Abstract:
:Recently epidemiological studies suggest females lose neuroprotection from neurodegenerative diseases as they go through menopause. It has been hypothesized that this neuroprotection is hormone-dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to play a role in memory, PKC, ERK, and connexin-43, in regions of the brain associated with memory decline in an attempt to elucidate significant changes that occur post-estrus. Total whole cell lysates were compared to isolated mitochondrial protein because mitochondrial function is known to be altered during aging. As hypothesized, protein concentrations differed depending on age, gender, and brain region. Additionally, many of these changes occurred within mitochondria but not within whole cell lysates indicating that these are epigenetic alterations. These findings accentuate the complexity of aging and provide insight into the gender-specific cellular processes that occur throughout this process.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Evola CM,Hudson TL,Huang L,Corbett AM,Mayes DAdoi
10.18632/aging.101538subject
Has Abstractpub_date
2018-08-31 00:00:00pages
2148-2169issue
8issn
1945-4589pii
101538journal_volume
10pub_type
杂志文章相关文献
Aging-US文献大全abstract::Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cel...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103321
更新日期:2020-06-10 00:00:00
abstract::Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however, indicates that rapamycin treatment produces some benefits to energy metabolism, even in the context of T2D. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101117
更新日期:2016-11-30 00:00:00
abstract::To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. BMSCs from mice 2 months of age were isolated, and their cellular age determined (over 80% Scal-1+ C...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103569
更新日期:2020-07-25 00:00:00
abstract:BACKGROUND:Progestogens have been widely used for the treatment of inoperable endometrial cancer or younger patients with endometrial cancer. Identifying markers that are predictive of a response to progestogens is critical for successful therapy. Molecular imaging with 18F-fluorodeoxyglucose positron emission tomograp...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103352
更新日期:2020-07-08 00:00:00
abstract::Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose indivi...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101855
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102397
更新日期:2019-10-31 00:00:00
abstract:BACKGROUND:Gastric cancer is a common malignancy and had poor response to treatment due to its strong heterogeneity. This study aimed to identify essential genes associated with diffuse type gastric cancer and construct a powerful prognostic model. RESULTS:We conducted a weighted gene co-expression network analysis (W...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103743
更新日期:2020-09-11 00:00:00
abstract::Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mas...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103286
更新日期:2020-06-05 00:00:00
abstract::The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversib...
journal_title:Aging
pub_type: 社论
doi:10.18632/aging.100202
更新日期:2010-09-01 00:00:00
abstract::Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102562
更新日期:2019-12-21 00:00:00
abstract::Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100867
更新日期:2015-12-01 00:00:00
abstract::Bladder cancer (BC) is one of the most commonly diagnosed urologic carcinomas, with high recurrence and death rates. Circular RNAs (circRNAs) are a class of noncoding RNAs which are anomalously expressed in cancers and involved in the progression of cancers. In this study, we found that circSEMA5A was upregulated in B...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103971
更新日期:2020-11-07 00:00:00
abstract::The actin-binding protein Girdin is involved in a variety of cellular processes, including pancreatic cancer. The objective of this study is to explore the role and the mechanism of Girdin in pancreatic cancer by quantitative acetylome and phosphorylome analysis. We firstly found that Girdin was overexpressed in pancr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103032
更新日期:2020-05-05 00:00:00
abstract:OBJECTIVE:To assess the value of real-time three-dimensional echocardiography (RT-3DE) in evaluating changes in left atrial volume and function in type 2 diabetes mellitus (DM) and type 2 diabetic nephropathy (DN) patients. METHOD:104 control subjects, 109 DN patients, and 111 DM patients were recruited and underwent ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202218
更新日期:2020-12-03 00:00:00
abstract::In this study, we investigated the role of macrophage stimulating 1 (Mst1) and the AMPK-Sirt1 signaling pathway in the oxidative stress-induced mitochondrial dysfunction and apoptosis seen in rheumatoid arthritis-related fibroblast-like synoviocytes (RA-FLSs). Mst1 mRNA and protein expression was significantly higher ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103643
