparent life-prolonging phenotype of the food restriction regimen. ...

journal_title：Aging

authors： Gat-Yablonski G,Finka A,Pinto G,Quadroni M,Shtaif B,Goloubinoff P

更新日期：2016-08-01 00:00:00

abstract：:The study was aimed at evaluation of the role of secondary oxidative stress in the stress-induced premature senescence (SIPS) of human fibroblasts induced by H2O2. Two fibroblast lines were used: lung MRC-5 and ear H8F2p25LM fibroblasts. The lines differed considerably in sensitivity to H2O2 (IC50 of 528 and 33.5 μM, ...

journal_title：Aging

authors： Pieńkowska N,Bartosz G,Pichla M,Grzesik-Pietrasiewicz M,Gruchala M,Sadowska-Bartosz I

更新日期：2020-01-21 00:00:00

abstract：:Circular RNAs (circRNAs) play important roles in cancer progression. hsa_circRNA6448-14 originates from exon 5 to exon 11 of the TGFBI gene. We investigated the roles of hsa_circRNA6448-14 in esophageal squamous cell carcinoma (ESCC) with microarrays and quantitative real-time polymerase chain reaction (qRT-PCR), Kapl...

journal_title：Aging

authors： Zhang Y,Yuan X,Yue N,Wang L,Liu J,Dai N,Yang H,Fan R,Zhou F

更新日期：2020-08-15 00:00:00

abstract：:The solute carrier (SLC) family is the largest group of membrane transporters, but their functions in ovarian cancer (OV) remain unclear. We analyzed SLC family members with amino acids-transporting functions in OV. The mRNA expression levels and prognostic values of SLCs in OV were analyzed in the Gene Expression Pro...

journal_title：Aging

authors： Sun T,Bi F,Liu Z,Yang Q

更新日期：2020-07-09 00:00:00

abstract：:Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6 and α-tubulin were...

journal_title：Aging

authors： Li J,Zhou Y,Yan Y,Zheng Z,Hu Y,Wu W

更新日期：2020-08-29 00:00:00

abstract：:Long non-coding RNA (lncRNA) Ewing sarcoma associated transcript 1 (EWSAT1) has been identified as an oncogene, and its dysregulation is closed corrected with tumor progression in Ewing sarcoma. Recently, high-through put analysis reveals that EWSAT1 is also highly expressed in human nasopharyngeal carcinoma (NPC). Ho...

journal_title：Aging

authors： Song P,Yin SC

更新日期：2016-11-03 00:00:00

abstract：:The regulation of mechanistic target of rapamycin (mTOR) signaling contributes to the metabolic effects of a calorie restriction (CR) diet. We assayed the effect of CR on the activity of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) in the liver of mice at six different times across the day. CR effects on mTORC1...

journal_title：Aging

authors： Tulsian R,Velingkaar N,Kondratov R

更新日期：2018-07-16 00:00:00

abstract：:Circular RNAs (circRNAs) have been reported to be involved in many diseases. But there is no report on circRNAs in non-obstructive azoospermia (NOA). The purpose of this paper is to explore the circular RNA expression profile and potential functions of circRNAs in NOA patients. We first preformed circRNA expression pr...

journal_title：Aging

authors： Bo H,Liu Z,Tang R,Gong G,Wang X,Zhang H,Zhu F,Zhou D,Zhu W,Tan Y,Fan L

更新日期：2020-02-06 00:00:00

abstract：:Bedaquiline (a.k.a., Sirturo) is an anti-microbial agent, which is approved by the FDA for the treatment of multi-drug resistant pulmonary tuberculosis (TB). Bedaquiline is a first-in-class diaryl-quinoline compound, that mechanistically inhibits the bacterial ATP-synthase, and shows potent activity against both drug-...

journal_title：Aging

authors： Fiorillo M,Lamb R,Tanowitz HB,Cappello AR,Martinez-Outschoorn UE,Sotgia F,Lisanti MP

更新日期：2016-08-01 00:00:00

abstract：:Nucleic acid sequence analyses are fundamental to all aspects of biological research, spanning aging, mitochondrial DNA (mtDNA) and cancer, as well as microbial and viral evolution. Over the past several years, significant improvements in DNA sequencing, including consensus sequence analysis, have proven invaluable fo...

