Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production.

abstract：:Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...

journal_title：Aging

authors： Chen CC,Wong TY,Chin TY,Lee WH,Kuo CY,Hsu YC

更新日期：2020-08-05 00:00:00

abstract：:This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...

journal_title：Aging

authors： Qian X,Jia H,Zhang Y,Ma B,Qin G,Wu Z

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Progestogens have been widely used for the treatment of inoperable endometrial cancer or younger patients with endometrial cancer. Identifying markers that are predictive of a response to progestogens is critical for successful therapy. Molecular imaging with 18F-fluorodeoxyglucose positron emission tomograp...

journal_title：Aging

authors： Wu C,Chen R,Xu L,Chen Y,Wang Y,Huang G,Liu J

更新日期：2020-07-08 00:00:00

abstract：:Commensal microbes have mutualistic relationships with their host and mainly live in the host intestine. There are many studies on the relationships between commensal microbes and host physiology. However, there are inconsistent results on the effects of commensal microbes on host lifespan. To clarify this controversy...

journal_title：Aging

authors： Lee HY,Lee SH,Lee JH,Lee WJ,Min KJ

更新日期：2019-07-12 00:00:00

abstract：BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...

journal_title：Aging

authors： Chen YH,Chen SH,Hou J,Ke ZB,Wu YP,Lin TT,Wei Y,Xue XY,Zheng QS,Huang JB,Xu N

更新日期：2019-10-31 00:00:00

abstract：:Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness...

journal_title：Aging

authors： Lee Y,Hwang W,Jung J,Park S,Cabatbat JJ,Kim PJ,Lee SJ

更新日期：2016-05-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...

journal_title：Aging

authors： Yang H,Jiang Y,Zhang Y,Xu Y,Zhang C,Han J,Su F,Liu X,Mi K,Liu B,Shang D

更新日期：2019-12-18 00:00:00

abstract：:The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...

journal_title：Aging

authors： Lopriore P,Capitanio N,Panatta E,Di Daniele N,Gambacurta A,Melino G,Amelio I

更新日期：2018-12-08 00:00:00

abstract：:Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and d...

journal_title：Aging

authors： Valentini E,Zampieri M,Malavolta M,Bacalini MG,Calabrese R,Guastafierro T,Reale A,Franceschi C,Hervonen A,Koller B,Bernhardt J,Slagboom PE,Toussaint O,Sikora E,Gonos ES,Breusing N,Grune T,Jansen E,Dollé ME,Moreno-Vi

更新日期：2016-08-29 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery smooth muscle cell (PASMC) dysfunction. However, the underlying mechanisms of PASMC dysfunction remain largely unknown. Here, we show that mitochondrial fragmentation contributes to PASMC dysfunction through enhancement of endoplasmic reticulum...

journal_title：Aging

authors： Zhuan B,Wang X,Wang MD,Li ZC,Yuan Q,Xie J,Yang Z

更新日期：2020-11-18 00:00:00

abstract：:Genetic factors combined with oxidative stress are major determinants of age-related hearing loss (ARHL), one of the most prevalent disorders of the elderly. Dwarf grey mice, Ggt1dwg/dwg, are homozygous for a loss of function mutation of the g-glutamyl transferase 1 gene, which encodes an important antioxidant enzyme ...

journal_title：Aging

authors： Ding D,Jiang H,Chen GD,Longo-Guess C,Muthaiah VP,Tian C,Sheppard A,Salvi R,Johnson KR

更新日期：2016-04-01 00:00:00

abstract：:New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1) are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs, exposure to the dietary polyphenol resveratrol (RSV) revealed its differential capacity to generate a distinct P...

journal_title：Aging

authors： Verdura S,Cuyàs E,Cortada E,Brunet J,Lopez-Bonet E,Martin-Castillo B,Bosch-Barrera J,Encinar JA,Menendez JA

更新日期：2020-01-04 00:00:00

abstract：:Of all the major organ systems in the body, the ovaries of females are the first to exhibit impaired function with advancing age. Until recently, traditional thinking was that female mammals are provided with a non-renewable pool of oocyte-containing follicles at birth that are depleted during postnatal life to exhaus...

journal_title：Aging

authors： Niikura Y,Niikura T,Tilly JL

更新日期：2009-12-12 00:00:00

abstract：:Alternative splicing (AS) changes are considered to be critical in predicting treatment response. Our study aimed to investigate differential splicing patterns and to elucidate the role of splicing factor (SF) as prognostic markers of low-grade glioma (LGG). We downloaded RNA-seq data from a cohort of 516 LGG tumors i...

journal_title：Aging

authors： Liu WR,Li CY,Xu WH,Liu XJ,Tang HD,Huang HN

更新日期：2020-07-13 00:00:00

abstract：:Circular RNAs (circRNAs) have been reported to be involved in many diseases. But there is no report on circRNAs in non-obstructive azoospermia (NOA). The purpose of this paper is to explore the circular RNA expression profile and potential functions of circRNAs in NOA patients. We first preformed circRNA expression pr...

journal_title：Aging

authors： Bo H,Liu Z,Tang R,Gong G,Wang X,Zhang H,Zhu F,Zhou D,Zhu W,Tan Y,Fan L

更新日期：2020-02-06 00:00:00

abstract：:Elderly patients with type 2 diabetes mellitus (T2DM) exhibit considerable periodontitis frequency, which causes tooth loss and poor quality of life. To investigate the impact of periodontitis on gut microbiota, we used 16S rRNA amplicon sequencing to characterize the composition and structure of gut microbiota among ...

