Abstract:
BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module 10 revealed the most relevance with Treg cells. Functional annotation showed that biological processes and pathways were mainly related to activation of the immune system and the processes of immunoreaction. Four hub genes were selected: LCK, MAP4K1, SLAMF6, and RHOH. Further validation showed that the four hub genes well-distinguished tumor and normal tissues and were good prognostic biomarkers for ccRCC. CONCLUSION:The identified hub genes facilitate our knowledge of the underlying molecular mechanism of how Treg cells affect ccRCC in anti-tumor immune therapy. METHODS:The CIBERSORT algorithm was performed to evaluate tumor-infiltrating immune cells based on the Cancer Genome Atlas cohort. Weighted gene co-expression network analysis was conducted to explore the modules related to Treg cells. Gene Ontology analysis and pathway enrichment analysis were performed for functional annotation and a protein-protein interaction network was built. Samples from the International Cancer Genomics Consortium database was used as a validation set.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Chen YH,Chen SH,Hou J,Ke ZB,Wu YP,Lin TT,Wei Y,Xue XY,Zheng QS,Huang JB,Xu Ndoi
10.18632/aging.102397subject
Has Abstractpub_date
2019-10-31 00:00:00pages
9478-9491issue
21issn
1945-4589pii
102397journal_volume
11pub_type
杂志文章相关文献
Aging-US文献大全abstract:BACKGROUND:SARS-CoV-2 has raged around the world since March, 2020. We aim to describe the clinical characteristics and risk factors of severe patients with COVID-19 in Guangzhou. RESULTS:The severity and mortality of COVID-19 was 10.4% and 0.3% respectively. And each 1-year increase in age (OR, 1.057; 95% CI, 1.018-1...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103803
更新日期:2020-08-15 00:00:00
abstract::Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202405
更新日期:2020-12-26 00:00:00
abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202302
更新日期:2020-12-03 00:00:00
abstract::The loss of regenerative capacity of tissues is one of the major characteristics of aging. Liver represents a powerful system for investigations of mechanisms by which aging reduces regenerative capacity of tissues. The studies within last five years revealed critical role of epigenetic silencing in the inhibition of ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100060
更新日期:2009-06-22 00:00:00
abstract::Cellular senescence arrests the proliferation of mammalian cells at risk for neoplastic transformation, and is also associated with aging. However, the factors that cause cellular senescence during aging are unclear. Excessive reactive oxygen species (ROS) have been shown to cause cellular senescence in culture, and a...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100423
更新日期:2012-01-01 00:00:00
abstract::Cellular senescence is considered a stress response imposing a stable cell cycle arrest to restrict the growth of damaged cells. More recently however, cellular senescence was identified during mouse embryo development at particular structures during specific periods of time. This programmed cell senescence has been p...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103968
更新日期:2020-09-29 00:00:00
abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103907
更新日期:2020-10-08 00:00:00
abstract::Our objectives were to evaluate: 1) the associations of cognitive frailty with various health outcomes including disability, hospitalization, and death; 2) whether the associations differed by multimorbidity. We included data of 5113 Chinese older adults (aged 60+ years) who had baseline cognition and physical frailty...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104078
更新日期:2020-11-18 00:00:00
abstract::In this study, we investigated the effects of G-protein coupled estrogen receptor (GPER) activation in the early phase of retinopathy of prematurity (ROP) and its association with endoplasmic reticulum (ER) stress using primary murine retinal microglia as an experimental model. Fluorescence microscopy results show tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103733
更新日期:2020-09-13 00:00:00
abstract::Mounting evidence suggests that noncoding RNAs (ncRNAs) contribute to the pathogenesis of cardiovascular diseases. However, their role in essential hypertension (EH) is still unclear. We therefore identified differentially expressed long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in EH patients from a high-...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103137
更新日期:2020-05-11 00:00:00
abstract::Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood. In eukaryotic cells, methionine can be converted to cysteine thr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100491
更新日期:2012-10-01 00:00:00
abstract::The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103931
更新日期:2020-10-14 00:00:00
abstract::Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6 and α-tubulin were...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103537
更新日期:2020-08-29 00:00:00
abstract::Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103465
更新日期:2020-08-05 00:00:00
abstract::Despite the accumulating evidence from in vitro and animal experiments supporting the role of kynurenine (a tryptophan metabolite) in a number of degenerative age-related changes, the relationship between kynurenine and frailty in older adults is not well understood. We collected blood samples from 73 participants who...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104179
更新日期:2020-11-13 00:00:00
abstract::Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101148
更新日期:2016-12-28 00:00:00
abstract::This study compares the longitudinal histological characteristics of proximal humeral implants with different spatial structures in rabbits. Thirty skeletally-mature male rabbits were divided into a trabecular structure group and regular hexahedron structure group according to the different spatial structures of a bio...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202391
更新日期:2021-01-20 00:00:00
abstract::Oxidative stress and inflammation play vital roles in Parkinson's disease (PD) development. Thus, telomere length is expected to be shortened in this disease, but current data are inconclusive. We performed a case-control study of 261 patients with PD and 270 sex and age-matched healthy controls treated at the Peking ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103878
更新日期:2020-10-29 00:00:00
abstract::MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epide...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101791
更新日期:2019-02-08 00:00:00
abstract::Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100654
更新日期:2014-04-01 00:00:00
abstract::Histones and their variants are subjected to several post-translational modifications (PTMs). Histones PTMs play an important role in the regulation of gene expression and are critical for the development and progression of many types of cancer, including breast cancer. In this study, we used two-dimensional TAU/SDS e...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102577
更新日期:2019-12-08 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202275
更新日期:2020-12-09 00:00:00
abstract::FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202293
更新日期:2020-12-01 00:00:00
abstract::Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem cell-derived exosomes have exhibited promising therapeutic effects. In this study, we performed intracerebroventricular microinject...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103692
更新日期:2020-09-23 00:00:00
abstract::Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101908
更新日期:2019-04-14 00:00:00
abstract::Myocardial infarction is characterized by sudden ischemia and cardiomyocyte death. Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain damage under ischemic conditions. Mitophagy is a mechanism by which damaged mitochondria are removed by autophagy to maintain mitochondrial structure...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102899
更新日期:2020-03-10 00:00:00
abstract:INTRODUCTION:Circulating non-coding RNA is an ideal source to discover novel biomarkers for non-invasive screening. However, studies for the discovery of universal miRNAs in serum and exosomes for breast cancer early diagnosis are limited. METHODS:Based on bioinformatic analysis, in vitro and in vivo studies were perf...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202388
更新日期:2021-01-20 00:00:00
abstract::In this study, we investigated the role of calreticulin (CALR) in the pathogenesis of natural killer/T-cell lymphoma (NKTCL). CALR expression was significantly higher in the NKTCL tissues than normal control tissues in the GSE80632 dataset. High CALR expression correlated with poorer overall survival of NKTCL patients...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104030
更新日期:2020-11-18 00:00:00
abstract::The Mitochondrial Free Radical Theory of Aging (MFRTA) is currently one of the most widely accepted theories used to explain aging. From MFRTA three basic predictions can be made: long-lived individuals or species should produce fewer mitochondrial Reactive Oxygen Species (mtROS) than short-lived individuals or specie...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100137
更新日期:2010-04-01 00:00:00
abstract::Genome stability of human embryonic stem cells (hESC) is an important issue because even minor genetic alterations can negatively impact cell functionality and safety. The incorrect repair of DNA double-stranded breaks (DSBs) is the ultimate cause of the formation of chromosomal aberrations. Using G2 radiosensitivity ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100336
更新日期:2011-06-01 00:00:00