Abstract:
:PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about the function of the protein in the protection against metal induced oxidative stress. Deletion of PaMth1 was found to lead to a decreased resistance against exogenous oxidative stress and to a shortened lifespan suggesting a role of PaMTH1 as a longevity assurance factor in a new molecular pathway involved in lifespan control.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Kunstmann B,Osiewacz HDdoi
10.18632/aging.100029subject
Has Abstractpub_date
2009-03-03 00:00:00pages
328-34issue
3issn
1945-4589journal_volume
1pub_type
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