N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

abstract：BACKGROUND:Chromosome 1p/19q codeletion is increasingly being recognized as the crucial genetic marker for glioma patients and have been included in WHO classification of glioma in 2016. Fluorescent in situ hybridization, a widely used method in detecting 1p/19q status, has some methodological limitations which might i...

journal_title：Aging

authors： Wang ZL,Zhao Z,Wang Z,Zhang CB,Jiang T

更新日期：2019-02-02 00:00:00

abstract：BACKGROUND:Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inope...

journal_title：Aging

authors： Chen D,Feng X,Lv Z,Xu X,Lu Y,Wu W,Wu H,Liu H,Cao L,Ye S,Chen J,Wu J

更新日期：2019-10-25 00:00:00

abstract：:The development and progression of hepatocellular carcinoma (HCC) is accompanied with persistent oxidative stress, but the molecular basis is not well defined. Superoxide dismutase 2 (SOD2) is an important mitochondrial antioxidant and a key aging factor. Here we investigated the expression and clinical significance o...

journal_title：Aging

authors： Wang R,Yin C,Li XX,Yang XZ,Yang Y,Zhang MY,Wang HY,Zheng XF

更新日期：2016-06-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...

journal_title：Aging

authors： Yang H,Jiang Y,Zhang Y,Xu Y,Zhang C,Han J,Su F,Liu X,Mi K,Liu B,Shang D

更新日期：2019-12-18 00:00:00

abstract：:FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we ...

journal_title：Aging

authors： Zhong L,Zhang Y,Li M,Song Y,Liu D,Yang X,Yang D,Qu H,Lai L,Wang Q,Chen Z

更新日期：2020-12-01 00:00:00

abstract：:Stressors that disrupt homeostasis advance aging. Glucocorticoids regulate multiple processes that determine the aging trajectory. Debate exists regarding life-course circulating glucocorticoid concentrations. Rodent and nonhuman primate studies indicate circulating glucocorticoids fall from early life. We measured fa...

journal_title：Aging

authors： Yang S,Gerow KG,Huber HF,Considine MM,Li C,Mattern V,Comuzzie AG,Ford SP,Nathanielsz PW

更新日期：2017-05-09 00:00:00

abstract：:Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. ...

journal_title：Aging

authors： Reifsnyder PC,Flurkey K,Te A,Harrison DE

更新日期：2016-11-30 00:00:00

abstract：:Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...

journal_title：Aging

authors： Darst BF,Koscik RL,Hogan KJ,Johnson SC,Engelman CD

更新日期：2019-02-24 00:00:00

abstract：:Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro- and macrovascular complications that increase the morbidity and mortality of patients. The risk of diabetic complications has a strong genetic component. To this end, we sought to evaluate the association of 40 single nucleotide polymorphism...

journal_title：Aging

authors： Montesanto A,Bonfigli AR,Crocco P,Garagnani P,De Luca M,Boemi M,Marasco E,Pirazzini C,Giuliani C,Franceschi C,Passarino G,Testa R,Olivieri F,Rose G

更新日期：2018-02-04 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, and immune-related genes (IRGs) are key contributors to its development. In this study, the gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database and the...

journal_title：Aging

authors： Wan B,Liu B,Huang Y,Yu G,Lv C

更新日期：2019-12-10 00:00:00

abstract：:Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...

journal_title：Aging

authors： Patrick A,Seluanov M,Hwang C,Tam J,Khan T,Morgenstern A,Wiener L,Vazquez JM,Zafar H,Wen R,Muratkalyeva M,Doerig K,Zagorulya M,Cole L,Catalano S,Lobo Ladd AA,Coppi AA,Coşkun Y,Tian X,Ablaeva J,Nevo E,Gladyshev VN

更新日期：2016-05-01 00:00:00

abstract：:Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. Since strong consensus regarding commonly altered MRs in hepatocellular carcinoma (HCC) is lacking, we generated a compendium of HCC datasets from 21 studies and identified a c...

journal_title：Aging

authors： Li Z,Lou Y,Tian G,Wu J,Lu A,Chen J,Xu B,Shi J,Yang J

更新日期：2019-12-18 00:00:00

abstract：:In this study, we constructed a model using a Cox proportional hazards model based on the expression of eight immune-related genes that were associated with prognosis in prostate cancer: EDNRB, ANGPTL2, TNFSF15, TNFRSF10D, EDN2, BMP2, NLRP14, and PLK1. We then identified associations between risk scores calculated wit...

journal_title：Aging

authors： Liu Z,Zhong J,Cai C,Lu J,Wu W,Zeng G

更新日期：2020-11-10 00:00:00

abstract：:Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown proliferative restrictions of adult SCs forced to re-enter the cell cycle. By comparing juvenile and adult SCs in explant cultures, ...

journal_title：Aging

authors： Laos M,Anttonen T,Kirjavainen A,af Hällström T,Laiho M,Pirvola U

更新日期：2014-06-01 00:00:00

abstract：:The relationship between aging and daily "circadian" behavior in humans is bidirectional: on the one hand, dysfunction of circadian clocks promotes age-related maladies; on the other, aging per se leads to changes and disruption in circadian behavior and physiology. For the latter case, recent research suggests that c...

