System level characterization of small molecule drugs and their affected long noncoding RNAs.

abstract：:Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain a...

journal_title：Aging

authors： Wang Y,Song Y,Pang Y,Yu Z,Hua W,Gu Y,Qi J,Wu H

更新日期：2020-06-29 00:00:00

abstract：:Age can significantly affect human physiology and disease risk. Recent studies have shown that age may affect the composition and function of the gut microbiota, but the underlying mechanisms remain largely unknown. Non-human primates are an ideal model for uncovering how age shapes the gut microbiota, as their microb...

journal_title：Aging

authors： Duan J,Yin B,Li W,Chai T,Liang W,Huang Y,Tan X,Zheng P,Wu J,Li Y,Li Y,Zhou W,Xie P

更新日期：2019-12-14 00:00:00

abstract：:Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...

journal_title：Aging

authors： Xu W,Song C,Wang X,Li Y,Bai X,Liang X,Wu J,Liu J

更新日期：2021-01-05 00:00:00

abstract：:Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that the expression of HSD...

journal_title：Aging

authors： Huang H,Liu R,Huang Y,Feng Y,Fu Y,Chen L,Chen Z,Cai Y,Zhang Y,Chen Y

更新日期：2020-07-17 00:00:00

abstract：:Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by analyzing The Cancer Genome Atlas cohort, we found that FAM84B amplification was ...

journal_title：Aging

authors： Zhang X,Xu J,Yan R,Zhang Y,Hu Z,Fu H,You Q,Cai Q,Yang D

更新日期：2020-04-14 00:00:00

abstract：:Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and interstitial conditions ...

journal_title：Aging

authors： Yanagida K,Maejima Y,Santoso P,Otgon-Uul Z,Yang Y,Sakuma K,Shimomura K,Yada T

更新日期：2014-03-01 00:00:00

abstract：:The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...

journal_title：Aging

authors： Zheng HX,Zhao Y,Xu Y,Zhang ZJ,Zhu JJ,Fan YF,Lin N

更新日期：2019-06-19 00:00:00

abstract：:Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in ...

journal_title：Aging

authors： Xu Y,Chen T,Li X,Qu YK,An JN,Zheng HX,Zhang ZJ,Lin N

更新日期：2016-12-20 00:00:00

abstract：:The flavonoids in Ageratum conyzoides L. have been used in traditional medicine due to its anti-inflammatory and antibacterial properties. However, the specific mechanism of its antibacterial effect, and the potential therapeutic effect on vaginitis have not been well explained. The growth curves of E. coli, S. aurues...

journal_title：Aging

authors： Lin Z,Lin Y,Zhang Z,Shen J,Yang C,Jiang M,Hou Y

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND:Progestogens have been widely used for the treatment of inoperable endometrial cancer or younger patients with endometrial cancer. Identifying markers that are predictive of a response to progestogens is critical for successful therapy. Molecular imaging with 18F-fluorodeoxyglucose positron emission tomograp...

journal_title：Aging

authors： Wu C,Chen R,Xu L,Chen Y,Wang Y,Huang G,Liu J

更新日期：2020-07-08 00:00:00

abstract：:Although the influenza virus only infects the respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults are more likely to develop disability following influenza infection; however, this relationship is understudied. We hypothesized...

journal_title：Aging

authors： Bartley JM,Pan SJ,Keilich SR,Hopkins JW,Al-Naggar IM,Kuchel GA,Haynes L

更新日期：2016-04-01 00:00:00

abstract：:Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...

journal_title：Aging

authors： Patrick A,Seluanov M,Hwang C,Tam J,Khan T,Morgenstern A,Wiener L,Vazquez JM,Zafar H,Wen R,Muratkalyeva M,Doerig K,Zagorulya M,Cole L,Catalano S,Lobo Ladd AA,Coppi AA,Coşkun Y,Tian X,Ablaeva J,Nevo E,Gladyshev VN

更新日期：2016-05-01 00:00:00

abstract：UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovati...

journal_title：Aging

authors： Vitale G,Brugts MP,Ogliari G,Castaldi D,Fatti LM,Varewijck AJ,Lamberts SW,Monti D,Bucci L,Cevenini E,Cavagnini F,Franceschi C,Hofland LJ,Mari D,Janssen J

更新日期：2012-09-01 00:00:00

abstract：:Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old m...

journal_title：Aging

authors： Dong Q,Gao H,Shi Y,Zhang F,Gu X,Wu A,Wang D,Chen Y,Bandyopadhyay A,Yeh IT,Daniel BJ,Chen Y,Zou Y,Rebel VL,Walter CA,Lu J,Huang C,Sun LZ

更新日期：2016-11-15 00:00:00

abstract：OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...

journal_title：Aging

authors： Ma X,Yu X,Zhou Q

更新日期：2020-02-15 00:00:00

abstract：:Angiogenesis - the growth of new blood capillaries- is impaired in aging animals. Biophysical factors such as changes in cell size control endothelial cell (EC) proliferation and differentiation. However, the effects of aging on EC size and the mechanism by which changes in cell size control age-dependent decline in E...

journal_title：Aging

authors： Mammoto T,Torisawa YS,Muyleart M,Hendee K,Anugwom C,Gutterman D,Mammoto A