journal_title：Aging

authors： Li J,Lu H,Wu H,Huang S,Chen L,Gui Q,Zhou W,Yang Y,Wu Y,Zhang H,Zhang Q,Yang Y

更新日期：2020-11-25 00:00:00

abstract：:One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phospho...

journal_title：Aging

authors： Obukhova LA,Skulachev VP,Kolosova NG

更新日期：2009-04-22 00:00:00

abstract：:To identify an immune-related prognostic signature based on long non-coding RNAs (lncRNAs) and find immunotherapeutic targets for bladder urothelial carcinoma, we downloaded RNA-sequencing data from The Cancer Genome Atlas (TCGA) dataset. Functional enrichment analysis demonstrated bladder urothelial carcinoma was rel...

journal_title：Aging

authors： Song Y,Jin D,Chen J,Luo Z,Chen G,Yang Y,Liu X

更新日期：2020-06-24 00:00:00

abstract：:In this study, we investigated the role of calreticulin (CALR) in the pathogenesis of natural killer/T-cell lymphoma (NKTCL). CALR expression was significantly higher in the NKTCL tissues than normal control tissues in the GSE80632 dataset. High CALR expression correlated with poorer overall survival of NKTCL patients...

journal_title：Aging

authors： Zheng Y,Li C,Xin P,Peng Q,Zhang W,Liu S,Zhu X

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...

journal_title：Aging

authors： Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

更新日期：2019-12-19 00:00:00

abstract：:Dietary interventions, including a low-protein diet (LPD) and methionine (Met) restriction, have shown longevity, anti-aging and metabolic health effects. We previously reported that the LPD has a renoprotective effect against diabetic kidney disease (DKD) in rats with type 2 diabetes and obesity. However, it is uncle...

journal_title：Aging

authors： Kitada M,Ogura Y,Monno I,Xu J,Koya D

更新日期：2020-03-06 00:00:00

abstract：:PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...

journal_title：Aging

authors： Kunstmann B,Osiewacz HD

更新日期：2009-03-03 00:00:00

abstract：:Elderly patients with coronavirus disease 2019 (COVID-19) are more likely to develop severe or critical pneumonia, with a high fatality rate. To date, there is no model to predict the severity of COVID-19 in elderly patients. In this study, patients who maintained a non-severe condition and patients who progressed to ...

journal_title：Aging

authors： Zeng F,Deng G,Cui Y,Zhang Y,Dai M,Chen L,Han D,Li W,Guo K,Chen X,Shen M,Pan P

更新日期：2020-11-10 00:00:00

abstract：:How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal s...

journal_title：Aging

authors： Yu R,Sun Y,Ye KX,Feng Q,Lim SL,Mahendran R,Cheah IK,Foo RSY,Chua RY,Gwee X,Loh M,Sarmugam R,Khine WWT,Chao YX,Larbi A,Lee YK,Kumar AP,Kennedy BK,Kua EH,Feng L

更新日期：2020-11-18 00:00:00

abstract：:In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted brain magnetic resonance imaging data were analyzed from 45 adults with NSCLP after palatoplasty: 24 subjects were assessed before AR ...

journal_title：Aging

authors： Li Z,Zhang W,Li C,Wang M,Wang S,Chen R,Zhang X

更新日期：2020-07-03 00:00:00

abstract：:Leptin signaling influences osteoblastogenesis and modulates the fate of mesenchymal stem cells (MSCs) during bone and cartilage regeneration. Although MSCs abound in the osteosarcoma (OS) microenvironment, and leptin exhibits pro-tumorigenic properties, leptin's influence on OS progression and chemoresistant signalin...

journal_title：Aging

authors： Feng H,Zhang Q,Zhao Y,Zhao L,Shan B

更新日期：2020-04-14 00:00:00

abstract：UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovati...

journal_title：Aging

authors： Vitale G,Brugts MP,Ogliari G,Castaldi D,Fatti LM,Varewijck AJ,Lamberts SW,Monti D,Bucci L,Cevenini E,Cavagnini F,Franceschi C,Hofland LJ,Mari D,Janssen J

更新日期：2012-09-01 00:00:00

abstract：:Exosomes play important roles in proliferation and microenvironment modulation of many types of cancers, including colorectal cancer (CRC). However, the inhibitory effect of CRC cells-derived exosomes in angiogenesis has not been fully discussed. In this study, the roles of microRNA-183-5p (miR-183-5p) in abundant in ...

journal_title：Aging

authors： Shang A,Wang X,Gu C,Liu W,Sun J,Zeng B,Chen C,Ji P,Wu J,Quan W,Yao Y,Wang W,Sun Z,Li D

更新日期：2020-05-03 00:00:00

abstract：:Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...

journal_title：Aging

authors： Patrick A,Seluanov M,Hwang C,Tam J,Khan T,Morgenstern A,Wiener L,Vazquez JM,Zafar H,Wen R,Muratkalyeva M,Doerig K,Zagorulya M,Cole L,Catalano S,Lobo Ladd AA,Coppi AA,Coşkun Y,Tian X,Ablaeva J,Nevo E,Gladyshev VN

更新日期：2016-05-01 00:00:00

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00