更新日期:2020-07-21 00:00:00
abstract::Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and d...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101022
更新日期:2016-08-29 00:00:00
abstract::Autophagy plays an important role in cell survival under diverse stress conditions. Here, we show that white LED light exposure for 24 h significantly activated autophagy-related genes and increased autophagosome formation in hippocampal neural cells (HT-22). Concurrently, the rhythmic pattern of clock-related gene ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101878
更新日期:2019-03-28 00:00:00
abstract::Stressors that disrupt homeostasis advance aging. Glucocorticoids regulate multiple processes that determine the aging trajectory. Debate exists regarding life-course circulating glucocorticoid concentrations. Rodent and nonhuman primate studies indicate circulating glucocorticoids fall from early life. We measured fa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101235
更新日期:2017-05-09 00:00:00
abstract::There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recru...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102151
更新日期:2019-08-26 00:00:00
abstract::Bedaquiline (a.k.a., Sirturo) is an anti-microbial agent, which is approved by the FDA for the treatment of multi-drug resistant pulmonary tuberculosis (TB). Bedaquiline is a first-in-class diaryl-quinoline compound, that mechanistically inhibits the bacterial ATP-synthase, and shows potent activity against both drug-...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100983
更新日期:2016-08-01 00:00:00
abstract::Alternative splicing (AS) changes are considered to be critical in predicting treatment response. Our study aimed to investigate differential splicing patterns and to elucidate the role of splicing factor (SF) as prognostic markers of low-grade glioma (LGG). We downloaded RNA-seq data from a cohort of 516 LGG tumors i...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103491
更新日期:2020-07-13 00:00:00
abstract::Melanoma is a skin malignancy with a high mutation frequency of genetic alterations. MicroRNA (miR)-200b-3p is involved in various cancers, while in melanoma its bio-function remains unknown. In this study, we found that miR-200b-3p was down-regulated in melanoma tissues and cell lines compared to benign nevus cells. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103909
更新日期:2020-11-16 00:00:00
abstract::Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight junctions (TJs) remains unclear. In the present study, we found that high salt d...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103348
更新日期:2020-06-22 00:00:00
abstract::Chronic inflammation, increased reactivity to self-antigens and incidences of cancer are hallmarks of aging. However, the underlying mechanisms are not well understood. Age-associated alterations in the DNA either due to oxidative damage, defects in DNA repair or epigenetic modifications such as methylation that lead ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100121
更新日期:2010-03-20 00:00:00
abstract::The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102110
更新日期:2019-07-22 00:00:00
abstract::Most muscle pathologies are characterized by the progressive loss of muscle tissue due to chronic degeneration combined with the inability of regeneration machinery to replace the damaged muscle. These pathological changes, known as muscle wasting, can be attributed to the activation of several proteolytic systems, su...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100050
更新日期:2009-05-13 00:00:00
abstract::Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions in arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles in the regulation of lipid metabolism and the inflammatory response. However, little is kn...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202273
更新日期:2021-01-10 00:00:00
abstract::Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102275
更新日期:2019-09-12 00:00:00
abstract::Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature senescence under sublethal oxidative stress, however underlying mechanism remains unknown. Here, we showed that exogenous H2O2 induces a rapid phosphorylation and co-localization of ATM, H2A.X, 53BP1 leading to DNA damage response (DDR) acti...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100673
更新日期:2014-06-01 00:00:00
abstract::Increased activation of catabolic pathways, including apoptosis causes sarcopenia. However, the precise molecular mechanism that initiates apoptosis during aging is not well understood. Here, we report that aging alters miRNA expression profile in mouse skeletal muscle as evidenced by miRNA microarray and real-time PC...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101207
更新日期:2017-03-22 00:00:00