Abstract:
:Amyotrophic lateral sclerosis (ALS) is one of the most common motoneuronal disease, characterized by motoneuronal loss and progressive paralysis. Despite research efforts, ALS remains a fatal disease, with a survival of 2-5 years after disease onset. Numerous gene mutations have been correlated with both sporadic (sALS) and familiar forms of the disease, but the pathophysiological mechanisms of ALS onset and progression are still largely uncertain. However, a common profile is emerging in ALS pathological features, including misfolded protein accumulation and a cross-talk between neuroinflammatory and degenerative processes. In particular, astrocytes and microglial cells have been proposed as detrimental influencers of perineuronal microenvironment, and this role may be exerted via gap junctions (GJs)- and hemichannels (HCs)-mediated communications. Herein we investigated the role of the main astroglial GJs-forming connexin, Cx43, in human ALS and the effects of focal spinal cord motoneuronal depletion onto the resident glial cells and Cx43 levels. Our data support the hypothesis that motoneuronal depletion may affect glial activity, which in turn results in reactive Cx43 expression, further promoting neuronal suffering and degeneration.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Spitale FM,Vicario N,Rosa MD,Tibullo D,Vecchio M,Gulino R,Parenti Rdoi
10.18632/aging.103561subject
Has Abstractpub_date
2020-06-24 00:00:00pages
12598-12608issue
13issn
1945-4589pii
103561journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::Spinal cord injury (SCI) causes long-term and severe disability, influencing the quality of life and triggering serious socioeconomic consequences. Lack of effective pharmacotherapies for SCI is largely attributable to an incomplete understanding of its pathogenesis. Caspase recruitment domain family member 6 (CARD6) ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102561
更新日期:2019-12-16 00:00:00
abstract::In this study, we investigated the mechanistic role and prognostic significance of the long coding RNA (lncRNA) KCNQ1OT1 in colorectal cancer (CRC). KCNQ1OT1 levels were significantly higher in CRC tissues than adjacent normal colorectal tissues (n=79). High KCNQ1OT1 expression correlated with poorer prognosis in CRC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103334
更新日期:2020-06-21 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102377
更新日期:2019-10-30 00:00:00
abstract::Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.101784
更新日期:2019-01-23 00:00:00
abstract::Lung cancer remains the most lethal cancer worldwide because of its high metastasis potential. Epithelial-mesenchymal transition (EMT) is known as the first step of the metastasis cascade, but the potential regulatory mechanisms of EMT have not been clearly established. In this study, we first found that low CUEDC1 ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103329
更新日期:2020-10-25 00:00:00
abstract::Reducing the expression of the Indy (I'm Not Dead Yet) gene in lower organisms extends life span by mechanisms resembling caloric restriction. Similarly, deletion of the mammalian homolog, mIndy (Slc13a5), encoding for a plasma membrane tricarboxylate transporter, protects from aging- and diet-induced adiposity and in...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100854
更新日期:2015-12-01 00:00:00
abstract::Detecting low-abundance mutations is very important for cancer diagnosis and treatment. Here we describe an improved targeted sequencing analysis that dramatically increases sequencing depth. Seven colorectal cancer (CRC) patients and seven healthy adults were enrolled in this study. We examined genetic mutations in t...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102657
更新日期:2020-01-12 00:00:00
abstract::In this retrospective study we assessed the efficacy and safety of tocilizumab in patients with critical or severe coronavirus disease 2019 (COVID-19). We enrolled 181 patients admitted to Huoshenshan Hospital (Wuhan, China) with confirmed COVID-19 between January 2020 and February 2020. Ninety-two patients were treat...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103988
更新日期:2020-10-08 00:00:00
abstract::Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients' survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCG...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103972
更新日期:2020-11-10 00:00:00
abstract::Combination treatment is a promising strategy to improve prognosis of hepatocellular carcinoma (HCC). Sorafenib is a traditional first-line agent approved for the treatment of advanced HCC, though with limited efficacy. Previously, we reported that lonafarnib, an orally bioavailable non-peptide inhibitor targeting far...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102165
更新日期:2019-08-13 00:00:00
abstract:BACKGROUND:Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inope...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102292
更新日期:2019-10-25 00:00:00
abstract::Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101256
更新日期:2017-06-28 00:00:00
abstract::The relationship between aging and daily "circadian" behavior in humans is bidirectional: on the one hand, dysfunction of circadian clocks promotes age-related maladies; on the other, aging per se leads to changes and disruption in circadian behavior and physiology. For the latter case, recent research suggests that c...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100366
更新日期:2011-08-01 00:00:00
abstract::Multiple recent advances in machine learning enabled computer systems to exceed human performance in many tasks including voice, text, and speech recognition and complex strategy games. Aging is a complex multifactorial process driven by and resulting in the many minute changes transpiring at every level of the human ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.102475
更新日期:2019-11-25 00:00:00
abstract::Studies in young mammals on the molecular effects of food restriction leading to prolong adult life are scares. Here, we used high-throughput quantitative proteomic analysis of whole rat livers to address the molecular basis for growth arrest and the apparent life-prolonging phenotype of the food restriction regimen. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101009
更新日期:2016-08-01 00:00:00
abstract::Of all the major organ systems in the body, the ovaries of females are the first to exhibit impaired function with advancing age. Until recently, traditional thinking was that female mammals are provided with a non-renewable pool of oocyte-containing follicles at birth that are depleted during postnatal life to exhaus...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100105
更新日期:2009-12-12 00:00:00
abstract::Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported t...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102337
更新日期:2019-10-07 00:00:00
abstract::Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD). Diverse studies have shown a bidirectional relationship between Klotho and inflammation, a risk factor for the development of CVD. In this work we aimed to evaluate the association between Klotho and inflammatory cytoki...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102734
更新日期:2020-01-27 00:00:00
abstract::Docetaxel is a first-line anticancer drug widely used in the treatment of advanced prostate cancer. However, its therapeutic efficacy is limited by its side effects and the development of chemoresistance by the tumor. Using a gene differential expression microarray, we identified 449 genes differentially expressed in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102600
更新日期:2019-12-29 00:00:00
abstract::Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103669
更新日期:2021-01-05 00:00:00
abstract::Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202405
更新日期:2020-12-26 00:00:00
abstract::Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mas...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103286
更新日期:2020-06-05 00:00:00
abstract::Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104122
更新日期:2020-11-12 00:00:00
abstract::Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103363
更新日期:2020-06-19 00:00:00
abstract::In addition to its traditional role in the regulation of calcium homeostasis and bone metabolism, vitamin D also exhibits immunomodulatory, anti-proliferative and cancer preventive activities. Molecular mechanisms that confer the chemo-preventive properties to vitamin D are poorly understood. We previously reported th...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100450
更新日期:2012-04-01 00:00:00
abstract::Bone volume inadequacy is an emerging clinical problem impairing the feasibility and longevity of dental implants. Human bone marrow mesenchymal stem cells (HBMSCs) have been widely used in bone remodeling and regeneration. This study examined the effect of long noncoding RNAs (lncRNAs)-H19 on the human amnion-derived...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103277
更新日期:2020-05-20 00:00:00
abstract::Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102856
更新日期:2020-02-26 00:00:00
abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103907
更新日期:2020-10-08 00:00:00
abstract::DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more ...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100281
更新日期:2011-02-01 00:00:00
abstract::N6-methyladenosine (m6A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m6A RNA methylation regulators. However, the expression of m6A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 cen...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103811
更新日期:2020-09-20 00:00:00