Abstract:
:Age can significantly affect human physiology and disease risk. Recent studies have shown that age may affect the composition and function of the gut microbiota, but the underlying mechanisms remain largely unknown. Non-human primates are an ideal model for uncovering how age shapes the gut microbiota, as their microbial composition is highly similar to that of humans and is not easily affected by confounding factors. Here, using the 16S rRNA and metagenomic sequencing methods, we characterized the microbial phenotypes of 16 female cynomolgus macaques from three age groups (young, adult and old). Our findings revealed significant differences in microbial composition among the three groups. With increased age, the relative abundances of Veillonellaceae, Coriobacteriaceae and Succinivibrionaceae were significantly increased, Ruminococcaceae and Rikenellaceae were significantly decreased at the family level. Functional enrichment showed that genes that differed among the three groups were mainly involved in arginine biosynthesis, purine metabolism and microbial polysaccharides metabolism. Moreover, CAZymes corresponding to polysaccharide degrading activities were also observed among the three groups. In conclusion, we characterized the composition and function of the gut microbiota at different ages, and our findings provide a new entry point for understanding the effects of age on the human body.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Duan J,Yin B,Li W,Chai T,Liang W,Huang Y,Tan X,Zheng P,Wu J,Li Y,Li Y,Zhou W,Xie Pdoi
10.18632/aging.102541subject
Has Abstractpub_date
2019-12-14 00:00:00pages
12080-12096issue
24issn
1945-4589pii
102541journal_volume
11pub_type
杂志文章相关文献
Aging-US文献大全abstract::Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray and public database ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202164
更新日期:2020-12-03 00:00:00
abstract::The general transcription factor, CREB has been shown to play an essential role in promoting cell proliferation, neuronal survival and synaptic plasticity in the nervous system. However, its function in stress response remains to be elusive. In the present study, we demonstrated that CREB plays a major role in mediati...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103474
更新日期:2020-06-17 00:00:00
abstract:OBJECTIVE:This study aimed to explore the effect of silencing hTERT on the CSC-like characteristics and radioresistance of CNE-2R cells. RESULTS:Silencing hTERT suppressed CNE-2R cell proliferation and increased the cell apoptosis rate and radiosensitivity in vitro. Moreover, it could also inhibit the growth of xenogr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104167
更新日期:2020-11-24 00:00:00
abstract::Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103276
更新日期:2020-05-21 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is one of the most common motoneuronal disease, characterized by motoneuronal loss and progressive paralysis. Despite research efforts, ALS remains a fatal disease, with a survival of 2-5 years after disease onset. Numerous gene mutations have been correlated with both sporadic (sAL...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103561
更新日期:2020-06-24 00:00:00
abstract::Spinal cord injury (SCI) causes long-term and severe disability, influencing the quality of life and triggering serious socioeconomic consequences. Lack of effective pharmacotherapies for SCI is largely attributable to an incomplete understanding of its pathogenesis. Caspase recruitment domain family member 6 (CARD6) ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102561
更新日期:2019-12-16 00:00:00
abstract::The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102035
更新日期:2019-06-19 00:00:00
abstract::Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. The association between METH gene polymorphisms and prostate cancer susceptibility remains ambiguous. Thus, we performed an updated meta-analysis of METH single-nuc...
journal_title:Aging
pub_type: 杂志文章,meta分析,评审
doi:10.18632/aging.101584
更新日期:2018-10-18 00:00:00
abstract::Long alpha-synuclein gene (SNCA) promoter (Rep1) allele-carriers are linked to higher risk for Parkinson's disease (PD) and faster motor progression. Non-motor symptoms including autonomic, neuropsychiatric, and sleep disorders are common in PD. However, the relationship between SNCA Rep1 microsatellite lengths and no...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104111
更新日期:2020-10-20 00:00:00
abstract::Accumulating evidence suggests that early-life diet may program one's health status by causing permanent alternations in specific organs, tissues, or metabolic or homeostatic pathways, and such programming effects may propagate across generations through heritable epigenetic modifications. However, it remains uninvest...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100932
更新日期:2016-05-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102377
更新日期:2019-10-30 00:00:00
abstract:UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovati...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100484
更新日期:2012-09-01 00:00:00
abstract::Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100960
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:We analyzed clinical parameters and risk factors for coronavirus disease 2019 (COVID-19)-related liver damage. RESULTS:Of the 332 COVID-19 patients, 306 and 26 were included in the non-critical and critical groups, respectively. The median time from onset to admission was 4.0 (2.0-8.0) days. Of the 332 COVID...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103860
更新日期:2020-10-01 00:00:00
abstract::The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101805
更新日期:2019-02-05 00:00:00
abstract::Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102774
更新日期:2020-02-10 00:00:00
abstract::Adipocyte differentiation involves a series of highly synergistic processes, including clone amplification, proliferation arrest, and terminal differentiation. However, the mechanisms that control these different steps remain unclear. Emerging studies support that miRNAs play an important role in regulating adipogenes...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103649
更新日期:2020-09-14 00:00:00
abstract::Renal dysfunction is a risk factor for morbidity and mortality in cardiac surgery patients. Serum Cystatin C (sCysC) is a well-recognized marker of early renal dysfunction but few reports evaluate its prognostic cardio-vascular role. The aim of the study is to consider the prognostic value of sCysC for cardiovascular ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101403
更新日期:2018-03-27 00:00:00
abstract::Histones and their variants are subjected to several post-translational modifications (PTMs). Histones PTMs play an important role in the regulation of gene expression and are critical for the development and progression of many types of cancer, including breast cancer. In this study, we used two-dimensional TAU/SDS e...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102577
更新日期:2019-12-08 00:00:00
abstract::Hepatoblastoma (HB) is a malignant embryonal tumor of the liver that consists of heterogenous populations of stem/progenitor cells. Although circular RNAs (circRNAs) play an essential role in tumor development, the effects of circRNA on the proliferation of HB cells, especially cancer stem cells (CSCs), remain unclear...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103748
更新日期:2020-10-14 00:00:00
abstract::Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102856
更新日期:2020-02-26 00:00:00
abstract::Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that the expression of HSD...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103530
更新日期:2020-07-17 00:00:00
abstract::Docetaxel is a first-line anticancer drug widely used in the treatment of advanced prostate cancer. However, its therapeutic efficacy is limited by its side effects and the development of chemoresistance by the tumor. Using a gene differential expression microarray, we identified 449 genes differentially expressed in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102600
更新日期:2019-12-29 00:00:00
abstract::Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101601
更新日期:2018-10-25 00:00:00
abstract::Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature senescence under sublethal oxidative stress, however underlying mechanism remains unknown. Here, we showed that exogenous H2O2 induces a rapid phosphorylation and co-localization of ATM, H2A.X, 53BP1 leading to DNA damage response (DDR) acti...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100673
更新日期:2014-06-01 00:00:00
abstract::Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202405
更新日期:2020-12-26 00:00:00
abstract::Aged liver is usually impaired in response to hepatic injury. Tissue-specific stem cells participate in the repair of tissue injury. However, how oval cells (OCs) respond to injury and how the process is regulated by tissue microenvironment in aged mice have not been fully understood. In this study, taking advantage o...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101665
更新日期:2018-12-04 00:00:00
abstract::Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight junctions (TJs) remains unclear. In the present study, we found that high salt d...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103348
更新日期:2020-06-22 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202275
更新日期:2020-12-09 00:00:00
abstract::Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102562
更新日期:2019-12-21 00:00:00