journal_title：Aging

authors： Brown SA,Schmitt K,Eckert A

更新日期：2011-08-01 00:00:00

abstract：:The actin-binding protein Girdin is involved in a variety of cellular processes, including pancreatic cancer. The objective of this study is to explore the role and the mechanism of Girdin in pancreatic cancer by quantitative acetylome and phosphorylome analysis. We firstly found that Girdin was overexpressed in pancr...

journal_title：Aging

authors： Yang L,Fu Q,Miao L,Ding Q,Li X,Wang J,Jiang G,Wang Y

更新日期：2020-05-05 00:00:00

abstract：:Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...

journal_title：Aging

authors： Fu K,Hui B,Wang Q,Lu C,Shi W,Zhang Z,Rong D,Zhang B,Tian Z,Tang W,Cao H,Wang X,Chen Z

更新日期：2020-02-10 00:00:00

abstract：:The loss of regenerative capacity of tissues is one of the major characteristics of aging. Liver represents a powerful system for investigations of mechanisms by which aging reduces regenerative capacity of tissues. The studies within last five years revealed critical role of epigenetic silencing in the inhibition of ...

journal_title：Aging

authors： Jin J,Wang GL,Timchenko L,Timchenko NA

更新日期：2009-06-22 00:00:00

abstract：:Although observational studies have reported a positive association between obstructive sleep apnea syndrome (OSAS) and breast cancer (BC) risk, causality remains inconclusive. We aim to explore whether OSAS is associated with etiology of BC by conducting a two-sample Mendelian randomization (MR) study in a Chinese po...

journal_title：Aging

authors： Gao XL,Jia ZM,Zhao FF,An DD,Wang B,Cheng EJ,Chen Y,Gong JN,Liu D,Huang YQ,Yang JJ,Wang SJ

更新日期：2020-02-29 00:00:00

abstract：:Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Ectopic expression o...

journal_title：Aging

authors： Yan L,You WQ,Sheng NQ,Gong JF,Hu LD,Tan GW,Chen HQ,Wang ZG

更新日期：2018-12-06 00:00:00

abstract：:According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast ca...

journal_title：Aging

authors： Chen PS,Hsu HP,Phan NN,Yen MC,Chen FW,Liu YW,Lin FP,Feng SY,Cheng TL,Yeh PH,Omar HA,Sun Z,Jiang JZ,Chan YS,Lai MD,Wang CY,Hung JH

更新日期：2021-01-10 00:00:00

abstract：:Inhalation anesthetics have been demonstrated to have protective effects against myocardial ischemia reperfusion injury (MIRI). O-linked GlcNAcylation (O-GlcNAc) modifications have been shown to protect against MIRI. This study aimed to investigate whether O-GlcNAcylation and necroptosis signaling were important for s...

journal_title：Aging

authors： Zhang J,Yu P,Hua F,Hu Y,Xiao F,Liu Q,Huang D,Deng F,Wei G,Deng W,Ma J,Zhu W,Zhang J,Yu S

更新日期：2020-11-20 00:00:00

abstract：:SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulate...

journal_title：Aging

authors： Liu A,Zhang S,Li W,Xu B,Lei R,Zhu S

更新日期：2020-01-11 00:00:00

abstract：:In this study, we investigated the effects of G-protein coupled estrogen receptor (GPER) activation in the early phase of retinopathy of prematurity (ROP) and its association with endoplasmic reticulum (ER) stress using primary murine retinal microglia as an experimental model. Fluorescence microscopy results show tha...

journal_title：Aging

authors： Li R,Wang Y,Chen P,Meng J,Zhang H

更新日期：2020-09-13 00:00:00

abstract：:Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...

journal_title：Aging

authors： Cui L,Xue H,Wen Z,Lu Z,Liu Y,Zhang Y

更新日期：2020-11-12 00:00:00

abstract：:Kidney clear cell carcinoma (KIRC) is the most prevalent kidney malignancy. Accumulating evidence shows that high expression of TIP-B1 correlates with development of tumor progression. However, the detailed functions of TIP-B1 in the KIRC remain to be further elucidated. Here, we firstly found TIP-B1 expression was si...

journal_title：Aging

authors： Yin L,Gao S,Shi H,Wang K,Yang H,Peng B

更新日期：2019-09-27 00:00:00

abstract：:The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell surface-associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perle...

journal_title：Aging

authors： Dos Santos M,Michopoulou A,André-Frei V,Boulesteix S,Guicher C,Dayan G,Whitelock J,Damour O,Rousselle P

更新日期：2016-04-01 00:00:00

abstract：:Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...

journal_title：Aging

authors： Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV

更新日期：2016-07-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...

journal_title：Aging

authors： Zhang G,Xu Y,Zou C,Tang Y,Lu J,Gong Z,Ma G,Zhang W,Jiang P

更新日期：2019-10-30 00:00:00

abstract：:The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. In Alzheimer's Disease, T-cells were identified as important...

journal_title：Aging

authors： Fischer M,Ruhnau J,Schulze J,Obst D,Flöel A,Vogelgesang A

更新日期：2020-06-30 00:00:00