journal_title：Aging

authors： Annis S,Fleischmann Z,Logan R,Mullin-Bernstein Z,Franco M,Saürich J,Tilly JL,Woods DC,Khrapko K

更新日期：2020-04-28 00:00:00

abstract：:PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...

journal_title：Aging

authors： Kunstmann B,Osiewacz HD

更新日期：2009-03-03 00:00:00

abstract：:Cardiomyocyte apoptosis is a major cause of myocardial ischemia/reperfusion (MI/R) injury, in which the activation of the signal transducer and activator of transcription 1 (STAT1) plays an important role. The E3-ubiquitin ligase TRIM6 has been implicated in regulating STAT1 activity, however, whether it is associated...

journal_title：Aging

authors： Zeng G,Lian C,Yang P,Zheng M,Ren H,Wang H

更新日期：2019-06-06 00:00:00

abstract：:The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) w...

journal_title：Aging

authors： Liao Y,Feng Y,Wang B,Wang H,Huang J,Wu Y,Wu Z,Chen X,Yang C,Fu X,Sun H

更新日期：2020-10-14 00:00:00

abstract：:In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted brain magnetic resonance imaging data were analyzed from 45 adults with NSCLP after palatoplasty: 24 subjects were assessed before AR ...

journal_title：Aging

authors： Li Z,Zhang W,Li C,Wang M,Wang S,Chen R,Zhang X

更新日期：2020-07-03 00:00:00

abstract：:Despite improvements in surgical procedures and comprehensive therapies, pancreatic cancer remains one of the most aggressive and deadly human malignancies. It is therefore necessary to determine which cellular mediators associate with prognosis in pancreatic cancer so as to improve the treatment of this disease. In t...

journal_title：Aging

authors： Li Y,Kong R,Chen H,Zhao Z,Li L,Li J,Hu J,Zhang G,Pan S,Wang Y,Wang G,Chen H,Sun B

更新日期：2019-07-21 00:00:00

abstract：:Recently epidemiological studies suggest females lose neuroprotection from neurodegenerative diseases as they go through menopause. It has been hypothesized that this neuroprotection is hormone-dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to pl...

journal_title：Aging

authors： Evola CM,Hudson TL,Huang L,Corbett AM,Mayes DA

更新日期：2018-08-31 00:00:00

abstract：:Progressive loss of ovarian estrogen (E2) production is a hallmark feature of, if not a driving force behind, reproductive aging and the menopause. Recent genetic studies in mice have shown that female germline or oogonial stem cells (OSCs) contribute to maintenance of adult ovarian function and fertility under physio...

journal_title：Aging

authors： Satirapod C,Wang N,MacDonald JA,Sun M,Woods DC,Tilly JL

更新日期：2020-04-17 00:00:00

abstract：:Accumulating evidence suggests that early-life diet may program one's health status by causing permanent alternations in specific organs, tissues, or metabolic or homeostatic pathways, and such programming effects may propagate across generations through heritable epigenetic modifications. However, it remains uninvest...

journal_title：Aging

authors： Xia B,de Belle JS

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Genome-wide association studies (GWAS) and the candidate gene based association studies have identified a panel of variants associated with atrial fibrillation (AF), however, most of the identified single nucleotide polymorphisms (SNPs) were found located within intergenic or intronic genomic regions, and whe...

journal_title：Aging

authors： Xu C,Zhang R,Xia Y,Xiong L,Yang W,Wang P

更新日期：2020-09-09 00:00:00

abstract：:Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth...

journal_title：Aging

authors： Zhang J,Chen Q,Du D,Wu T,Wen J,Wu M,Zhang Y,Yan W,Zhou S,Li Y,Jin Y,Luo A,Wang S

更新日期：2019-01-23 00:00:00

abstract：:Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar body following TubA treatment. However, a previous study demonstrated that homozygous Hdac6 knockout (KO) mice can be viable and fertile. Therefore, we asked wh...

journal_title：Aging

authors： Choi YJ,Kang MH,Hong K,Kim JH

更新日期：2019-03-26 00:00:00

abstract：:In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) FAM181A-AS1 in human gliomas. TCGA, GTEx and CGGA database analyses showed that high FAM181A-AS1 expression correlates with advanced tumor stage and poor survival of glioma patients. FAM181A-AS1 expression is hi...

journal_title：Aging

authors： Jiang X,Chen D

更新日期：2020-10-20 00:00:00