更新日期：2019-09-05 00:00:00

abstract：:Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated that miR-214-3p is abnormally expressed in various malignant tumors. However, the biological function it plays in CRC and the potential mechanism are unclear. Here, we demonstrated that miR-214-3p was obvi...

journal_title：Aging

authors： Zhou Z,Wu L,Liu Z,Zhang X,Han S,Zhao N,Bao H,Yuan W,Chen J,Ji J,Shu X

更新日期：2020-05-15 00:00:00

abstract：:The frailty index (FI) is one of the most widespread tools used to predict poor, health-related outcomes in older persons. The selection of clinical and functional deficits to include in a FI is mostly based on the users' clinical experience. However, this approach may not be sufficiently accurate to predict health ou...

journal_title：Aging

authors： Zucchelli A,Marengoni A,Rizzuto D,Calderón-Larrañaga A,Zucchelli M,Bernabei R,Onder G,Fratiglioni L,Vetrano DL

更新日期：2020-04-28 00:00:00

abstract：:To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA ...

journal_title：Aging

authors： Ko CH,Wu SJ,Wang ST,Chang YF,Chang CS,Kuan TS,Chuang HY,Chang CM,Chou W,Wu CH

更新日期：2020-07-26 00:00:00

abstract：:Exosomes play important roles in proliferation and microenvironment modulation of many types of cancers, including colorectal cancer (CRC). However, the inhibitory effect of CRC cells-derived exosomes in angiogenesis has not been fully discussed. In this study, the roles of microRNA-183-5p (miR-183-5p) in abundant in ...

journal_title：Aging

authors： Shang A,Wang X,Gu C,Liu W,Sun J,Zeng B,Chen C,Ji P,Wu J,Quan W,Yao Y,Wang W,Sun Z,Li D

更新日期：2020-05-03 00:00:00

abstract：:Combination treatment is a promising strategy to improve prognosis of hepatocellular carcinoma (HCC). Sorafenib is a traditional first-line agent approved for the treatment of advanced HCC, though with limited efficacy. Previously, we reported that lonafarnib, an orally bioavailable non-peptide inhibitor targeting far...

journal_title：Aging

authors： Wang J,Wei H,Huang Y,Chen D,Zeng G,Lian Y,Huang Y

更新日期：2019-08-13 00:00:00

abstract：:Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...

journal_title：Aging

authors： Guest I,Ilic Z,Scrable H,Sell S

更新日期：2015-12-01 00:00:00

abstract：:Cardiomyocyte apoptosis is a major cause of myocardial ischemia/reperfusion (MI/R) injury, in which the activation of the signal transducer and activator of transcription 1 (STAT1) plays an important role. The E3-ubiquitin ligase TRIM6 has been implicated in regulating STAT1 activity, however, whether it is associated...

journal_title：Aging

authors： Zeng G,Lian C,Yang P,Zheng M,Ren H,Wang H

更新日期：2019-06-06 00:00:00

abstract：:Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Relative risks an...

journal_title：Aging

authors： Zhang D,Dai C,Zhou L,Li Y,Liu K,Deng YJ,Li N,Zheng Y,Hao Q,Yang S,Song D,Wu Y,Zhai Z,Cao S,Dai Z

更新日期：2020-06-02 00:00:00

abstract：:Lung cancer remains the most lethal cancer worldwide because of its high metastasis potential. Epithelial-mesenchymal transition (EMT) is known as the first step of the metastasis cascade, but the potential regulatory mechanisms of EMT have not been clearly established. In this study, we first found that low CUEDC1 ex...

journal_title：Aging

authors： Cui Y,Song Y,Yan S,Cao M,Huang J,Jia D,Liu Y,Zhang S,Fan W,Cai L,Li C,Xing Y

更新日期：2020-10-25 00:00:00

abstract：:A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative ...

journal_title：Aging

authors： Pretorius E,Swanepoel AC,Buys AV,Vermeulen N,Duim W,Kell DB

更新日期：2014-10-01 00:00:00

abstract：:Blood brain barrier (BBB) disruption is a crucial factor contributing to secondary brain injury after intracerebral hemorrhage (ICH). Heat shock protein B8 (HSPB8) has been recently reported to confer neuroprotection against against ischaemic stroke through maintaining BBB integrity. However, the role of HSPB8 in ICH ...

journal_title：Aging

authors： Hou Y,Hu Z,Gong X,Yang B

更新日期：2020-09-04 00:00:00

abstract：:Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...

journal_title：Aging

authors： Sgarbi G,Matarrese P,Pinti M,Lanzarini C,Ascione B,Gibellini L,Dika E,Patrizi A,Tommasino C,Capri M,Cossarizza A,Baracca A,Lenaz G,Solaini G,Franceschi C,Malorni W,Salvioli S

更新日期：2014-04-01 00:00:00

abstract：:N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects ...

journal_title：Aging

authors： Shaposhnikov MV,Zemskaya NV,Koval LA,Schegoleva EV,Zhavoronkov A,Moskalev AA

更新日期：2018-09-20 00:00:00

abstract：:Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains...

journal_title：Aging

authors： Foscarin S,Raha-Chowdhury R,Fawcett JW,Kwok JCF

更新日期：2017-06-28 00:00:00